N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis

Gut and Liver

Volumn 7, Issue 3, 2013, Pages 357-362

  Du, Bing Qing ^a,b   Yang, Yue Ming ^b   Chen, Yong Hua ^a   Liu, Xu Bao ^a   Mai, Gang ^a  

^a SICHUAN UNIVERSITY   (China)

^b PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTONOMOUS REGION   (China)

Author keywords

Acetylcysteine; Acute necrotizing pancreatitis; Laser Doppler flowmetry; Pancreatic microvascular perfusion; Taurocholic acid

Indexed keywords

ACETYLCYSTEINE; AMYLASE;

ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; HISTOPATHOLOGY; LASER DOPPLER FLOWMETRY; MICROCIRCULATION; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS HEMORRHAGE; PANCREAS NECROSIS; RAT;

EID: 84879388167     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2013.7.3.357     Document Type: Article

References (27)

1. Slavin J, Ghaneh P, Sutton R, et al. Management of necrotizing pancreatitis. World J Gastroenterol 2001;7:476-481. (Pubitemid 32780655)
2. de Beaux AC, Palmer KR, Carter DC. Factors influencing morbidity and mortality in acute pancreatitis: an analysis of 279 cases. Gut 1995;37:121-126.
3. Schneider L, Pietschmann M, Hartwig W, et al. Inosine reduces microcirculatory disturbance and inflammatory organ damage in experimental acute pancreatitis in rats. Am J Surg 2006;191:510-514. (Pubitemid 43384148)
4. Zhang S, Peng XG, Liu CC, Liu H, Lu Y. Low-dose dopamine reduces inflammatory factors of acute pancreatitis in rats. Hepatobiliary Pancreat Dis Int 2007;6:646-649.
5. Zhou ZG, Chen YD, Sun W, Chen Z. Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats. World J Gastroenterol 2002;8:933-936.
6. Kim H, Seo JY, Roh KH, Lim JW, Kim KH. Suppression of NF-kappaB activation and cytokine production by N-acetylcysteine in pancreatic acinar cells. Free Radic Biol Med 2000;29:674-683.
7. Sunamura M, Yamauchi J, Shibuya K, et al. Pancreatic microcirculation in acute pancreatitis. J Hepatobiliary Pancreat Surg 1998;5:62-68. (Pubitemid 128662559)
8. Andersson E, Axelsson J, Pedersen LC, Elm T, Andersson R. Treatment with anti-factor VIIa in acute pancreatitis in rats: blocking both coagulation and inflammation? Scand J Gastroenterol 2007;42:765-770. (Pubitemid 46763573)
9. Pela R, Calcagni AM, Subiaco S, Isidori P, Tubaldi A, Sanguinetti CM. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 1999;66:495-500.
10. Ramudo L, Manso MA, Sevillano S, de Dios I. Kinetic study of TNF-alpha production and its regulatory mechanisms in acinar cells during acute pancreatitis induced by bile-pancreatic duct obstruction. J Pathol 2005;206:9-16. (Pubitemid 40613429)
11. Shi C, Zhao X, Wang X, Andersson R. Role of nuclear factor-kappaB, reactive oxygen species and cellular signaling in the early phase of acute pancreatitis. Scand J Gastroenterol 2005;40:103-108.
12. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275(6 Pt 1):G1402-G1414.
13. Virlos IT, Mason J, Schofield D, McCloy RF, Eddleston JM, Siriwardena AK. Intravenous n-acetylcysteine, ascorbic acid and selenium-based anti-oxidant therapy in severe acute pancreatitis. Scand J Gastroenterol 2003;38:1262-1267. (Pubitemid 38096085)
14. Narasimhan S, Khwaja HA, Dutta S, Mitchenere P. Use of N-acetylcysteine for postnecrosectomy peripancreatic collections in a patient with severe, acute pancreatitis. Can J Surg 2008;51:E133-E134.
15. Wittel UA, Wiech T, Chakraborty S, et al. Taurocholate-induced pancreatitis: a model of severe necrotizing pancreatitis in mice. Pancreas 2008;36:e9-e21.
16. Grewal HP, Mohey el Din A, Gaber L, Kotb M, Gaber AO. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody. Am J Surg 1994;167:214-218.
17. Xiping Z, Yan P, Xinmei H, et al. Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis. Inflammation 2010;33:259-266.
18. Schneider L, Hackert T, Heck M, et al. Capsaicin reduces tissue damage in experimental acute pancreatitis. Pancreas 2009;38:676-680.
19. Panek J, Zasada J, Poźniczek M. Microcirculatory disturbance in the course of acute pancreatitis. Przegl Lek 2007;64:435-437.
20. Zhang XP, Li ZJ, Zhang J. Inflammatory mediators and microcirculatory disturbance in acute pancreatitis. Hepatobiliary Pancreat Dis Int 2009;8:351-357.
21. Ramudo L, De Dios I, Yubero S, Vicente S, Manso MA. ICAM-1 and CD11b/CD18 expression during acute pancreatitis induced by bile-pancreatic duct obstruction: effect of N-acetylcysteine. Exp Biol Med (Maywood) 2007;232:737-743. (Pubitemid 46827815)
22. Konturek PC, Dembinski A, Warzecha Z, et al. Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis. World J Gastroenterol 2005;11:6322-6329. (Pubitemid 43014000)
23. Phillips AR, Farrant GJ, Abu-Zidan FM, Cooper GJ, Windsor JA. A method using laser Doppler flowmetry to study intestinal and pancreatic perfusion during an acute intestinal ischaemic injury in rats with pancreatitis. Eur Surg Res 2001;33:361-369. (Pubitemid 34114151)
24. Briskin BS, Bukatko VN. Laser doppler flowmetry for assessment of acute pancreatitis treatment efficacy. Khirurgiia (Mosk) 2003:20-25.
25. Mumcu S, Alhan E, Türkyilmaz S, Kural BV, Erçin C, Kalyoncu NI. Effects of N-acetylcysteine on acute necrotizing pancreatitis in rats. Eur Surg Res 2005;37:173-178. (Pubitemid 41160150)
26. Yagci G, Gul H, Simsek A, et al. Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats. J Gastroenterol 2004;39:268-276. (Pubitemid 38519433)
27. Leme AS, Lichtenstein A, Arantes-Costa FM, Landucci EC, Martins MA. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and N-acetylcysteine. Shock 2002;18:428-433.