Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 411-416

  Tynebor, Robert M ^a   Chen, Meng Hsin ^a   Natarajan, Swaminathan R ^a   O'Neill, Edward A ^a   Thompson, James E ^a   Fitzgerald, Catherine E ^a   O'Keefe, Stephen J ^a   Doherty, James B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

p38 inhibitors; Pyridopyridazin 6 one; Rheumatoid arthritis; Selective

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PYRIDOPYRIDAZIN 6 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; MITOGEN-ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIDAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650510476     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.128     Document Type: Article

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