Saturation diving alters folate status and biomarkers of DNA damage and repair

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Zwart, Sara R ^a   Jessup, J Milburn ^b   Ji, Jiuping ^b   Smith, Scott M ^c  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOUBLE STRANDED DNA; FERRITIN; FOLIC ACID; IRON; POLY(ADENOSINE DIPHOSPHATE RIBOSE); SUPEROXIDE DISMUTASE; VITAMIN; OXYGEN;

ARTICLE; BLOOD OXYGEN TENSION; CONTROLLED STUDY; DIET RESTRICTION; DIVING; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ERYTHROCYTE; HABITAT; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; IRON STORAGE; MALE; NORMAL HUMAN; NUTRITIONAL REQUIREMENT; OXYGEN SATURATION; PERIPHERAL BLOOD MONONUCLEAR CELL; SEA; BLOOD; BLOOD ANALYSIS; GOVERNMENT; UNITED STATES;

BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; DIVING; DNA DAMAGE; DNA REPAIR; FOLIC ACID; HUMANS; HYPEROXIA; IRON; OXYGEN; UNITED STATES; UNITED STATES NATIONAL AERONAUTICS AND SPACE ADMINISTRATION;

EID: 84863023577     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031058     Document Type: Article

References (31)

1. Djurhuus R, Segadal K, Svardal AM, (2006) Glutathione in blood cells decreases without DNA breaks after a simulated saturation dive to 250 msw. Aviat Space Environ Med 77: 597-604.
2. Krog J, Tonnesen EK, Jepsen CF, Parner E, Segadal K, et al. (2010) Natural killer cells as biomarkers of hyperbaric stress during a dry heliox saturation dive. Aviat Space Environ Med 81: 467-474.
3. Smith SM, Davis-Street JE, Fesperman JV, Smith MD, Rice BL, et al. (2004) Nutritional assessment during a 14-d saturation dive: the NASA Extreme Environment Mission Operations V Project. J Nutr 134: 1765-1771.
4. Murray RD, Jacey MJ, (1977) Shallow habitat air dives I and II: human hematologic responses to compressed air saturation diving. Aviat Space Environ Med 48: 1012-1017.
5. Zwart SR, Kala G, Smith SM, (2009) Body iron stores and oxidative damage in humans increased during and after a 10- to 12-day undersea dive. J Nutr 139: 90-95.
6. Gilman SC, Biersner RJ, Piantadosi C, (1982) Serum ferritin increases during deep saturation dives. Aviat Space Environ Med 53: 1014-1016.
7. Ho PI, Ortiz D, Rogers E, Shea TB, (2002) Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 70: 694-702.
8. Toyokuni S, (2009) Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci 100: 9-16.
9. Stevens RG, Graubard BI, Micozzi MS, Neriishi K, Blumberg BS, (1994) Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 56: 364-369.
10. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, et al. (2008) Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 100: 996-1002.
11. Tang D, Kang R, Zeh HJ 3rd, Lotze MT, (2011) High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal 14: 1315-1335.
12. Redon CE, Nakamura AJ, Zhang YW, Ji JJ, Bonner WM, et al. (2010) Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res 16: 4532-4542.
13. D'Amours D, Desnoyers S, D'Silva I, Poirier GG, (1999) Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 342 (Pt 2): 249-268.
14. Kinders RJ, Hollingshead M, Lawrence S, Ji J, Tabb B, et al. (2010) Development of a validated immunofluorescence assay for gammaH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity. Clin Cancer Res 16: 5447-5457.
15. Smith S, Oliver SM, Zwart S, Kala G, Kelly P, et al. (2006) Nutritional status in self-neglecting elderly. J Nutr 136: 2534-2541.
16. Zwart SR, Crawford GE, Gillman PL, Kala G, Rodgers AS, et al. (2009) Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans. J Appl Physiol 107: 54-62.
17. Zwart SR, Oliver SM, Fesperman JV, Kala G, Krauhs J, et al. (2009) Nutritional status assessment before, during, and after long-duration head-down bed rest. Aviat Space Environ Med 80: A15-A22.
18. Cook JD, Flowers CH, Skikne BS, (2003) The quantitative assessment of body iron. Blood 101: 3359-3364.
19. Juiping J, Kinders RJ, Zhang Y, Rubinstein L, Kummar S, et al. (2011) Modeling pharmacodynamic response to the poly(ADP-ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells. PLoS ONE 6: e26152.
20. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, et al. (2008) GammaH2AX and cancer. Nat Rev Cancer 8: 957-967.
21. Solier S, Pommier Y, (2009) The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell Cycle 8: 1853-1859.
22. Rice L, Ruiz W, Driscoll T, Whitley CE, Tapia R, et al. (2001) Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass. Ann Intern Med 134: 652-656.
23. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH, (1996) Control of red blood cell mass in spaceflight. J Appl Physiol 81: 98-104.
24. Rice L, Alfrey CP, (2005) The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem 15: 245-250.
25. Gliszczynska-Swiglo A, (2006) Antioxidant activity of water soluble vitamins in the TEAC (trolox equivalent antioxidant capacity) and the FRAP (ferric reducing antioxidant power) assays. Food Chem 96: 131-136.
26. Gliszczynska-Swiglo A, (2007) Folates as antioxidants. Food Chem 101: 1480-1483.
27. Gliszczynska-Swiglo A, Muzolf M, (2007) pH-Dependent radical scavenging activity of folates. J Agric Food Chem 55: 8237-8242.
28. Patro BS, Adhikari S, Mukherjee T, Chattopadhyay S, (2006) Folic acid as a Fenton-modulator: possible physiological implication. Med Chem 2: 407-413.
29. Suh JR, Oppenheim EW, Girgis S, Stover PJ, (2000) Purification and properties of a folate-catabolizing enzyme. J Biol Chem 275: 35646-35655.
30. Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE, (2005) The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr 135: 437-443.
31. Henning BF, Tepel M, Riezler R, Naurath HJ, (2001) Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. Gerontology 47: 30-35.