Effect of tetrahydrobiopterin and exercise training on endothelium- dependent vasorelaxation in SHR

Journal of Physiology and Biochemistry

Volumn 69, Issue 2, 2013, Pages 277-287

  Guerrero, François ^a   Thioub, Sanéo ^a   Goanvec, Christelle ^a   Theunissen, Sigrid ^b   Feray, Annie ^a   Balestra, Costantino ^b   Mansourati, Jacques ^a,c  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^b Haute Ecole Bruxelles Brabant   (Belgium)

^c BREST UNIVERSITY HOSPITAL   (France)

Author keywords

Endothelial dysfunction; Exercise; Hypertension; Nitric oxide; Rat; Tetrahydrobiopterin

Indexed keywords

ACETYLCHOLINE; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; EXERCISE; FEMORAL ARTERY; HYPERTENSION; ISOMETRICS; MALE; NONHUMAN; ORGAN; RAT; SEDENTARY LIFESTYLE; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; TENSION; TREADMILL EXERCISE; VASODILATATION; WISTAR KYOTO RAT;

ANIMALS; BIOPTERIN; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; HYPERTENSION; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASODILATION;

ANIMALIA; RATTUS;

EID: 84879411566     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0210-y     Document Type: Article

References (43)

1. Brunner H, Cockcroft JR, Deanfield J et al (2005) Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 23:233-246
2. Chen SJ, Wu CC, Yen MH (2001) Exercise training activates large-conductance calcium-activated K(+) channels and enhances nitric oxide production in rat mesenteric artery and thoracic aorta. J Biomed Sci 8:248-255
3. Chu TF, Huang TY, Jen CJ, Chen HI (2000) Effects of chronic exercise on calcium signaling in rat vascular endothelium. Am J Physiol Heart Circ Physiol 279:H1441-H1446
4. Cosentino F, Barker JE, Brand MP et al (2001) Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol 21:496-502
5. de Waard MC, van der Velden J, Boontje NM et al (2009) Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction. Am J Physiol Heart Circ Physiol 296:H1513-H1523
6. Du YH, Guan YY, Alp NJ, Channon KM, Chen AF (2008) Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation 117:1045-1054
7. Durrant JR, Seals DR, Connell ML et al (2009) Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol 587:3271-3285
8. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR (2005) Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 568:1057-1065
9. Garry A, Edwards DH, Fallis IF, Jenkins RL, Griffith TM (2009) Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. Cardiovasc Res 84:218-226
10. Goto C, Higashi Y, Kimura M et al (2003) Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 108:530-535
11. Graham DA, Rush JW (2004) Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 96:2088-2096
12. Grijalva J, Hicks S, Zhao X et al (2008) Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. Cardiovasc Diabetol 7:34
13. Hambrecht R, Adams V, Erbs S et al (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107:3152-3158
14. Haram PM, Adams V, Kemi OJ et al (2006) Time-course of endothelial adaptation following acute and regular exercise. Eur J Cardiovasc Prev Rehabil 13:585-591
15. Heylen E, Guerrero F, Mansourati J, Theron M, Thioub S, Saiag B (2008) Effect of training frequency on endothelium-dependent vasorelaxation in rats. Eur J Cardiovasc Prev Rehabil 15:52-58
16. Higashi Y, Yoshizumi M (2004) Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacol Ther 102:87-96
17. Higashi Y, Sasaki S, Nakagawa K et al (2002) Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 15:326-332
18. Hong HJ, Hsiao G, Cheng TH, Yen MH (2001) Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 38:1044-1048
19. Hyndman ME, Verma S, Rosenfeld RJ, Anderson TJ, Parsons HG (2002) Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function. Am J Physiol Heart Circ Physiol 282:H2167-H2172
20. Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y (2005) Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. J Hypertens 23:1375-1382
21. Kesaniemi YK, Danforth E Jr, Jensen MD, Kopelman PG, Lefebvre P, Reeder BA (2001) Dose-response issues concerning physical activity and health: an evidence-based symposium. Med Sci Sports Exerc 33:S351-S358
22. Landmesser U, Drexler H (2007) Endothelial function and hypertension. Curr Opin Cardiol 22:316-320
23. Landmesser U, Dikalov S, Price SR et al (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111:1201-1209
24. Li H, Witte K, August M et al (2006) Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 47:2536-2544
25. Maiorana A, O'Driscoll G, Taylor R, Green D (2003) Exercise and the nitric oxide vasodilator system. Sports Med 33:1013-1035
26. Musicki B, Liu T, Strong T et al (2008) Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis. J Sex Med 5:552-561
27. Newsholme P, Homem De Bittencourt PI, Oh C, De Vito G, Murphy C, Krause MS (2010) Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide. Clin Sci (Lond) 118:341-349
28. Noguchi K, Hamadate N, Matsuzaki T et al (2010) Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol 631:28-35
29. Pellegrin M, Berthelot A, Houdayer C, Gaume V, Deckert V, Laurant P (2007) New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endothelial vasodilator function in apolipoprotein E-deficient mice. Atherosclerosis 190:35-42
30. Podjarny E, Benchetrit S, Rathaus M et al (2003) Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. Nephron 94:p6-p9
31. Porkert M, Sher S, Reddy U et al (2008) Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens 22:401-407
32. Rush JW, Ford RJ (2007) Nitric oxide, oxidative stress and vascular endothelium in health and hypertension. Clin Hemorheol Microcirc 37:185-192
33. Schachinger V, Britten MB, Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101:1899-1906
34. Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM (2009) Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol 587:3885-3897
35. Sun MW, Zhong MF, Gu J, Qian FL, Gu JZ, Chen H (2008) Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitric oxide synthase and heme oxygenase. Hypertens Res 31:805-816
36. Sun MW, Qian FL, Wang J et al (2008) Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endothelium-dependent vasodilatation and insulin sensitivity in aged spontaneously hypertensive rats. Hypertens Res 31:543-552
37. Takaya T, Hirata K, Yamashita T et al (2007) A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression. Arterioscler Thromb Vasc Biol 27:1632-1637
38. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N, Pescatello L (2001) The acute versus the chronic response to exercise. Med Sci Sports Exerc 33:S438-S445, discussion S452-433
39. Tinken TM, Thijssen DH, Hopkins N, Dawson EA, Cable NT, Green DJ (2010) Shear stress mediates endothelial adaptations to exercise training in humans. Hypertension 55:312-318
40. Wallace JP (2003) Exercise in hypertension. A clinical review. Sports Med 33:585-598
41. Widder JD, Guzik TJ, Mueller CF et al (2007) Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol 27:762-768
42. Yang D, Levens N, Zhang JN, Vanhoutte PM, Feletou M (2003) Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension 41:136-142
43. Zheng JS, Yang XQ, Lookingland KJ et al (2003) Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation 108:1238-1245