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Volumn 61, Issue 2, 2013, Pages 139-148

Molecular beacons: A novel optical diagnostic tool

Author keywords

Diagnosis; Fluorescence resonance energy transfer (FRET); Molecular beacons (MBs); Nucleic acid probe

Indexed keywords

BACTERIUM DETECTION; ENVIRONMENTAL FACTOR; FLUORESCENCE IMAGING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; INTERMETHOD COMPARISON; MICROARRAY ANALYSIS; MOLECULAR BEACON; MOLECULAR DIAGNOSIS; MOLECULAR IMAGING; MOLECULAR RECOGNITION; NUCLEIC ACID PROBE; REVIEW; STRUCTURE ANALYSIS; VIRUS DETECTION;

EID: 84879459753     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-012-0209-7     Document Type: Review
Times cited : (26)

References (66)
  • 2
    • 77957760079 scopus 로고    scopus 로고
    • Rapid drug susceptibility testing with a molecular beacon assay is associated with earlier diagnosis and treatment of multidrug-resistant tuberculosis in California
    • 20702667 10.1128/JCM.01236-10
    • Banerjee R, Allen J, Lin SY et al (2010) Rapid drug susceptibility testing with a molecular beacon assay is associated with earlier diagnosis and treatment of multidrug-resistant tuberculosis in California. J Clin Microbiol 48:3779-3781
    • (2010) J Clin Microbiol , vol.48 , pp. 3779-3781
    • Banerjee, R.1    Allen, J.2    Lin, S.Y.3
  • 5
    • 84863133743 scopus 로고    scopus 로고
    • Real-time nucleic acid sequence-based amplification assay for rapid detection and quantification of agr functionality in clinical Staphylococcus aureus isolates
    • 22219302 10.1128/JCM.06253-11 1:CAS:528:DC%2BC38Xls1eqtrw%3D
    • Chen L, Shopsin B, Zhao Y et al (2012) Real-time nucleic acid sequence-based amplification assay for rapid detection and quantification of agr functionality in clinical Staphylococcus aureus isolates. J Clin Microbiol 50:657-661
    • (2012) J Clin Microbiol , vol.50 , pp. 657-661
    • Chen, L.1    Shopsin, B.2    Zhao, Y.3
  • 7
    • 35648997987 scopus 로고    scopus 로고
    • Rapid and highly sensitive qualitative real-time assay for detection of respiratory syncytial virus A and B using NASBA and molecular beacon technology
    • DOI 10.1016/j.jviromet.2007.05.030, PII S0166093407002145
    • Deiman B, Schrover C, Moore C et al (2007) Rapid and highly sensitive qualitative real-time assay for detection of respiratory syncytial virus A and B using NASBA and molecular beacon technology. J Virol Methods 146:29-35 (Pubitemid 350030935)
    • (2007) Journal of Virological Methods , vol.146 , Issue.1-2 , pp. 29-35
    • Deiman, B.1    Schrover, C.2    Moore, C.3    Westmoreland, D.4    Van De Wiel, P.5
  • 8
    • 0035075442 scopus 로고    scopus 로고
    • Single-mismatch detection using gold-quenched fluorescent oligonucleotid
    • DOI 10.1038/86762
    • Dubertret B, Calame M, Libchaber AJ (2001) Single-mismatch detection using gold-quenched fluorescent oligonucleotides. Nat Biotechnol 19:365-370 (Pubitemid 32275347)
    • (2001) Nature Biotechnology , vol.19 , Issue.4 , pp. 365-370
    • Dubertret, B.1    Calame, M.2    Libchaber, A.J.3
  • 9
    • 0037403272 scopus 로고    scopus 로고
    • High-density, microsphere-based fiber optic DNA microarrays
    • DOI 10.1016/S0956-5663(03)00021-6
    • Epstein JR, Leung AP, Lee KH et al (2003) High-density, microsphere-based fiber optic DNA microarrays. Biosens Bioelectron 18:541-546 (Pubitemid 36428642)
    • (2003) Biosensors and Bioelectronics , vol.18 , Issue.5-6 , pp. 541-546
    • Epstein, J.R.1    Leung, A.P.K.2    Lee, K.-H.3    Walt, D.R.4
  • 10
    • 79953219732 scopus 로고    scopus 로고
    • Development of a molecular-beacon-based multi-allelic real-time RT-PCR assay for the detection of human coronavirus causing severe acute respiratory syndrome (SARS-CoV): A general methodology for detecting rapidly mutating viruses
    • 21221674 10.1007/s00705-010-0906-7 1:CAS:528:DC%2BC3MXjvFemsLg%3D
    • Hadjinicolaou AV, Farcas GA et al (2011) Development of a molecular-beacon-based multi-allelic real-time RT-PCR assay for the detection of human coronavirus causing severe acute respiratory syndrome (SARS-CoV): a general methodology for detecting rapidly mutating viruses. Arch Virol 156:671-680
    • (2011) Arch Virol , vol.156 , pp. 671-680
    • Hadjinicolaou, A.V.1    Farcas, G.A.2
  • 11
    • 36148950150 scopus 로고    scopus 로고
    • Simplified detection of Mycobacterium tuberculosis in sputum using smear microscopy and PCR with molecular beacons
    • DOI 10.1099/jmm.0.47265-0
    • Haldar S, Chakravorty S, Bhalla M et al (2007) Simplified detection of Mycobacterium tuberculosis in sputum using smear microscopy and PCR with molecular beacons. J Med Microbiol 56(Pt10):1356-1362 (Pubitemid 350105605)
    • (2007) Journal of Medical Microbiology , vol.56 , Issue.10 , pp. 1356-1362
    • Haldar, S.1    Chakravorty, S.2    Bhalla, M.3    De Majumdar, S.4    Tyagi, J.S.5
  • 12
    • 33845447405 scopus 로고    scopus 로고
    • A molecular beacon DNA microarray system for rapid detection of E. coli O157:H7 that eliminates the risk of a false negative signal
    • DOI 10.1016/j.bios.2006.04.032, PII S0956566306002302
    • Kim H, Kane MD, Kim S et al (2007) A molecular beacon DNA microarray system for rapid detection of E. coli O157:H7 that eliminates the risk of a false negative signal. Biosens Bioelectron 22:1041-1047 (Pubitemid 44894894)
    • (2007) Biosensors and Bioelectronics , vol.22 , Issue.6 , pp. 1041-1047
    • Kim, H.1    Kane, M.D.2    Kim, S.3    Dominguez, W.4    Applegate, B.M.5    Savikhin, S.6
  • 13
    • 0346765512 scopus 로고    scopus 로고
    • Viral hepatitis B
    • DOI 10.1016/S0140-6736(03)15108-2
    • Lai CL, Ratziu V, Yuen MF et al (2003) Viral hepatitis B. Lancet 362:2089-2094 (Pubitemid 38032767)
    • (2003) Lancet , vol.362 , Issue.9401 , pp. 2089-2094
    • Lai, C.L.1    Ratziu, V.2    Yuen, M.-F.3    Poynard, T.4
  • 14
    • 22144451845 scopus 로고    scopus 로고
    • Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens
    • DOI 10.1128/JCM.43.7.3136-3139.2005
    • Landry ML, Garner R, Ferguson D (2005) Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens. J Clin Microbiol 43:3136-3139 (Pubitemid 40981313)
    • (2005) Journal of Clinical Microbiology , vol.43 , Issue.7 , pp. 3136-3139
    • Landry, M.L.1    Garner, R.2    Ferguson, D.3
  • 15
    • 4544345020 scopus 로고    scopus 로고
    • DNA sequence detection using selective fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles
    • DOI 10.1021/ac049173n
    • Li H, Rothberg LJ (2004) DNA sequence detection using selective fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles. Anal Chem 76:5414-5417 (Pubitemid 39249424)
    • (2004) Analytical Chemistry , vol.76 , Issue.18 , pp. 5414-5417
    • Li, H.1    Rothberg, L.J.2
  • 16
    • 34249878496 scopus 로고    scopus 로고
    • Several concerns about the primer design in the universal molecular beacon real-time PCR assay and its application in HBV DNA detection
    • DOI 10.1007/s00216-007-1281-4, Vapor Generation for Atomic Spectroscopy
    • Li X, Huang Y, Song C et al (2007) Several concerns about the primer design in the universal molecular beacon real-time PCR assay and its application in HBV DNA detection. Anal Bioanal Chem 388:979-985 (Pubitemid 46870698)
    • (2007) Analytical and Bioanalytical Chemistry , vol.388 , Issue.4 , pp. 979-985
    • Li, X.1    Huang, Y.2    Song, C.3    Zhao, M.4    Li, Y.5
  • 17
    • 48949116125 scopus 로고    scopus 로고
    • Molecular beacons: An optimal multifunctional biological probe
    • 18489905 10.1016/j.bbrc.2008.05.038 1:CAS:528:DC%2BD1cXptVKlu7w%3D
    • Li Y, Zhou X, Ye D (2008) Molecular beacons: an optimal multifunctional biological probe. Biochem Biophys Res Commun 373:457-461
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 457-461
    • Li, Y.1    Zhou, X.2    Ye, D.3
  • 18
    • 85061111173 scopus 로고    scopus 로고
    • A study on the sero-epidemiology of hepatitis B in chinese population a aged over 3 years old
    • Liang XF, Chen YS, Wang XJ et al (2005) A study on the sero-epidemiology of hepatitis B in chinese population a aged over 3 years old. Zhonghua Liu Xing Bing Xue Za Zhi 26:618-655
    • (2005) Zhonghua Liu Xing Bing Xue Za Zhi , vol.26 , pp. 618-655
    • Liang, X.F.1    Chen, Y.S.2    Wang, X.J.3
  • 19
    • 84877120985 scopus 로고    scopus 로고
    • Establishment of molecular beacon real-time PCR for detecting p53 gene single nucleotide polymorphism
    • 22126769 1:CAS:528:DC%2BC38Xmt1Sltw%3D%3D
    • Liao N, Gao JH, Zeng WS et al (2011) Establishment of molecular beacon real-time PCR for detecting p53 gene single nucleotide polymorphism. Nan Fang Yi Ke Da Xue Xue Bao 31:1875-1878
    • (2011) Nan Fang Yi Ke da Xue Xue Bao , vol.31 , pp. 1875-1878
    • Liao, N.1    Gao, J.H.2    Zeng, W.S.3
  • 20
    • 84870529759 scopus 로고    scopus 로고
    • Quantitative detection of p21 mRNA in tumor cells based on molecular beacon
    • 1:CAS:528:DC%2BC3cXhtVCjs7vO
    • Liu B, Yang XH, Wang KM et al (2010a) Quantitative detection of p21 mRNA in tumor cells based on molecular beacon. Acta Chim Sinica 68:1303-1307
    • (2010) Acta Chim Sinica , vol.68 , pp. 1303-1307
    • Liu, B.1    Yang, X.H.2    Wang, K.M.3
  • 21
    • 73549085174 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism detection of a double-stranded DNA target by a ribonucleotide-carrying molecular beacon and thermostable RNase HII
    • 19891952 10.1016/j.ab.2009.10.042 1:CAS:528:DC%2BC3cXksVaitg%3D%3D
    • Liu XP, Hou JL, Liu JH (2010b) A novel single nucleotide polymorphism detection of a double-stranded DNA target by a ribonucleotide-carrying molecular beacon and thermostable RNase HII. Anal Biochem 398:83-92
    • (2010) Anal Biochem , vol.398 , pp. 83-92
    • Liu, X.P.1    Hou, J.L.2    Liu, J.H.3
  • 22
    • 34547754407 scopus 로고    scopus 로고
    • Molecular beacon-style hybridization assay for quantitative analysis of surface invasive cleavage reactions
    • DOI 10.1021/ac070424c
    • Lockett MR, Shortreed MR, Smith LM (2007) Molecular beacon-style hybridization assay for quantitative analysis of surface invasive cleavage reactions. Anal Chem 79:6031-6036 (Pubitemid 47229860)
    • (2007) Analytical Chemistry , vol.79 , Issue.15 , pp. 6031-6036
    • Lockett, M.R.1    Shortreed, M.R.2    Smith, L.M.3
  • 24
    • 0034754359 scopus 로고    scopus 로고
    • Turning the spotlight on cellular imaging
    • DOI 10.1038/nbt1101-1013
    • Mitchell P (2001) Turning the spotlight on cellular imaging. Nat Biotechnol 19:1013-1018 (Pubitemid 33041885)
    • (2001) Nature Biotechnology , vol.19 , Issue.11 , pp. 1013-1017
    • Mitchell, P.1
  • 25
    • 34247122719 scopus 로고    scopus 로고
    • PreTect™ HPV-Proofer: Real-time detection and typing of E6/E7 mRNA from carcinogenic human papillomaviruses
    • DOI 10.1016/j.jviromet.2007.01.036, PII S0166093407000626
    • Molden T, Kraus I, Skomedal H et al (2007) PreTect (TM) HPV-proofer: real-time detection and typing of E6/E7 mRNA from carcinogenic human papillomaviruses. J Virol Methods 142:204-212 (Pubitemid 46590424)
    • (2007) Journal of Virological Methods , vol.142 , Issue.1-2 , pp. 204-212
    • Molden, T.1    Kraus, I.2    Skomedal, H.3    Nordstrom, T.4    Karlsen, F.5
  • 26
    • 84869028676 scopus 로고    scopus 로고
    • Molecular beacons: Powerful tools for imaging RNA in living cells
    • 21876785
    • Monroy-Contreras R, Vaca L (2011) Molecular beacons: powerful tools for imaging RNA in living cells. J Nucleic Acids 2011:741723
    • (2011) J Nucleic Acids , vol.2011 , pp. 741723
    • Monroy-Contreras, R.1    Vaca, L.2
  • 27
    • 33846628101 scopus 로고    scopus 로고
    • Monitoring HCV RNA viral load by locked nucleic acid molecular beacons real time PCR
    • DOI 10.1016/j.jviromet.2006.11.014, PII S016609340600396X
    • Morandi L, Ferrari D, Lombardo C et al (2007) Monitoring HCV RNA viral load by locked nucleic acid molecular beacons real time PCR. J Virol Methods 140:148-154 (Pubitemid 46185604)
    • (2007) Journal of Virological Methods , vol.140 , Issue.1-2 , pp. 148-154
    • Morandi, L.1    Ferrari, D.2    Lombardo, C.3    Pession, A.4    Tallini, G.5
  • 28
    • 33645904476 scopus 로고    scopus 로고
    • Simultaneous detection of pathogens in clinical samples from patients with community-acquired pneumonia by real-time PCR with pathogen-specific molecular beacon probes
    • 16597874 10.1128/JCM.44.4.1440-1446.2006 1:CAS:528:DC%2BD28XkvVamtro%3D
    • Morozumi M, Nakayama E, Iwata S et al (2006) Simultaneous detection of pathogens in clinical samples from patients with community-acquired pneumonia by real-time PCR with pathogen-specific molecular beacon probes. J Clin Microbiol 44:1440-1446
    • (2006) J Clin Microbiol , vol.44 , pp. 1440-1446
    • Morozumi, M.1    Nakayama, E.2    Iwata, S.3
  • 29
    • 80555144145 scopus 로고    scopus 로고
    • Molecular-beacon-based tricomponent probe for SNP analysis in folded nucleic acids
    • 21956816 10.1002/chem.201101987 1:CAS:528:DC%2BC3MXht1Crtr7E
    • Nguyen C, Grimes J, Gerasimova YV et al (2011) Molecular-beacon-based tricomponent probe for SNP analysis in folded nucleic acids. Chemistry 17:13052-13058
    • (2011) Chemistry , vol.17 , pp. 13052-13058
    • Nguyen, C.1    Grimes, J.2    Gerasimova, Y.V.3
  • 30
    • 3843054927 scopus 로고    scopus 로고
    • Peptide linked molecular beacons for efficient delivery and rapid mRNA detection in living cells
    • 15084673 10.1093/nar/gnh063
    • Nitin N, Santangelo PJ, Kim G et al (2004) Peptide linked molecular beacons for efficient delivery and rapid mRNA detection in living cells. Nucleic Acids Res 32:e58
    • (2004) Nucleic Acids Res , vol.32 , pp. 58
    • Nitin, N.1    Santangelo, P.J.2    Kim, G.3
  • 31
    • 0032143301 scopus 로고    scopus 로고
    • PNA molecular beacons for rapid detection of PCR amplicons
    • DOI 10.1006/mcpr.1998.0175
    • Ortiz E, Estrada G, Lizardi P (1998) PNA molecular beacons for rapid detection of PCR amplicons. Mol Cell Probes 12:219-226 (Pubitemid 28410194)
    • (1998) Molecular and Cellular Probes , vol.12 , Issue.4 , pp. 219-226
    • Ortiz, E.1    Estrada, G.2    Lizardi, P.M.3
  • 33
    • 16444382036 scopus 로고    scopus 로고
    • Real-time detection of gene expression in cancer cells using molecular beacon imaging: New strategies for cancer research
    • DOI 10.1158/0008-5472.CAN-04-3196
    • Peng XH, Cao ZH, Xia JT et al (2005) Real-time detection of gene expression in cancer cells using molecular beacon imaging: new strategies for cancer research. Cancer Res 65:1909-1917 (Pubitemid 40478620)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1909-1917
    • Peng, X.-H.1    Cao, Z.-H.2    Xia, J.-T.3    Carlson, G.W.4    Lewis, M.M.5    Wood, W.C.6    Yang, L.7
  • 34
    • 0035891415 scopus 로고    scopus 로고
    • Real-time monitoring of intracellular mRNA hybridization inside single living cells
    • DOI 10.1021/ac010633b
    • Perlette J, Tan W (2001) Real-time monitoring of intracellular mRNA hybridization inside single living cells. Anal Chem 73:5544-5550 (Pubitemid 33108566)
    • (2001) Analytical Chemistry , vol.73 , Issue.22 , pp. 5544-5550
    • Perlette, J.1    Tan, W.2
  • 35
    • 0032848696 scopus 로고    scopus 로고
    • Detection of adenovirus using PCR and molecular beacon
    • DOI 10.1016/S0166-0934(99)00074-9, PII S0166093499000749
    • Poddar SK (1999) Detection of adenovirus using PCR and molecular beacon. J Virol Methods 82:19-26 (Pubitemid 29415708)
    • (1999) Journal of Virological Methods , vol.82 , Issue.1 , pp. 19-26
    • Poddar, S.K.1
  • 36
    • 2942534199 scopus 로고    scopus 로고
    • Development of real-time NASBA assays with molecular beacon detection to quantify mRNA coding for HHV-8 lytic and latent genes
    • DOI 10.1186/1471-2334-2-18
    • Polstra A, Goudsmit J, Cornelissen M (2002) Development of real-time NASBA assays with molecular beacon detection to quantify mRNA coding for HHV-8 lytic and latent genes. BMC Infect Dis 2:18 (Pubitemid 38750898)
    • (2002) BMC Infectious Diseases , vol.2 , pp. 18
    • Polstra, A.M.1    Goudsmit, J.2    Cornelissen, M.3
  • 37
    • 36549032790 scopus 로고    scopus 로고
    • Subcellular localization of hepatitis E virus (HEV) replicase
    • DOI 10.1016/j.virol.2007.07.036, PII S0042682207005016
    • Rehman S, Kapur N, Durgapal H et al (2008) Subcellular localization of hepatitis E virus (HEV) replicase. Virology 370:77-92 (Pubitemid 350179904)
    • (2008) Virology , vol.370 , Issue.1 , pp. 77-92
    • Rehman, S.1    Kapur, N.2    Durgapal, H.3    Panda, S.K.4
  • 38
    • 3843132105 scopus 로고    scopus 로고
    • Dual FRET molecular beacons for mRNA detection in living cells
    • 15084672 10.1093/nar/gnh062
    • Santangelo PJ, Nix B, Tsourkas A et al (2004) Dual FRET molecular beacons for mRNA detection in living cells. Nucleic Acids Res 32:e57
    • (2004) Nucleic Acids Res , vol.32 , pp. 57
    • Santangelo, P.J.1    Nix, B.2    Tsourkas, A.3
  • 39
    • 33645158637 scopus 로고    scopus 로고
    • Nanostructured probes for RNA detection in living cells
    • 16463087 10.1007/s10439-005-9003-6
    • Santangelo P, Nitin N, Bao G (2006) Nanostructured probes for RNA detection in living cells. Ann Biomed Eng 34:39-50
    • (2006) Ann Biomed Eng , vol.34 , pp. 39-50
    • Santangelo, P.1    Nitin, N.2    Bao, G.3
  • 40
    • 16444379116 scopus 로고    scopus 로고
    • P53-dependent activation of a molecular beacon in tumor cells following exposure to doxorubicin chemotherapy
    • Shah R, El-Deiry WS (2004) p53-dependent activation of a molecular beacon in tumor cells following exposure to doxorubicin chemotherapy. Cancer Biol Ther 3:871-875 (Pubitemid 41351054)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.9 , pp. 871-875
    • Shah, R.1    El-Deiry, W.S.2
  • 41
    • 85027916674 scopus 로고    scopus 로고
    • Development of a quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes
    • 21728031 10.1007/s12033-011-9432-4 1:CAS:528:DC%2BC38XhsVCjtLk%3D
    • Sidoti F, Bergallo M, Terlizzi ME et al (2012) Development of a quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes. Mol Biotechnol 50:221-228
    • (2012) Mol Biotechnol , vol.50 , pp. 221-228
    • Sidoti, F.1    Bergallo, M.2    Terlizzi, M.E.3
  • 43
    • 0037596871 scopus 로고    scopus 로고
    • Molecular Beacon reverse transcription-PCR of human chorionic gonadotropin-β-3, -5, and -8 mRNAs has prognostic value breast cancer
    • DOI 10.1373/49.7.1074
    • Span PN, Manders P, Heuvel JJ et al (2003) Molecular beacon reverse transcription-PCR of human chorionic gonadotropin-beta-3, -5, and -8 mRNAs has prognostic value in breast cancer. Clin Chem 49:1074-1080 (Pubitemid 36751093)
    • (2003) Clinical Chemistry , vol.49 , Issue.7 , pp. 1074-1080
    • Span, P.N.1    Manders, P.2    Heuvel, J.J.T.M.3    Thomas, C.M.G.4    Bosch, R.R.5    Beex, L.V.A.M.6    Sweep, C.G.J.7
  • 45
    • 40849094132 scopus 로고    scopus 로고
    • Molecular beacon-based real-time PCR method for detection of 15 high-risk and 5 low-risk HPV types
    • 18281103 10.1016/j.jviromet.2007.12.009 1:CAS:528:DC%2BD1cXjtleiu7Y%3D
    • Takacs T, Jeney C, Kovacs L et al (2008) Molecular beacon-based real-time PCR method for detection of 15 high-risk and 5 low-risk HPV types. J Virol Methods 149:153-162
    • (2008) J Virol Methods , vol.149 , pp. 153-162
    • Takacs, T.1    Jeney, C.2    Kovacs, L.3
  • 46
    • 0034599374 scopus 로고    scopus 로고
    • Molecular beacons: A novel DNA probe for nucleic acid and protein studies
    • 10785794 10.1002/(SICI)1521-3765(20000403)6:7<1107: AID-CHEM1107>3.3.CO;2-0 1:CAS:528:DC%2BD3cXisVynsbo%3D
    • Tan W, Fang X, Li J et al (2000) Molecular beacons: a novel DNA probe for nucleic acid and protein studies. Chemistry 6:1107-1111
    • (2000) Chemistry , vol.6 , pp. 1107-1111
    • Tan, W.1    Fang, X.2    Li, J.3
  • 48
    • 39049124806 scopus 로고    scopus 로고
    • Monitoring p21 mRNA expression in living cell based on molecular beacon fluorescence increasing rate
    • DOI 10.1007/s11434-007-0511-7
    • Tang HX, Yang XH, Wang KM et al (2008) Monitoring p21 mRNA expression in living cell based on molecular beacon fluorescence increasing rate. Chin. Sci Bull 53:357-361 (Pubitemid 351236778)
    • (2008) Chinese Science Bulletin , vol.53 , Issue.3 , pp. 357-361
    • Tang, H.1    Yang, X.2    Wang, K.3    Tan, W.4    Liu, B.5    He, L.6    Wang, W.7
  • 49
    • 0041561193 scopus 로고    scopus 로고
    • Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons
    • DOI 10.1021/ac034295l
    • Tsourkas A, Behlke MA, Xu Y et al (2003) Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons. Anal Chem 75:3697-3703 (Pubitemid 36962100)
    • (2003) Analytical Chemistry , vol.75 , Issue.15 , pp. 3697-3703
    • Tsourkas, A.1    Behlke, M.A.2    Xu, Y.3    Bao, G.4
  • 51
    • 0029670262 scopus 로고    scopus 로고
    • Molecular beacons: Probes that fluoresce upon hybridization
    • DOI 10.1038/nbt0396-303
    • Tyagi S, Kramer FR (1996) Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 14:303-308 (Pubitemid 3035126)
    • (1996) Nature Biotechnology , vol.14 , Issue.3 , pp. 303-308
    • Tyagi, S.1    Kramer, F.R.2
  • 52
    • 0033764715 scopus 로고    scopus 로고
    • Wavelength-shifting molecular beacons
    • 11062440 10.1038/81192 1:CAS:528:DC%2BD3cXotVSltrc%3D
    • Tyagi S, Marras SA, Kramer FR (2000) Wavelength-shifting molecular beacons. Nat Biotechnol 18:1191-1196
    • (2000) Nat Biotechnol , vol.18 , pp. 1191-1196
    • Tyagi, S.1    Marras, S.A.2    Kramer, F.R.3
  • 53
    • 41149148662 scopus 로고    scopus 로고
    • Quencher-free molecular beacons: A new strategy in fluorescence based nucleic acid analysis
    • 18362974 10.1039/b705468h 1:CAS:528:DC%2BD1cXjs12htr0%3D
    • Venkatesan N, Seo YJ, Kim BH (2008) Quencher-free molecular beacons: a new strategy in fluorescence based nucleic acid analysis. Chem Soc Rev 37:648-663
    • (2008) Chem Soc Rev , vol.37 , pp. 648-663
    • Venkatesan, N.1    Seo, Y.J.2    Kim, B.H.3
  • 54
    • 7944227916 scopus 로고    scopus 로고
    • Design and optimization of molecular beacon real-time polymerase chain reaction assays
    • Vet JA, Marras SA, Herdewijn P (2004) Design and optimization of molecular beacon real-time polymerase chain reaction assays. Methods Mol Biol 288:273-290
    • (2004) Methods Mol Biol , vol.288 , pp. 273-290
    • Vet, J.A.1    Marras, S.A.2    Herdewijn, P.3
  • 56
    • 27744550395 scopus 로고    scopus 로고
    • Polyacrylamide gel film immobilized molecular beacon array for single nucleotide mismatch detection
    • DOI 10.1166/jnn.2005.086
    • Wang Y, Wang H, Gao L et al (2005) Polyacrylamide gel film immobilized molecular beacon array for single nucleotide mismatch detection. J Nanosci Nanotechnol 5:653-658 (Pubitemid 44502219)
    • (2005) Journal of Nanoscience and Nanotechnology , vol.5 , Issue.4 , pp. 653-658
    • Wang, Y.1    Wang, H.2    Gao, L.3    Liu, H.4    Lu, Z.5    He, N.6
  • 57
    • 50849120356 scopus 로고    scopus 로고
    • Imaging and characterizing influenza A virus mRNA transport in living cells
    • 18653528 10.1093/nar/gkn475 1:CAS:528:DC%2BD1cXhtVGkt7%2FP
    • Wang W, Cui ZQ, Han H et al (2008) Imaging and characterizing influenza A virus mRNA transport in living cells. Nucleic Acids Res 36:4913-4928
    • (2008) Nucleic Acids Res , vol.36 , pp. 4913-4928
    • Wang, W.1    Cui, Z.Q.2    Han, H.3
  • 58
    • 79959696590 scopus 로고    scopus 로고
    • Expression patterns of prion protein gene in differential genotypes sheep: Quantification using molecular beacon real-time RT-PCR
    • 21318242 10.1007/s11262-011-0579-7 1:CAS:528:DC%2BC3MXntlSiu7s%3D
    • Wang C, Wu R, Li FD et al (2011) Expression patterns of prion protein gene in differential genotypes sheep: quantification using molecular beacon real-time RT-PCR. Virus Genes 42:457-462
    • (2011) Virus Genes , vol.42 , pp. 457-462
    • Wang, C.1    Wu, R.2    Li, F.D.3
  • 59
    • 33746499783 scopus 로고    scopus 로고
    • Optical detection of DNA hybridization based on fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles
    • DOI 10.1016/j.ab.2006.01.018, PII S0003269706000352
    • Wu ZS, Jiang JH, Fu L et al (2006) Optical detection of DNA hybridization based on fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles. Anal Biochem 353:22-29 (Pubitemid 44275172)
    • (2006) Analytical Biochemistry , vol.353 , Issue.1 , pp. 22-29
    • Wu, Z.-S.1    Jiang, J.-H.2    Fu, L.3    Shen, G.-L.4    Yu, R.-Q.5
  • 60
    • 33646066554 scopus 로고    scopus 로고
    • Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells
    • 16216300 10.1016/j.chemosphere.2005.08.013 1:CAS:528:DC%2BD28XjvFWgtL8%3D
    • Xu Y, Yu RM, Zhang X et al (2006) Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells. Chemosphere 63:772-784
    • (2006) Chemosphere , vol.63 , pp. 772-784
    • Xu, Y.1    Yu, R.M.2    Zhang, X.3
  • 61
    • 31344445425 scopus 로고    scopus 로고
    • Monitoring nucleic acids using molecular beacons
    • DOI 10.2174/138920105775159322
    • Yang CJ, Medley CD, Tan W (2005) Monitoring nucleic acids using molecular beacons. Curr Pharm Biotechnol 6:445-452 (Pubitemid 43137065)
    • (2005) Current Pharmaceutical Biotechnology , vol.6 , Issue.6 , pp. 445-452
    • Yang, C.J.1    Medley, C.D.2    Tan, W.3
  • 64
    • 27744511635 scopus 로고    scopus 로고
    • Rapid detection of codon 460 mutations in the UL97 gene of ganciclovir-resistant cytomegalovirus clinical isolates by real-time PCR using molecular beacons
    • DOI 10.1016/j.mcp.2005.06.008, PII S0890850805000459
    • Yeo AC, Chan KP, Kumarasinghe G et al (2005) Rapid detection of codon 460 mutations in the UL97 gene of ganciclovir-resistant cytomegalovirus clinical isolates by real-time PCR using molecular beacons. Mol Cell Probes 19:389-393 (Pubitemid 41586135)
    • (2005) Molecular and Cellular Probes , vol.19 , Issue.6 , pp. 389-393
    • Yeo, A.C.1    Chan, K.P.2    Kumarasinghe, G.3    Yap, H.K.4
  • 65
    • 34447505922 scopus 로고    scopus 로고
    • Primary Application Study in Early Diagnosis of Bladder Cancer by Survivin Molecular Beacons
    • DOI 10.1016/j.urology.2007.03.023, PII S0090429507003779
    • Zhao J, He D, He H et al (2007) Primary application study in early diagnosis of bladder cancer by survivin molecular beacons. Urology 70:60-64 (Pubitemid 47081103)
    • (2007) Urology , vol.70 , Issue.1 , pp. 60-64
    • Zhao, J.1    He, D.2    He, H.3    Li, L.4    Zhang, L.-L.5    Wang, X.-Y.6


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