Contribution of plasma-derived molecules to mucosal immune defence, disease and repair in the airways

Scandinavian Journal of Immunology

Volumn 47, Issue 4, 1998, Pages 302-313

  Persson, C G A ^a,b   Erjefalt J S ^c,d   Greiff, L ^d   Erjefalt I ^b   Korsgren, M ^d   Linden, M ^b   Sundler, F ^d   Andersson, M ^a   Svensson, C ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMA PROTEIN;

EXUDATE; HUMAN; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOREGULATION; LAMINA PROPRIA; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT MUCOSA; REVIEW;

ABSORPTION; ALBUMINS; ALLERGENS; ANIMALS; BIOLOGICAL MARKERS; EPITHELIUM; EXUDATES AND TRANSUDATES; HUMANS; IMMUNITY, MUCOSAL; NASAL MUCOSA; RESPIRATORY SYSTEM;

EID: 0031966572     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00317.x     Document Type: Review

References (93)

1. Brandtzaeg P. The role of humoural mucosal immunity in the induction and maintenance of chronic airway infections. Am J Respir Crit Care Med 1995;151:2081-7.
2. Fazekas de St Groth S. Studies in experimental immunology of influenza. IX. The mode of action of pathotopic adjuvants. Aus J Exp Biol Med Sci 1951;29:339-52.
3. Persson CGA. Role of plasma exudation in asthmatic airways. Lancet 1986;2:1126-9.
4. Persson CGA. Plasma exudation from tracheobronchial microvessels in health and disease. In: J Butler ed. The Bronchial Circulation. New York: Dekker, 1992:443-76.
5. Persson CGA, Svensson C, Greiff L et al. Editorial. The use of the nose to study the inflammatory response of the respiratory tract. Thorax 1992;47:993-1000.
6. Persson CGA, Erjefält I. Inflammatory leakage of macromolecules from the vascular compartment into the tracheal lumen. Acta Physiol Scand 1986;126:615-6.
7. Persson CGA, Erjefält I, Alkner U et al. Plasma exudation as a first line respiratory mucosal defence. Clin Exp Allergy 1991;21:17-24.
8. Persson CGA, Andersson M, Greiff L et al. Airway permeability. Clin Exp Allergy 1995;23:807-14.
9. Persson CGA. Airway epithelium and microcirculation. Eur Respir Rev 1994;4:352-62.
10. McDonald M. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli. Am J Physiol 1994;266:61-83.
11. Hultström D, Svensjö E. Intravital and electron microscopic study of bradykinin-induced vascular permeability changes using FITC-dextran as a tracer. J Pathol 1979;129:125-33.
12. Erjefält JS, Sundler F, Persson CGA. Eosinophils, neutrophils and venular gaps in the airway mucosa at epithelial removal-restitution. Am J Respir Crit Care Med 1996;153:1666-74.
13. Feng D, Nagy JA, Hipp J, Dvorak HF, Dvorak AM. Vesiculovacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med 1996;183:1981-6.
14. Grega GJ, Persson CGA, Svensjö E. Endothelial cell reactions to inflammatory mediators assessed in vivo by fluid and solute flux analysis. In: Ryan US ed. Endothelial Cells. Florida: Boca Raton, 1988:103-122.
15. Erjefält JS, Erjefält I, Sundler F, Persson CGA. Epithelial pathways for luminal entry of bulk plasma. Clin Exp Allergy 1995;25:187-95.
16. Persson CGA, Erjefält JS, Andersson M, Greiff L, Svensson C. Extravasation, lamina propria flooding, and lumenal entry of bulk plasma exudate in mucosal defence, inflammation, and repair. Pulm Pharmacol 1996;9:129-39.
17. Erjefält I, Persson CGA. Inflammatory passage of plasma macromolecules into airway tissue and lumen. Pulm Pharmacol 1989;2:93-102.
18. Svensson C, Greiff L, Andersson M, Alkner U, Grönneberg R, Persson CGA. Antiallergic actions of high topical doses of terbutaline in human nasal airways. Allergy 1995;50:884-90.
19. Salomonsson P, Grönneberg R, Gilljam H et al. Bronchial exudation of bulk plasma at allergen challenge in allergic asthma. Am Rev Respir Dis 1992;146:1535-42.
20. Svensson C, Grönneberg R, Andersson M et al. Allergen challenge-induced entry of alpha-2-macroglobulin and tryptase into human nasal and bronchial airways. J Allergy Clin Immunol 1995;96:239-46.
21. Greiff L, Alkner U, Pipkorn U, Persson CGA. The 'nasal pool' device applies controlled concentrations of solutes on human nasal airway mucosa and samples its surface exudations/secretions. Clin Exp Allergy 1990;20:253-9.
22. Persson CGA, Erjefält I, Gustafsson B, Luts A. Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa. Int Arch Allergy Appl Immunol 1990;92:148-53.
23. Gustafsson B, Persson CGA. Asymmetrical effects of increases in hydrostatic pressure on macromolecular movement across the airway mucosa. A study in guinea-pig tracheal tube preparation. Clin Exp Allergy 1991;21:121-6.
24. Kondo M, Finkbeiner WE, Widdicombe JH. Change in permeability of dog tracheal epithelium in response to hydrostatic pressure. Am J Physiol 1992;262:176-82.
25. Persson CGA, Svensjö E. Vascular responses and their suppression: drugs interfering with venular permeability. In: Bonta IL, Bray MA, Parnham MJ, eds. Handbook of Inflammation, Vol. 5. Amsterdam: Elsevier, 1985:61-82.
26. Brattsand R, Selroos O. Current drugs for respiratory diseases. Glucocorticoids. In: C Page ed. Drugs and The Lung. London: Academic Press, 1994:101-220.
27. Greiff L, Andersson M, Svensson C, Alkner U, Persson CGA. Glucocorticoids may not inhibit plasma exudation by direct vascular antipermeability effects in human airways. Eur Respir J 1994;7:1120-4.
28. Persson CGA. Airway microcirculation, epithelium, and glucocorticoids. In: Schleimer RP, Busse WW, O'Byrne PM, eds. Inhaled Glucocorticoids in Asthma, Mechanisms and Clinical Actions. New York: Dekker, 1997:167-201.
29. Persson CGA, Erjefält I, Andersson P. Leakage of macromolecules from guinea-pig tracheobronchial microcirculation. Effects of allergen, leukotrienes, tachykinins and anti-asthma drugs. Acta Physiol Scand 1986;127:95-105.
30. Erjefält I, Persson CGA. Pharmacological control of plasma exudation into tracheobronchial airways. Am Rev Respir Dis 1991;143:1008-14.
31. Erjefält I, Persson CGA. Long duration and high potency of antiexudative effects of formoterol in guinea-pig tracheobronchial airways. Am Rev Respir Dis 1991;144:788-91.
32. Persson CGA. Plasma exudation and asthma. Lung 1988;166:1-23.
33. Persson CGA. Airway mucosal exudation of plasma. In: Takishima T, Shimura S, eds. Airway Secretion. Physiological Bases for the Control of Mucous Hypersecretion. New York: Dekker, 1994:451-68.
34. Van de Graaf EA, Out TA, Roos CM, Jansen HM. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids. Am Rev Respir Dis 1991;143:362-8.
35. Svensson C, Klementsson H, Andersson M, Pipkorn U, Alkner U, Persson CGA. Glucocorticoid-induced attenuation of mucosal exudation of bradykinins and fibrinogen in seasonal allergic rhinitis. Allergy 1994;49:177-83.
36. Farr BM, Gwaltney JM Jr, Hendley JO. A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection. J Infect Dis 1990;162:1173-7.
37. Greiff L, Andersson M, Svensson C, Åkerlund A, Alkner U, Persson CGA. Effects of two weeks' topical budesonide treatment on microvascular exudative responsiveness in healthy human nasal airways. Eur Respir J 1997 (in press).
38. Erjefält I, Persson CGA. Increased sensitivity to toluene diisocyanate (TDI) in airways previously exposed to low doses of TDI. Clin Exp Allergy 1992;22:854-62.
39. Erjefält JS, Erjefält I, Sundler F, Persson CGA. Effects of topical budesonide on epithelial restitution in vivo in guinea-pig trachea. Thorax 1995;50:785-92.
40. Schleimer RP, Busse WW, O'Byrne PM, eds. Inhaled Glucocorticoids in Asthma. Mechanisms and Clinical Actions. New York: Dekker, 1997.
41. Greiff L, Erjefält I, Wollmer P et al. Effects of nicotine on the human nasal airway mucosa. Thorax 1993;48:651-5.
42. Greiff L, Svensson C, Andersson M, Persson CGA. Effects of topical capsaicin in seasonal allergic rhinitis. Thorax 1995;50:225-9.
43. Bascom R, Kagey-Sobotka A, Proud D. Effect of intranasal capsaicin on symptoms and mediator release. J Pharmacol Exp Ther 1991;259:1323-7.
44. 2-macroglobulin. Thorax 1997;52:964-8.
45. Persson CGA. Mucosal exudation in respiratory defence: Neural or non-neural control? Int Arch Allergy Immunol 1991;94:222-6.
46. Prescott T, Kaliner MA. Vascular mechanisms in rhinitis. In: Busse WW, Holgate ST, eds. Asthma and Rhinitis. Oxford: Blackwell, 1995:777-90.
47. Persson CGA, Erjefält I, Sundler F. Airway microvascular and epithelial leakage of plasma induced by PAF-acether and capsaicin. Am Rev Respir Dis 1987; 135:A401.
48. Svensson C, Baumgarten CR, Pipkorn U, Alkner U, Persson CGA. Reversibility and reproducibility of histamine-induced plasma leakage in the human nasal airways. Thorax 1989;44:13-8.
49. Herman AR, Liu MC, Wagner EM, Proud D. Dissociation of bradykinin-induced plasma exudation and reactivity in the peripheral airways. Am J Respir Crit Care Med 1996;154:418-23.
50. Minnicozzi M, Durán WN, Gleich GJ, Egan RW. Eosinophil granule proteins increase microvascular macromolecular transport in the hamster cheek pouch. J Immunol 1994;153:2664.
51. Liu MC, Hubbard WC, Proud D et al. Immediate and late inflammatory responses to ragweed antigen challenge in the peripheral airways in asthmatic airways. Am Rev Respir Dis 1991;144:51-8.
52. Erjefält I, Greiff L, Alkner U, Persson CGA. Allergen-induced biphasic plasma exudation responses in guinea-pig large airways. Am Rev Respir Dis 1993;148:695-701.
53. Erjefält I, Persson CGA. Effects of budesonide on allergen- and toluenediisocyanate (TDI)-induced late phase airway exudation of bulk plasma. Am J Respir Crit Care Med 1995;151:A223.
54. Persson CGA, Gustafsson B, Luts A, Sundler F, Erjefält I. Toluene diisocyanate produces an increase in airway tone that outlasts the inflammatory exudation phase. Clin Exp Allergy 1991;21:715-24.
55. Webber SE, Widdicombe JG. The transport of albumin across the ferret in vitro whole trachea. J Physiol 1989;408:457-72.
56. Blombäck B, Blombäck M, Edman P, Hessel B. Human fibrinopeptides: isolation, characterization and structure. Biochim Biophys Acta 1966;115:371-80.
57. Tang L, Eaton JW. Fibrin(ogen) mediates acute inflammatory responses to biomaterials. J Exp Med 1993;178:2147-56.
58. Roman J, McDonald JA. Fibronectins and fibronectin receptors in lung development, injury, and repair. In: Crystal RG, West JB et al., eds. Lung: Scientific Foundations, 2nd edn. Philadelphia: Lippincott, 1997:737-56.
59. Erjefält JS, Erjefält I, Sundler F, Persson CGA. Microcirculation-derived factors in airway epithelial repair in vivo. Microvasc Res 1994;48:161-78.
60. Gray AJ, Reeves JT, Harrisson NK, Winlove P, Laurent GJ. Growth factors for human fibroblasts in the solute remaining after clot formation. J Cell Sci 1990;96:271-4.
61. Grainger DJ, Kemp PR, Metcalfe JC et al. The serum concentration of active transforming growth factor-B is severely depressed in advanced atherosclerosis. Nature Med 1995;1:74-9.
62. 2-Macroglobulin, Its Receptor, and Related Proteins. New York: New York Academy of Science, 1994.
63. Persson CGA, Alkner U, Andersson M, Greiff L, Linden M, Svensson C. Histamine challenge-induced 'lamina propria lavage' and mucosal output of IL-6 in human airways. Eur Respir J 1995;8(suppl 19):125S.
64. Woolley KL, Ädelroth E, Woolley MJ, Jordana M, O'Byrne PM. Effects of allergen challenge on oesinophils, eosinophil cationic protein and granulocyte-macrophage colony-stimulating factor in mild asthmatics. Am J Respir Crit Care Med 1995;151:1915-24.
65. 2-maroglobulin. Biochem J 1987;245:781-7.
66. 2-macroglobulin and ECP in children with seasonal allergic rhinitis (abstract). Am J Respir Crit Care Med 1997 (in press).
67. Erjefält JS, Erjefält I, Sundler F, Persson CGA. In vivo restitution of airway epithelium. Cell Tissue Res 1995;281:305-16.
68. Wilhelm DL. Regeneration of tracheal epithelium. J Pathol Bacteriol 1953;95:543-50.
69. Persson CGA, Erjefält JS. Airway epithelial restitution following shedding and denudation. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations, 2nd edn. New York: Raven.
70. Zahm JM, Chevillard M, Puchelle E. Wound repair of human surface respiratory epithelium. Am J Respir Cell Mol Biol 1991;5:242-8.
71. Persson CGA, Erjefält JS, Erjefält I, Korsgren M, Nilsson M, Sundler F. Epithelial shedding-restitution as a causative process in airway inflammation. J Clin Exp Allergy 1996;26:746-55.
72. Davidson JM. Wound repair. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates, 2nd edn. New York: Raven, 1992:809-19.
73. Erjefält JS, Korsgren M, Nilsson MC, Sundler F, Persson CGA. Association between inflammation and epithelial damage-restitution processes in allergic airways in vivo. Clin Exp Allergy 1997;27:1344-55.
74. Erjefält JS, Korsgren M, Nilsson MC, Sundler F, Persson CGA. Prompt epithelial damage- and restitution-processes in allergen challenged guinea-pig trachea. Clin Exp Allergy 1997;27:1458-70.
75. Persson CGA, Erjefält JS. Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development. Trends Pharmacol Sci 1997;18:117-23.
76. Persson CGA. Centennial notions of asthma as an eosinophilic, desquamative, exudative, and steroid-sensitive disease. Lancet 1977;350:1021-4.
77. Naylor B. The shedding of the mucosa of the bronchial tree in asthma. Thorax 1962;17:69-72.
78. Dunnill MS. The pathology of asthma with special reference to the change in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
79. Erjefält JS, Greiff L, Andersson M, Persson G, Svensson C, Persson CGA. Eosinophil lysis and clusters of free eosinophil granules (Cfegs) in rhinitis and asthma (abstract). Am J Respir Crit Care Med 1997;155:A977.
80. Åkerlund A, Greiff L, Andersson M, Bende M, Alkner U, Persson CGA. Mucosal exudation of fibrinogen in corona virus-induced common cold. Acta Otolaryngol (Stockh) 1993;113:642-8.
81. Svensson C, Andersson M, Greiff L, Alkner U, Persson CGA. Exudative hyperresponsiveness of the airway microcirculation in seasonal allergic rhinitis. Clin Exp Allergy 1995;25:942-50.
82. Greiff L, Andersson M, Åkerlund A et al. Microvascular exudative hyperresponsiveness in human corona virus-induced common cold. Thorax 1994;49:121-7.
83. Gustafsson B, Persson CGA. Allergen-induced mucosal exudation of plasma into rat ileum and its inhibition by budesonide. Scand J Gastroenterol 1992;27:587-93.
84. Persson CGA, Gustafsson B, Erjefält JS, Sundler F. Mucosal exudation of plasma is a non-injurious intestinal defense mechanism. Allergy 1993;48:581-6.
85. McHugh KJ, Svensjö E, Persson CGA. Exudative and absorptive permeability in different phases of an experimental colitis condition. Scand J Gastroenterol 1996;31:900-5.
86. Hurley JV. Types of pulmonary microvascular injury. Ann NY Acad Sci 1992;384:269-86.
87. Riegler M, Feil W, Lindroth J, Wong M. Real-time morphometry to quantify time course of rapid epithelial restitution. Pathol Res Pract 1992;188:443-8.
88. Persson CGA. In vivo veritas. Thorax 1996;51:441-3.
89. Persson CGA. Discoveries in complex biosystems. Nature Biotech 1997;15:927.
90. Korsgren M, Erjefält JS, Korsgren O, Sundler F, Persson CGA. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J Exp Med 1997;185:885-92.
91. Lefort J, Bachelet C-B, Leduc D, Vargaftig BB. Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness. J Allergy Clin Immunol 1996;97:788-99.
92. Minnicozzi M et al. Lack of eosinophil release of MBP in a murine model of allergic pulmonary inflammation. Am J Respir Crit Care Med 1997;155:A627.
93. Persson CGA, Erjefält JS, Korsgren M, Sundler F. The mouse trap. Trends Pharmacol Sci 1997;18:465-7.