Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Tondeleir, Davina ^a   Drogat, Benjamin ^a,b,c   Slowicka, Karolina ^a,b   Bakkali, Karima ^a   Bartunkova, Sonia ^a,b   Goossens, Steven ^a,b   Haigh, Jody J ^a,b   Ampe, Christophe ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 2; ACTIN; GATA2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROID CELL; ERYTHROPOIESIS; GROWTH RETARDATION; HOMOZYGOSITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENE; VASCULARIZATION; YOLK SAC; ANIMAL; CELL CULTURE; CIRCULATION; CYTOLOGY; ERYTHROID PRECURSOR CELL; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL; MALE; METABOLISM; PHYSIOLOGY;

MAMMALIA; MUS;

ACTINS; ANIMALS; BLOOD CIRCULATION; CELLS, CULTURED; EMBRYONIC DEVELOPMENT; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; FEMALE; GATA2 TRANSCRIPTION FACTOR; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, KNOCKOUT;

EID: 84879476033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067855     Document Type: Article

References (45)

1. Vandekerckhove J, Weber K, (1978) At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol 126: 783-802.
2. Ponte P, Gunning P, Blau H, Kedes L, (1983) Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3′ untranslated regions are isotype specific but are conserved in evolution. Mol Cell Biol 3: 1783-1791.
3. Moos M, Gallwitz D, (1983) Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence. EMBO J 2: 757-761.
4. McHugh KM, Crawford K, Lessard JL, (1991) A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat. Dev Biol 148: 442-458.
5. Khaitlina SY, (2001) Functional specificity of actin isoforms. Int Rev Cytol 202: 35-98.
6. Hoock TC, Newcomb PM, Herman IM, (1991) Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury. J Cell Biol 112: 653-664.
7. Watanabe H, Kislauskis EH, Mackay CA, Mason-Savas A, Marks SC Jr, (1998) Actin mRNA isoforms are differentially sorted in normal osteoblasts and sorting is altered in osteoblasts from a skeletal mutation in the rat. J Cell Sci 111 (Pt 9): 1287-1292.
8. Hill MA, Gunning P, (1993) Beta and gamma actin mRNAs are differentially located within myoblasts. J Cell Biol 122: 825-832.
9. Dugina V, Zwaenepoel I, Gabbiani G, Clement S, Chaponnier C, (2009) Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci 122: 2980-2988.
10. Visa N, Percipalle P, (2010) Nuclear functions of actin. Cold Spring Harb Perspect Biol 2: a000620.
11. Hofmann WA, Stojiljkovic L, Fuchsova B, Vargas GM, Mavrommatis E, et al. (2004) Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol 6: 1094-1101.
12. Xu YZ, Thuraisingam T, Morais DA, Rola-Pleszczynski M, Radzioch D, (2010) Nuclear translocation of beta-actin is involved in transcriptional regulation during macrophage differentiation of HL-60 cells. Mol Biol Cell 21: 811-820.
13. Tondeleir D, Lambrechts A, Mueller M, Jonckheere V, Doll T, et al. (2012) Cells lacking beta-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics.
14. Bunnell TM, Burbach BJ, Shimizu Y, Ervasti JM, (2011) beta-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell 22: 4047-4058.
15. Crawford K, Flick R, Close L, Shelly D, Paul R, et al. (2002) Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period. Mol Cell Biol 22: 5887-5896.
16. Kumar A, Crawford K, Close L, Madison M, Lorenz J, et al. (1997) Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A 94: 4406-4411.
17. Schildmeyer LA, Braun R, Taffet G, Debiasi M, Burns AE, et al. (2000) Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J 14: 2213-2220.
18. Bunnell TM, Ervasti JM, (2010) Delayed embryonic development and impaired cell growth and survival in Actg1 null mice. Cytoskeleton (Hoboken) 67: 564-572.
19. Shmerling D, Danzer CP, Mao X, Boisclair J, Haffner M, et al. (2005) Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement. Genesis 42: 229-235.
20. Ema M, Takahashi S, Rossant J, (2006) Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 107: 111-117.
21. Drogat B, Kalucka J, Gutierrez L, Hammad H, Goossens S, et al. (2010) Vegf regulates embryonic erythroid development through Gata1 modulation. Blood 116: 2141-2151.
22. Nagy A (2003) Manipulating the Mouse Embryo: a laboratory manual. Cold Spring Harbor: Laboratoty Cold Spring Harbor. IX, 764.
23. Tsai FY, Orkin SH, (1997) Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89: 3636-3643.
24. Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, et al. (2007) A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development 134: 1703-1712.
25. Liu C, Levenstein M, Chen J, Tsifrina E, Yonescu R, et al. (1999) SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. Exp Hematol 27: 313-325.
26. Morris JF, Rauscher FJ 3rd, Davis B, Klemsz M, Xu D, et al. (1995) The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro. Blood 86: 3640-3647.
27. Lacaud G, Gore L, Kennedy M, Kouskoff V, Kingsley P, et al. (2002) Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood 100: 458-466.
28. Liao W, Ho CY, Yan YL, Postlethwait J, Stainier DY, (2000) Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 127: 4303-4313.
29. Tewari R, Gillemans N, Wijgerde M, Nuez B, von Lindern M, et al. (1998) Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. EMBO J 17: 2334-2341.
30. Bose F, Fugazza C, Casalgrandi M, Capelli A, Cunningham JM, et al. (2006) Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters. Mol Cell Biol 26: 3942-3954.
31. Woo AJ, Moran TB, Schindler YL, Choe SK, Langer NB, et al. (2008) Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol 28: 2675-2689.
32. Dolcet X, Llobet D, Pallares J, Matias-Guiu X, (2005) NF-kB in development and progression of human cancer. Virchows Arch 446: 475-482.
33. Semenza GL, (2001) HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13: 167-171.
34. Lee BK, Iyer VR, (2012) Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation. J Biol Chem 287: 30906-30913.
35. Kaplan J, Calame K, (1997) The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression. Nucleic Acids Res 25: 1108-1116.
36. Orford RL, Robinson C, Haydon JM, Patient RK, Guille MJ, (1998) The maternal CCAAT box transcription factor which controls GATA-2 expression is novel and developmentally regulated and contains a double-stranded-RNA-binding subunit. Mol Cell Biol 18: 5557-5566.
37. Nyabi O, Naessens M, Haigh K, Gembarska A, Goossens S, et al. (2009) Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells. Nucleic Acids Res 37: e55.
38. Peckham M, Miller G, Wells C, Zicha D, Dunn GA, (2001) Specific changes to the mechanism of cell locomotion induced by overexpression of beta-actin. J Cell Sci 114: 1367-1377.
39. Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G, (2004) Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 432: 625-630.
40. Medvinsky A, Rybtsov S, Taoudi S, (2011) Embryonic origin of the adult hematopoietic system: advances and questions. Development 138: 1017-1031.
41. Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, et al. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371: 221-226.
42. Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, et al. (2012) Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest 122: 3705-3717.
43. Huang Z, Dore LC, Li Z, Orkin SH, Feng G, et al. (2009) GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol 29: 5168-5180.
44. Olson EN, Nordheim A, (2010) Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol 11: 353-365.
45. Zheng B, Han M, Bernier M, Wen JK, (2009) Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression. FEBS J 276: 2669-2685.