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Volumn 92, Issue 24-26, 2013, Pages 1215-1221

Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway

Author keywords

Oxidative stress; p38MAPK iNOS signaling pathway; Quercetin; Spinal cord injury

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIOXIDANT; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; METHYLPREDNISOLONE; MITOGEN ACTIVATED PROTEIN KINASE P38; QUERCETIN; SUPEROXIDE DISMUTASE;

EID: 84879414250     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.05.007     Document Type: Article
Times cited : (79)

References (31)
  • 1
    • 84870297577 scopus 로고    scopus 로고
    • Dietary antioxidant, quercetin, protects sertoli-germ cell coculture from atrazine-induced oxidative damage
    • S.O. Abarikwu, A.B. Pant, and E.O. Farombi Dietary antioxidant, quercetin, protects sertoli-germ cell coculture from atrazine-induced oxidative damage J Biochem Mol Toxicol 26 11 2012 477 485
    • (2012) J Biochem Mol Toxicol , vol.26 , Issue.11 , pp. 477-485
    • Abarikwu, S.O.1    Pant, A.B.2    Farombi, E.O.3
  • 2
    • 0017650830 scopus 로고
    • Objective clinical assessment of motor function after experimental spinal cord injury in the rat
    • AS, and C.H. Tator Objective clinical assessment of motor function after experimental spinal cord injury in the rat J Neurosurg 47 4 1977 577 581
    • (1977) J Neurosurg , vol.47 , Issue.4 , pp. 577-581
    • Tator, C.H.1
  • 3
    • 84858151224 scopus 로고    scopus 로고
    • Antioxidant therapies in traumatic brain and spinal cord injury
    • M. Bains, and E.D. Hall Antioxidant therapies in traumatic brain and spinal cord injury Biochim Biophys Acta 1822 5 2012 675 684
    • (2012) Biochim Biophys Acta , vol.1822 , Issue.5 , pp. 675-684
    • Bains, M.1    Hall, E.D.2
  • 4
    • 10544242207 scopus 로고    scopus 로고
    • MASCIS evaluation of open field locomotor scores: Effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study
    • D.M. Basso, M.S. Beattie, J.C. Bresnahan, D.K. Anderson, A.I. Faden, and J.A. Gruner MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study J Neurotrauma 13 7 1996 343 359
    • (1996) J Neurotrauma , vol.13 , Issue.7 , pp. 343-359
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3    Anderson, D.K.4    Faden, A.I.5    Gruner, J.A.6
  • 5
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • N.R. Bhat, P. Zhang, J.C. Lee, and E.L. Hogan Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures J Neurosci 18 5 1998 1633 1641
    • (1998) J Neurosci , vol.18 , Issue.5 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 6
    • 84870700764 scopus 로고    scopus 로고
    • Role of quercetin in vascular physiology
    • S. Chirumbolo Role of quercetin in vascular physiology Can J Physiol Pharmacol 90 12 2012 1652 1657
    • (2012) Can J Physiol Pharmacol , vol.90 , Issue.12 , pp. 1652-1657
    • Chirumbolo, S.1
  • 7
    • 33947695576 scopus 로고    scopus 로고
    • Nitric oxide in the injured spinal cord: Synthases cross-talk, oxidative stress and inflammation
    • A. Conti, M. Miscusi, S. Cardali, A. Germanò, H. Suzuki, and S. Cuzzocrea Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation Brain Res Rev 54 1 2007 205 218
    • (2007) Brain Res Rev , vol.54 , Issue.1 , pp. 205-218
    • Conti, A.1    Miscusi, M.2    Cardali, S.3    Germanò, A.4    Suzuki, H.5    Cuzzocrea, S.6
  • 8
    • 0036165251 scopus 로고    scopus 로고
    • Pharmacological inhibitors of MAPK pathways
    • J.M. English, and M.H. Cobb Pharmacological inhibitors of MAPK pathways Trends Pharmacol Sci 23 1 2002 40 45
    • (2002) Trends Pharmacol Sci , vol.23 , Issue.1 , pp. 40-45
    • English, J.M.1    Cobb, M.H.2
  • 9
    • 10744227768 scopus 로고    scopus 로고
    • Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
    • R.J. Gum, M.M. McLaughlin, S. Kumar, Z. Wang, M.J. Bower, and J.C. Lee Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket J Biol Chem 273 25 1998 15605 15610
    • (1998) J Biol Chem , vol.273 , Issue.25 , pp. 15605-15610
    • Gum, R.J.1    McLaughlin, M.M.2    Kumar, S.3    Wang, Z.4    Bower, M.J.5    Lee, J.C.6
  • 10
    • 0032176882 scopus 로고    scopus 로고
    • Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies
    • B.H. Juurlink, and P.G. Paterson Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies J Spinal Cord Med 21 4 1998 309 334
    • (1998) J Spinal Cord Med , vol.21 , Issue.4 , pp. 309-334
    • Juurlink, B.H.1    Paterson, P.G.2
  • 11
    • 0034202211 scopus 로고    scopus 로고
    • Antioxidants and cancer, part 3: Quercetin
    • D.W. Lamson, and M.S. Brignall Antioxidants and cancer, part 3: quercetin Altern Med Rev 5 3 2000 196 208
    • (2000) Altern Med Rev , vol.5 , Issue.3 , pp. 196-208
    • Lamson, D.W.1    Brignall, M.S.2
  • 13
    • 33749463870 scopus 로고    scopus 로고
    • Antioxidation of quercetin against spinal cord injury in rats
    • J.B. Liu, T.S. Tang, and H.L. Yang Antioxidation of quercetin against spinal cord injury in rats Chin J Traumatol 9 5 2006 303 307
    • (2006) Chin J Traumatol , vol.9 , Issue.5 , pp. 303-307
    • Liu, J.B.1    Tang, T.S.2    Yang, H.L.3
  • 14
    • 80052039486 scopus 로고    scopus 로고
    • Current role of methylprednisolone in the treatment of acute spinal cord injury
    • R. Lukáš, I. Zýková, P. Barsa, and J. Srám Current role of methylprednisolone in the treatment of acute spinal cord injury Acta Chir Orthop Traumatol Cech 78 4 2011 305 313
    • (2011) Acta Chir Orthop Traumatol Cech , vol.78 , Issue.4 , pp. 305-313
    • Lukáš, R.1    Zýková, I.2    Barsa, P.3    Srám, J.4
  • 15
    • 84865257818 scopus 로고    scopus 로고
    • Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury
    • D.M. Maggio, K. Chatzipanteli, N. Masters, S.P. Patel, W.D. Dietrich, and D.D. Pearse Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury J Neurotrauma 29 12 2012 2244 2249
    • (2012) J Neurotrauma , vol.29 , Issue.12 , pp. 2244-2249
    • Maggio, D.M.1    Chatzipanteli, K.2    Masters, N.3    Patel, S.P.4    Dietrich, W.D.5    Pearse, D.D.6
  • 16
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev 43 2 1991 109 142
    • (1991) Pharmacol Rev , vol.43 , Issue.2 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 17
    • 84859364830 scopus 로고    scopus 로고
    • Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart
    • S.F. Nabavi, S.M. Nabavi, M. Mirzaei, and A.H. Moghaddam Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart Food Funct 3 4 2012 437 441
    • (2012) Food Funct , vol.3 , Issue.4 , pp. 437-441
    • Nabavi, S.F.1    Nabavi, S.M.2    Mirzaei, M.3    Moghaddam, A.H.4
  • 18
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls, and controls
    • C. Nathan, and Q.W. Xie Nitric oxide synthases: roles, tolls, and controls Cell 78 6 1994 915 918
    • (1994) Cell , vol.78 , Issue.6 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 20
    • 50549086554 scopus 로고    scopus 로고
    • The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats
    • M.A. Papiez, A. Cierniak, W. Krzysciak, M. Bzowska, H.M. Taha, and A. Jozkowicz The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats Food Chem Toxicol 46 9 2008 3053 3058
    • (2008) Food Chem Toxicol , vol.46 , Issue.9 , pp. 3053-3058
    • Papiez, M.A.1    Cierniak, A.2    Krzysciak, W.3    Bzowska, M.4    Taha, H.M.5    Jozkowicz, A.6
  • 21
    • 55849108858 scopus 로고    scopus 로고
    • Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    • K.K. Park, K. Liu, Y. Hu, P.D. Smith, C. Wang, and B. Cai Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway Science 322 5903 2008 963 966
    • (2008) Science , vol.322 , Issue.5903 , pp. 963-966
    • Park, K.K.1    Liu, K.2    Hu, Y.3    Smith, P.D.4    Wang, C.5    Cai, B.6
  • 22
    • 0023580381 scopus 로고
    • Therapeutic model for experimental spinal cord injury in the rat: I. Mortality and motor deficit
    • P.L. Perot Jr., W.A. Lee, C.Y. Hsu, E.L. Hogan, R.D. Cox, and A.J. Gross Therapeutic model for experimental spinal cord injury in the rat: I. Mortality and motor deficit Cent Nerv Syst Trauma 4 3 1987 149 159
    • (1987) Cent Nerv Syst Trauma , vol.4 , Issue.3 , pp. 149-159
    • Perot, Jr.P.L.1    Lee, W.A.2    Hsu, C.Y.3    Hogan, E.L.4    Cox, R.D.5    Gross, A.J.6
  • 23
  • 24
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • M. Raman, W. Chen, and M.H. Cobb Differential regulation and properties of MAPKs Oncogene 26 22 2007 3100 3112
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 25
    • 84871604354 scopus 로고    scopus 로고
    • Protective role of quercetin on polychlorinated biphenyls (aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats
    • S. Sekaran, S. Kandaswamy, K. Gunasekaran, E. Perumal, F.Y. Afsar Basha, and B.J. Madhan Mohan Protective role of quercetin on polychlorinated biphenyls (aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats J Biochem Mol Toxicol 26 12 2012 522 532
    • (2012) J Biochem Mol Toxicol , vol.26 , Issue.12 , pp. 522-532
    • Sekaran, S.1    Kandaswamy, S.2    Gunasekaran, K.3    Perumal, E.4    Afsar Basha, F.Y.5    Madhan Mohan, B.J.6
  • 26
    • 84876416213 scopus 로고    scopus 로고
    • Protective effect of ginkgolide B against acute spinal cord injury in rats and its correlation with the Jak/STAT signaling pathway
    • Y. Song, Z. Zeng, C. Jin, J. Zhang, B. Ding, and F. Zhang Protective effect of ginkgolide B against acute spinal cord injury in rats and its correlation with the Jak/STAT signaling pathway Neurochem Res 38 3 2013 610 619
    • (2013) Neurochem Res , vol.38 , Issue.3 , pp. 610-619
    • Song, Y.1    Zeng, Z.2    Jin, C.3    Zhang, J.4    Ding, B.5    Zhang, F.6
  • 27
    • 0038291933 scopus 로고    scopus 로고
    • Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
    • J.P. Spencer, G.G. Kuhnle, R.J. Williams, and C. Rice-Evans Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites Biochem J 372 Pt 1 2003 173 181
    • (2003) Biochem J , vol.372 , Issue.PART 1 , pp. 173-181
    • Spencer, J.P.1    Kuhnle, G.G.2    Williams, R.J.3    Rice-Evans, C.4
  • 28
    • 77952357815 scopus 로고    scopus 로고
    • Postinjury estrogen treatment of chronic spinal cord injury improves locomotor function in rats
    • E.A. Sribnick, S. Samantaray, A. Das, J. Smith, D.D. Matzelle, and S.K. Ray Postinjury estrogen treatment of chronic spinal cord injury improves locomotor function in rats J Neurosci Res 88 8 2012 1738 1750
    • (2012) J Neurosci Res , vol.88 , Issue.8 , pp. 1738-1750
    • Sribnick, E.A.1    Samantaray, S.2    Das, A.3    Smith, J.4    Matzelle, D.D.5    Ray, S.K.6
  • 29
    • 0036135787 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and neurologic injury: Possible relationship to cerebral protection by anesthetics
    • J.X. Wilson, and A.W. Gelb Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics J Neurosurg Anesthesiol 14 1 2002 66 79
    • (2002) J Neurosurg Anesthesiol , vol.14 , Issue.1 , pp. 66-79
    • Wilson, J.X.1    Gelb, A.W.2
  • 30
    • 0034680734 scopus 로고    scopus 로고
    • P38 MAPK, but not p42/p44 MAPK mediated inducible nitric oxide synthase expression in C6 glioma cells
    • X. Xu, and A. Malave P38 MAPK, but not p42/p44 MAPK mediated inducible nitric oxide synthase expression in C6 glioma cells Life Sci 67 26 2000 3221 3230
    • (2000) Life Sci , vol.67 , Issue.26 , pp. 3221-3230
    • Xu, X.1    Malave, A.2
  • 31
    • 0033600914 scopus 로고    scopus 로고
    • Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
    • R. Yu, W. Lei, S. Mandlekar, M.J. Weber, C.J. Der, and J. Wu Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals J Biol Chem 274 39 1999 27545 27552
    • (1999) J Biol Chem , vol.274 , Issue.39 , pp. 27545-27552
    • Yu, R.1    Lei, W.2    Mandlekar, S.3    Weber, M.J.4    Der, C.J.5    Wu, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.