Treatment with anti-factor VIIa in acute pancreatitis in rats: Blocking both coagulation and inflammation?

Scandinavian Journal of Gastroenterology

Volumn 42, Issue 6, 2007, Pages 765-770

  Andersson, Ellen ^a   Axelsson, Jakob ^a   Pedersen, Lars Christian ^b   Elm, Torben ^b   Andersson, Roland ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Active site inactivated factor VIIa; Acute pancreatitis; Anticoagulation; Antioxidant; Rat

Indexed keywords

ACETYLCYSTEINE; BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 7A INHIBITOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; TAURODEOXYCHOLIC ACID;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLON; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ILEUM; LUNG; MALE; MULTIPLE ORGAN FAILURE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREAS DUCT; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

ACUTE DISEASE; ANIMALS; BLOOD COAGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VIIA; INFLAMMATION; INTERLEUKIN-6; MALE; MONOKINES; OXIDATIVE STRESS; PANCREATITIS; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34248593271     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520701295632     Document Type: Article

References (43)

1. Bone RC. Modulators of coagulation. A critical appraisal of their role in sepsis. Arch Intern Med 1992;152:1381-9.
2. Edwards RL, Rickies FR. Delayed hypersensitivity in man: effects of systemic anticoagulation. Science 1978;200:541-3.
3. Kakakios AM, Ryan J, Geczy CL. Effects of locally administered heparins on delayed, type hypersensitivity reactions. Int Arch Allergy Appl Immunol 1990;93:300-7.
4. Cirino G, Cicala C, Bucci MR, Sorrentino L, Maraganore JM, Stone SR. Thrombin as an inflammatory mediator through activation of its receptor. J Exp Med 1996;182:821-7.
5. Tapparelli C, Metternich R, Ehrhardt C, Cook NS. Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile. Trends Pharmacol Sci 1993;14:366-76.
6. rd. A cell-based model of hemostasis. Thromb Haemost 2001;85:958-65.
7. Ferrara JJ, Kan C, Luterman A, Curreri PW. Effects of fibrinogen degradation fragments D and E on cell-mediated immunity. J Surg Res 1989;47:134-7.
8. Bar-Shavit R, Kahn A, Mudd MS, Wilner GD, Mann KG, Fenton JW. Localisation of a chemotactic domain in human thrombin. Biochemistry 1985;23:397-400.
9. Senior RM, Skogen WF, Griffen GL, Wilner GD. Effects of fibrinogen derivatives upon the inflammatory response. J Clin Invest 1986;77:1014-9.
10. Camerer E, Rottingen J-A, Iversen J-G, Prydz H. Coagulation factors VII and X induce Ca 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 1996;271:29034-42.
11. Poulsen LJ, Jacobsen N, Sorensen BB, Bergenhem NCH, Kelly JD, Foster DC, et al. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation FVII to tissue factor. J Biol Chem 1998;273:6228-32.
12. Sorensen BB, Freskgard P, Nielsen LS, Rao LVM, Ezban M, Petersen LC. FVIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of FVIIa and is independent of the tissue factor cytoplasmic domain. J Biol Chem 1999;274:21349-54.
13. Camerer E, Gjernes E, Wigert MT, Pringle S, Prytz H. Binding of FVIIa to tissue factor on keratinocytes induces gene expression. J Biol Chem 2000;275:6580-5.
14. Taylor FB Jr, Chang AC, Peer GT, Li A, Ezban M, Hedner U. Active site inhibited FVIIa (DEGR VIIa) attenuates the coagulant and interleukin-6 and -8, but not tumour necrosis factor, responses of the baboon to LD100 Escherichia coli. Blood 1998;91:1609-15.
15. Taylor FB Jr, Chang A, Ruf W, Morrisey JH, Hinshaw L, Catlett R, et al. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock 1991;33:127-34.
16. Taylor FB Jr, Chang AC, Peer GT, Mather T, Blick K, Catlett R, et al. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood 1991;78:364-8.
17. Carraway MS, Welthy-Wolf KE, Miller DL, Ortel TL, Idell S, Ghio AJ, et al. Blockade of tissue factor: a rescue strategy for multi-organ failure in established sepsis. Am J Respir Cri Care Med 2003;176:1200-9.
18. Cotgreave IA. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997;38:205-27.
19. Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H. Nacetylcysteine suppresses TNF-induced NF-B activation through inhibition of IB kinases. FEBS Lett 2000;472:196-202.
20. Kim H, Seo J, Roh KH, Lim JW, Kim KH. Suppression of NF-B activation and cytokine production by N-acetylcysteine in pancreatic acinar cells. Free Radic Biol Med 2000;29:674-83.
21. Wang XD, Deng XM, Haraldsen P, Andersson R, Ihse I. Antioxidant and calcium channel blockers counteract endothelial barrier injury induced by acute pancreatitis in the rats. Scand J Gastroenterol 1995;30:1129-36.
22. Sevillano S, de la Mano AM, De Dios I, Ramudo L, Manso MA. Major pathological mechanisms of acute pancreatitis are prevented by N-acetylcysteine. Digestion 2003;68:34-40.
23. Demols A, Van Laethem JL, Quertinmont E, Legros F, Louis H, Le Moine O, et al. N-acetylcysteine decreases severity of acute pancreatitis in mice. Pancreas 2000;20:161-9.
24. Inagaki T, Hoshino M, Hayakawa T, Ohara H, Yamada T, Yamada H, et al. Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas 1997;14:1-8.
25. Carr C, Bild GS, Chang ACK, Peer GT, Palmier MO, Frazier RB, et al. Recombinant E. coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in a baboon Gram-negative model of septic shock. Circ Shock 1994;44:126-37.
26. Standiford TJ, Kunkel SL, Greenberger MJ, Laichalk LL, Strieter RM. Expression and regulation of chemokines in bacterial pneumonia. J Leuk Biol 1996;59:24-8.
27. Martinez-Mier G, Toledo-Pereyra LH, McDuffie JE, Warner RL, Hsiao C, Staleton SR, et al. Exogenous nitric oxide downregulates MIP-2 and MIP-1 alpha chemokines and MAPK p44/42 after ischemia and reperfusion of the rat kidney. J Invest Surg 2002;15:287-96.
28. Kojima Y, Suzuki S, Tsuchiya Y, Konno H, Baba S, Nakamura S. Regulation of pro-inflammatory and antiinflammatory cytokine responses by Kuppfer cells in endotoxin-enhanced reperfusion injury after total hepatic ischemia. Transpl Int 2003;16:231-40.
29. Pastor CM, Rubbia-Brandt L, Hadengue A, Jordan M, Morel P, Frossard JL. Role of macrophage inflammatory protein-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Lab Invest 2003;83:471-8.
30. Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, May AK, et al. Endotoxin potentiates lung injury in cerulein-induced pancreatitis. Am J Surg 2003;86:526-30.
31. Bradley PP, Priebat DA, Christensen RD, Rohstein G. Measurement of cutaneous inflammation: estimation pf neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-9.
32. Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, Inoue M, et al. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Physiol 1992;262:G669-76.
33. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
34. Taylor FB Jr, Chang A, Ruf W, Morrisey JH, Hinshaw L, Catlett R, et al. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock 1991;33:127-34.
35. Levi M, ten Cate H, Bauer KA, van der Poll T, Edgington TS, Buller HR, et al. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93:114-20.
36. Biemond BJ, Levi M, ten Cate H, Soule HR, Morris LD, Foster DL, et al. Complete inhibition of endotoxin-induced coagulation activation in chimpanzees with a monoclonal Fab fragment against factor VII/VIIa. Thromb Hemost 1995;73:223-30.
37. Johanson K, Aarden L, Choi Y, de Groot E, Creasey A. The proinflammatory cytokine response to coagulation and endotoxin in whole blood. Blood 1996;87:5051-60.
38. Creasy AA, Chang ACK, Feigen L, Wun TC, Taylor FB Jr, Hinshaw LB. Tissue factor pathway inhibitor reduces mortality from Escherichia Coli septic shock. J Clin Invest 1993;91:2850-60.
39. Alfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski K, et al. Activated protein C decreases inflammation and improves survival in experimental acute pancreatitis. Pancreatology 2004;3-4:284.
40. Driscoll KE. Macrophage inflammatory proteins: biology and role in pulmonary inflammation. Exp Lung Res 1994;20:473-90.
41. Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, et al. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J Exp Med 1990;172:911-9.
42. Ludwicka-Bradley A, Tourkina E, Suzuki S, Tyson E, Bonner M, Fenton JW, et al. Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-gamma activation. Am J Resp Cell Mol Biol 2000;22:235-43.
43. Wang XL, Gjernes E, Prydz H. Factor VIIa induces tissuefactor dependent up-regulation of interleukin-8 in a human keratinocyte line. J Biol Chem 2002;277:23620-6.