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Volumn 38, Issue 3, 2013, Pages 610-619

Protective effect of ginkgolide B against acute spinal cord injury in rats and its correlation with the JAK/STAT signaling pathway

Author keywords

Apoptosis; Ginkgolide B; JAK STAT signaling pathway; Spinal cord injury

Indexed keywords

CASPASE 3; GINKGOLIDE B; JANUS KINASE; JANUS KINASE 2; MESSENGER RNA; METHYLPREDNISOLONE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BAX; PROTEIN BCL 2; STAT PROTEIN; STAT3 PROTEIN;

EID: 84876416213     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0959-y     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 84862984631 scopus 로고    scopus 로고
    • PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury
    • 21720761 10.1007/s11033-011-1127-1 1:CAS:528:DC%2BC38Xjt12qsrg%3D
    • Zhao T, Qi Y, Li Y, Xu K (2012) PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury. Mol Biol Rep 39(4):3541-3547
    • (2012) Mol Biol Rep , vol.39 , Issue.4 , pp. 3541-3547
    • Zhao, T.1    Qi, Y.2    Li, Y.3    Xu, K.4
  • 2
    • 36949009656 scopus 로고    scopus 로고
    • Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury
    • 17703359 10.1007/s11064-007-9426-6 1:CAS:528:DC%2BD2sXhsVSmurvN
    • Dasari VR, Spomar DG, Li L, Gujrati M, Rao JS, Dinh DH (2008) Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Neurochem Res 33(1):134-149
    • (2008) Neurochem Res , vol.33 , Issue.1 , pp. 134-149
    • Dasari, V.R.1    Spomar, D.G.2    Li, L.3    Gujrati, M.4    Rao, J.S.5    Dinh, D.H.6
  • 3
    • 55849108858 scopus 로고    scopus 로고
    • Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    • 18988856 10.1126/science.1161566 1:CAS:528:DC%2BD1cXhtlaltLzK
    • Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322(5903):963-966
    • (2008) Science , vol.322 , Issue.5903 , pp. 963-966
    • Park, K.K.1    Liu, K.2    Hu, Y.3    Smith, P.D.4    Wang, C.5    Cai, B.6    Xu, B.7    Connolly, L.8    Kramvis, I.9    Sahin, M.10    He, Z.11
  • 4
    • 77951533730 scopus 로고    scopus 로고
    • SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury
    • 20410127 10.1523/JNEUROSCI.5007-09.2010 1:CAS:528:DC%2BC3cXhtVWlsLzO
    • Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M (2010) SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci 30(16):5754-5766
    • (2010) J Neurosci , vol.30 , Issue.16 , pp. 5754-5766
    • Dominguez, E.1    Mauborgne, A.2    Mallet, J.3    Desclaux, M.4    Pohl, M.5
  • 5
    • 0034119666 scopus 로고    scopus 로고
    • Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury
    • 10757326 10.1089/neu.2000.17.203 1:STN:280:DC%2BD3c3hvVamsA%3D%3D
    • Hayashi M, Ueyama T, Nemoto K, Tamaki T, Senba E (2000) Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. J Neurotrauma 17(3):203-218
    • (2000) J Neurotrauma , vol.17 , Issue.3 , pp. 203-218
    • Hayashi, M.1    Ueyama, T.2    Nemoto, K.3    Tamaki, T.4    Senba, E.5
  • 6
    • 0030913044 scopus 로고    scopus 로고
    • Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury
    • 9182957 10.1111/j.1460-9568.1997.tb01455.x 1:STN:280:DyaK2szisF2ntw%3D%3D
    • Yao GL, Kato H, Khalil M, Kiryu S, Kiyama H (1997) Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury. Eur J Neurosci 9(5):1047-1054
    • (1997) Eur J Neurosci , vol.9 , Issue.5 , pp. 1047-1054
    • Yao, G.L.1    Kato, H.2    Khalil, M.3    Kiryu, S.4    Kiyama, H.5
  • 7
  • 8
    • 79954454008 scopus 로고    scopus 로고
    • Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice
    • 21496122 10.1111/j.1460-9568.2011.07646.x
    • Paterniti I, Esposito E, Mazzon E, Bramanti P, Cuzzocrea S (2011) Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice. Eur J Neurosci 33(8):1411-1420
    • (2011) Eur J Neurosci , vol.33 , Issue.8 , pp. 1411-1420
    • Paterniti, I.1    Esposito, E.2    Mazzon, E.3    Bramanti, P.4    Cuzzocrea, S.5
  • 9
    • 79960007964 scopus 로고    scopus 로고
    • GSK-3β: A signaling pathway node modulating neural stem cell and endothelial cell interactions
    • 21253820 10.1007/s10456-011-9201-9 1:CAS:528:DC%2BC3MXmslagsrc%3D
    • Li Q, Michaud M, Canosa S, Kuo A, Madri JA (2011) GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis 14(2):173-185
    • (2011) Angiogenesis , vol.14 , Issue.2 , pp. 173-185
    • Li, Q.1    Michaud, M.2    Canosa, S.3    Kuo, A.4    Madri, J.A.5
  • 11
    • 78649710769 scopus 로고    scopus 로고
    • Mast cell homeostasis and the JAK-STAT pathway
    • 20535135 10.1038/gene.2010.35 1:CAS:528:DC%2BC3cXhsV2gtbrE
    • Morales JK, Falanga YT, Depcrynski A, Fernando J, Ryan JJ (2010) Mast cell homeostasis and the JAK-STAT pathway. Genes Immun 11(8):599-608
    • (2010) Genes Immun , vol.11 , Issue.8 , pp. 599-608
    • Morales, J.K.1    Falanga, Y.T.2    Depcrynski, A.3    Fernando, J.4    Ryan, J.J.5
  • 12
    • 77953019852 scopus 로고    scopus 로고
    • Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
    • 20471303 10.1016/j.drup.2010.04.001 1:CAS:528:DC%2BC3cXntVSmur8%3D
    • Lai SY, Johnson FM (2010) Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches. Drug Resist Updat 13(3):67-78
    • (2010) Drug Resist Updat , vol.13 , Issue.3 , pp. 67-78
    • Lai, S.Y.1    Johnson, F.M.2
  • 13
    • 57049182470 scopus 로고    scopus 로고
    • Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal cerebral ischemia/reperfusion injury in rats
    • 19000414
    • Yang QZ, Lei C, Lu ZH, Wang BR, Xiong LZ (2008) Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal cerebral ischemia/reperfusion injury in rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20(11):641-644
    • (2008) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue , vol.20 , Issue.11 , pp. 641-644
    • Yang, Q.Z.1    Lei, C.2    Lu, Z.H.3    Wang, B.R.4    Xiong, L.Z.5
  • 14
    • 51849153310 scopus 로고    scopus 로고
    • JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
    • 18636982 10.1111/j.1471-4159.2008.05566.x 1:CAS:528:DC%2BD1cXht1KgtLnM
    • Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M (2008) JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat. J Neurochem 107(1):50-60
    • (2008) J Neurochem , vol.107 , Issue.1 , pp. 50-60
    • Dominguez, E.1    Rivat, C.2    Pommier, B.3    Mauborgne, A.4    Pohl, M.5
  • 15
    • 60849088258 scopus 로고    scopus 로고
    • STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes
    • 19228956 10.1523/JNEUROSCI.2621-08.2009 1:CAS:528:DC%2BD1MXisV2htbc%3D
    • Xu J, Chen S, Chen H, Xiao Q, Hsu CY, Michael D, Bao J (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J Neurosci 29(7):2022-2026
    • (2009) J Neurosci , vol.29 , Issue.7 , pp. 2022-2026
    • Xu, J.1    Chen, S.2    Chen, H.3    Xiao, Q.4    Hsu, C.Y.5    Michael, D.6    Bao, J.7
  • 16
    • 9444271638 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis
    • 15319365 1:CAS:528:DC%2BD2cXotFGhsr0%3D
    • Townsend PA, Scarabelli TM, Pasini E, Gitti G, Menegazzi M, Suzuki H, Knight RA, Latchman DS, Stephanou A (2004) Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion- induced apoptosis. FASEB J 18(13):1621-1623
    • (2004) FASEB J , vol.18 , Issue.13 , pp. 1621-1623
    • Townsend, P.A.1    Scarabelli, T.M.2    Pasini, E.3    Gitti, G.4    Menegazzi, M.5    Suzuki, H.6    Knight, R.A.7    Latchman, D.S.8    Stephanou, A.9
  • 17
    • 0035142665 scopus 로고    scopus 로고
    • Activation of STAT proteins and growth control
    • 11169589 10.1002/1521-1878(200102)23:2<161: AID-BIES1023>3.0.CO;2-0 1:CAS:528:DC%2BD3MXptVOrsrc%3D
    • Bromberg JF (2001) Activation of STAT proteins and growth control. BioEssays 23(2):161-169
    • (2001) BioEssays , vol.23 , Issue.2 , pp. 161-169
    • Bromberg, J.F.1
  • 18
    • 0035952638 scopus 로고    scopus 로고
    • G protein coupled receptor signaling through the Src and Stat3 pathway: Role in proliferation and transformation
    • 11313907 10.1038/sj.onc.1204186 1:CAS:528:DC%2BD3MXivValtro%3D
    • Ram PT, Iyengar R (2001) G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene 20(13):1601-1606
    • (2001) Oncogene , vol.20 , Issue.13 , pp. 1601-1606
    • Ram, P.T.1    Iyengar, R.2
  • 20
    • 77954709824 scopus 로고    scopus 로고
    • Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons
    • 20492356 1:CAS:528:DC%2BC3cXhtVWktrfN
    • Wang G, Zhou D, Wang C, Gao Y, Zhou Q, Qian G, DeCoster MA (2010) Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons. J Neurochem 114(4):1039-1048
    • (2010) J Neurochem , vol.114 , Issue.4 , pp. 1039-1048
    • Wang, G.1    Zhou, D.2    Wang, C.3    Gao, Y.4    Zhou, Q.5    Qian, G.6    Decoster, M.A.7
  • 22
    • 33749578057 scopus 로고    scopus 로고
    • Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract on various kinds of diseases
    • 17005090 10.1007/BF02836532
    • Wang GX, Cao FL, Chen J (2006) Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract on various kinds of diseases. Chin J Integr Med 12(3):234-239
    • (2006) Chin J Integr Med , vol.12 , Issue.3 , pp. 234-239
    • Wang, G.X.1    Cao, F.L.2    Chen, J.3
  • 23
    • 34547824397 scopus 로고    scopus 로고
    • EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    • 17356006 10.1096/fj.06-7649com 1:CAS:528:DC%2BD2sXptFKhtbc%3D
    • Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007) EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease. FASEB J 21(10):2400-2408
    • (2007) FASEB J , vol.21 , Issue.10 , pp. 2400-2408
    • Tchantchou, F.1    Xu, Y.2    Wu, Y.3    Christen, Y.4    Luo, Y.5
  • 24
    • 79952445447 scopus 로고    scopus 로고
    • Inhibition of cPLA2 activation by Ginkgo biloba extract protects spinal cord neurons from glutamate excitotoxicity and oxidative stress-induced cell death
    • 21182525 10.1111/j.1471-4159.2010.07160.x 1:CAS:528:DC%2BC3MXjvFWnt7s%3D
    • Zhao Z, Liu N, Huang J, Lu PH, Xu XM (2011) Inhibition of cPLA2 activation by Ginkgo biloba extract protects spinal cord neurons from glutamate excitotoxicity and oxidative stress-induced cell death. J Neurochem 116(6):1057-1065
    • (2011) J Neurochem , vol.116 , Issue.6 , pp. 1057-1065
    • Zhao, Z.1    Liu, N.2    Huang, J.3    Lu, P.H.4    Xu, X.M.5
  • 25
    • 1342279441 scopus 로고    scopus 로고
    • Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons
    • 14988036 10.1016/j.brainres.2003.12.018 1:CAS:528:DC%2BD2cXhsVOmsLs%3D
    • Massieu L, Morán J, Christen Y (2004) Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons. Brain Res 1002(1-2):76-85
    • (2004) Brain Res , vol.1002 , Issue.1-2 , pp. 76-85
    • Massieu, L.1    Morán, J.2    Christen, Y.3
  • 26
    • 77957296588 scopus 로고    scopus 로고
    • Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor
    • 20709055 10.1016/j.ejphar.2010.08.002 1:CAS:528:DC%2BC3cXht1CgurrE
    • Xiao Q, Wang C, Li J, Hou Q, Li J, Ma J, Wang W, Wang Z (2010) Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor. Eur J Pharmacol 647(1-3):48-54
    • (2010) Eur J Pharmacol , vol.647 , Issue.1-3 , pp. 48-54
    • Xiao, Q.1    Wang, C.2    Li, J.3    Hou, Q.4    Li, J.5    Ma, J.6    Wang, W.7    Wang, Z.8
  • 27
    • 57349142905 scopus 로고    scopus 로고
    • Effects of ginkgolide B on neuronal discharges in paraventricular nucleus of rat hypothalamic slices
    • 19037319 10.1007/s12264-008-2716-4 1:CAS:528:DC%2BD1MXhtVyqs77E
    • Lin Y, Wang R, Wang X, He RR, Wu YM (2008) Effects of ginkgolide B on neuronal discharges in paraventricular nucleus of rat hypothalamic slices. Neurosci Bull 24(6):345-350
    • (2008) Neurosci Bull , vol.24 , Issue.6 , pp. 345-350
    • Lin, Y.1    Wang, R.2    Wang, X.3    He, R.R.4    Wu, Y.M.5
  • 29
    • 77954621405 scopus 로고    scopus 로고
    • Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells
    • 20333467 10.1007/s10495-010-0492-x 1:CAS:528:DC%2BC3cXmsFSmtrc%3D
    • Shi C, Wu F, Yew DT, Xu J, Zhu Y (2010) Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Apoptosis 15(6):715-727
    • (2010) Apoptosis , vol.15 , Issue.6 , pp. 715-727
    • Shi, C.1    Wu, F.2    Yew, D.T.3    Xu, J.4    Zhu, Y.5
  • 30
    • 80052039486 scopus 로고    scopus 로고
    • Current role of methylprednisolone in the treatment of acute spinal cord injury
    • 21888840
    • Lukáš R, Zýková I, Barsa P, Srám J (2011) Current role of methylprednisolone in the treatment of acute spinal cord injury. Acta Chir Orthop Traumatol Cech 78(4):305-313
    • (2011) Acta Chir Orthop Traumatol Cech , vol.78 , Issue.4 , pp. 305-313
    • Lukáš, R.1    Zýková, I.2    Barsa, P.3    Srám, J.4
  • 32
    • 77952357815 scopus 로고    scopus 로고
    • Postinjury estrogen treatment of chronic spinal cord injury improves locomotor function in rats
    • 20091771 1:CAS:528:DC%2BC3cXltVGisr4%3D [PubMed: 20091771]
    • Sribnick EA, Samantaray S, Das A, Smith J, Matzelle DD, Ray SK, Banik NL (2010) Postinjury estrogen treatment of chronic spinal cord injury improves locomotor function in rats. J Neurosci Res 88(8):1738-1750 [PubMed: 20091771]
    • (2010) J Neurosci Res , vol.88 , Issue.8 , pp. 1738-1750
    • Sribnick, E.A.1    Samantaray, S.2    Das, A.3    Smith, J.4    Matzelle, D.D.5    Ray, S.K.6    Banik, N.L.7
  • 33
    • 0023580381 scopus 로고
    • Therapeutic model for experimental spinal cord injury in the rat: I. Mortality and motor deficit
    • 3442814
    • Perot PL Jr, Lee WA, Hsu CY, Hogan EL, Cox RD, Gross AJ (1987) Therapeutic model for experimental spinal cord injury in the rat: I. Mortality and motor deficit. Cent Nerv Syst Trauma 4(3):149-159
    • (1987) Cent Nerv Syst Trauma , vol.4 , Issue.3 , pp. 149-159
    • Perot Jr., P.L.1    Lee, W.A.2    Hsu, C.Y.3    Hogan, E.L.4    Cox, R.D.5    Gross, A.J.6
  • 34
    • 15744387138 scopus 로고    scopus 로고
    • Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury
    • 15232723 10.1007/s00586-003-0550-y
    • Cayli SR, Kocak A, Yilmaz U, Tekiner A, Erbil M, Ozturk C, Batcioglu K, Yologlu S (2004) Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. Eur Spine J 13(8):724-732
    • (2004) Eur Spine J , vol.13 , Issue.8 , pp. 724-732
    • Cayli, S.R.1    Kocak, A.2    Yilmaz, U.3    Tekiner, A.4    Erbil, M.5    Ozturk, C.6    Batcioglu, K.7    Yologlu, S.8
  • 35
    • 80755187943 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy
    • 21833841 10.1007/s11064-011-0576-1 1:CAS:528:DC%2BC3MXhtVShsrjO
    • Xu Z, Xue T, Zhang Z, Wang X, Xu P, Zhang J, Lei X, Li Y, Xie Y, Wang L, Fang M, Chen Y (2011) Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. Neurochem Res 36(12):2208-2215
    • (2011) Neurochem Res , vol.36 , Issue.12 , pp. 2208-2215
    • Xu, Z.1    Xue, T.2    Zhang, Z.3    Wang, X.4    Xu, P.5    Zhang, J.6    Lei, X.7    Li, Y.8    Xie, Y.9    Wang, L.10    Fang, M.11    Chen, Y.12
  • 36
    • 0017650830 scopus 로고
    • Objective clinical assessment of motor function after experimental spinal cord injury in the rat
    • 903810 10.3171/jns.1977.47.4.0577 1:STN:280:DyaE1c%2FgslarsQ%3D%3D
    • Rivlin AS, Tator CH (1977) Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47(4):577-581
    • (1977) J Neurosurg , vol.47 , Issue.4 , pp. 577-581
    • Rivlin, A.S.1    Tator, C.H.2
  • 38
    • 79951581677 scopus 로고    scopus 로고
    • Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway
    • 21052840 10.1007/s10495-010-0552-2 1:CAS:528:DC%2BC3MXhs1Gju7g%3D
    • Choi JK, Kim KH, Park H, Park SR, Choi BH (2011) Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway. Apoptosis 16(2):127-134
    • (2011) Apoptosis , vol.16 , Issue.2 , pp. 127-134
    • Choi, J.K.1    Kim, K.H.2    Park, H.3    Park, S.R.4    Choi, B.H.5
  • 39
    • 84864376057 scopus 로고    scopus 로고
    • Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury
    • 22453521 10.1007/s11064-012-0756-7 1:CAS:528:DC%2BC38XksFehsrw%3D
    • Rong W, Wang J, Liu X, Jiang L, Wei F, Hu X, Han X, Liu Z (2012) Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. Neurochem Res 37(8):1615-1623
    • (2012) Neurochem Res , vol.37 , Issue.8 , pp. 1615-1623
    • Rong, W.1    Wang, J.2    Liu, X.3    Jiang, L.4    Wei, F.5    Hu, X.6    Han, X.7    Liu, Z.8
  • 40
    • 25144435000 scopus 로고    scopus 로고
    • Expression and effect of Caspase-3 in neurons after tractive spinal cord injury in rats
    • 16042868 1:CAS:528:DC%2BD2MXpvVWqtL4%3D
    • Liu L, Pei FX, Tang KL, Xu JZ, Li QH (2005) Expression and effect of Caspase-3 in neurons after tractive spinal cord injury in rats. Chin J Traumatol 8(4):220-224
    • (2005) Chin J Traumatol , vol.8 , Issue.4 , pp. 220-224
    • Liu, L.1    Pei, F.X.2    Tang, K.L.3    Xu, J.Z.4    Li, Q.H.5
  • 42
    • 36249029171 scopus 로고    scopus 로고
    • Guanosine reduces apoptosis and inflammation associated with restoration of function in rats with acute spinal cord injury
    • 18404454 10.1007/s11302-007-9079-6 1:CAS:528:DC%2BD2sXhsVWju7vL
    • Jiang S, Bendjelloul F, Ballerini P, D'Alimonte I, Nargi E, Jiang C, Huang X, Rathbone MP (2007) Guanosine reduces apoptosis and inflammation associated with restoration of function in rats with acute spinal cord injury. Purinergic Signal 3(4):411-421
    • (2007) Purinergic Signal , vol.3 , Issue.4 , pp. 411-421
    • Jiang, S.1    Bendjelloul, F.2    Ballerini, P.3    D'Alimonte, I.4    Nargi, E.5    Jiang, C.6    Huang, X.7    Rathbone, M.P.8
  • 43
    • 43049170332 scopus 로고    scopus 로고
    • Enhanced regeneration in spinal cord injury by concomitant treatment with granulocyte colony-stimulating factor and neuronal stem cells
    • 18406145 10.1016/j.jocn.2007.03.020 1:CAS:528:DC%2BD1cXlslGit7o%3D
    • Pan HC, Cheng FC, Lai SZ, Yang DY, Wang YC, Lee MS (2008) Enhanced regeneration in spinal cord injury by concomitant treatment with granulocyte colony-stimulating factor and neuronal stem cells. J Clin Neurosci 15(6):656-664
    • (2008) J Clin Neurosci , vol.15 , Issue.6 , pp. 656-664
    • Pan, H.C.1    Cheng, F.C.2    Lai, S.Z.3    Yang, D.Y.4    Wang, Y.C.5    Lee, M.S.6
  • 44
    • 80055006693 scopus 로고    scopus 로고
    • P53- and Bax-mediated apoptosis in injured rat spinal cord
    • 21748659 10.1007/s11064-011-0530-2 1:CAS:528:DC%2BC3MXos1Omsb0%3D
    • Kotipatruni RR, Dasari VR, Veeravalli KK, Dinh DH, Fassett D, Rao JS (2011) p53- and Bax-mediated apoptosis in injured rat spinal cord. Neurochem Res 36(11):2063-2074
    • (2011) Neurochem Res , vol.36 , Issue.11 , pp. 2063-2074
    • Kotipatruni, R.R.1    Dasari, V.R.2    Veeravalli, K.K.3    Dinh, D.H.4    Fassett, D.5    Rao, J.S.6
  • 45
    • 79953719964 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
    • 21210296 10.1007/s11010-010-0709-x 1:CAS:528:DC%2BC3MXjvFejtLk%3D
    • Ola MS, Nawaz M, Ahsan H (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351(1-2):41-58
    • (2011) Mol Cell Biochem , vol.351 , Issue.1-2 , pp. 41-58
    • Ola, M.S.1    Nawaz, M.2    Ahsan, H.3
  • 46
    • 33846420989 scopus 로고    scopus 로고
    • Effects of buyang huanwu decoction on apoptosis of nervous cells and expressions of Bcl-2 and bax in the spinal cord of ischemia-reperfusion injury in rabbits
    • 16817283
    • Fan L, Wang K, Cheng B (2006) Effects of buyang huanwu decoction on apoptosis of nervous cells and expressions of Bcl-2 and bax in the spinal cord of ischemia-reperfusion injury in rabbits. J Tradit Chin Med 26(2):153-156
    • (2006) J Tradit Chin Med , vol.26 , Issue.2 , pp. 153-156
    • Fan, L.1    Wang, K.2    Cheng, B.3
  • 47
    • 0242551447 scopus 로고    scopus 로고
    • Apoptosis modulatory activities of transiently expressed Bcl-2: Roles in cytochrome C release and Bax regulation
    • 14739607 10.1023/A:1026187526113 1:CAS:528:DC%2BD3sXotFelsrs%3D
    • Hou Q, Cymbalyuk E, Hsu SC, Xu M, Hsu YT (2003) Apoptosis modulatory activities of transiently expressed Bcl-2: roles in cytochrome C release and Bax regulation. Apoptosis 8(6):617-629
    • (2003) Apoptosis , vol.8 , Issue.6 , pp. 617-629
    • Hou, Q.1    Cymbalyuk, E.2    Hsu, S.C.3    Xu, M.4    Hsu, Y.T.5
  • 48
    • 79953117898 scopus 로고    scopus 로고
    • Developmental patterns of caspase-3, bax and bcl-2 proteins expression in the human spinal ganglia
    • 18415689 10.1007/s10735-008-9171-4 1:CAS:528:DC%2BD1cXkvFGlur8%3D
    • Vukojevic K, Carev D, Sapunar D, Petrovic D, Saraga-Babic M (2008) Developmental patterns of caspase-3, bax and bcl-2 proteins expression in the human spinal ganglia. J Mol Histol 39(3):339-349
    • (2008) J Mol Histol , vol.39 , Issue.3 , pp. 339-349
    • Vukojevic, K.1    Carev, D.2    Sapunar, D.3    Petrovic, D.4    Saraga-Babic, M.5
  • 49
    • 0033782260 scopus 로고    scopus 로고
    • Caspase pathways, neuronal apoptosis, and CNS injury
    • 11063050 10.1089/neu.2000.17.811 1:STN:280:DC%2BD3crgvFOjsA%3D%3D
    • Eldadah BA, Faden AI (2000) Caspase pathways, neuronal apoptosis, and CNS injury. J Neurotrauma 17(10):811-829
    • (2000) J Neurotrauma , vol.17 , Issue.10 , pp. 811-829
    • Eldadah, B.A.1    Faden, A.I.2
  • 50
    • 0038649642 scopus 로고    scopus 로고
    • Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury
    • 12794736 10.1002/cne.10733
    • Hains BC, Black JA, Waxman SG (2003) Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol 462(3):328-341
    • (2003) J Comp Neurol , vol.462 , Issue.3 , pp. 328-341
    • Hains, B.C.1    Black, J.A.2    Waxman, S.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.