-
1
-
-
0034644537
-
Ras and Rho GTPases: A family reunion
-
Bar-Sagi D, Hall A,. Ras and Rho GTPases: a family reunion. Cell 2000; 103: 227-38.
-
(2000)
Cell
, vol.103
, pp. 227-238
-
-
Bar-Sagi, D.1
Hall, A.2
-
3
-
-
34249100668
-
Stopping ras in its tracks
-
Der CJ, van Dyke T,. Stopping ras in its tracks. Cell 2007; 129: 855-7.
-
(2007)
Cell
, vol.129
, pp. 855-857
-
-
Der, C.J.1
Van Dyke, T.2
-
4
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J,. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
5
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M,. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53: 549-54.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Arnheim, N.5
Perucho, M.6
-
6
-
-
0025196234
-
Analysis or fas gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing
-
Tada M, Yokosuka O, Omata M, Ohto M, Isono K,. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing. Cancer 1990; 66: 930-5. (Pubitemid 20307926)
-
(1990)
Cancer
, vol.66
, Issue.5
, pp. 930-935
-
-
Tada, M.1
Yokosuka, O.2
Omata, M.3
Ohto, M.4
Isono, K.5
-
7
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE,. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
8
-
-
0023271954
-
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung
-
Rodenhuis S, van de Wetering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL,. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 1987; 317: 929-35.
-
(1987)
N Engl J Med
, vol.317
, pp. 929-935
-
-
Rodenhuis, S.1
Van De Wetering, M.L.2
Mooi, W.J.3
Evers, S.G.4
Van Zandwijk, N.5
Bos, J.L.6
-
9
-
-
24944582633
-
GAPs in growth factor signalling
-
Bernards A, Settleman J,. GAPs in growth factor signalling. Growth Factors 2005; 23: 143-9.
-
(2005)
Growth Factors
, vol.23
, pp. 143-149
-
-
Bernards, A.1
Settleman, J.2
-
11
-
-
0023514705
-
Linkage of NF1 to 12 chromosome 17 markers: A summary of eight concurrent reports
-
Skolnick MH, Ponder B, Seizinger B,. Linkage of NF1 to 12 chromosome 17 markers: a summary of eight concurrent reports. Genomics 1987; 1: 382-3.
-
(1987)
Genomics
, vol.1
, pp. 382-383
-
-
Skolnick, M.H.1
Ponder, B.2
Seizinger, B.3
-
12
-
-
19444387096
-
RASA1: Variable phenotype with capillary and arteriovenous malformations
-
Boon LM, Mulliken JB, Vikkula M,. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev 2005; 15: 265-9.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 265-269
-
-
Boon, L.M.1
Mulliken, J.B.2
Vikkula, M.3
-
13
-
-
59849104569
-
Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression
-
Ohta M, Seto M, Ijichi H, Miyabayashi K, Kudo Y, Mohri D, Asaoka Y, Tada M, Tanaka Y, Ikenoue T, Kanai F, Kawabe T, et al. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Gastroenterology 2009; 136: 206-16.
-
(2009)
Gastroenterology
, vol.136
, pp. 206-216
-
-
Ohta, M.1
Seto, M.2
Ijichi, H.3
Miyabayashi, K.4
Kudo, Y.5
Mohri, D.6
Asaoka, Y.7
Tada, M.8
Tanaka, Y.9
Ikenoue, T.10
Kanai, F.11
Kawabe, T.12
-
14
-
-
2442467712
-
2+ oscillations
-
2+ oscillations. Embo J 2004; 23: 1749-60.
-
(2004)
Embo J
, vol.23
, pp. 1749-1760
-
-
Walker, S.A.1
Kupzig, S.2
Bouyoucef, D.3
Davies, L.C.4
Tsuboi, T.5
Bivona, T.G.6
Cozier, G.E.7
Lockyer, P.J.8
Buckler, A.9
Rutter, G.A.10
Allen, M.J.11
Philips, M.R.12
-
15
-
-
22944439089
-
2+
-
2+. J Cell Biol 2005; 170: 183-90.
-
(2005)
J Cell Biol
, vol.170
, pp. 183-190
-
-
Liu, Q.1
Walker, S.A.2
Gao, D.3
Taylor, J.A.4
Dai, Y.F.5
Arkell, R.S.6
Bootman, M.D.7
Roderick, H.L.8
Cullen, P.J.9
Lockyer, P.J.10
-
16
-
-
33744511934
-
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins
-
Kupzig S, Deaconescu D, Bouyoucef D, Walker SA, Liu Q, Polte CL, Daumke O, Ishizaki T, Lockyer PJ, Wittinghofer A, Cullen PJ,. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem 2006; 281: 9891-900.
-
(2006)
J Biol Chem
, vol.281
, pp. 9891-9900
-
-
Kupzig, S.1
Deaconescu, D.2
Bouyoucef, D.3
Walker, S.A.4
Liu, Q.5
Polte, C.L.6
Daumke, O.7
Ishizaki, T.8
Lockyer, P.J.9
Wittinghofer, A.10
Cullen, P.J.11
-
17
-
-
34249018367
-
GEFs and GAPs: Critical elements in the control of small G proteins
-
Bos JL, Rehmann H, Wittinghofer A,. GEFs and GAPs: critical elements in the control of small G proteins. Cell 2007; 129: 865-77.
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
18
-
-
14844290235
-
Hypermethylation of NAD(P)H: Quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma
-
Tada M, Yokosuka O, Fukai K, Chiba T, Imazeki F, Tokuhisa T, Saisho H,. Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma. J Hepatol 2005; 42: 511-9.
-
(2005)
J Hepatol
, vol.42
, pp. 511-519
-
-
Tada, M.1
Yokosuka, O.2
Fukai, K.3
Chiba, T.4
Imazeki, F.5
Tokuhisa, T.6
Saisho, H.7
-
19
-
-
33646672648
-
Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients
-
Tanaka Y, Kanai F, Tada M, Asaoka Y, Guleng B, Jazag A, Ohta M, Ikenoue T, Tateishi K, Obi S, Kawabe T, Yokosuka O, et al. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Oncogene 2006; 25: 2950-2.
-
(2006)
Oncogene
, vol.25
, pp. 2950-2952
-
-
Tanaka, Y.1
Kanai, F.2
Tada, M.3
Asaoka, Y.4
Guleng, B.5
Jazag, A.6
Ohta, M.7
Ikenoue, T.8
Tateishi, K.9
Obi, S.10
Kawabe, T.11
Yokosuka, O.12
-
20
-
-
17744380191
-
TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
-
Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB,. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J 2000; 19: 6778-91.
-
(2000)
EMBO J
, vol.19
, pp. 6778-6791
-
-
Kanai, F.1
Marignani, P.A.2
Sarbassova, D.3
Yagi, R.4
Hall, R.A.5
Donowitz, M.6
Hisaminato, A.7
Fujiwara, T.8
Ito, Y.9
Cantley, L.C.10
Yaffe, M.B.11
-
21
-
-
68849105590
-
Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
-
Seto M, Ohta M, Asaoka Y, Ikenoue T, Tada M, Miyabayashi K, Mohri D, Tanaka Y, Ijichi H, Tateishi K, Kanai F, Kawabe T, et al. Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. Mol Carcinog 2009; 48: 703-12.
-
(2009)
Mol Carcinog
, vol.48
, pp. 703-712
-
-
Seto, M.1
Ohta, M.2
Asaoka, Y.3
Ikenoue, T.4
Tada, M.5
Miyabayashi, K.6
Mohri, D.7
Tanaka, Y.8
Ijichi, H.9
Tateishi, K.10
Kanai, F.11
Kawabe, T.12
-
22
-
-
28244447471
-
P53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells
-
Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, et al. p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res 2005; 65: 10822-9.
-
(2005)
Cancer Res
, vol.65
, pp. 10822-10829
-
-
Ohta, M.1
Tateishi, K.2
Kanai, F.3
Watabe, H.4
Kondo, S.5
Guleng, B.6
Tanaka, Y.7
Asaoka, Y.8
Jazag, A.9
Imamura, J.10
Ijichi, H.11
Ikenoue, T.12
-
23
-
-
34547619642
-
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers
-
Jin H, Wang X, Ying J, Wong AH, Cui Y, Srivastava G, Shen ZY, Li EM, Zhang Q, Jin J, Kupzig S, Chan AT, et al. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci USA 2007; 104: 12353-8.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12353-12358
-
-
Jin, H.1
Wang, X.2
Ying, J.3
Wong, A.H.4
Cui, Y.5
Srivastava, G.6
Shen, Z.Y.7
Li, E.M.8
Zhang, Q.9
Jin, J.10
Kupzig, S.11
Chan, A.T.12
-
24
-
-
77953186827
-
Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer
-
Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, et al. Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer. Cancer Sci 2010; 101: 1261-1269.
-
(2010)
Cancer Sci
, vol.101
, pp. 1261-1269
-
-
Tada, M.1
Kanai, F.2
Tanaka, Y.3
Sanada, M.4
Nannya, Y.5
Tateishi, K.6
Ohta, M.7
Asaoka, Y.8
Seto, M.9
Imazeki, F.10
Yoshida, H.11
Ogawa, S.12
-
25
-
-
20444426889
-
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity
-
Kolfschoten IG, van Leeuwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM, Agami R,. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 2005; 121: 849-58.
-
(2005)
Cell
, vol.121
, pp. 849-858
-
-
Kolfschoten, I.G.1
Berns, K.2
Mullenders, J.3
Beijersbergen, R.L.4
Bernards, R.5
Voorhoeve, P.M.6
Agami, R.7
Van Leeuwen, B.8
-
26
-
-
0032544675
-
Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog
-
Allen M, Chu S, Brill S, Stotler C, Buckler A,. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. Gene 1998; 218: 17-25.
-
(1998)
Gene
, vol.218
, pp. 17-25
-
-
Allen, M.1
Chu, S.2
Brill, S.3
Stotler, C.4
Buckler, A.5
-
27
-
-
1442310498
-
Focus on gastric cancer
-
Ushijima T, Sasako M,. Focus on gastric cancer. Cancer Cell 2004; 5: 121-5.
-
(2004)
Cancer Cell
, vol.5
, pp. 121-125
-
-
Ushijima, T.1
Sasako, M.2
-
28
-
-
0342748644
-
Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas
-
Shim YH, Kang GH, Ro JY,. Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 2000; 80: 689-95.
-
(2000)
Lab Invest
, vol.80
, pp. 689-695
-
-
Shim, Y.H.1
Kang, G.H.2
Ro, J.Y.3
-
29
-
-
0035300558
-
CpG island methylation in premalignant stages of gastric carcinoma
-
Kang GH, Shim YH, Jung HY, Kim WH, Ro JY, Rhyu MG,. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 2001; 61: 2847-51.
-
(2001)
Cancer Res
, vol.61
, pp. 2847-2851
-
-
Kang, G.H.1
Shim, Y.H.2
Jung, H.Y.3
Kim, W.H.4
Ro, J.Y.5
Rhyu, M.G.6
-
30
-
-
0001119305
-
HMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
-
Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS, Ho JC,. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 1999; 59: 159-64.
-
(1999)
Cancer Res
, vol.59
, pp. 159-164
-
-
Leung, S.Y.1
Yuen, S.T.2
Chung, L.P.3
Chu, K.M.4
Chan, A.S.5
Ho, J.C.6
-
31
-
-
0033105363
-
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability
-
Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, et al. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999; 59: 1090-5.
-
(1999)
Cancer Res
, vol.59
, pp. 1090-1095
-
-
Fleisher, A.S.1
Esteller, M.2
Wang, S.3
Tamura, G.4
Suzuki, H.5
Yin, J.6
Zou, T.T.7
Abraham, J.M.8
Kong, D.9
Smolinski, K.N.10
Shi, Y.Q.11
Rhyu, M.G.12
-
32
-
-
0035932396
-
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma
-
Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M,. E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene 2001; 20: 1525-8.
-
(2001)
Oncogene
, vol.20
, pp. 1525-1528
-
-
MacHado, J.C.1
Oliveira, C.2
Carvalho, R.3
Soares, P.4
Berx, G.5
Caldas, C.6
Seruca, R.7
Carneiro, F.8
Sobrinho-Simoes, M.9
-
33
-
-
18344389720
-
Causal relationship between the loss of RUNX3 expression and gastric cancer
-
Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002; 109: 113-24.
-
(2002)
Cell
, vol.109
, pp. 113-124
-
-
Li, Q.L.1
Ito, K.2
Sakakura, C.3
Fukamachi, H.4
Inoue, K.5
Chi, X.Z.6
Lee, K.Y.7
Nomura, S.8
Lee, C.W.9
Han, S.B.10
Kim, H.M.11
Kim, W.J.12
-
34
-
-
20444475352
-
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer
-
Chen H, Tu SW, Hsieh JT,. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem 2005; 280: 22437-44.
-
(2005)
J Biol Chem
, vol.280
, pp. 22437-22444
-
-
Chen, H.1
Tu, S.W.2
Hsieh, J.T.3
|