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Volumn 12, Issue 6, 2013, Pages 865-877

RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; MEMBRANE PROTEIN; OLAPARIB; RAD51C PROTEIN; UNCLASSIFIED DRUG;

EID: 84879308097     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0950     Document Type: Article
Times cited : (114)

References (37)
  • 1
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe N. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
    • (2006) Cancer Res , vol.66 , pp. 8109-8115
    • McCabe, N.1
  • 2
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature 2005;434:913-7.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 3
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 4
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010;376: 235-44.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3    Domchek, S.M.4    Audeh, M.W.5    Weitzel, J.N.6
  • 5
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor ola-parib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor ola-parib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-51.
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3    Friedlander, M.4    Powell, B.5    Bell-McGuinn, K.M.6
  • 6
    • 35948968410 scopus 로고    scopus 로고
    • Targeting poly(ADP-ribose) polymerase: A two-armed strategy for cancer therapy
    • Plummer ER, Calvert H. Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy. Clin Cancer Res 2007;13: 6252-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 6252-6256
    • Plummer, E.R.1    Calvert, H.2
  • 7
    • 79960150694 scopus 로고    scopus 로고
    • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
    • Johnson N, Li Y-C, Walton ZE, Cheng KA, Li D, Rodig SJ, et al. Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med 2011;17:875-82.
    • (2011) Nat Med , vol.17 , pp. 875-882
    • Johnson, N.1    Li, Y.-C.2    Walton, Z.E.3    Cheng, K.A.4    Li, D.5    Rodig, S.J.6
  • 8
    • 79952747328 scopus 로고    scopus 로고
    • Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
    • Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A 2011;108:3406-11.
    • (2011) Proc Natl Acad Sci u S A , vol.108 , pp. 3406-3411
    • Patel, A.G.1    Sarkaria, J.N.2    Kaufmann, S.H.3
  • 9
    • 77953916351 scopus 로고    scopus 로고
    • Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability
    • Smeenk G, de Groot AJ, Romeijn RJ, van Buul PP, Zdzienicka MZ, Mullenders LH, et al. Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability. Mutat Res 2010;689:50-8.
    • (2010) Mutat Res , vol.689 , pp. 50-58
    • Smeenk, G.1    De Groot, A.J.2    Romeijn, R.J.3    Van Buul, P.P.4    Zdzienicka, M.Z.5    Mullenders, L.H.6
  • 10
    • 59149088203 scopus 로고    scopus 로고
    • Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice
    • Kuznetsov SG, Haines DC, Martin BK, Sharan SK. Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res 2009;69:863-72.
    • (2009) Cancer Res , vol.69 , pp. 863-872
    • Kuznetsov, S.G.1    Haines, D.C.2    Martin, B.K.3    Sharan, S.K.4
  • 11
    • 33847350610 scopus 로고    scopus 로고
    • RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females
    • Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, et al. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol 2007;176:581-92.
    • (2007) J Cell Biol , vol.176 , pp. 581-592
    • Kuznetsov, S.1    Pellegrini, M.2    Shuda, K.3    Fernandez-Capetillo, O.4    Liu, Y.5    Martin, B.K.6
  • 12
    • 0037205472 scopus 로고    scopus 로고
    • Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability
    • French CA. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem 2002;277:19322-30.
    • (2002) J Biol Chem , vol.277 , pp. 19322-19330
    • French, C.A.1
  • 14
    • 30444445118 scopus 로고    scopus 로고
    • Interplay between human DNA repair proteins at a unique double-strand break in vivo
    • Rodrigue A, Lafrance M, Gauthier MC, McDonald D, Hendzel M, West SC, et al. Interplay between human DNA repair proteins at a unique double-strand break in vivo. Embo J 2006;25:222-31.
    • (2006) Embo J , vol.25 , pp. 222-231
    • Rodrigue, A.1    Lafrance, M.2    Gauthier, M.C.3    McDonald, D.4    Hendzel, M.5    West, S.C.6
  • 16
    • 33846217112 scopus 로고    scopus 로고
    • Biology of SNU cell lines
    • Ku JL, Park JG. Biology of SNU cell lines. Cancer Res Treat 2005; 37:1-19.
    • (2005) Cancer Res Treat , vol.37 , pp. 1-19
    • Ku, J.L.1    Park, J.G.2
  • 17
    • 33845734986 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations
    • Ahn SH, Son BH, Yoon K-S, Noh D-Y, Han W, Kim S-W, et al. BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations. Cancer Lett 2007;245:90-5.
    • (2007) Cancer Lett , vol.245 , pp. 90-95
    • Ahn, S.H.1    Son, B.H.2    Yoon, K.-S.3    Noh, D.-Y.4    Han, W.5    Kim, S.-W.6
  • 18
    • 84875512435 scopus 로고    scopus 로고
    • The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines
    • Nam H-J, Kim H-P, Yoon Y-K, Song S-H, Min A-R, Han S-W, et al. The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines. Invest New Drugs 2012;30:2148-60.
    • (2012) Invest New Drugs , vol.30 , pp. 2148-2160
    • Nam, H.-J.1    Kim, H.-P.2    Yoon, Y.-K.3    Song, S.-H.4    Min, A.-R.5    Han, S.-W.6
  • 19
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AOH, Zander SAL, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008;105: 17079-84.
    • (2008) Proc Natl Acad Sci u S A , vol.105 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3    Van Der Burg, E.4    Nygren, A.O.H.5    Zander, S.A.L.6
  • 20
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
    • Ratnam K, Low JA. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin Cancer Res 2007;13: 1383-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 1383-1388
    • Ratnam, K.1    Low, J.A.2
  • 21
    • 65949095892 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin
    • Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AOH, et al. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res 2009;69:3850-5.
    • (2009) Cancer Res , vol.69 , pp. 3850-3855
    • Hay, T.1    Matthews, J.R.2    Pietzka, L.3    Lau, A.4    Cranston, A.5    Nygren, A.O.H.6
  • 23
    • 33751282001 scopus 로고    scopus 로고
    • The polycomb group protein enhancer of Zeste 2: Its links to DNA repair and breast cancer
    • Zeidler M, Kleer CG. The polycomb group protein enhancer of Zeste 2: its links to DNA repair and breast cancer. J Mol Histol 2006;37:219-23.
    • (2006) J Mol Histol , vol.37 , pp. 219-223
    • Zeidler, M.1    Kleer, C.G.2
  • 24
    • 84861474647 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
    • Stefansson OA, Esteller M. EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells. Breast Cancer Res 2011;13:309.
    • (2011) Breast Cancer Res , vol.13 , pp. 309
    • Stefansson, O.A.1    Esteller, M.2
  • 25
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 26
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12:852-61.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3    Swenerton, K.4    Robidoux, A.5    Tonkin, K.6
  • 27
    • 33644640440 scopus 로고    scopus 로고
    • Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis
    • Abe K, Osakabe K, Nakayama S, Endo M, Tagiri A, Todoriki S, et al. Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis. Plant Physiol 2005;139:896-908.
    • (2005) Plant Physiol , vol.139 , pp. 896-908
    • Abe, K.1    Osakabe, K.2    Nakayama, S.3    Endo, M.4    Tagiri, A.5    Todoriki, S.6
  • 29
    • 77951720395 scopus 로고    scopus 로고
    • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
    • Meindl A, Hellebrand H, Wiek C, Erven V, Wappenschmidt B, Nieder-acher D, et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet 2010;42:410-4.
    • (2010) Nat Genet , vol.42 , pp. 410-414
    • Meindl, A.1    Hellebrand, H.2    Wiek, C.3    Erven, V.4    Wappenschmidt, B.5    Nieder-Acher, D.6
  • 31
    • 33847307543 scopus 로고    scopus 로고
    • Role of RAD51C and XRCC3 in genetic recombination and DNA repair
    • Liu Y, Tarsounas M, O'Regan P, West SC. Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem 2007;282: 1973-9.
    • (2007) J Biol Chem , vol.282 , pp. 1973-1979
    • Liu, Y.1    Tarsounas, M.2    O'Regan, P.3    West, S.C.4
  • 32
    • 78751629661 scopus 로고    scopus 로고
    • BRCA1 CpG Island hypermethylation predicts sensitivity to poly (adenosine diphosphate)-ribose polymerase inhibitors
    • Veeck J, Ropero S, Setien F, Gonzalez-Suarez E, Osorio A, Benitez J, et al. BRCA1 CpG island hypermethylation predicts sensitivity to poly (adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol 2010;28:e563-4.
    • (2010) J Clin Oncol , vol.28
    • Veeck, J.1    Ropero, S.2    Setien, F.3    Gonzalez-Suarez, E.4    Osorio, A.5    Benitez, J.6
  • 33
    • 79951887369 scopus 로고    scopus 로고
    • Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2
    • Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S, et al. Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. J Natl Cancer Inst 2011;103:334-46.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 334-346
    • Drew, Y.1    Mulligan, E.A.2    Vong, W.T.3    Thomas, H.D.4    Kahn, S.5    Kyle, S.6
  • 34
    • 79451472565 scopus 로고    scopus 로고
    • Require-ment for NBS1 in the S phase checkpoint responseto DNAmethylation combined with PARP inhibition
    • Horton JK, Stefanick DF, Zeng JY, Carrozza MJ, Wilson SH. Require-ment for NBS1 in the S phase checkpoint responseto DNAmethylation combined with PARP inhibition. DNA Repair (Amst) 2011;10:225-34.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 225-234
    • Horton, J.K.1    Stefanick, D.F.2    Zeng, J.Y.3    Carrozza, M.J.4    Wilson, S.H.5
  • 35
    • 80054765897 scopus 로고    scopus 로고
    • Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy
    • Ibragimova I, Cairns P. Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy. Methods Mol Biol 2011;780:277-91.
    • (2011) Methods Mol Biol , vol.780 , pp. 277-291
    • Ibragimova, I.1    Cairns, P.2


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