The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4120-4126

  Wrobleski, Stephen T ^a   Lin, Shuqun ^a   Murali Dhar, T G ^a   Dyckman, Alaric J ^a   Li, Tianle ^a   Pitt, Sidney ^a   Zhang, Rosemary ^a   Fan, Yi ^a   Doweyko, Arthur M ^a   Tokarski, John S ^a   Kish, Kevin F ^a   Kiefer, Susan E ^a   Sack, John S ^a   Newitt, John A ^a   Witmer, Mark R ^a   McKinnon, Murray ^a   Barrish, Joel C ^a   Dodd, John H ^a   Schieven, Gary L ^a   Leftheris, Katerina ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Inhibitors; Kinase; p38

Indexed keywords

3 AMINO 4 METHYL N CYCLOPROPYLBENZAMIDE; HISTIDINE; LEUCINE; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; THREONINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOSYNTHESIS; BLOOD; CONTROLLED STUDY; DISSOCIATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; MONONUCLEAR CELL; PH; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879420782     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.047     Document Type: Article

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