Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a chinese population environmentally exposed to cadmium

Toxicology and Applied Pharmacology

Volumn 271, Issue 1, 2013, Pages 78-85

  Zhang, Chen ^a,b   Liang, Yihuai ^a,b   Lei, Lijian ^c   Zhu, Guoying ^a   Chen, Xiao ^a   Jin, Taiyi ^a,b   Wu, Qing ^a,b  

^a FUDAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Cadmium; Hypermethylation; KLOTHO; Pyrosequencing; RASAL1; Renal dysfunction

Indexed keywords

CADMIUM; CREATININE; KLOTHO PROTEIN; RAS PROTEIN; RASAL1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD LEVEL; CADMIUM BLOOD LEVEL; CADMIUM URINE LEVEL; CHINESE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PYROSEQUENCING; URINE LEVEL;

Β(2)-MICROGLOBULIN; ALB; ALBUMIN; B2M; BCD; BLOOD CADMIUM; CADMIUM; CD; EGFR; ESTIMATED GLOMERULAR FILTRATION RATE; HYPERMETHYLATION; KLOTHO; N-ACETYL-Β-D-GLUCOSAMINIDASE; NAG; PYROSEQUENCING; RASAL1; RENAL DYSFUNCTION; SCR; SERUM CREATININE; UCD; URINARY CADMIUM;

ASIAN CONTINENTAL ANCESTRY GROUP; CADMIUM; CHINA; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; FEMALE; GLOMERULAR FILTRATION RATE; GLUCURONIDASE; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RENAL INSUFFICIENCY;

EID: 84879317742     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.04.025     Document Type: Article

References (46)

1. Azuma M., Koyama D., Kikuchi J., Yoshizawa H., Thasinas D., Shiizaki K., Kuro-o M., Furukawa Y., Kusano E. Promoter methylation confers kidney-specific expression of the Klotho gene. FASEB J. 2012, 26:4264-4274.
2. Bechtel W., McGoohan S., Zeisberg E.M., Muller G.A., Kalbacher H., Salant D.J., Muller C.A., Kalluri R., Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat. Med. 2010, 16:544-550.
3. Bernard A. Cadmium & its adverse effects on human health. Indian J. Med. Res. 2008, 128:557-564.
4. Gobe G., Crane D. Mitochondria, reactive oxygen species and cadmium toxicity in the kidney. Toxicol. Lett. 2010, 198:49-55.
5. Hare R.S. Endogenous creatinine in serum and urine. Proc. Soc. Exp. Biol. Med. 1950, 74:148-151.
6. Hossain M.B., Vahter M., Concha G., Broberg K. Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women. Environ. Health Perspect. 2012, 120:879-884.
7. Hu M.C., Shi M., Zhang J., Quinones H., Kuro-o M., Moe O.W. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int. 2010, 78:1240-1251.
8. Jarup L., Akesson A. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol. 2009, 238:201-208.
9. Jin T., Nordberg G., Wu X., Ye T., Kong Q., Wang Z., Zhuang F., Cai S. Urinary N-acetyl-beta-d-glucosaminidase isoenzymes as biomarker of renal dysfunction caused by cadmium in a general population. Environ. Res. 1999, 81:167-173.
10. Jin T., Nordberg M., Frech W., Dumont X., Bernard A., Ye T.T., Kong Q., Wang Z., Li P., Lundstrom N.G., Li Y., Nordberg G.F. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals 2002, 15:397-410.
11. Jin T., Kong Q., Ye T., Wu X., Nordberg G.F. Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment. Biometals 2004, 17:513-518.
12. Jin T., Wu X., Tang Y., Nordberg M., Bernard A., Ye T., Kong Q., Lundstrom N.G., Nordberg G.F. Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China. Biometals 2004, 17:525-530.
13. 2+-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:12353-12358.
14. Johri N., Jacquillet G., Unwin R. Heavy metal poisoning: the effects of cadmium on the kidney. Biometals 2010, 23:783-792.
15. Klein J., Kavvadas P., Prakoura N., Karagianni F., Schanstra J.P., Bascands J.L., Charonis A. Renal fibrosis: insight from proteomics in animal models and human disease. Proteomics 2011, 11:805-815.
16. Kuro-o M. Klotho in health and disease. Curr. Opin. Nephrol. Hypertens. 2012, 21:362-368.
17. Lameire N., Van Biesen W. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am. J. Kidney Dis. 2002, 39:S1-S266.
18. Lei L., Chang X., Rentschler G., Tian L., Zhu G., Chen X., Jin T., Broberg K. A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin. Toxicol. Appl. Pharmacol. 2012, 265:373-379.
19. Levey A.S., Stevens L.A., Schmid C.H., Zhang Y.P., Castro A.F., Feldman H.I., Kusek J.W., Eggers P., Van Lente F., Greene T., Coresh J. A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 2009, 150:604-607.
20. Liakopoulos V., Georgianos P.I., Eleftheriadis T., Sarafidis P.A. Epigenetic mechanisms and kidney diseases. Curr. Med. Chem. 2011, 18:1733-1739.
21. Liang Y., Lei L., Nilsson J., Li H., Nordberg M., Bernard A., Nordberg G.F., Bergdahl I.A., Jin T. Renal function after reduction in cadmium exposure: an 8-year follow-up of residents in cadmium-polluted areas. Environ. Health Perspect. 2012, 120:223-228.
22. Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int. 2006, 69:213-217.
23. Meran S., Steadman R. Fibroblasts and myofibroblasts in renal fibrosis. Int. J. Exp. Pathol. 2011, 92:158-167.
24. Nordberg G.F., Piscatror M., Nordberg M. On the distribution of cadmium in blood. Acta Pharmacol. Toxicol. (Copenh) 1971, 30:289-295.
25. Nordberg G.F., Jin T., Kong Q., Ye T., Cai S., Wang Z., Zhuang F., Wu X. Biological monitoring of cadmium exposure and renal effects in a population group residing in a polluted area in China. Sci. Total Environ. 1997, 199:111-114.
26. Ohta M., Seto M., Ijichi H., Miyabayashi K., Kudo Y., Mohri D., Asaoka Y., Tada M., Tanaka Y., Ikenoue T., Kanai F., Kawabe T., Omata M. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Gastroenterology 2009, 136:206-216.
27. Ozanne S.E., Constancia M. Mechanisms of disease: the developmental origins of disease and the role of the epigenotype. Nat. Clin. Pract. Endocrinol. Metab. 2007, 3:539-546.
28. Pan J., Zhong J., Gan L.H., Chen S.J., Jin H.C., Wang X., Wang L.J. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol. 2011, 32:729-735.
29. Seto M., Ohta M., Ikenoue T., Sugimoto T., Asaoka Y., Tada M., Mohri D., Kudo Y., Ijichi H., Tateishi K., Otsuka M., Hirata Y., Maeda S., Koike K., Omata M. Reduced expression of RAS protein activator like-1 in gastric cancer. Int. J. Cancer 2011, 128:1293-1302.
30. Singh K.P., Kumari R., Pevey C., Jackson D., DuMond J.W. Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett. 2009, 279:84-92.
31. Strutz F., Zeisberg M. Renal fibroblasts and myofibroblasts in chronic kidney disease. J. Am. Soc. Nephrol. 2006, 17:2992-2998.
32. Sun C.Y., Chang S.C., Wu M.S. Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int. 2012, 81:640-650.
33. Takiguchi M., Achanzar W.E., Qu W., Li G., Waalkes M.P. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp. Cell Res. 2003, 286:355-365.
34. Thijssen S., Lambrichts I., Maringwa J., Van Kerkhove E. Changes in expression of fibrotic markers and histopathological alterations in kidneys of mice chronically exposed to low and high Cd doses. Toxicology 2007, 238:200-210.
35. Tucker S.M., Boyd P.J., Thompson A.E., Price R.G. Automated assay of N-acetyl-beta-glucosaminidase in normal and pathological human urine. Clin. Chim. Acta 1975, 62:333-339.
36. Vernon M.A., Mylonas K.J., Hughes J. Macrophages and renal fibrosis. Semin. Nephrol. 2010, 30:302-317.
37. Vidt D.G., Ridker P.M., Monyak J.T., Schreiber M.J., Cressman M.D. Longitudinal assessment of estimated glomerular filtration rate in apparently healthy adults: a post hoc analysis from the JUPITER study (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin). Clin. Ther. 2011, 33:717-725.
38. Wang L., Wang X., Wang X., Jie P., Lu H., Zhang S., Lin X., Lam E.K., Cui Y., Yu J., Jin H. Klotho is silenced through promoter hypermethylation in gastric cancer. Am. J. Cancer Res. 2011, 1:111-119.
39. Wang B., Li Y., Shao C., Tan Y., Cai L. Cadmium and its epigenetic effects. Curr. Med. Chem. 2012, 2611-2620.
40. Wang B., Li Y., Tan Y., Miao X., Liu X.D., Shao C., Yang X.H., Turdi S., Ma L.J., Ren J., Cai L. Low-dose Cd induces hepatic gene hypermethylation, along with the persistent reduction of cell death and increase of cell proliferation in rats and mice. PLoS One 2012, 7:e33853.
41. Xie B., Zhou J., Yuan L., Ren F., Liu D.C., Li Q., Shu G. Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. Hum. Pathol. 2013, 44:795-801.
42. Young G.H., Wu V.C. KLOTHO methylation is linked to uremic toxins and chronic kidney disease. Kidney Int. 2012, 81:611-612.
43. Zeisberg E.M., Zeisberg M. The role of promoter hypermethylation in fibroblast activation and fibrogenesis. J. Pathol. 2013, 229:264-273.
44. Zhang J., Fu Y., Li J., Wang J., He B., Xu S. Effects of subchronic cadmium poisoning on DNA methylation in hens. Environ. Toxicol. Pharmacol. 2009, 27:345-349.
45. Zhou Z.H., Lei Y.X., Wang C.X. Analysis of aberrant methylation in DNA repair genes during malignant transformation of human bronchial epithelial cells induced by cadmium. Toxicol. Sci. 2012, 125:412-417.
46. Zhu H., Li K., Liang J., Zhang J., Wu Q. Changes in the levels of DNA methylation in testis and liver of SD rats neonatally exposed to 5-aza-2'-deoxycytidine and cadmium. J. Appl. Toxicol. 2011, 31:484-495.