Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats

Journal of Gastroenterology

Volumn 39, Issue 3, 2004, Pages 268-276

  Yagci, Gokhan ^a   Gul, Husamettin ^a   Simsek, Abdurrahman ^a   Buyukdogan, Varol ^a   Onguru, Onder ^a   Zeybek, Nazif ^a   Aydin, Ahmet ^a   Balkan, Mujdat ^a   Yildiz, Oguzhan ^a   Sen, Dervis ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Glutathione peroxidase activity; N acetylcysteine; Nitrite nitrate; Pancreatitis; Rats; Sodium taurocholate

Indexed keywords

ACETYLCYSTEINE; AMYLASE; ANTIOXIDANT; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRATE; NITRITE; SCAVENGER; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TAUROCHOLIC ACID; TRIACYLGLYCEROL LIPASE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLEEDING; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; EDEMA; ENZYME ACTIVITY; FAT NECROSIS; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MORTALITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SCORING SYSTEM; TIME; TISSUE NECROSIS;

ACETYLCYSTEINE; ACUTE DISEASE; AMYLASES; ANIMALS; ANTIOXIDANTS; CHOLAGOGUES AND CHOLERETICS; GLUTATHIONE PEROXIDASE; LIPASE; MALE; MALONDIALDEHYDE; NITRATES; NITRITES; PANCREATITIS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TAUROCHOLIC ACID; TIME FACTORS;

EID: 11144356781     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00535-003-1287-4     Document Type: Article

References (37)

1. Schoenberg MH, Buchler M, Beger HG. Oxygen radicals in experimental acute pancreatitis. Hepatogastroenterology 1994;41: 313-9.
2. Schulz HU, Niederau C. Oxidative stress-induced changes in pancreatic acinar cells: insights from in vitro studies. Hepatogastroenterology 1994;41:309-12.
3. Sweiry JH, Mann GE. Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol Suppl 1996;219:10-5.
4. Rinderknecht H. Genetic determinants of mortality in acute necrotizing pancreatitis. Int J Pancreatol 1994;16:11-5.
5. Lerch MM, Adler G. Experimental animal models of acute pancreatitis. Int J Pancreatol 1994;15:159-70.
6. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-304.
7. Aho HJ, Nevalainen TJ, Aho AJ. Experimental pancreatitis in the rat. Development of pancreatic necrosis, ischemia and edema after intraductal sodium taurocholate injection. Eur Surg Res 1983;15:28-36.
8. Spormann H, Sokolowski A, Letko G. Effect of temporary ischemia upon development and histological patterns of acute pancreatitis in the rat. Pathol Res Pract 1989;184:507-13.
9. Bulucu F, Vural A, Aydin A, Sayal A. Oxidative stress status in adults with nephrotic syndrome. Clin Nephrol 2000;53:169-73.
10. Orhan H, Marol S, Hepsen IF, Sabin G. Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats. Toxicology 1999;139:219-32.
11. Tracey WR, Tse J, Carter G. Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors. J Pharmacol Exp Ther 1995;272:1011-5.
12. Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, et al. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 1996;111:1081-91.
13. Fujimoto K, Hosotani R, Doi R, Wada M, Lee JU, Koshiba T, et al. Role of neutrophils in cerulein-induced pancreatitis in rats: possible involvement of apoptosis. Digestion 1997;58:421-30.
14. Frossard JL, Saluja A, Bhagat L, Lee HS, Bhatia M, Hofbauer B, et al. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 1999;116:694-701.
15. Tsuji N, Watanabe N, Okamoto T, Niitsu Y. Specific interaction of pancreatic elastase and leucocytes to produce oxygen radicals and its implication in pancreatitis. Gut 1994;35:1659-64.
16. Rau B, Gansauge F, Schoenberg MH, Poch B, Beger HG. PMN-leukocytes in experimental acute pancreatitis: source of oxygen free radical generation (abstract)? Digestion 1998;59:229.
17. Leme AS, Lichtenstein A, Arantes-Costa FM, Landucci EC, Martins MA. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and N-acetylcysteine. Shock 2002;18:428-33.
18. Niederau C, Niederau M, Borchard F, Ude K, Luthen R, Strohmeyer G, et al. Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas 1992;7:486-96.
19. Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 2001;280:G1197-208.
20. Demols A, Van Laethem JL, Quertinmont E, Legros F, Louis H, Le Moine O, et al. N-acetylcysteine decreases severity of acute pancreatitis in mice. Pancreas 2000;20:161-9.
21. De Vries N, De Flora S. N-acetyl-1-cysteine. J Cell Biochem Suppl 1993;17F:270-7.
22. Zhou ZG, Chen YD. Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. World J Gastroenterol 2002;8:406-12.
23. Werner J, Rivera J, Fernandez-del Castillo C, Lewandrowski K, Adrie C, Rattner DW, et al. Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis. Surgery 1997;121:23-30.
24. Liu X, Nakano I, Yamaguchi H, Ito T, Goto M, Koyanagi S, et al. Protective effect of nitric oxide on development of acute pancreatitis in rats. Dig Dis Sci 1995;40:2162-9.
25. Werner J, Fernandez-del Castillo C, Rivera JA, Kollias N, Lewandrowski KB, Rattner DW, et al. On the protective mechanisms of nitric oxide in acute pancreatitis. Gut 1998;43:401-7.
26. Molero X, Guarner F, Salas A, Mourelle M, Puig V, Malagelada JR. Nitric oxide modulates pancreatic basal secretion and response to cerulein in the rat: effects in acute pancreatitis. Gastroenterology 1995;108:1855-62.
27. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1. EMBO J 1991;10: 2247-58.
28. Schmidt KN, Amstad P, Cerutti P, Baeuerle PA. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappaB. Chem Biol 1995;2:13-22.
29. Schmidt KN, Amstad P, Cerutti P, Baeuerle PA. Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB. Adv Exp Med Biol 1996;387:63-8.
30. Bhatia M, Brady M, Kang YK, Costello E, Newton DJ, Christmas SE, et al. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Am J Physiol Gastrointest Liver Physiol 2002;282:G77-85.
31. Seo JY, Kim H, Seo JT, Kim KH. Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants. Pharmacology 2002;64:63-70.
32. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275:G1402-14.
33. Kim H, Seo JY, Kim KH. NF-kappaB and cytokines in pancreatic acinar cells. J Korean Med Sci 2000;15:S53-4.
34. Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 1999;116:420-30.
35. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996;20:463-6.
36. Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997;46:1733-42.
37. Luthen R, Niederau C, Niederau M, Ferrell LD, Grendell JH. Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreas. Gastroenterology 1995;109:573-81.