Rhododendrin ameliorates skin inflammation through inhibition of NF-κB, MAPK, and PI3K/Akt signaling

European Journal of Pharmacology

Volumn 714, Issue 1-3, 2013, Pages 7-14

  Jeon, Yoon Jae ^a   Kim, Byung Hak ^a   Kim, Sunghwan ^a   Oh, Ikhoon ^b   Lee, Sooryun ^b   Shin, Jongheon ^b   Kim, Tae Yoon ^a  

^a The Catholic University of Korea   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Anti inflammatory activity; Inflammatory skin disease; Keratinocyte; Rhododendrin

Indexed keywords

CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RHODODENDRIN; RHODODENDRON BRACHYCARPUM EXTRACT; STRESS ACTIVATED PROTEIN KINASE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DERMATITIS; DOWN REGULATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KERATINOCYTE; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHODODENDRON; RHODODENDRON BRACHYCARPUM; TREATMENT OUTCOME; UPREGULATION;

ANTI-INFLAMMATORY ACTIVITY; INFLAMMATORY SKIN DISEASE; KERATINOCYTE; RHODODENDRIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; GLYCOSIDES; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; PHENOLS; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT LEAVES; PROTO-ONCOGENE PROTEINS C-AKT; RHODODENDRON; SKIN;

EID: 84879470271     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.041     Document Type: Article

References (57)

1. Baldwin Jr., A.S., 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683. (Pubitemid 26130197)
2. Barker, J.N., Mitra, R.S., Griffiths, C.E., Dixit, V.M., Nickoloff, B.J., 1991. Keratinocytes as initiators of inflammation. Lancet 337, 211-214.
3. Bickers, D.R., Athar, M., 2006. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 126, 2565-2575. (Pubitemid 44764040)
4. Bonizzi, G., Karin, M., 2004. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280-288. (Pubitemid 38610351)
5. Calzado, M.A., Bacher, S., Schmitz, M.L., 2007. NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr. Med. Chem. 14, 367-376.
6. Chang, CL., Zhang, L.J., Chen, R.Y., Kuo, L.M., Huang, J.P., Huang, H.C., Lee, K.H., Wu, Y.C., Kuo, Y.H., 2010. Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. J. Nat. Prod. 73, 1482-1488.
7. Chevalley, I., Marston, A., Hostettmann, K., 2000. New phenolic radical scavengers from saxifraga cuneifolia. Pharm. Biol. 38, 222-228. (Pubitemid 30616127)
8. Chuong, CM., Nickoloff, B.J., Elias, P.M., Goldsmith, LA, Macher, E., Maderson, P.A., Sundberg, J.P., Tagami, H., Plonka, P.M., Thestrup-Pederson, K., Bernard, B.A., Schroder, J.M., Dotto, P., Chang, CM., Williams, M.L., Feingold, K.R., King, L.E., Kligman, A.M., Rees, J.L, Christophers, E., 2002. What is the 'true' function of skin? Exp. Dermatol. 11, 159-187.
9. Danne, A., Petereit, F., Nahrstedt, A., 1994. Flavan-3-ols, prodelphinidins and further polyphenols from Cistus salvifolius. Phytochemistry 37, 533-538. (Pubitemid 2149366)
10. Faurschou, A., Gniadecki, R., 2008. TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes. Exp. Dermatol. 17, 992-997.
11. Gabr, S.A., Al-Ghadir, A.H., 2012. Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Arch. Dermatol. Res. 304, 451-457.
12. Geest, CR., Coffer, P.J., 2009. MAPK signaling pathways in the regulation of hematopoiesis. J. Leukocytes Biol. 86, 237-250.
13. Gloire, G., Legrand-Poels, S., Piette, J., 2006. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 72, 1493-1505. (Pubitemid 44666727)
14. Gupta, S.C., Sundaram, C, Reuter, S., Aggarwal, B.B., 2010. Inhibiting NF-kappaB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 1799, 775-787.
15. Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., Kikugawa, K., 2003. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J. 22, 3356-3366. (Pubitemid 36834865)
16. Hayden, M.S., Ghosh, S., 2004. Signaling to NF-kappaB. Genes Dev. 18, 2195-2224.
17. Hayden, M.S., Ghosh, S., 2012. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 26, 203-234.
18. Huang, W.Y., Cai, Y.Z., Zhang, Y, 2010. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr. Cancer 62, 1-20.
19. Ivanenkov, Y.A., Balakin, K.V., Lavrovsky, Y, 2011. Small molecule inhibitors of NF-κB and JAK/STAT signal transduction pathways as promising antiinflammatory therapeutics. Mini Rev. Med. Chem. 11, 55-78.
20. Kaminska, B., 2005. MAPK signalling pathways as molecular targets for antiinflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754, 253-262. (Pubitemid 41797706)
21. Karin, M., Cao, Y., Greten, F.R., Li, Z.W., 2002. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301-310. (Pubitemid 37328783)
22. Kennedy, D.O., Wightman, E.L., 2011. Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. Adv. Nutr. 2, 32-50.
23. Kim, J.J., Lee, S.B., Park, J.K., Yoo, YD., 2010. TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L). Cell Death Differ. 17, 1420-1434.
24. Kim, M.H., Nugroho, A., Choi, J., Park, J.H., Park, HJ., 2011. Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. Arch. Pharm. Res. 34, 971-978.
25. Kim, T.H., Cho, K.H., Jung, WS., Lee, M.S., 2012. Herbal medicines for Parkinson's disease: a systematic review of randomized controlled trials. PLoS One 7, e35695.
26. Kitagaki, H., Ono, N., Hayakawa, K., Kitazawa, T., Watanabe, K., Shiohara, T., 1997. Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J. Immunol. 159, 2484-2491. (Pubitemid 127681044)
27. Korkina, LG., 2007. Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health. Cell. Mol. Biol. (Noisy-le-grand) 53, 15-25. (Pubitemid 46799688)
28. Kostova, I., Bhatia, S., Grigorov, P., Balkansky, S., Parmar, V.S., Prasad, A.K., Saso, L., 2011. Coumarins as antioxidants. Curr. Med. Chem. 18, 3929-3951.
29. Koyasu, S., 2003. The role of PI3K in immune cells. Nat. Immunol. 4, 313-319.
30. Kumar, G.P., Khanum, F., 2012. Neuroprotective potential of phytochemicals. Pharmacogn. Rev. 6, 81-90.
31. Lawrence, T., 2009. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect. Biol. 1, a001651.
32. Lee, CS., Lee, S.A., Kim, Y.J., Seo, S.J., Lee, M.W, 2011. 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-alpha-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-kappaB-pathways. Int. Immunopharmacol. 11, 1715-1723.
33. Locksley, R.M., Killeen, N., Lenardo, M.J., 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501. (Pubitemid 32201945)
34. Na, K., Kim, K.E., Park, S.T., Kim, T.Y., 2007. EC-SOD suppresses contact hypersensi-tivity in mouse skin by impairing Langerhans cell migration. J. Invest. Dermatol. 127, 1930-1937. (Pubitemid 47075360)
35. Niebuhr, M., Heratizadeh, A., Wichmann, K., Satzger, I., Werfel, T., 2011. Intrinsic alterations of pro-inflammatory mediators in unstimulated and TLR-2 stimulated keratinocytes from atopic dermatitis patients. Exp. Dermatol. 20, 468-472.
36. Oberyszyn, T.M., Conti, C.J., Ross, M.S., Oberyszyn, A.S., Tober, K.L., Rackoff, A.I., Robertson, F.M., 1998. Beta2 integrin/ICAM-1 adhesion molecule interactions in cutaneous inflammation and tumor promotion. Carcinogenesis 19, 445-455. (Pubitemid 28375447)
37. Okkenhaug, K., Vanhaesebroeck, B., 2003. PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol. 3, 317-330. (Pubitemid 37328684)
38. Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israel, A., Krieg, T., Rajewsky, K., Haase, I., 2002. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417, 861-866. (Pubitemid 34670334)
39. Pastore, S., Mascia, F., Mariotti, F., Dattilo, C., Mariani, V., Girolomoni, G., 2005. ERK1/2 regulates epidermal chemokine expression and skin inflammation. J. Immunol. 174, 5047-5056.
40. Qi, S., Xin, Y., Guo, Y., Diao, Y., Kou, X., Luo, L., Yin, Z., 2012. Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-kappaB signaling pathways. Int. Immunopharmacol. 12, 278-287.
41. Reilly, D.M., Parslew, R., Sharpe, G.R., Powell, S., Green, M.R., 2000. Inflammatory mediators in normal, sensitive and diseased skin types. Acta Dermato Venereol. 80, 171-174.
42. Robert, C., Kupper, T.S., 1999. Inflammatory skin diseases, T cells, and immune surveillance. N. Engl. J. Med. 341, 1817-1828.
43. Schon, M.P., Zollner, T.M., Boehncke, W.H., 2003. The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders. J. Invest. Dermatol. 121, 951-962. (Pubitemid 37430959)
44. Shiohara, T., Hayakawa, J., Mizukawa, Y., 2004. Animal models for atopic dermatitis: are they relevant to human disease? J. Dermatol. Sci. 36, 1-9. (Pubitemid 39370020)
45. Singh, B.N., Shankar, S., Srivastava, R.K., 2011. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharmacol. 82, 1807-1821.
46. Sung, Y.Y., Kim, Y.S., Kim, H.K., 2012. Illicium verum extract inhibits TNF-alpha- and IFN-gamma-induced expression of chemokines and cytokines in human kera-tinocytes. J. Ethnopharmacol. 144, 182-189.
47. Sur, I., Ulvmar, M., Toftgard, R., 2008. The two-faced NF-kappaB in the skin. Int. Rev. Immunol. 27, 205-223.
48. Tak, P.P., Firestein, G.S., 2001. NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 107, 7-11. (Pubitemid 32047405)
49. Thuan, N.D., do, H.a., Thuong, T., Na, P.T., Lee, M.K., Lee, J.P., Seo, J.H., Min, H.W., Kim, B.S., Bae, K., J.C., 2007. A phenylpropanoid glycoside with antioxidant activity from Picria tel-ferae. Arch. Pharm. Res. 30, 1062-1066.
50. Tobin, D.J., 2006. Biochemistry of human skin - our brain on the outside. Chem. Soc. Rev. 35, 52-67. (Pubitemid 43485013)
51. Tokunaga, C., Yoshino, K., Yonezawa, K., 2004. mTOR integrates amino acid- and energy-sensing pathways. Biochem. Biophys. Res. Commun. 313, 443-446. (Pubitemid 37543606)
52. Vane, J.R., Bakhle, Y.S., Botting, R.M., 1998. Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38, 97-120. (Pubitemid 28231490)
53. Watanabe, Y., Suzuki, O., Haruyama, T., Akaike, T., 2003. Interferon-gamma induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis. J. Cell. Biochem. 89, 244-253. (Pubitemid 36547259)
54. Young, C.N., Koepke, J.I., Terlecky, L.J., Borkin, M.S., Boyd Savoy, L., Terlecky, S.R., 2008. Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease. J. Invest. Dermatol. 128, 2606-2614.
55. Yousuf, S., Choudhary, M.I., Rahman, A.U., 2010. Separation of phenylpropanoids and evaluation of their antioxidant activity. Methods Mol. Biol. 594, 357-377.
56. Yu, E.S., Min, H.J., Lee, K., Lee, M.S., Nam, J.W., Seo, E.K., Hong, J.H., Hwang, E.S., 2009. Anti-inflammatory activity of p-coumaryl alcohol-gamma-O-methyl ether is mediated through modulation of interferon-gamma production in Th cells. Br. J. Pharmacol. 156, 1107-1114.
57. Zhou, Q., Mrowietz, U., Rostami-Yazdi, M., 2009. Oxidative stress in the pathogen-esis of psoriasis. Free Radical Biol. Med. 47, 891-905.