-
1
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M, (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
3
-
-
35148847384
-
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
-
Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, et al. (2007) Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12: 355-366.
-
(2007)
Cancer Cell
, vol.12
, pp. 355-366
-
-
Itahana, K.1
Mao, H.2
Jin, A.3
Itahana, Y.4
Clegg, H.V.5
-
4
-
-
77449101168
-
Mdm2-mediated ubiquitylation: p53 and beyond
-
Marine JC, Lozano G (2010) Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ 17: 93-102.
-
(2010)
Cell Death Differ
, vol.17
, pp. 93-102
-
-
Marine, J.C.1
Lozano, G.2
-
5
-
-
33847365838
-
MDM2-regulated degradation of HIPK2 prevents p53 Ser46 phosphorylation and DNA damage-induced apoptosis
-
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, et al. (2007) MDM2-regulated degradation of HIPK2 prevents p53 Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25: 739-750.
-
(2007)
Mol Cell
, vol.25
, pp. 739-750
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
-
6
-
-
26844462296
-
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations
-
Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G, (2005) HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett 579: 5473-80.
-
(2005)
FEBS Lett
, vol.579
, pp. 5473-5480
-
-
Di Stefano, V.1
Mattiussi, M.2
Sacchi, A.3
D'Orazi, G.4
-
7
-
-
0031457978
-
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
-
Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, et al. (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90: 181-192.
-
(1997)
Cell
, vol.90
, pp. 181-192
-
-
Zeng, L.1
Fagotto, F.2
Zhang, T.3
Hsu, W.4
Vasicek, T.J.5
-
8
-
-
10644290911
-
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
-
Rui Y, Xu Z, Lin S, Li Q, Rui H, et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J 23: 4583-4594.
-
(2004)
EMBO J
, vol.23
, pp. 4583-4594
-
-
Rui, Y.1
Xu, Z.2
Lin, S.3
Li, Q.4
Rui, H.5
-
9
-
-
33846421621
-
Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death
-
Li Q, Wang X, Wu X, Rui Y, Liu W, et al. (2007) Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res 67: 66-74.
-
(2007)
Cancer Res
, vol.67
, pp. 66-74
-
-
Li, Q.1
Wang, X.2
Wu, X.3
Rui, Y.4
Liu, W.5
-
10
-
-
0033521002
-
Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling
-
Zhang Y, Neo SY, Wang X, Han J, Lin SC, (1999) Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J Biol Chem 274: 35247-35254.
-
(1999)
J Biol Chem
, vol.274
, pp. 35247-35254
-
-
Zhang, Y.1
Neo, S.Y.2
Wang, X.3
Han, J.4
Lin, S.C.5
-
11
-
-
0026849821
-
Definition of a consensus binding site for p53
-
el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B, (1992) Definition of a consensus binding site for p53. Nat Genet 1: 45-49.
-
(1992)
Nat Genet
, vol.1
, pp. 45-49
-
-
el-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
12
-
-
0028145057
-
p53 tagged sites from human genomic DNA
-
Tokino T, Thiagalingam S, el-Deiry WS, Waldman T, Kinzler KW, et al. (1994) p53 tagged sites from human genomic DNA. Hum Mol Genet 3: 1537-1542.
-
(1994)
Hum Mol Genet
, vol.3
, pp. 1537-1542
-
-
Tokino, T.1
Thiagalingam, S.2
el-Deiry, W.S.3
Waldman, T.4
Kinzler, K.W.5
-
13
-
-
36349020165
-
MDM2 chaperones the p53 tumor suppressor
-
Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M, (2007) MDM2 chaperones the p53 tumor suppressor. J Biol Chem 282: 32603-32612.
-
(2007)
J Biol Chem
, vol.282
, pp. 32603-32612
-
-
Wawrzynow, B.1
Zylicz, A.2
Wallace, M.3
Hupp, T.4
Zylicz, M.5
-
14
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, et al. (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-8.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
-
15
-
-
69949171963
-
Axin determines cell fate by controlling the p53 activation threshold after DNA damage
-
Li Q, Lin S, Wang X, Lian G, Lu Z, et al. (2009) Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol 11: 1128-1134.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1128-1134
-
-
Li, Q.1
Lin, S.2
Wang, X.3
Lian, G.4
Lu, Z.5
-
16
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274: 948-53.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
Elenbaas, B.4
Moreau, J.5
-
17
-
-
33644673642
-
Structural details on mdm2-p53 interaction
-
Chi SW, Lee SH, Kim DH, Ahn MJ, Kim JS, et al. (2005) Structural details on mdm2-p53 interaction. J Biol Chem 280: 38795-802.
-
(2005)
J Biol Chem
, vol.280
, pp. 38795-38802
-
-
Chi, S.W.1
Lee, S.H.2
Kim, D.H.3
Ahn, M.J.4
Kim, J.S.5
-
18
-
-
0035845853
-
UV-radiation induces dose- dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts
-
Latonen L, Taya Y, Laiho M, (2001) UV-radiation induces dose- dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 20: 6784-6793.
-
(2001)
Oncogene
, vol.20
, pp. 6784-6793
-
-
Latonen, L.1
Taya, Y.2
Laiho, M.3
-
19
-
-
34247340469
-
Axin bridges Daxx to p53
-
Lin SC, Li Q, (2007) Axin bridges Daxx to p53. Cell Res 17: 301-302.
-
(2007)
Cell Res
, vol.17
, pp. 301-302
-
-
Lin, S.C.1
Li, Q.2
-
20
-
-
0037007236
-
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
-
Legube G, Linares LK, Lemercier C, Scheffner M, Khochbin S, et al. (2002) Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. Embo J 21: 1704-1712.
-
(2002)
Embo J
, vol.21
, pp. 1704-1712
-
-
Legube, G.1
Linares, L.K.2
Lemercier, C.3
Scheffner, M.4
Khochbin, S.5
-
21
-
-
33746648187
-
Critical role for Daxx in regulating Mdm2
-
Tang J, Qu LK, Zhang J, Wang W, Michaelson JS, et al. (2006) Critical role for Daxx in regulating Mdm2. Nat Cell Biol 8: 855-862.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 855-862
-
-
Tang, J.1
Qu, L.K.2
Zhang, J.3
Wang, W.4
Michaelson, J.S.5
|