Immunomodulation of voltage-dependent K+ channels in macrophages: Molecular and biophysical consequences

Journal of General Physiology

Volumn 135, Issue 2, 2010, Pages 135-147

  Villalonga, Nuria ^a   David, Miren ^b   Biejanska, Joanna ^a   Vicente, Rubén ^a   Comes, Nuria ^a   Valenzuela, Carmen ^b   Felipe, Antonio ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; LIPOPOLYSACCHARIDE; MARGATOXIN; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.5; SCORPION VENOM;

ANIMAL; ARTICLE; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; MACROPHAGE; METABOLISM; MOUSE; RAT;

ANIMALS; CELL LINE; DEXAMETHASONE; HUMANS; IMMUNOMODULATION; KV1.3 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE POTENTIALS; MICE; RATS; SCORPION VENOMS;

EID: 75749130706     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200910334     Document Type: Article

References (46)

1. Arias, C, M. Guizy, M. David, S. Marzian, T. González, N. Decher, and C. Valenzuela. 2007. Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels. Amstliesiology. 107:641-651. doi:10.1097/01.anes.0000282100.32923.5c (Pubitemid 47480571)
2. + channel mRNA in vitro and in vivo. Receptors Channels. 1:287-293.
3. Ben, Y, J. Chen, R. Zhu, L. Gao, and C. Bai. 2008. Upregulation. of AQP3 and AQP5 induced, by dexamethasone and arnbroxol in. A54.9 cells. Respir. Physiol. Neumbiol 161:111-118. doi:10.1016/ j.resp.2007.12.007 (Pubitemid 351551584)
4. Cahalan, M.D., and KG. Chandy. 1997. Ion channels in the immune system as targets for immunosuppression. Curr. Opin, Biotechnol, 8:749-756. doi:10.1016/S0958-1669(97)80130-9 (Pubitemid 27517253)
5. Eder, C. 1998. Ion channels in microglia (brain macrophages). Am. J Physiol. 275:C327-C342. (Pubitemid 128734828)
6. + uptake, and cell volume. Am. J. Physiol, 265:C1230-C1238.
7. Fordyce, C.B., R. Jagasia, X. Zhu, and L.C. Schlichter. 2005. Microglia Kv1.3 channels contribute to their ability to kill, neurons. J. Neurosci 25:7139-7149. doi:10.1523/JNEUROSCI.1251-05.2005
8. Franqueza, L., C. Valenzuela, E. Delpón, M. Longobardo, R. Caballero, and J. Tamargo. 1998. Effects of propafenone and 5-hydroxy- propafenone on hKv1.5 channels. Br. J. Pharmacol. 1.25:969-978. doi:10.1038/sj.bjp.0702129 (Pubitemid 28495357)
9. Freedman, B.D., M.A. Price, and. C.J. Deutsch. 1992. Evidence for voltage modulation of IL-2 production in mitogen-stimulated human, peripheral, blood lymphocytes. J. Immunol. 149:3784-3794.
10. Camper, N., S.M. Huber, K. Badawi, and F. Lang. 2000. Cell volume-sensitive sodium channels upregulated by glucocorticoids in U937 macrophages. Pflugers Arch. 441:281-286. doi: 10.1007/ s004.240000410
11. Gonzalez, T., M. Longobardo, R. Caballero, E. Delpón, J. Tamargo, and C. Valenzuela. 2001. Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels. J. Pharmacol Exp. Ther. 296:573-583. (Pubitemid 32112488)
12. + channels, types Kv.1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed, in mammalian, cell lines. Mol Pharmacol. 45:1227-1234.
13. Gutman, C.A., K.G. Chandy, S. Grissmer, M. Lazdunski, D. McKinnon, L.A. Pardo, C.A. Robertson, B. Rudy, M.C. Sanguinetti, W. StÜhmer, and X. Wang. 2005. International Union, of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev. 57:473-508. doi:10.1124/pr.57.4.10 (Pubitemid 43036437)
14. Hille, B. 2001. Ion Channels of Excitable Membranes. 3rd ed. Sinauer Associates, Inc., Sunderland, MA. 814 pp.
15. Judge, S. I. J.M. Lee, CT. Bever Jr., and P.M. Hoffman. 2006. Voltage-gated potassium channels in multiple sclerosis: overview and new implications for treatment of central nervous system, inflammation, and degeneration.J. Rehabil Res. Dexi. 43:111-122. doi:10.1682/JRRD. 2004.09.0116
16. Kotecha, S.A., and L.C. Schlichter. 1999. A Kv1.5 to Kvl.3 switch in. endogenous hippocampal microglia and a role in proliferation. J Neurosci 19:10680-10693.
17. + channels in Jurkat T-lymphocytes. Pflugers Arch. 447:168-174, doi: 10.1007/s00424-003-l148-2
18. + channel gene expression in rat; ventricular myocytes. Neuropharmacology. 35:1001-1006. doi:10.1016/0028-3908(96)00095-0
19. Lloberas, J., C. Soler, and A. Celada. 1998. Dexamethasone enhances macrophage colony stimulating factor- and granulocyte macrophage colony stimulating factor-stimulated proliferation of bone marrow-derived macrophages. Int. Immunol. 10:593-599. doi:10.1093/intimm/10.5.593 (Pubitemid 28221460)
20. Mackenzie, A.B., H. Chirakkal, and RA. North. 2003. Kv1.3 potassium channels in human alveolar macrophages. Am. J. Physiol Lung Cell, Mol, Physiol, 285:L862-L868. (Pubitemid 37158833)
21. Martínez-Mármol, R., N. Villalonga, L. Solé, R. Vicente, M. M. Tamkun, C. Soler, and. A. Felipe. 2008. Multiple Kv1.5 targeting to membrane surface microdomains. J. Cell. Physiol 217:667-673. doi:10.1002/jcp.21538
22. Morsink, M.C, N.G. Van Gemert, P.J. Steenbergen, M.Joëls, E.R. De Kloet, and N.A. Datson. 2007. Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes. Brain Res. 1150:14-20. doi:10.1016/j.brainres.2007.02.083
23. Mullen, K.M. M. Rozycka, H. Rus, L. Hu, C. Cudrici, E. Zafranskaia, M.W. Pennington, D.C.Johns, S.I. Judge, and P.A. Calabresi. 2006. Potassium channels Kv1.3 and Kv1.5 are expressed, on blood-derived dendritic cells in the central nervous system, Ann, Neurol. 60:118-127. doi: 10.1002/ana. 20884
24. Olsson, S., and R. Sundler. 2006. The role of lipid rafts in LPS-induced signaling in a macrophage cell line. Mol Immunol 43:607612. doi:10.1016/j. molimm.2005.04.011
25. Pannasch, U., K Färber, C. Noite, M. Blonski, S. Van Chin, A. Messing, and H. Kettenmann. 2006. The potassium channels Kv1.5 and Kv1.3 modulate distinct functions of microglia. Mol Cell. Neurosci. 33:401-411. doi:10.1016/j.mcn.2006.08.009 (Pubitemid 44820855)
26. + channel occurs by a cooperative mechanism. Biophys. J. 69:896-903. doi: 10.1016/S0006-3495 (95) 79963-79965
27. Panyi, C, Z. Varga, and R. Gaspar. 2004, Ion. channels and lymphocyte activation. Immunol. Lett. 92:55-66. doi:10.1016/j.imlet.2003.11.020
28. Park, S.A., YC. Lee, T.Z. Ma.J.A. Park, M.K Han, H.H. Lee, H.C Kim, and YC Kwak. 2006. hKv1.5 channels playa pivotal role in the functions of human alveolar macrophages. Biochem. Biophys. Res. Commun, 346:567-571, doi:10.1016/j.bbrc.2006.05.149
29. Po, S., D.J. Snyders, R. Baker, M.M. Tamkun, and P.B. Bennett. 1992. Functional expression of an inactivating potassium channel cloned from human heart. Circ. Res. 71:732-736.
30. + channels induced by lipopolysaccharide in microglia. Mol Cells. 7:610-614.
31. Roma-Ferrer, M., A. Etxebarria, L. Solé, A. Oliveras, N. Comes, A. VillaiToel, and A. Felipe. 2009. Functional implications of KCNE subunit expression for the Kv7.5 (KCNQ5) channel. Cell. Physiol Biochem. 24:325-334. doi: .10.1159/000257425
32. Solé, L., M. Roura-Ferrer, M. Pérez-Verdaguer, A. Oliveras, M. Calvo, J.M. Fernández-Fernández, and A. Felipe. 2009. KCNE4 suppresses Kv1.3 currents lay modulating trafficking, surface expression and channel gating.J Cell. Sci 122:3738-3748. doi:10.1242/jcs.056689
33. Soler, C, R. Valdês, J. Garcia-Manteiga, J. Xaus, M. Comalada, F.J. Casado, M. Modolell, B. Nicholson, C. MacLeod, A. Felipe, et al. 2001, Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cntl and Cnt2 through, tumor necrosis factoralpha-dependent and -independent mechanisms. J. Biol. Chem. 276:30043-30049. doi:10.1074/jbc.M101807200 (Pubitemid 37385080)
34. + channel gene expression, in ventricle of rat heart. Circ. Res. 75:1006-1013.
35. + channel subunit composition following hormone induction, of Kv 1.5 gene expression. Bwchemistry. 35:14149-14156. doi:10.1021/bi961290s
36. + channel gene transcription and expression in clonal pituitary cells. Neuron. 11:359-369. doi:10.1016/0896-6273(93)90191-S
37. Uebele, V.N., S.K. England, A. Chaudhary, M.M. Tamkun, and DJ. Snyders. 1996. Functional differences in KvI.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunils. J Biol Chem, 271:2406-2412. doi:10.1074/jbc.271.5.2406
38. + channel responses during proliferation and activation in macrophages.J Biol. Chem. 278:46307-46320. d.oi:10.1074/jlx.M304388200
39. Vicente, R., A. Escalada, C. Soler, M. Grande, A. Celada, M.M. Tamkun, C. Solsona, and A. Felipe. 2005. Pattern of Kv beta subunit expression in macrophages depends upon proliferation and the mode of activation.J. Immunol 174:4736-4744 (Pubitemid 40504555)
40. + channel in macrophages.J. Biol. Chem. 281:37675-37685. doi: 10.1074/jbc.M605617200
41. Vicente, R, N. Villalonga, M. Calvo, A. Escalada, C. Solsona, C. Soler, M.M. Timkun, and A. Felipe. 2008. Kv1.5 association, modifies KvI.3 traffic and membrane localization.J. Biol Chem. 283:8756-8764. doi:10.1074/jbc.M708223200
42. Villalonga, N., A. Escalada, R. Vicente, E. Sánchez-Tilló, A. Celada, C. Solsona, and A. Felipe. 2007. Kvl.3/Kvl.5 heteromeric channels compromise pharmacological responses in macrophages. Biochem.. Biophys. Res. Commun, 352:913-918. doi:10.1016/j.bbrc .2006.11.120 (Pubitemid 44894372)
43. Villalonga, N., R. Martínez-Mármol, M, Roura-Ferrer, M. David, C. Valenzuela, C. Soler, and. A, Felipe. 2008. Cell cycle-dependent, expression of Kv1.5 is involved in myoblast proliferation, Biochim. Biophys. Ada. 1783:728-736. doi: 10.1016/ j.bbamcr.2008.01.001
44. 2+ current in neonatal mice. Circ. Res. 85:168-173.
45. Xaus, J., M. Comalada, A.F. Valledor, M. Cardó, C. Herrero, C. Soler, J. Lloberas, and A. Celada. 2001. Molecular mechanisms involved in macrophage survival, proliferation, activation, or apoptosis. Immunobiology. 204:543-550. doi:10.1078/ 0171-2985-100091
46. Zsiros, E., K. Kis-Toth, P. Hajdu, R. Gaspar, J. Bielanska, A. Felipe, E. Rajnavolgyi, and G. Panyi. 2009. Developmental switch of the expression of"ion channels in human dendritic cells. J. Immunol. 183:4483-4492. doi:10.4049/jimmimol.0803003