A whey protein hydrolysate promotes insulinotropic activity in a clonal pancreatic β-cell line and enhances glycemic function in ob/ob mice

Journal of Nutrition

Volumn 143, Issue 7, 2013, Pages 1109-1114

  Gaudel, Celine ^a,d   Nongonierma, Alice B ^b,d   Maher, Samuel ^a,d,e   Flynn, Sarah ^a,d   Krause, Mauricio ^a,d   Murray, Brian A ^c,d   Kelly, Phillip M ^c,d   Baird, Alan W ^a,d   FitzGerald, Richard J ^b,d   Newsholme, Philip ^a,d,f  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF LIMERICK   (Ireland)

^c TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^d Food for Health Ireland   (Ireland)

^e ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^f CURTIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN HYDROLYSATE; UNCLASSIFIED DRUG; WHEY PROTEIN HYDROLYSATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENOTYPE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN RESISTANCE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL;

ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTESTINES; MICE; MICE, OBESE; MILK PROTEINS; PROTEIN HYDROLYSATES;

ANIMALIA; MUS;

EID: 84879486166     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.174912     Document Type: Article

References (37)

1. Schrezenmeir J, Jagla A. Milk and diabetes. J Am Coll Nutr. 2000;19: S176-90.
2. WHO. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: WHO; 2006.
3. Manders RJ, Koopman R, Sluijsmans WE, van den Berg R, Verbeek K, Saris WH, Wagenmakers AJ, van Loon LJ. Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men. J Nutr. 2006;136:1294-9.
4. Tremblay A, Gilbert J-A. Milk products, insulin resistance syndrome and Type 2 diabetes. J Am Coll Nutr. 2009;28:S91-102.
5. FitzGerald RJ, Meisel H. Milk protein hydrolysates and bioactive peptides. In: Fox PF, McSweeney PLH, editors. Advanced dairy chemistry. 1st vol. Proteins Part B. 3rd ed. New York: Kluwer Academic/Plenum Publishers; 2003. p. 675-98.
6. Korhonen H, Pilhanto A. Bioactive peptides: production and functionality. Int Dairy J. 2006;16:945-60.
7. Pihlanto A. Whey proteins and peptides. Nutrafoods. 2011;10:29-42.
8. Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB. Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med. 2005;165:997-1003.
9. Manders RJ, Praet SF, Meex RC, Koopman R, de Roos AL,Wagenmakers AJ, Saris WH, van Loon LJ. Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients. Diabetes Care. 2006;29:2721-2.
10. Frid AH, Nilsson M, Holst JJ, Björck IM. Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. Am J Clin Nutr. 2005;82:69-75.
11. Dixon G, Nolan J, McClenaghan N, Flatt P, Newsholme P. A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11: the functional significance of L-alanine. J Endocrinol. 2003;179:447-54.
12. Newsholme P, Brennan L, and Bender K. Amino acid metabolism, b-cell function, and diabetes. Diabetes. 2006;55S2:S39-47.
13. Luhovyy BL, Akhavan T, Anderson GH. Whey proteins in the regulation of food intake and satiety. J Am Coll Nutr. 2007;26:S704-12.
14. Geerts BF, Dongen MGJv, Flameling B, Moerland MM, Kam MLd, Cohen AF, Romijn JA, Gerhardt CC, Kloek J, Burggraaf J. Hydrolyzed casein decreases postprandial glucose concentrations in T2DM patients irrespective of leucine content. J Diet Suppl. 2011;8:280-92.
15. van Loon LJ, Saris WH, Verhagen H, Wagenmakers AJ. Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr. 2000;72:96-105.
16. Nongonierma AB, FitzGerald D. Tryptophan-containing milk proteinderived dipeptides inhibit xanthine oxidase. Peptides. 2012;37:263-72.
17. Spellman D, OCuinn G, FitzGerald RJ. Bitterness in Bacillus proteinase hydrolysates of whey proteins. Food Chem. 2009;114:440-6.
18. Mounier J, Rea MC, O'Connor PM, Fitzgerald GF, Cogan TM. Growth characteristics of Brevibacterium, Corynebacterium, Microbacterium, and Staphylococcus spp. isolated from surface-ripened cheese. Appl Environ Microbiol. 2007;73:7732-9.
19. Kiely A, McClenaghan NH, Flatt PR, Newsholme P. Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic b-cell line. J Endocrinol. 2007;195:113-23.
20. Pruznak AM, Kazi AA, Frost RA, Vary TC, Lang CH. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1- b-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr. 2008;138:1887-94.
21. Krause MS, McClenaghan NH, Flatt PR, de Bittencourt PI, Murphy C, Newsholme P. L-arginine is essential for pancreatic beta-cell functional integrity, metabolism and defense from inflammatory challenge. J Endocrinol. 2011;211:87-97.
22. Newsholme P, Bender K, Kiely A, Brennan L. Amino acid metabolism, insulin secretion and diabetes. Biochem Soc Trans. 2007;35:1180-6.
23. Gault VA, OHarte FPM, Flatt PR. Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential? Neuropeptides. 2003;37:253-63.
24. Gault VA, Flatt PR, OHarte FPM. Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem Biophys Res Commun. 2003;308:207-13.
25. Akhavan T, Luhovyy BL, Brown PH, Cho CE, Anderson GH. Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults. Am J Clin Nutr. 2010;91:966-75.
26. Power O, Hallihan A, Jakeman P. Human insulinotropic response to oral ingestion of native and hydrolysed whey protein. Amino Acids. 2009;37:333-9.
27. van Loon LJC, Kruijshoop M, Menheere PPCA, Wagenmakers AJM, Saris WHM, Keizer HA. Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. Diabetes Care. 2003;26:625-30.
28. Morifuji .M. Ishizaka M, Baba S, Fukuda K, Matsumoto H, Koga J, Kanegae M, HiguchiM. Comparison of different sources and degrees of hydrolysis of dietary protein: effect on plasma amino acids, dipeptides, and insulin responses in human subjects. J Agric Food Chem. 2010;58: 8788-97.
29. Gardner MLG. Entry of peptides of dietary origin into the circulation. Nutr Health. 1983;1983:163-71.
30. Castell-Auv'i A, Cedo L, Pallares V, Blay MT, Pinent M, Motilva MJ, Arola L, Ardevol A. Development of a coculture system to evaluate the bioactivity of plant extracts on pancreatic beta-cells. Planta Med. 2010; 76:1576-81.
31. Foltz M, Meynen EE, Bianco V, van Platerink C, Koning TMMG, Kloek J. Angiotensin converting enzyme inhibitory peptides from a lactotripeptideenriched milk beverage are absorbed intact into the circulation. J Nutr. 2007;137:953-8.
32. Lacroix IME, Li-Chan ECY. Dipeptidyl peptidase-IV inhibitory activity of dairy protein hydrolysates. Int Dairy J. 2012;25:97-102.
33. Nongonierma AB, FitzGerald RJ. Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk protein-derived dipeptides and hydrolysates. Peptides. 2013;39:157-63.
34. Shertzer HG, Woods SE, Krishan M, Genter MB, Pearson KJ. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. J Nutr. 2011;141:582-7.
35. Xu Q, Wang J, Liu Y, Xue C. Hydrolysis method for whey protein and the hypoglycemic activity of its peptides in diabetic KKAy mice. Wei Sheng Yan Jiu. 2011;40:624-7.
36. Nakaoka F, Sasakawa Y, Yamamoto K, Nakao M, Nakamura M, Tong C, Fukuhama C, Kagawa K. Anti-diabetic effects of globin digest and its active ingredient Leu-Ser-Glu-Leu in ICR mice, streptozotocin-induced diabetic mice and KK-Ay mice. Life Sci. 2010;86:424-34.
37. Toedebusch RG, Childs TE, Hamilton SR, Crowley JR, Booth FW, Roberts MD. Postprandial leucine and insulin responses and toxicological effects of a novel whey protein hydrolysate-based supplement in rats. J Int Soc Sports Nutr. 2012;9:24.