Capsaicin reduces tissue damage in experimental acute pancreatitis

Pancreas

Volumn 38, Issue 6, 2009, Pages 676-680

  Schneider, Lutz ^a   Hackert, Thilo ^a   Heck, Matthias ^a   Hartwig, Werner ^a   Fritz, Stefan ^a   Strobel, Oliver ^a   Gebhard, Martha Maria ^a   Werner, Jens ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acute pancreatitis; Capsaicin; CGRP

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CERULETIDE; GLYCODEOXYCHOLIC ACID; NEUROPEPTIDE;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; ERYTHROCYTE; HISTOLOGY; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; MALE; MICROCIRCULATION; MICROSCOPY; MORTALITY; NONHUMAN; PANCREAS; PANCREAS NECROSIS; PATHOGENESIS; PRIORITY JOURNAL; RAT; SURVIVAL; TISSUE INJURY;

AMYLASES; ANIMALS; BLOOD FLOW VELOCITY; CAERULEIN; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CELL ADHESION; GLYCODEOXYCHOLIC ACID; LEUKOCYTES; MALE; PANCREATITIS, ACUTE NECROTIZING; RATS; RATS, WISTAR;

EID: 68949093917     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181a5ef3a     Document Type: Article

References (38)

1. Menger MD, Plusczyk T, Vollmar B. Microcirculatory derangements in acute pancreatitis. J Hepatobiliary Pancreat Surg. 2001;8:187-194.
2. Wang XD, Wang Q, Andersson R, et al. Alterations in intestinal function in acute pancreatitis in an experimental model. Br J Surg. 1996;83: 1537-1543.
3. Zhou ZG, Chen YD. Influencing factors of pancreatic microcirculatory impairment in acute pancreatitis. World J Gastroenterol. 2002;8: 406-412.
4. Vollmar B, Menger MD. Microcirculatory dysfunction in acute pancreatitis. A new concept of pathogenesis involving vasomotion-associated arteriolar constriction and dilation. Pancreatology. 2003;3:181-190.
5. Klar E, Herfarth C, Messmer K. Therapeutic effect of isovolemic hemodilution with dextran 60 on the impairment of pancreatic microcirculation in acute biliary pancreatitis. Ann Surg. 1990; 211:346-353.
6. Feher E, Burnstock G, Varndell IM, et al. Calcitonin gene - related peptide - immunoreactive nerve fibres in the small intestine of the guinea-pig: electron-microscopic immunocytochemistry. Cell Tissue Res. 1986;245:353-358.
7. Allen JM, Bishop AE, Daly MJ, et al. Effect of inhibition of acid secretion on the regulatory peptides in the rat stomach. Gastroenterology. 1986;90:970-977.
8. Sternini C, De Giorgio R, Furness JB. Calcitonin gene - related peptide neurons innervating the canine digestive system. Regul Pept. 1992;42:15-26.
9. Seifert H, Sawchenko P, Chesnut J, et al. Receptor for calcitonin gene - related peptide: binding to exocrine pancreas mediates biological actions. Am J Physiol. 1985;249:G147-151.
10. Bayliss WM. On the origin from the spinal cord of the vaso-dilator fibres of the hind-limb and on the nature of these fibres. J Physiol. 1901;26:173-209
11. Geppetti P, Nassini R, Materazzi S, et al. The concept of neurogenic inflammation. BJU Int. 2008;101(suppl 3):2-6. Review.
12. Brain SD, Williams TJ, Tippins JR, et al. Calcitonin gene - related peptide is a potent vasodilator. Nature. 1985;313:54-56.
13. Di Pette DJ, Schwarzenberger K, Kerr N, et al. Systemic and regional hemodynamic effects of calcitonin gene - related peptide. Hypertension. 1987;9:III142-146.
14. Pawlik WW, Obuchowicz R, Biernat J, et al. Role of calcitonin gene related peptide in the modulation of intestinal circulatory, metabolic, and myoelectric activity during ischemia/reperfusion. J Physiol Pharmacol. 2000;51:933-942.
15. Debas HT, Nelson MT, Bunnett NW, et al. Selective release of somatostatin by calcitonin gene - related peptide and influence on pancreatic secretion. Ann N - Acad Sci. 1992;657:289-298.
16. Inoue K, Hirota M, Kimura Y, et al. Further evidence for endothelin as an important mediator of pancreatic and intestinal ischemia in severe acute pancreatitis. Pancreas. 2003;26:218-223.
17. Hashiba Y, Ishikawa N, Sumita T, et al. Capsaicin-sensitive nerves exert an inhibitory effect on the development of fibrin-induced pulmonary edema in rats. Am Rev Respir Dis. 1989;140:652-658.
18. Warzecha Z, Dembinski A, Ceranowicz P, et al. Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery. J Physiol Pharmacol. 2001;52:679-704.
19. Kline LW, Pang PK. Nitric oxide modulates the calcitonin gene - related peptide - induced relaxation in guinea pig gallbladder strips in vitro. Regul Pept. 1994;50:207-212.
20. Clementi G, Caruso A, Prato A, et al. A role for nitric oxide in the anti-ulcer activity of calcitonin gene - related peptide. Eur J Pharmacol. 1994;256:R7-8.
21. Lipowsky HH, House SD, Firrell JC. Leukocyte endothelium adhesion and microvascular hemodynamics. Adv Exp Med Biol. 1988;242:85-93.
22. Hackert T, Werner J, Gebhard MM, et al. Effects of heparin in experimental models of acute pancreatitis and post-ERCP pancreatitis. Surgery. 2004;135(2):131-138.
23. DiPette DJ, Schwarzenberger K, Kerr N, et al. Dose-dependent systemic and regional hemodynamic effects of calcitonin gene - related peptide. Am J Med Sci. 1989;297:65-70.
24. Arulmani U, Schuijt MP, Heiligers JP, et al. Effects of the calcitonin gene - related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP - induced regional haemodynamic changes in anaesthetized rats. Basic Clin Pharmacol Toxicol. 2004;94:291-297.
25. Wang MW, Young AA, Rink TJ, et al. 8-37 h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo. FEBS Lett. 1991;291:195-198.
26. Hughes SR, Brain SD. Nitric oxide-dependent release of vasodilator quantities of calcitonin gene - related peptide from capsaicin-sensitive nerves in rabbit skin. Br J Pharmacol. 1994;111:425-430.
27. Schneider L, Hartwig W, Flemming T, et al. Protective effects and antiinflammatory pathways of exogenous calcitonin gene - related peptide (CGRP) in severe necrotizing pancreatitis in rats. Pancreatology. 2009. In press.
28. Monneret G, Pachot A, Laroche B, et al. Procalcitonin and calcitonin gene - related peptide decrease LPS-induced TNF production by human circulating blood cells. Cytokine. 2000;12:762-764.
29. Raud J, Lundeberg T, Brodda-Jansen G, et al. Potent anti-inflammatory action of calcitonin gene - related peptide. Biochem Biophys Res Commun. 1991;180:1429-1435.
30. Springer TA. Adhesion receptors of the immune system. Nature. 1990;346:425-434.
31. Werner J, Z'graggen K, Fernandez-del Castillo C, et al. Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg. 1999;229:834-842.
32. Li Y, Jiang YC, Owyang C. Central CGRP inhibits pancreatic enzyme secretion by modulation of vagal parasympathetic outflow. Am J Physiol. 1998;275:G957-963.
33. Ikeura T, Kataoka Y, Wakabayashi T, et al. Effects of sensory denervation by neonatal capsaicin administration on experimental pancreatitis induced by dibutyltin dichloride. Med Mol Morphol. 2007;40:141-149.
34. Noble MD, Romac J, Wang Y, et al. Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol. 2006;291:G128-G134.
35. Nathan JD, Peng RY, Wang Y, et al. Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol. 2002;283:G938-946.
36. Liddle RA, Nathan JD. Neurogenic inflammation and pancreatitis. Pancreatology. 2004;4:551-559; discussion 559-560.
37. Maggi CA. Tachykinins and calcitonin gene - related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog Neurobiol. 1995;45:1-98.
38. Orliac ML, Peroni RN, Abramoff T, et al. Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. Eur J Pharmacol. 2007;566:145-152.