Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells

Journal of Applied Toxicology

Volumn 33, Issue 8, 2013, Pages 756-765

  Wei, Jianteng ^a,c   Liu, Ming ^a   Liu, Haizhou ^a   Wang, Hui ^a,c   Wang, Fengxia ^d   Zhang, Yuyan ^e   Han, Lijun ^a   Lin, Xiukun ^a,b  

^a INSTITUTE OF OCEANOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d SHANDONG UNIVERSITY   (China)

^e QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Lysosomal membrane permeabilization; Mitochondrial depolarization; Oleanolic acid; ROS

Indexed keywords

ASCORBIC ACID; CASPASE 3; CASPASE 9; CATHEPSIN B; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLEANOLIC ACID; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LYSOSOME MEMBRANE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CYTOCHROMES C; DNA FRAGMENTATION; HUMANS; LYSOSOMES; MITOCHONDRIA; OLEANOLIC ACID; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES;

EID: 84879499444     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2725     Document Type: Article

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