Iron status and its relations with oxidative damage and bone loss during long-duration space flight on the International Space Station

American Journal of Clinical Nutrition

Volumn 98, Issue 1, 2013, Pages 217-223

  Zwart, Sara R ^a   Morgan, Jennifer L L ^b   Smith, Scott M ^c  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b OAK RIDGE ASSOCIATED UNIVERSITIES   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACUTE PHASE PROTEIN; FERRITIN; IRON; PROSTAGLANDIN F2 ALPHA; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BONE DENSITY; CORRELATIONAL STUDY; FEMALE; FEMUR; FERRITIN BLOOD LEVEL; HIP; HUMAN; IRON STORAGE; IRON TRANSPORT; MALE; OSTEOLYSIS; OXIDATIVE STRESS; PELVIS; QUANTITATIVE ANALYSIS; SPACE FLIGHT; TRANSFERRIN BLOOD LEVEL;

ADULT; BIOLOGICAL MARKERS; BONE DENSITY; BONE RESORPTION; DEOXYGUANOSINE; FEMALE; FEMUR; FERRITINS; HUMANS; IRON OVERLOAD; IRON, DIETARY; LINEAR MODELS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; OXIDATIVE STRESS; QUESTIONNAIRES; SPACE FLIGHT;

EID: 84879435126     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.056465     Document Type: Article

References (45)

1. Beard JL. Iron. In: Bowman BA, Russell RM, eds. Present knowledge in nutrition. 9th ed. Washington, DC: International Life Sciences Institute, 2006:430-44.
2. Crichton RR. Iron metabolism from molecular mechanisms to clinical consequences. 3rd ed. West Sussex, United Kingdom: John Wiley & Sons Ltd, 2009.
3. Morlière P, Salmon S, Aubailly M, Risler A, Santus R. Sensitization of skin fibroblasts to UVA by excess iron. Biochim Biophys Acta 1997; 1334:283-90.
4. Nelson JM, Stevens RG. Ferritin-iron increases killing of Chinese hamster ovary cells by X-irradiation. Cell Prolif 1992;25:579-85.
5. Loh A, Hadziahmetovic M, Dunaief JL. Iron homeostasis and eye disease. Biochim Biophys Acta 2009;1790:637-49.
6. Deleon E, Lederman M, Berenstein E, Meir T, Chevion M, Chowers I. Alteration in iron metabolism during retinal degeneration in rd10 mouse. Invest Ophthalmol Vis Sci 2009;50:1360-5.
7. Alfrey CP, Rice L, Udden MM, Driscoll TB. Neocytolysis: physiological down-regulator of red-cell mass. Lancet 1997;349:1389-90.
8. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH. Control of red blood cell mass in spaceflight. J Appl Physiol 1996;81: 98-104.
9. Leach CS. Biochemical and hematologic changes after short-term space flight. Microgravity Q 1992;2:69-75.
10. Smith SM. Red blood cell and iron metabolism during space flight. Nutrition 2002;18:864-6.
11. Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE. The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr 2005;135:437-43.
12. Smith SM, Zwart SR, Kloeris V, Heer M. Nutritional biochemistry of space flight. New York, NY: Nova Science Publishers, 2009.
13. National Aeronautics and Space Administration. Nutrition requirements, standards, and operating bands for exploration missions. Houston, TX: Lyndon B. Johnson Space Center, 2005 (JSC Document no. 63555).
14. Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2001.
15. Smith SM, Heer M, Wang Z, Huntoon CL, Zwart SR. Long-duration space flight and bed rest effects on testosterone and other steroids. J Clin Endocrinol Metab 2012;97:270-8.
16. Smith SM, Heer MA, Shackelford L, Sibonga JD, Ploutz-Snyder L, Zwart SR. Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J Bone Miner Res 2012;27:1896-906.
17. Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih CY, Nillen JL, Davis-Street JE, et al. Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes. Am J Physiol 1999;277:R1-10.
18. Smith SM, Wastney ME, O'Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Bone markers, calcium metabolism, and calcium kinetics during extendedduration space flight on the Mir space station. J Bone Miner Res 2005; 20:208-18.
19. Smith SM, Davis-Street JE, Rice BL, Nillen JL, Gillman PL, Block G. Nutritional status assessment in semiclosed environments: groundbased and space flight studies in humans. J Nutr 2001;131:2053-61.
20. Soller BR, Cabrera M, Smith SM, Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition 2002;18: 930-6.
21. Zwart SR, Jessup JM, Ji J, Smith SM. Saturation diving alters folate status and biomarkers of DNA damage and repair. PLoS ONE 2012;7: e31058.
22. Zwart SR, Kala G, Smith SM. Body iron stores and oxidative damage in humans increased during and after a 10- to 12-day undersea dive. J Nutr 2009;139:90-5.
23. Smith SM, Davis-Street JE, Fesperman JV, Smith MD, Rice BL, Zwart SR. Nutritional assessment during a 14-d saturation dive: the NASA Extreme Environment Mission Operations V Project. J Nutr 2004;134: 1765-71.
24. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003;101:3359-64.
25. Beilby J, Olynyk J, Ching S, Prins A, Swanson N, Reed W, Harley H, Garcia-Webb P. Transferrin index: an alternative method for calculating the iron saturation of transferrin. Clin Chem 1992;38:2078-81.
26. Northrop-Clewes CA. Interpreting indicators of iron status during an acute phase response-lessons from malaria and human immunodeficiency virus. Ann Clin Biochem 2008;45:18-32.
27. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340:448-54.
28. Beguin Y. The soluble transferrin receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Haematologica 1992;77:1-10.
29. Semba RD, Kumwenda N, Hoover DR, Taha TE, Mtimavalye L, Broadhead R, Eisinger W, Miotti PG, Chiphangwi JD. Assessment of iron status using plasma transferrin receptor in pregnant women with and without human immunodeficiency virus infection in Malawi. Eur J Clin Nutr 2000;54:872-7.
30. Mendes JFR, Arrruda SF, de Almeida Siquira EM, Ito MK, da Silva EF. Iron status and oxidative stress biomarkers in adults: a preliminary study. Nutrition 2009;25:379-84.
31. Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic Res 2007;41:324-8.
32. Syrovatka P, Kraml P, Potockova J, Fialova L, Vejrazka M, Crkovska J, Andel M. Relationship between increased body iron stores, oxidative stress and insulin resistance in healthy men. Ann Nutr Metab 2009;54:268-74.
33. Pouraram H, Elmadfa I, Dorosty AR, Abtahi M, Neyestani TR, Sadeghian S. Long-term consequences of iron-fortified flour consumption in nonanemic men. Ann Nutr Metab 2012;60:115-21.
34. Biemond P, van Eijk HG, Swaak AJ, Koster JF. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J Clin Invest 1984;73:1576-9.
35. Aubailly M, Santus R, Salmon S. Ferrous ion release from ferritin by ultraviolet-A radiations. Photochem Photobiol 1991;54:769-73.
36. Reif DW, Schubert J, Aust SD. Iron release from ferritin and lipid peroxidation by radiolytically generated reducing radicals. Arch Biochem Biophys 1988;264:238-43.
37. Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, et al. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 2010;116:2582-9.
38. Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G, Takahashi K, Nishihira J, Izumi H, Sakamoto W. Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 2004;197: 93-100.
39. Kim BJ, Ahn SH, Bae SJ, Kim EH, Lee SH, Kim HK, Choe JW, Koh JM, Kim GS. Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: a 3-year retrospective longitudinal study. J Bone Miner Res 2012;27:2279-90
40. Ashrafian H. Hepcidin: the missing link between hemochromatosis and infections. Infect Immun 2003;71:6693-700.
41. Siegel EM, Patel N, Lu B, Lee JH, Nyitray AG, Huang X, Villa LL, Franco EL, Giuliano AR. Circulating biomarkers of iron storage and clearance of incident human papillomavirus infection. Cancer Epidemiol Biomarkers Prev 2012;21:859-65.
42. Crucian BE, Stowe RP, Pierson DL, Sams CF. Immune system dysregulation following short- vs long-duration spaceflight. Aviat Space Environ Med 2008;79:835-43.
43. Wilson JW, Ott CM, Honer zu Bentrup K, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, et al. Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proc Natl Acad Sci USA 2007;104: 16299-304.
44. Ganz T. Hepcidin-a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol 2006;306: 183-98.
45. Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011;117: 4425-33.