Time-course of endothelial adaptation following acute and regular exercise

European Journal of Preventive Cardiology

Volumn 13, Issue 4, 2006, Pages 585-591

  Haram, Per Magnus ^a   Adams, Volker ^b   Kemi, Ole Johan ^a   Brubakk, Alf O ^a   Hambrecht, Rainer ^b   Ellingsen, Fyvind ^a,c   Wislã¸ff, Ulrik ^a,c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

cytokines; exercise capacity; functional electrical stimulation; heart failure; inflammation

Indexed keywords

ACETYLCHOLINE;

ABDOMINAL AORTA; ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; ENDOTHELIUM; EXERCISE; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; VASODILATATION;

ACETYLCHOLINE; ADAPTATION, PHYSIOLOGICAL; ANIMALS; AORTA, ABDOMINAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EXERTION; FEMALE; FOLLOW-UP STUDIES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL EXERTION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 33746684402     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/01.hjr.0000198920.57685.76     Document Type: Article

References (23)

1. Hambrecht R, Walther C, Möbius-Winkler S, Gielen S, Linke A, Conradi K, et al Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary disease. Circulation 2004; 109: 1371–1378.
2. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454–460.
3. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801–809.
4. Fichtlscherer S, Breuer S, Zeiher AM. Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes. Further evidence for the existence of the ‘vulnerable patient’. Circulation 2004; 110: 1926–1932.
5. Schächinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary disease. Circulation 2000; 101: 1899–1906.
6. Laughlin MH, Joseph B. Wolfe Memorial lecture. Physical activity in prevention and treatment of coronary disease: the battle line is in exercise vascular cell biology. Med Sci Sports Exerc 2004; 36: 352–362.
7. Wisløff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q., et al Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 2005; 307: 418–420.
8. Kemi OJ, Haram PM, Wisløff U, Ellingsen O. Aerobic fitness is associated with cardiomyocyte capacity and endothelial function in exercise training and detraining. Circulation 2004; 109: 2897–2904.
9. Kemi OJ, Haram PM, Loennechen JP, Osnes JB, Skomedal T, Wisløff U, Ø Ellingsen Moderate vs. high intensity: differential effects on aerobic fitness, cardiomyocyte contractility and endothelial function. Cardiovasc Res 2005; 67: 161–172.
10. Delp MD, Laughlin MH. Time course of enhanced endothelium-mediated dilation in aorta of trained rats. Med Sci Sports Exerc 1997; 29: 1454–1461.
11. Wisløff U, Helgerud J, Kemi OJ, Ellingsen O. Intensity-controlled treadmill running in rats: VO2max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001; 280: 1301–1310.
12. Ariëns EJ, Simonis AM, van Rossum JM. Drug-receptor interactions: interaction of one or more drugs with one receptor system. In: Ariëns EJ, editor. Molecular pharmacology. New York, NY: Academic Press; 1964. pp. 119–286.
13. Inoue N, Ramasamy S, Fukai T, Nerem RM, Harrison DG. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res 1996; 79: 32–37.
14. Benjamin EJ, Larson MG, Keyes MJ. Clinical correlates and heritability of flow-mediated dilation in the community: The Framingham Heart Study. Circulation 2004; 109: 613–619.
15. Johnson LR, Rush JW, Turk J.R., Price EM, Laughlin MH. Short-term exercise training increases Ach-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol 2001; 90: 1102–1110.
16. Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 1986; 250: 822–827.
17. Bergholm R, Makimattila S, Valkonen N, Liu M, Lahdenpera S, Taskinen M, et al Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo. Atherosclerosis 1999; 145: 341–349.
18. Hambrecht R, Adams V, Erbs V, Linke A, Krankel N, Shu Y, et al Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107: 3152–3158.
19. Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell SR, et al Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem 1999; 274: 30101–30108.
20. Fisslthaler B, Dimmeler S, Herman C, Busse R, Fleming I. Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand 2000; 168: 81–88.
21. Dimmeler S, Fleming I, Fissthalter B, Hermann C, Busse R, Zeither AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601.
22. Flemming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R. Phosphorylation of Thr(495) regulates Ca(2 +)/calmodulin-dependent endothelial nitric oxide synthase activity. Circulation Res 2001; 88: 68–75.
23. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al Effect of different intensities of exercise on endothelium-dependent vasodilatation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 2003; 108: 530–535.