Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis

World Journal of Gastroenterology

Volumn 11, Issue 40, 2005, Pages 6322-6329

  Konturek, Peter C ^a   Dembinski, Artur ^b   Warzecha, Zygmunt ^b   Burnat, Grzegorz ^a   Ceranowicz, Piotr ^b   Hahn, Eckhart G ^a   Dembinski, Marcin ^b   Tomaszewska, Romana ^b   Konturek, Stanislaw J ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Cerulein induced pancreatitis; Heat shock protein 70; PPAR ligand

Indexed keywords

CERULETIDE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 10; INTERLEUKIN 1BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; TRIACYLGLYCEROL LIPASE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DNA SYNTHESIS; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EVOKED RESPONSE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PANCREAS BLOOD FLOW; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE INJURY; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; WESTERN BLOTTING;

EID: 29544435794     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i40.6322     Document Type: Article

References (37)

1. Kingsnorth A. Role of cytokines and their inhibitors in acute pancreatitis. Gut 1997; 40: 1-4
2. Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications. Int J Obes Relat Metab Disord 2003; 27 (Suppl 3): S41-45
3. Mangelsdorf DJ, Thummel C, Beato ML, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835-839
4. Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-435
5. Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 82-86
6. Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA, Flanigan A, Murthy S, Lazar MA, Wu GD. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 1999; 104: 383-389
7. Rakonczay Z Jr, Takacs T, Boros I, Lonovics J. Heat shock proteins and the pancreas. J Cell Physiol 2003; 195: 383-391
8. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003; 304: 505-512
9. Wagner AC, Weber H, Jonas L, Nizze H, Strowski M, Fiedler F, Printz H, Steffen H, Goke B. Hyperthermia induces heat shock protein expression and protection against caerulein-induced pancreatitis in rats. Gastroenterology 1996; 111: 1333-1342
10. Tashiro M, Ernst SA, Edwards J, Williams JA. Hyperthermia induces multiple pancreatic heat shock proteins and protects against subsequent arginine-induced acute pancreatitis in rats. Digestion 2002; 65: 118-126
11. Konturek PC, Jaworek J, Maniatoglou A, Bonior J, Meixner H, Konturek SJ, Hahn EG. Leptin modulates the inflammatory response in acute pancreatitis. Digestion 2002; 65: 149-160
12. Konturek PC, Brzozowski T, Kania T, Konturek SJ, Kwiecien S, Pajdo R, Hahn EG. Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rats. Eur J Pharmacol 2003; 38: 468-476
13. Konturek SJ, Szlachcic A, Dembinski A, Warzecha Z, Jaworek J, Stachura J. Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats. Int J Pancreatol 1994; 15: 19-28
14. Warzecha Z, Dembinski A, Ceranowicz P, Konturek SJ, Tomaszewska R, Stachura J, Konturek PC. IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis. J Physiol Pharmacol 2003; 54: 575-590
15. Warzecha Z, Dembinski A, Konturek PC, Ceranowicz P, Konturek SJ. Epidermal growth factor protects against pancreatic damage in cerulein-induced pancreatitis. Digestion 1999; 60: 314-323
16. Giles KW, Myers A. An improvement diphenylamine method for the estimation of deoxyribonucleic acid. Nature 1965; 206: 93
17. Warzecha Z, Dembinski A, Ceranowicz P, Konturek SJ, Tomaszewska R, Stachura J, Nakamura T, Konturek PC. Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis. Eur J Pharmacol 2004; 486: 107-119
18. Konturek PC, Brzozowski T, Kania J, Konturek SJ, Hahn EG. Nitric oxide-releasing aspirin protects gastric mucosa against ethanol damage in rats with functional ablation of sensory nerves. Inflamm Res 2003; 52: 359-365
19. Hashimoto K, Ethridge RT, Saito H, Rajaraman S, Evers BM. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. Pancreas 2003; 27: 58-66
20. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82
21. Meier CA, Chicheportiche R, Juge-Aubry CE, Dreyer MG, Dayer JM. Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activate receptor gamma. Cytokine 2002; 18: 320-328
22. Imamoto E, Yoshida N, Uchiyama K, Kuroda M, Kokura S, Ichikawa H, Naito Y, Tanigawa T, Yoshikawa T. Inhibitory effect of pioglitazone on expression of adhesion molecules on neutrophils and endothelial cells. Biofactors 2004; 20: 37-47
23. Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002; 106: 679-684
24. Fu K, Sarras MP Jr, De Lisle RC, Andrews GK. Expression of oxidative stress-responsive genes and cytokine genes during caerulein-induced acute pancreatitis. Am J Physiol 1997; 273: G696-G705
25. Norman JG, Fink GW, Denham W. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction. Dig Dis Sci 1997; 42: 1783-1788
26. Warzecha Z, Dembinski A, Ceranowicz P. Calcitonin gene-related peptide can attenuate or augment pancreatic damage in caerulein-induced pancreatitis in rats. J Physiol Pharmacol 1999; 50: 49-62
27. Moore KW, O'Garra A, de Waal MR, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11: 165-190
28. Van de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220
29. Van Laethem JL, Marchant A, Delvaux A, Goldman M, Robberecht P, Velu T, Deviere J. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 1995; 108: 1917-1922
30. Warzecha Z, Dembinski A, Konturek PC, Ceranowicz P, Dembinski M, Stachura J, Konturek SJ. Hepatocyte growth factor attenuates pancreatic damage in caerulein-induced pancreatitis. Eur J Pharmacol 2001; 430: 113-121
31. Frossard JL, Bhagat L, Lee HS, Hietaranta AJ, Singh VP, Song AM, Steer ML, Saluja AK. Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas. Cut 2002; 50: 78-83
32. Takayama S, Reed JC, Homma S. Heat-shock proteins as regulators of apoptosis. Oncogene 2003; 22: 9041-9047
33. Bhagat L, Singh VP, Hietaranta AJ, Agrawal S, Steer ML, Saluja AK. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. J Clin Invest 2000; 106: 81-89
34. Dembinski A, Warzecha. Z, Konturek PC, Ceranowicz P, Konturek SJ, Tomaszewska R, Stachura J. Adaptation of pancreas to repeated caerulein-induced pancreatitis in rats. J Physiol Pharmacol 1996; 47: 455-467
35. Menger MD, Plusczyk T, Vollmar B. Microcirculatory derangements in acute pancreatitis. J Hepatobiliary Pancreat Surg 2001; 8: 187-194
36. Zhou ZG, Chen YD, Sun W, Chen Z. Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats. World J Gastroenterol 2002; 8: 933-936
37. Warzecha Z, Dembinski A, Ceranowicz P, Konturek PC, Stachura J, Konturek SJ. Protective effect of calcitonin gene-related peptide against caerulein-induced pancreatitis in rats. J Physiol Pharmacol 1997; 48: 775-787