JAK2 inhibition prevents innate immune responses and rescues animals from sepsis

Journal of Molecular Medicine

Volumn 88, Issue 8, 2010, Pages 851-859

  Peña, Geber ^a   Cai, Bolin ^a   Deitch, Edwin A ^a   Ulloa, Luis ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Alpha7nachr; Cytokines; HMGB1; Inflammation; Nicotinic receptors; Sepsis; TNF

Indexed keywords

BUNGAROTOXIN RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; LIPOPOLYSACCHARIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; CYTOKINE; ENZYME INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TYRPHOSTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME INHIBITION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MALE; MIXED INFECTION; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SEPSIS; SPLEEN CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CELL LINE; DRUG EFFECTS; IMMUNOLOGY; MACROPHAGE;

ANIMALS; CELL LINE; CYTOKINES; ENZYME INHIBITORS; HMGB1 PROTEIN; HUMANS; IMMUNITY, INNATE; JANUS KINASE 2; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; SEPSIS; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; TYRPHOSTINS;

EID: 77956464268     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0628-z     Document Type: Article

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