Structural basis for the high-affinity binding of pyrrolotriazine inhibitors of p38 MAP kinase

Acta Crystallographica Section D: Biological Crystallography

Volumn 64, Issue 7, 2008, Pages 705-710

  Sack, John S ^a   Kish, Kevin F ^a   Pokross, Matthew ^a   Xie, Dianlin ^a   Duke, Gerald J ^a   Tredup, Jeffrey A ^a   Kiefer, Susan E ^a   Newitt, John A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

p38 MAP kinase; Pyrrolotriazine based inhibitors

Indexed keywords

ANILIDE; BENZAMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

ANILIDES; BENZAMIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES;

EID: 45749127408     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444908010032     Document Type: Article

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