MiR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 26, 2013, Pages 10765-10770

  Patel, Vishal ^a   Williams, Darren ^a   Hajarnis, Sachin ^a   Hunter, Ryan ^a   Pontoglio, Marco ^b   Somlo, Stefan ^c   Igarashi, Peter ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b INSERM   (France)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autosomal dominant polycystic kidney disease; Cilia; Kinesin family member 3A

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1BETA; MICRORNA; MICRORNA 17-92; POLYCYSTIN 1; POLYCYSTIN 2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; CELL PROLIFERATION; GAIN OF FUNCTION MUTATION; GENE CLUSTER; GENE DOSAGE; GENE EXPRESSION; GENE REPRESSION; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; LOSS OF FUNCTION MUTATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURVIVAL; UPREGULATION;

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE; CILIA; KINESIN FAMILY MEMBER 3A;

ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; KIDNEY TUBULES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICRORNAS; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; TRPP CATION CHANNELS; UP-REGULATION;

MUS;

EID: 84879526558     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301693110     Document Type: Article

References (43)

1. Igarashi P, Somlo S (2002) Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 13(9):2384-2398.
2. Harris PC, Torres VE (2009) Polycystic kidney disease. Annu Rev Med 60:321-337.
3. Patel V, Chowdhury R, Igarashi P (2009) Advances in the pathogenesis and treatment of polycystic kidney disease. Curr Opin Nephrol Hypertens 18(2):99-106.
4. Lin F, et al. (2003) Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 100(9):5286-5291.
5. Patel V, et al. (2008) Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17(11):1578-1590.
6. Bartel DP (2009) MicroRNAs: Target recognition and regulatory functions. Cell 136(2): 215-233.
7. Mendell JT, Olson EN (2012) MicroRNAs in stress signaling and human disease. Cell 148(6):1172-1187.
8. Small EM, Olson EN (2011) Pervasive roles of microRNAs in cardiovascular biology. Nature 469(7330):336-342.
9. van Rooij E, Marshall WS, Olson EN (2008) Toward microRNA-based therapeutics for heart disease: The sense in antisense. Circ Res 103(9):919-928.
10. Patel V, et al. (2012) MicroRNAs regulate renal tubule maturation through modulation of Pkd1. J Am Soc Nephrol 23(12):1941-1948.
11. Patel V, Noureddine L (2012) MicroRNAs and fibrosis. Curr Opin Nephrol Hypertens 21(4):410-416.
12. Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA (2011) Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol 5:56.
13. Pandey P, et al. (2008) Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics 9:624.
14. Shao X, Somlo S, Igarashi P (2002) Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 13(7):1837-1846.
15. Tran U, et al. (2010) The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development 137(7):1107-1116.
16. Fedeles SV, et al. (2011) A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet 43(7):639-647.
17. Williams SS, Cobo-Stark P, James LR, Somlo S, Igarashi P (2008) Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease. Pediatr Nephrol 23(5):733-741.
18. Gresh L, et al. (2004) A transcriptional network in polycystic kidney disease. EMBO J 23(7):1657-1668.
19. Xiao C, et al. (2008) Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 9(4):405-414.
20. Ventura A, et al. (2008) Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132(5):875-886.
21. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(1): 15-20.
22. Cloonan N, et al. (2008) The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol 9(8):R127.
23. Sun H, et al. (2010) MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation. Mol Biol Rep 37(6):2951-2958.
24. Ma Z, et al. (2007) Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. Proc Natl Acad Sci USA 104(51):20386-20391.
25. Verdeguer F, et al. (2010) A mitotic transcriptional switch in polycystic kidney disease. Nat Med 16(1):106-110.
26. Bhunia AK, et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109(2):157-168.
27. Li X, et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol 7(12):1202-1212.
28. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435(7043):839-843.
29. Shibazaki S, et al. (2008) Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17(11): 1505-1516.
30. Hopp K, et al. (2012) Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity. J Clin Invest 122(11):4257-4273.
31. Hiesberger T, et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest 113(6):814-825.
32. Rossetti S, et al. (2009) Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease. Kidney Int 75(8):848-855.
33. Pei Y, et al. (2012) A missense mutation in PKD1 attenuates the severity of renal disease. Kidney Int 81(4):412-417.
34. Lantinga-van Leeuwen IS, et al. (2004) Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. Hum Mol Genet 13(24):3069-3077.
35. Bergmann C, et al. (2011) Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. J Am Soc Nephrol 22(11):2047-2056.
36. Wu G, et al. (2002) Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease. Hum Mol Genet 11(16):1845-1854.
37. Garcia-Gonzalez MA, et al. (2007) Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16(16):1940-1950.
38. Kim I, et al. (2008) Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol 19(3):455-468.
39. Pei Y, et al. (2001) Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. Am J Hum Genet 68(2):355-363.
40. Mendell JT (2008) miRiad roles for the miR-17-92 cluster in development and disease. Cell 133(2):217-222.
41. Nittner D, et al. (2012) Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol 14(9):958-965.
42. Conkrite K, et al. (2011) miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev 25(16):1734-1745.
43. Nishio S, et al. (2010) Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol 21(2):295-302. Diseases Diseases Diseases Diseases