Metabolomics study of type 2 diabetes and therapeutic effects of Tianqijiangtang-capsule using ultra-performance liquid chromatography/ electrospray ionization quadruple time-of-flight mass spectrometry

Analytical Methods

Volumn 5, Issue 9, 2013, Pages 2218-2226

  Wang, Xijun ^a   Zhang, Shuxiang ^a   Zhang, Aihua ^a   Yan, Guangli ^a   Wu, Xiuhong ^a   Han, Ying ^a   Sun, Hui ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPREHENSIVE ASSESSMENT; ENDOGENOUS METABOLITES; LOW MOLECULAR WEIGHT; PARTIAL LEAST SQUARES-DISCRIMINANT ANALYSIS; PHARMACOLOGICAL EFFECTS; PRINCIPAL COMPONENTS ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY;

BIOMOLECULES; DISCRIMINANT ANALYSIS; ELECTROSPRAY IONIZATION; INDUCTIVELY COUPLED PLASMA; LEAST SQUARES APPROXIMATIONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PATTERN RECOGNITION;

PRINCIPAL COMPONENT ANALYSIS;

EID: 84879527102     PISSN: 17599660     EISSN: 17599679     Source Type: Journal    
DOI: 10.1039/c3ay00027c     Document Type: Article

References (31)

1. C. E. Hagberg A. Mehlem A. Falkevall L. Muhl B. C. Fam H. Ortsäter P. Scotney D. Nyqvist E. Samén L. Lu S. Stone-Elander J. Proietto S. Andrikopoulos A. Sjöholm A. Nash U. Eriksson Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes Nature 2012 490 7420 426 430
2. J. Qin Y. Li Z. Cai S. Li J. Zhu F. Zhang S. Liang W. Zhang Y. Guan D. Shen Y. Peng D. Zhang Z. Jie W. Wu Y. Qin W. Xue J. Li L. Han D. Lu P. Wu Y. Dai X. Sun Z. Li A. Tang S. Zhong X. Li W. Chen R. Xu M. Wang Q. Feng M. Gong J. Yu Y. Zhang M. Zhang T. Hansen G. Sanchez J. Raes G. Falony S. Okuda M. Almeida E. LeChatelier P. Renault N. Pons J. M. Batto Z. Zhang H. Chen R. Yang W. Zheng S. Li H. Yang J. Wang S. D. Ehrlich R. Nielsen O. Pedersen K. Kristiansen J. Wang A metagenome-wide association study of gut microbiota in type 2 diabetes Nature 2012 490 7418 55 60
3. X. Wang H. Wang A. Zhang X. Lu H. Sun H. Dong P. Wang Metabolomics study on the toxicity of aconite root and its processed products using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis J. Proteome Res. 2012 11 2 1284 1301
4. 1H NMR- and GC-MS-based metabolite profiling Analyst 2011 136 20 4222 4231
5. M. Kleiner C. Wentrup C. Lott H. Teeling S. Wetzel J. Young Y. J. Chang M. Shah N. C. Verberkmoes J. Zarzycki G. Fuchs S. Markert K. Hempel B. Voigt D. Becher M. Liebeke M. Lalk D. Albrecht M. Hecker T. Schweder N. Dubilier Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use Proc. Natl. Acad. Sci. U. S. A. 2012 109 E1173 E1182
6. X. Wang H. Sun A. Zhang W. Sun P. Wang Z. Wang Potential role of metabolomics approaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine J. Pharm. Biomed. Anal. 2011 55 5 859 868
7. F. Courant A. L. Royer S. Chéreau M. L. Morvan F. Monteau J. P. Antignac B. Le Bizec Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples Analyst 2012 137 21 4958 4967
8. X. Wang H. Sun A. Zhang G. Jiao W. Sun Y. Yuan Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods Analyst 2011 136 23 5068 5076
9. Q. Teng D. R. Ekman W. Huang T. W. Collette Push-through direct injection NMR: an optimized automation method applied to metabolomics Analyst 2012 137 9 2226 2232
10. S. X. Zhang H. Sun W. J. Sun G. Z. Jiao X. J. Wang Proteomic study of serum proteins in a type 2 diabetes mellitus rat model by Chinese traditional medicine Tianqijiangtang capsule administration J. Pharm. Biomed. Anal. 2010 53 4 1011 1014
11. X. Wang A. Zhang Y. Han P. Wang H. Sun G. Song T. Dong Y. Yuan X. Yuan M. Zhang N. Xie H. Zhang H. Dong W. Dong Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease Mol. Cell. Proteomics 2012 11 8 370 380
12. A. Zhang H. Sun Y. Han Y. Yuan P. Wang G. Song X. Yuan M. Zhang N. Xie X. Wang Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach Analyst 2012 137 18 4200 4208
13. X. Wang A. Zhang H. Sun Future perspectives of Chinese medical formulae: chinmedomics as an effector OMICS 2012 16 7-8 414 421
14. H. Sun B. Ni A. Zhang M. Wang H. Dong X. Wang Metabolomics study on Fuzi and its processed products using ultra-performance liquid-chromatography/ electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis Analyst 2012 137 1 170 185
15. X. Wang B. Yang H. Sun A. Zhang Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets Anal. Chem. 2012 84 1 428 439
16. B. Yang A. Zhang H. Sun W. Dong G. Yan T. Li X. Wang Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry J. Pharm. Biomed. Anal. 2012 58 113 124
17. A. Zhang H. Sun P. Wang Y. Han X. Wang Modern analytical techniques in metabolomics analysis Analyst 2012 137 2 293 300
18. H. Dong A. Zhang H. Sun H. Wang X. Lu M. Wang B. Ni X. Wang Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods Mol. BioSyst. 2012 8 4 1206 1221
19. X. Wang H. Sun A. Zhang P. Wang Y. Han Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies J. Sep. Sci. 2011 34 24 3451 3459
20. A. Zhang H. Sun P. Wang Y. Han X. Wang Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity Pharmazie 2012 67 2 99 105
21. T. J. Wang M. G. Larson R. S. Vasan S. Cheng E. P. Rhee E. McCabe G. D. Lewis C. S. Fox P. F. Jacques C. Fernandez C. J. O'Donnell S. A. Carr V. K. Mootha J. C. Florez A. Souza O. Melander C. B. Clish R. E. Gerszten Metabolite profiles and the risk of developing diabetes Nat. Med. 2011 17 4 448 453
22. K. Suhre C. Meisinger A. Döring E. Altmaier P. Belcredi C. Gieger D. Chang M. V. Milburn W. E. Gall K. M. Weinberger H. W. Mewes M. Hrabé de Angelis H. E. Wichmann F. Kronenberg J. Adamski T. Illig Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting PLoS One 2010 5 11 e13953
23. L. C. Zhao X. D. Zhang S. X. Liao H. C. Gao H. Y. Wang D. H. Lin A metabonomic comparison of urinary changes in Zucker and GK rats J. Biomed. Biotechnol. 2010 2010 431894
24. Y. Bao T. Zhao X. Wang Y. Qiu M. Su W. Jia W. Jia Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers J. Proteome Res. 2009 8 4 1623 1630
25. X. Zhang Y. Wang F. Hao X. Zhou X. Han H. Tang L. Ji Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses J. Proteome Res. 2009 8 11 5188 5195
26. X. Li Z. Xu X. Lu X. Yang P. Yin H. Kong Y. Yu G. Xu Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus Anal. Chim. Acta 2009 633 2 257 262
27. A. D. Patterson J. A. Bonzo F. Li K. W. Krausz G. S. Eichler S. Aslam X. Tigno J. N. Weinstein B. C. Hansen J. R. Idle F. J. Gonzalez Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus J. Biol. Chem. 2011 286 22 19511 19522
28. R. Wang-Sattler Z. Yu C. Herder A. C. Messias A. Floegel Y. He K. Heim M. Campillos C. Holzapfel B. Thorand H. Grallert T. Xu E. Bader C. Huth K. Mittelstrass A. Döring C. Meisinger C. Gieger C. Prehn W. Roemisch-Margl M. Carstensen L. Xie H. Yamanaka-Okumura G. Xing U. Ceglarek J. Thiery G. Giani H. Lickert X. Lin Y. Li H. Boeing H. G. Joost M. H. de Angelis W. Rathmann K. Suhre H. Prokisch A. Peters T. Meitinger M. Roden H. E. Wichmann T. Pischon J. Adamski T. Illig Novel biomarkers for pre-diabetes identified by metabolomics Mol. Syst. Biol. 2012 8
29. T. J. Wang M. G. Larson R. S. Vasan S. Cheng E. P. Rhee E. McCabe G. D. Lewis C. S. Fox P. F. Jacques C. Fernandez C. J. O'Donnell S. A. Carr V. K. Mootha J. C. Florez A. Souza O. Melander C. B. Clish R. E. Gerszten Metabolite profiles and the risk of developing diabetes Nat. Med. 2011 17 4 448 453
30. A. Zhang H. Sun S. Dou W. Sun X. Wu P. Wang X. Wang Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry Analyst 2013 138 1 353 361
31. M. Tomita K. Kami Cancer. Systems biology, metabolomics, and cancer metabolism Science 2012 336 6084 990 991