Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4011-4018

  Lorenz, Martin ^a   Evers, Andreas ^b   Wagner, Michael ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b Sanofi Deutschland GmbH   (Germany)

Author keywords

Delivery technologies; Diabesity; Gastro intestinal hormones; GLP 1 receptor agonists

Indexed keywords

ALBIGLUTIDE; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; HUMAN SERUM ALBUMIN; INSULIN GLARGINE; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; SEMAGLUTIDE; SERUM ALBUMIN; TASPOGLUTIDE;

ANTIBODY PRODUCTION; ANTIDIABETIC ACTIVITY; DIABETIC OBESITY; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNE RESPONSE; INJECTION SITE REACTION; INSULIN LIKE ACTIVITY; INSULIN RELEASE; MONOTHERAPY; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREATITIS; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); POSTMARKETING SURVEILLANCE; PROTEIN CONFORMATION; PROTEIN FUNCTION; REVIEW; STEADY STATE; STOMACH ABSORPTION; STOMACH EMPTYING; TANDEM REPEAT; TREATMENT DURATION; VOMITING; WEIGHT REDUCTION;

CLINICAL TRIALS AS TOPIC; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOGLOBULIN FC FRAGMENTS; PEPTIDES; RECOMBINANT FUSION PROTEINS;

EID: 84879418684     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.022     Document Type: Review

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