Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells

Chemosphere

Volumn 63, Issue 5, 2006, Pages 772-784

  Xu, Yan ^a   Yu, Richard M K ^a   Zhang, Xiaowei ^a,b   Murphy, Margaret B ^a,b   Giesy, John P ^a,b   Lam, Michael H W ^a   Lam, Paul K S ^a   Wu, Rudolf S S ^a   Yu, Hongxia ^c  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^b National Food Safety and Toxicology Center   (United States)

^c NANJING UNIVERSITY   (China)

Author keywords

H295R; MeSO2 PCBs; Polychlorinated biphenyls; Steroidogenesis

Indexed keywords

ACTIVATION ANALYSIS; CELLS; ENVIRONMENTAL IMPACT; HORMONES; METABOLITES; POLYCHLORINATED BIPHENYLS; RNA;

ADRENOCORTICAL STEROIDOGENESIS; H295R; MESO2PCB; STEROIDOGENESIS;

ENDOCRINOLOGY;

ALDOSTERONE; ALDOSTERONE SYNTHASE; AROMATASE; CYTOCHROME P450 11A; CYTOCHROME P450 17; ESTRADIOL; HYDROCORTISONE; MESSENGER RNA; MESYLIC ACID DERIVATIVE; POLYCHLORINATED BIPHENYL; STEROID 21 MONOOXYGENASE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG; CYTOCHROME P450; HYDROXYSTEROID DEHYDROGENASE; STEROID;

ACTIVATION ANALYSIS; CELLS; ENDOCRINOLOGY; ENVIRONMENTAL IMPACT; HORMONES; METABOLITES; POLYCHLORINATED BIPHENYLS; RNA;

ENDOCRINE DISRUPTOR; GENE EXPRESSION; HORMONE; PCB; STEROID;

ADRENAL CORTEX CARCINOMA; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; STEROIDOGENESIS; TRANSCRIPTION INITIATION; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM;

ADRENOCORTICAL CARCINOMA; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; HUMANS; HYDROXYSTEROID DEHYDROGENASES; POLYCHLORINATED BIPHENYLS; STEROIDS; TUMOR CELLS, CULTURED;

EID: 33646066554     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2005.08.013     Document Type: Article

References (54)

1. Andric S.A., Kostic T.S., Dragisic S.M., Stojilkovic S.S., and Kovacevic R.Z. Acute in vivo and in vitro effects of Aroclors on rat testicular steroidogenesis. In: Robertson L.W., and Hansen L.G. (Eds). PCBs: Recent Advances in the Environmental Toxicology and Health Effects (2001), University Press of Kentucky, Lexington, USA 303-308
2. Baker V.A. Endocrine disrupters-testing strategies to assess human hazard. Toxicol. In vitro 15 (2001) 413-419
3. Bassett M.H., White P.C., and Rainey W.E. The regulation of aldosterone synthase expression. Mol. Cell Endocrinol. 217 (2004) 67-74
4. Bergman A., Athanasiadou M., Bergek S., Haraguchi K., Jensen S., and Wehler E.K. PCB and PCB methyl sulfones in mink treated with PCB and various PCB fractions. Ambio 21 (1992) 570-576
5. Bergman A., Norstrom R.J., Haraguchi K., Kuroki H., and Béland P. PCB and DDE methyl sulfones in mammals from Canada and Sweden. Environ. Toxicol. Chem. 13 (1994) 121-128
6. Berlin M., Gage J., and Holm S. Distribution and metabolism of 2,4,5,2′,5′-pentachlorobiphenyl. Arch. Environ. Health 30 (1975) 141-147
7. Biessmann A. Accumulation of polychlorinated biphenyls in steroidogenic tissue of gonads and adrenals in Japanese Quail. Arch. Environ. Contam. Toxicol. 10 (1981) 653-662
8. Brandt I. Tissue localization of polychlorinated biphenyls-chemical structure related to pattern of distribution. Acta Pharmacol. Toxicol. 40 (1977) 1-108
9. Brandt I., and Bergman A. PCB methyl sulfones and related compounds: identification of target cells and tissues in different species. Chemosphere 16 (1987) 1671-1676
10. Brilla C.G., and Weber K.T. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J. Lab. Clin. Med. 120 (1992) 893-901
11. Chauhan K.R., Kodavanti P.R., and McKinney J.D. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol. Appl. Pharmacol. 162 (2000) 10-21
12. Colby H.D. In vitro assessment of adrenocortical toxicity. J. Pharmacol. Toxicol. Methods 32 (1994) 1-6
13. Darney K.J., Zirkin B.R., and Ewing L.L. Testosterone autoregulation of its biosynthesis in the rat testis: inhibition of 17α-hydroxylase activity. J. Androl. 17 (1996) 137-142
14. Foster W.G. The reproductive toxicology of great lakes contaminants. Environ. Health Perspect. 103 Suppl. 9 (1995) 63-69
15. Fukuzawa N.H., Ohsako S., Nagano R., Sakaue M., Baba T., Aoki Y., and Tohyama C. Effects of 3,3′,4,4′,5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Toxicol. In vitro 17 (2003) 259-269
16. Gazdar A.F., Oie H.K., Shackleton C.H., Chen T.R., Triche T.J., Myers C.E., Chrousos G.P., Brennan M.F., Stein C.A., and La Rocca R.V. Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res. 50 (1990) 5488-5496
17. Giesy J.P., and Kannan K. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): implications for risk assessment. Crit. Rev. Toxicol. 28 (1998) 511-569
18. Goldman D., and Yawetz A. The interference of polychlorinated biphenyls (Aroclor 1254) with membrane regulation of the activities of cytochromes P-450C21 and P-450(17) alpha, lyase in guinea-pig adrenal microsomes. J. Steroid Biochem. Mol. Biol. 42 (1992) 37-47
19. Gregoraszczuk E.L., and Wojtowicz A.K. In vitro exposure of porcine ovarian follicular cells to PCB 153 alters steroid secretion but not their viability-preliminary study. Scientific World Journal 2 (2002) 261-267
20. Harvey P.W., and Everett D.J. The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?. J. Appl. Toxicol. 23 (2003) 81-87
21. Hilscherova K., Jones P.D., Gracia T., Newsted J.L., Zhang X., Sanderson J.T., Yu R.M.K., Wu R.S.S., and Giesy J.P. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol. Sci. 81 (2004) 78-89
22. James M.O. Polychlorinated biphenyls: metabolism and metabolites. In: Robertson L.W., and Hansen L.G. (Eds). PCBs: Recent Advances in the Environmental Toxicology and Health Effects (2001), University Press of Kentucky, Lexington, USA 35-46
23. Johansson M., Larsson C., Bergman A., and Lund B.O. Structure-activity relationship for inhibition of CYP11B1-dependent glucocorticoid synthesis in Y1 cells by aryl methyl sulfones. Pharmacol. Toxicol. 83 (1998) 225-230
24. Larsson C., Ellerichmann T., Hühnerfuss H., and Bergman A. Chiral PCB methyl sulfones in rat tissues after exposure to technical PCBs. Environ. Sci. Technol. 36 (2002) 2833-2838
25. Letcher R.J., Norstrom R.J., and Bergman A. Geographical distribution and identification of methyl sulfone PCB and DDE metabolites in pooled polar bear (Ursus maritimus) adipose tissue from western hemisphere arctic and sub-arctic regions. Sci. Total Environ. 160-161 (1995) 409-420
26. Letcher R.J., Norstrom R.J., and Muir D.C.G. Biotransformation versus bioaccumulation: sources of methyl sulfone PCB and 4,4′-DDE metabolites in the polar bear food chain. Environ. Sci. Technol. 32 (1998) 1656-1661
27. Letcher R.J., Klasson-Wehler E., and Bergman A. Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls. In: Paasivirta J. (Ed). The Handbook of Environmental Chemistry: New Types of Persistent Halogenated Compounds vol. 3 (2000), Springer-Verlag, Berlin 315-359 and references therein
28. Letcher R.J., Lemmen J.G., van der Burg B., Brouwer A., Bergman A., Giesy J.P., and van den Berg M. In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17β-estradiol-induced gene expression in several bioassay systems. Toxicol. Sci. 69 (2002) 362-372
29. Letcher R.J., Chu S.G., and Li H. Determination of hydroxylated polychlorinated biphenyls (HO-PCBs) in plasma by high performance liquid chromatography-electrospray-tandem quadrapole mass spectrometry. J. Anal. Toxicol. 29 (2004) 209-216
30. Li L.-A., and Wang P.-W. PCB126 induces differential changes in androgen, cortisol, and aldosterone biosynthesis in human adrenocortical H295R cells. Toxicol. Sci. 85 (2005) 530-540
31. Li L.-A., Wang P.-W., and Chang L.W. Polychlorinated biphenyl 126 stimulates basal and inducible aldosterone biosynthesis of human adrenocortical H295R cells. Toxicol. App. Pharmacol. 195 (2004) 92-102
32. Luu-The V., Lachance Y., Labrie C., Leblanc G., Thomas J.L., Strickler R.C., and Labrie F. Full length cDNA structure and deduced amino acid sequence of human 3β-hydroxy-5-ene steroid dehydrogenase. Mol. Endocrinol. 3 (1989) 1310-1312
33. Maervoet J., Covaci A., Schepens P., Sandau C.D., and Letcher R.J. A reassessment of the nomenclature of polychlorinated biphenyl (PCB) metabolites. Environ. Health Perspect. 112 (2004) 291-294
34. Mason J.I., Keeney D.S., Bird I.M., Rainey W.E., Morohashi K., Leers-Sucheta S., and Melner M.H. The regulation of 3β-hydroxysteroid dehydrogenase expression. Steroids 62 (1997) 164-168
35. Pang S., Carbunaru G., Haider A., Copeland K.C., Chang Y.T., Lutfallah C., and Mason J.I. Carriers for type II 3β-hydroxysteroid dehydrogenase (HSD3β2) deficiency can only be identified by HSD3β2 genotype study and not by hormone test. Clin. Endocrinol. (Oxf). 58 (2003) 323-331
36. Rainey W.E., Bird I.M., and Mason J.I. The NCI-H295 cell line: a pluripotent model for human adrenocortical studies. Mol. Cell. Endocrinol. 100 (1994) 45-50
37. Rhéaume E., Lachance Y., Zhao H.F., Breton N., Dumont M., de Launoit Y., Trudel C., Luu-The V., Simard J., and Labrie F. Structure and expression of a new complementary DNA encoding the almost exclusive 3β-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads. Mol. Endocrinol. 5 (1991) 1147-1157
38. Ribelin W.E. The effects of drugs and chemicals upon the structure of the adrenal gland. Fundam. Appl. Toxicol. 4 (1984) 105-119
39. Safe S., Wang F., Porter W., Duan R., and McDougal A. Ah receptor agonists as endocrine disrupters: antiestrogenic activity and mechanisms. Toxicol. Lett. 102-103 (1998) 343-347
40. Sandala G.M., Sonne-Hansen C., Dietz R., Muir D.C.G., Valters K., Bennett E.R., Born E.W., and Letcher R.J. Hydroxylated and methyl sulfone PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from East Greenland. Sci. Total Environ. 331 (2004) 125-141
41. Sanderson J.T., Heneweer M., Seinen W., Giesy J.P., and van den Berg M. Chloro-s-triazine herbicides and certain metabolites induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells. Organohalogen Compd. 42 (1999) 5-8
42. Sanderson J.T., Seinen W., Giesy J.P., and van den Berg M. 2-chloro-s-triazine herbicides induce aromatase (CYP-19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity. Toxicol. Sci. 54 (2000) 121-127
43. Sanderson J.T., Thomas J., Letcher R.J., Heneweer M., Giesy J.P., and Van den Berg M. Effects of chloro-s-triazine herbicides and metabolites on aromatase (CYP19) activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ. Health Perspect. 109 (2001) 1027-1031
44. Simon P. Q-Gene: processing quantitative real-time RT-PCR data. Bioinformatics 19 (2003) 1439-1440
45. Sinjari T., Wehler K., Hovander L., and Darnerud P.O. Hydroxylated polychlorinated biphenyls: distribution in the pregnant mouse. Xenobiotica 28 (1998) 31-40
46. Staels B., Hum D.W., and Miller W.L. Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal. Mol. Endocrinol. 7 (1993) 423-433
47. Stapleton H.M., Letcher R.J., and Baker J.E. Metabolism of PCBs by the deepwater sculpin (Myoxocephalus thompsoni). Environ. Sci. Technol. 35 (2001) 4747-4752
48. Strandgaard S., and Paulson O.B. Hypertension and human cerebrovascular disease. In: Swales J.D. (Ed). Textbook of Hypertension (1994), Blackwell Scientific Publications, Oxford 690-697
49. Sugawara T., and Fujimoto S. The potential function of steroid sulphatase activity in steroid production and steroidogenic acute regulatory protein expression. Biochem. J. 380 (2004) 153-160
50. Tong S.K., and Chung B.C. Analysis of zebrafish cyp19 promoters. J. Steroid Biochem. Mol. Biol. 86 (2003) 381-386
51. Ulrich B., and Stahlmann R. Developmental toxicity of polychlorinated biphenyls (PCBs): a systematic review of experimental data. Arch. Toxicol. 78 (2004) 252-268
52. van den Berg M., Birnbaum M.L., Bosveld B.T.C., Brumström B., Cook P., Feely M., Giesy J.P., Hanberg A., Hasegawa R., Kennedy S.W., Kubiak T., Larsen J.C., van Leeuwen F.X.R., Djien Liem A.K., Nolt C., Peterson R.E., Pollinger L., Safe S., Schrenk D., Tillitt D., Tusklind M., Younes M., Waren F., and Zacharewski T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 106 (1998) 775-792
53. Wiberg K., Letcher R.J., Sandau C., Duffe J., Norstrom R.J., Haglund P., and Bidleman T. Enantio-selective gas chromatography mass spectrometry of methylsulfonyl PCBs with application to arctic marine mammals. Anal. Chem. 70 (1998) 3845-3852
54. Zhang X., Yu R.M.K., Jones P.D., Lam G.K.W., Newsted J.L., Gracia T., Hecker M., Hilscherova K., Sanderson J.T., Wu R.S.S., and Giesy J.P. Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line. Environ. Sci. Technol. 39 (2005) 2777-2785