Risk assessment of coccidostatics during feed cross-contamination: Animal and human health aspects

Toxicology and Applied Pharmacology

Volumn 270, Issue 3, 2013, Pages 196-208

  Dorne, J L C M ^a   Fernandez Cruz M L ^b   Bertelsen, U ^a   Renshaw, D W ^c   Peltonen, K ^d   Anadon, A ^e   Feil, A ^f   Sanders, P ^g   Wester, P ^h   Fink Gremmels, J ⁱ  

^a EUROPEAN FOOD SAFETY AUTHORITY   (Italy)

^b INIA   (Spain)

^c FOOD STANDARDS AGENCY   (United Kingdom)

^d NATL VET AND FOOD RES INSTITUTE   (Finland)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^f ForschungsinstitutFuttermitteltechnik   (Germany)

^g Healthy Pigs Production and Experimentation Section   (France)

^h NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

ⁱ UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Animal health; Coccidiostatics; Coccidiostats; Cross contamination; Feed; Human health; Ionophoric; Non ionophoric; Non target species; Risk assessment; Toxicokinetics; Toxicology

Indexed keywords

COCCIDIOSTATIC AGENT; DECOQUINATE; DICLAZURIL; HALOFUGINONE; LASALOCID; MADURAMICIN; MONENSIN; NARASIN; NICARBAZIN; ROBENIDINE; SALINOMYCIN; SEMDURAMICIN;

ANIMAL FOOD; COCCIDIOSIS; HEALTH HAZARD; HORSE; HUMAN; KINETICS; NONHUMAN; PARASITE TRANSMISSION; REVIEW; RISK ASSESSMENT;

ANIMAL FEED; ANIMALS; CLINICAL TRIALS, PHASE I AS TOPIC; COCCIDIOSIS; COCCIDIOSTATS; FOOD CONTAMINATION; HEALTH STATUS; HUMANS; MEAT; RISK ASSESSMENT;

ANIMALIA; EQUIDAE; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 84879306927     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.12.014     Document Type: Review

References (99)

1. Anadón A., Martínez-Larrañaga M.R., Díaz M.J., Bringas P. Effect of tiamulin on antipyrine kinetics in chickens. J. Vet. Pharmacol. Ther. 1989, 12:94-98.
2. Anadón A., Martinez-Larrañaga M.R. Facteurs affectant la toxicité des ionophores anticoccidiens chez la volaille. Rev. Med. Vet. 1990, 141(1):17-24.
3. Anadón A., Reeve-Johnson L. Macrolide antibiotics, drug interactions and microsomal enzymes: implications for veterinary medicine. Res. Vet. Sci. 1999, 66(3):197-203.
4. Anderson T.D., Van Alstine W.G., Ficken M.D., Miskimins D.W., Carson T.L., Osweiler G.D. Acute monensin toxicosis in sheep: light and electron microscopic changes. Am. J. Vet. Res. 1984, 6:1142-1147. Geen referentie in tekst.
5. Bagg R., Vessie G.H., Dick P., Duffield T., Wilson J.B., Aramini J.J. Milk residues and performance of lactating dairy cows administered high doses of monensin. Can. J. Vet. Res. 2005, 69:180-185.
6. Bastianello S.S., Fourie N., Prozesky L., Nel P.W., Kellermann T.S. Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. II. Macropathology and histopathology. Onderstepoort. J. Vet. Res. 1995, 62:5-18.
7. Broz J., Frigg M. Incompatibility between lasalocid and chloramphenicol in broiler chicks after a long-term simultaneous administration. Vet. Res. Commun. 1987, 11(2):159-172.
8. Bruck R., Genina O., Aeed H., Alexiev R., Nagler A., Avni Y., Pines M. Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 2001, 33:379-386.
9. Caldeira C., Neves W.S., Cary P.M., Serrano P., Baptista M.A., Burdman E.A. Rhabdomyolysis, acute renal failure, and death after monensin ingestion. Am. J. Kidney Dis. 2001, 38:1108-1112.
10. Cannavan A., Ball G., Kennedy D.G. Nicarbazin contamination in feeds as a cause of residues in eggs. Food Addit. Contam. 2000, 17:829-836.
11. Confer A.W., Reavis D.U., Panciera R.J. Light and electron microscopic changes in skeletal and cardiac muscle of sheep with experimental monensin toxicosis. Vet. Pathol. 1993, 20(5):590-602.
12. Delahaut P., Pierret G., Ralet N., Dubois M.And, Gillard N. Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS. Food Addit. Contam. A Chem. Anal. Control Expo. Risk Assess. 2010, 27(6):801-809.
13. Dilov P., Dimitrov S., Dzhurov A., Nikolov A., Panchev I. Toxicity of sodium monensin for pigs. Vet.-Med Nauki. 1981, 18(8):55-63.
14. Dion A.K., Damaris A.M., Mark T.H. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opin. Drug Discov. 2009, 4:109-146.
15. Dirikolu L., Karpiesiuk W., Lehner A.E., Hugues C., Woods W.E., Harkins J.D., Boyles J., Atkinson A., Granstrom D.E., Tobin T. New therapeutic approaches for equine protozoal myeloencephalitis: pharmacokinetics of diclazuril sodium salts in horses. Vet. Ther. 2006, 7:52-63.
16. Drake J.N. Monensin-tiamulin interaction risk to pigs. Vet. Rec. 1981, 108:219-220.
17. Dubois M., Pierret G., Delahaut P. Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2004, 813(1-2):181-189.
18. EC (European Commission), 2002. Report of the Scientific Committee on Animal Nutrition on the use of semduramicin sodium in feedingstuffs for chickens for fattening, Adopted on 17 April 2002. http://www.ec.europa.eu/food/fs/sc/scan/out80_en.pdf.
19. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on the re-evaluation of coccidiostat Stenorol in accordance with article 9G of Council Directive70/524/EEC. EFSA J. 2003, 8:1-45. http://www.efsa.eu.int/science/feedap/feedap_opinions/186/opinion_feedap_04_en1.pdf.
20. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on the request from the Commission on the efficacy and safety of the coccidiostat Koffogran. EFSA J. 2003, 16:1-40. http://www.efsa.eu.int/science/feedap/feedap_opinions/185/opinion_feedap05_ej16_koffogran_en1.pdf.
21. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the coccidiostat Deccox in accordance with article 9G of Council Directive 70/524/EEC. EFSA J. 2003, 17:1-40. http://www.efsa.eu.int/science/feedap/feedap_opinions/184/opinion_feedap_06_en2.pdf.
22. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on the re-evaluation of coccidiostat Elancoban in accordance with article 9G of Council Directive 70/524/EEC. EFSA J. 2004, 42:1-61. http://www.efsa.europa.eu/science/feedap/feedap_opinions/288/opinion_feedap_011_en_amended1.pdf.
23. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the evaluation of coccidiostat Kokcisan 120G. EFSA J. 2004, 63:141. http://www.efsa.europa.eu/science/feedap/feedap_opinions/466/opinion18_feedap_ej63_kokcisan_en1.pdf.
24. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the re-evaluation of Cycostat 66G in accordance with Article 9G of Council Directive 70/524/EEC. EFSA J. 2004, 69:1-40. http://www.efsa.eu.int/science/feedap/feedap_opinions/493/opinion_feedap20_ej69_cycostat_en1.pdf.
25. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the re-evaluation of coccidiostat Sacox 120 micro Granulate as feed additive in accordance with article 9G of Council Directive 70/524/EEC. EFSA J. 2004, 76:1-49. http://www.efsa.europa.eu/science/feedap/feedap_opinions/509/opinion_feedap22_ej76_sacox_en1.pdf.
26. EFSA (European Food Safety Authority) Update of an opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the re-evaluation of coccidiostat Avatec in accordance with article 9G of Council Directive 70/524/EEC. EFSA J. 2004, 77:1-45. http://www.efsa.europa.eu/EFSA/Scientific_Opinion/opinion_feedap21_ej77_up_avatec_en1,0.pdf.
27. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the reevaluation of efficacy and safety of the coccidiostat Monteban G100 in accordance with Article 9G of Council Directive 70/524/EEC. EFSA J. 2004, 90:1-44. http://www.efsa.europa.eu/EFSA/Scientific_Opinion/opinion_feedap25_ej90_monteban_en1,0.pdf.
28. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission to update the opinion on the safety of "Cycostat 66G" based on robenidine in accordance with Council Directive 70/524/EEC (Article 9g). EFSA J. 2004, 98:1-4. http://www.efsa.eu.int/science/feedap/feedap_opinions/651/feedap_opinion29_ej98_cycostat66g_en1.pdf.
29. EFSA (European Food Safety Authority) Update of the Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a new request from the Commission related to the safety of "Bio-Cox 120G" based on Salinomycin sodium as a feed additive in accordance with Council Directive 70/524/EEC. EFSA J. 2005, 170:1-4. http://www.efsa.europa.eu/science/feedap/feedap_opinions/793/feedap_op_ej170_up_biocox120g_en1.pdf.
30. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the European Commission on the evaluation of the coccidiostat Coxidin (Monensin Sodium). EFSA J. 2005, 283:1-53. http://www.efsa.europa.eu/en/science/feedap/feedap_opinions/1220.html.
31. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or substances used in animal feed on the safety and efficacy of the coccidiostat Elancoban (monensin sodium) as a feed additive for calves for rearing and cattle for fattening in accordance with Regulation (EC) No 1831/2003. EFSA J. 2006, 387:1-33. http://www.efsa.europa.eu/EFSA/Scientific_Opinion/feedap_op_ej387_elancoban_en,2.pdf.
32. EFSA (European Food Safety Authority) Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the European Commission on the safety and efficacy of 'Clinacox 0.5%' based on diclazuril for rabbits for fattening and breeding. EFSA J. 2007, 506:1-32. http://www.efsa.europa.eu/EFSA/Scientific_Opinion/feedap_op_ej506_clinacox_rabbit_en,3.pdf.
33. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by narasin authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2007, 552:1-35. http://www.bezpecna-krmiva.cz/soubory/CONTAM_ej552_narasin_en.pdf.
34. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by lasalocid authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2007, 553:1-46.
35. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by salinomycin authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 591:1-38.
36. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by monensin authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 592:1-40.
37. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by semduramicin authorised for use as a feed additive. Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 593:1-27.
38. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by maduramicin authorised for use as a feed additive. Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 594:1-30.
39. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by robenidine authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 655:1-29.
40. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by decoquinate authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 656:1-26.
41. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by halofuginone hydrobromide authorised for use as a feed additive. Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 657:1-31.
42. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by nicarbazin authorised for use as a feed additive. Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 690:1-34.
43. EFSA (European Food Safety Authority) Updated scientific opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on a request from the European Commission on the safety of 'Clinacox 0.5%' (diclazuril) used in rabbits for fattening and breeding. EFSA J. 2008, 697:1-9. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178703718409.htm.
44. EFSA (European Food Safety Authority) Cross-contamination of non-target feedingstuffs by diclazuril authorised for use as a feed additive. Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 716:1-31.
45. EFSA (European Food Safety Authority) Scientific opinion on the safety and efficacy of Maxiban G160 (narasin and nicarbazin) for chickens for fatting. FEEDAP (EFSA Panel on Additives and Products or Substances used in Animal Feed). EFSA J. 2010, 8(4):1754. http://www.efsa.europa.eu/en/scdocs/doc/1574.pdf.
46. Elkin M., Ariel I., Miao H.Q., Nagler A., Pines M., de-Groot N., Hochberg A., Vlodavsky I. Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone. Cancer Res. 1999, 59:4111-4118.
47. Elkin M., Miao H.Q., Nagler A., Aingorn E., Reich R., Hemo I., Dou H.L., Pines M., Vlodavsky I. Halofuginone: a potent inhibitor of critical steps in angiogenesis progression. FASEB J. 2000, 14(15):2477-2485.
48. EMEA (European Medicines Agency) Diclazuril - summary report (1). Report of the Committee for Veterinary Medicinal Products. EMEA/MRL/086/96-FINAL http://www.emea.europa.eu/pdfs/vet/mrls/008696en.pdf.
49. EMEA (European Medicines Agency) "Halofuginone - summary report (1)", summary report of the Committee for Veterinary Medicinal Products, EMEA/MRL/485/98-FINAL. November 1998 http://www.emea.europa.eu/index/indexv1.htm.
50. EMEA (European Medicines Agency) Halofuginone - summary report (2), summary report of the Committee for Veterinary Medicinal Products, EMEA/MRL/741/00-FINAL, June 2000 http://www.emea.europa.eu/index/indexv1.htm.
51. EMEA (European Medicines Agency), 2003. Halocur: scientific discussion. CVMP/643/99-Rev.1. http://www.emea.europa.eu/vetdocs/PDFs/EPAR/halocur/064399en6.pdf.
52. EMEA (European Medicines Agency), 2004. Lasalocid sodium. Summary report of the Committee for Veterinary Medicinal Products. EMEA/MRL/912/04-FINAL, October 2004. http://www.emea.europa.eu/pdfs/vet/mrls/091204en.pdf.
53. EMEA (European Medicines Agency), 2004. Diclazuril (extension to all ruminants and porcine species) - summary report (2). Summary report of the Committee for Veterinary Medicinal Products. EMEA/MRL/895/04-Final. http://www.emea.europa.eu/pdfs/vet/mrls/089504en.pdf.
54. EMEA (European Medicines Agency), 2007. Summary report of the committee for medicinal products for veterinary use on the establishment of maximum residues limits. Monensin. EMEA/CVMP/185123/2007-Final. http://www.emea.europa.eu/pdfs/vet/mrls/Monensin.pdf.
55. Ernst R.A., Vohra P., Kratzer F.H., Kuhl H.J. Effect of halofuginone (Stenorol) on Chukar partridge (Alectoris chukar). Poult. Sci. 1996, 75:1493-1495.
56. FAO/WHO (Food and Agriculture Organisation/World Health Organization), 1999. Evaluation of certain veterinary drug residues in food. Fiftieth report of the Joint FAO/WHO Expert Committee on Food Additives, WHO Technical Report Series 888. http://www.whqlibdoc.whoint/trs/WHO_TRS_888.pdf.
57. Frigg M., Broz J., Weber G. Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics. Arch. Geflügelk 1983, 47:213-220.
58. Galitzer S.J., Bartley F.F., Oehme F.W. Preliminary studies on lasalocid toxicosis in cattle. Vet. Hum. Toxicol. 1982, 24:406-409.
59. Galitzer S.J., Oehme F.W., Bartley E.E., Dayton A.D. Lasalocid toxicity in cattle: acute clinicopathological changes. J. Anim. Sci. 1986, 62:1308-1316.
60. Gonzalez M., Barkema H.W., Keefe G.P. Monensin toxicosis in a dairy herd. Can. Vet. J. 2005, 46(10):910-912.
61. Veterinary Toxicology - Basic and Clinical Principles 2007, Elsevier - Academic Press, Oxford. first ed. R.C. Gupta (Ed.).
62. Hansen L.J., Eisenbesis H.G., Givens S.V. Toxic effects of lasalocid in horses. Am. J. Vet. Res. 1981, 42(3):456-461.
63. Huyben M.W., Sol J., Counotte G.H., Roumen M.P., Borst G.H. Salinomycin poisoning in veal calves. Vet. Rec. 2001, 149:183-184.
64. IFAH (International Federation for Animal Health) IFAH-Europe Report to the European Commission on The Future of Coccidiostats and Histomonostats. Final Tripartite, 16 July 2007 2007.
65. Johnston J.J., Britton W.M., MacDonald A., Primus T.M., Goodal M.J., Yoder C.A., Miller L.A., Fagerstone K.A. Quantification of plasma and egg 4, 4'-dinitrocarbanalide (DNC) residues for the efficient development of a nicarbazin based contraceptive for pest waterfowl. Pest. Manage. Sci. 2001, 58:197-202.
66. Kan C.A., Petz M. Residues of veterinary drugs in eggs and their distribution between yolk and white. J. Agric. Food Chem. 2000, 48(12):6397-6403.
67. Kennedy D.G., Hughes P.J., Blanchflower W.J. Ionophore residues in eggs in Northern Ireland: incidence and cause. Food Addit. Contam. 1998, 15(5):535-541.
68. Kouba R.F., et al. Presence of residues in eggs laid by chickens receiving decoquinate. J. Agr. Food Chem. 1972, 20(3):589-592.
69. Kouyoumdjian J.A., Morita M.P., Sato A.K., Pissolatti A.F. Fatal rhabdomyolysis alter acute sodium monensin (Rumensin) toxicity: case report. Arg. Neuropsiguiatr. 2001, 59(3A):596-598.
70. Kronfeld D.S. Lasalocid toxicosis is inadequately quantified for horses. Vet. Hum. Toxicol. 2002, 44(4):245-247.
71. Larrey D., Tinel M., Pessayre D. Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Biochem. Pharmacol. 1983, 32(9):1487-1493.
72. Matsuoka T., Novilla M.N., Thomson T.D., Donoho A.L. Review of monensin toxicosis in horses. J. Equine Vet. Sci. 1996, 16:8-15. Put et al in text.
73. McEvoy J.D.G., Smyth W.G., Kennedy D.G. Contamination of animal feedingstuffs with nicarbazin: investigations in a feed mill. Food Addit. Contam. 2003, 20(2):136-140.
74. Miller D.J.S., O'Connor J.J., Roberts N.L. Tiamulin/salinomycin interactions in pigs. Vet. Rec. 1986, 118:73-75.
75. Mortier L., Huet A.C., Charlier C., Daeseleire E., Delahaut P., Van Peteghem C. Incidence of residues of nine anticoccidials in eggs. Food Addit. Contam. 2005, 22:1120-1125.
76. Mortier L., Daeseleire E., Huyghebaert G., Grijspeerdt K., Van Peteghem C. Detection of residues of the coccidiostat diclazuril in poultry tissues by liquid chromatography-tandem mass spectrometry after withdrawal of medicated feed. J. Agric. Food Chem. 2005, 53(4):905-911.
77. Mulder P.P.J., Balzer-Rutgers P., te Brinke E.M., Bolck Y.J.C., Berendsen B.J.A., Gerçek H., Schat B., Van Rhijn J.A. Deposition and depletion of the coccidiostats toltrazuril and halofuginone in eggs. Anal. Chim. Acta 2005, 529:331-337.
78. Nagler A., Ohana M., Shibolet O., Shapira M.Y., Alper R., Vlodavsky I., Pines M., Ilan Y. Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone. Eur. J. Cancer 2004, 40:1397-1403.
79. Nebbia C., Ceppa L., Dacasto M., Nachtmann C., Carletti M. Oxidative monensin metabolism and cytochrome P450 3A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats. J. Vet. Pharmacol. Ther. 2001, 24(6):399-403.
80. Nicpon J., Czerw P., Harps O., Deegen E. Salinomycin poisoning in a Polish stud horse. Tierärztl Prax Ausg G Nutztiere 1997, 25(5):438-441.
81. Noser J., Wenk P., Sutter A., Schneider P. Kokzidiostatika in Eiern, Geflügelfleisch und Futtermitteln: Eine Stichproben-Kontrolle über den Nordwestschweizer Markt. Mitt. Lebensm Hyg. 2006, 97:107-120.
82. Novilla M.N., Folkerts T.M. Ionophores: monensin, lasalocid, salinomycin, narasin. Academic Press 1986, 359-363. New York, New York. J.L. Howard (Ed.).
83. Novilla M.N., Owen N.V., Todd G.C. The comparative toxicology of narasin in laboratory animals. Vet. Hum. Toxicol. 1994, 36:318-323.
84. Olejnik M., Szprengier-Juszkiewicz T., Jedziniak P. Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry. J. Chromatogr. A 2009, 1216(46):8141-8148.
85. PDV (Productschap Diervoeder) Animal feed standards for the production of pig meat in accordance with Japan standard. GMP-standard GMP17.1; 11-4-2003. Product Board Animal Feed, the Netherlands 2003, http://www.pdv.nl/lmbinaries/pdf1235_pdf_en_uk.pdf.
86. Pines M., Knopov V., Genina O., Lavelin I., Nagler A. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J. Hepatol. 1997, 27:391-398.
87. Rozza D.B., Vervuert I., Kamphues J., da Cruz C.E., Driemeier D. Monensin toxicosis in water buffaloes (Bubalus bubalis). J. Vet. Diagn. Invest. 2006, 18:494-496.
88. Sályi G., Molnár T., Glávits R., Bagó G.Y. Ionofór antibiotikumok okozta mérgezés juhokban. Magy. Állatorvosok Lapja 1988, 5:277-284.
89. Schrickx J.A., Fink-Gremmels J. Implications of ABC transporters on the disposition of typical veterinary medicinal products. Eur. J. Pharmacol. 2008, 585(2-3):510-519.
90. Segev G., Baneth G., Levitin B., Schlosberg A., Aroch I. Accidental poisoning of 17 dogs with lasalocid. Vet. Rec. 2004, 7:174-176.
91. Sharma N., Bhalla A., Varma S., Jain S., Singh S. Toxicity of maduramicin. Emerg. Med. J. 2005, 22(12):880-882.
92. Strauch W. Causes and control of carry-over and cross-contamination. Kraftfutter Feed Mag. 2002, 85(4):151-159. (Part 1). Kraftfutter/Feed Magazine. 85 (6), 239-249 (Part 2).
93. Story P., Doube A. A case of human poisoning by Salinomycin, an agricultural antibiotic. N.Z. Med. J. 2004, 117(1190):U799.
94. Van der Linde-Sipman J.S., van den Ingh T.S.G.A.M., van Nes J.J., Verhagen H., Kersten J.G.T.M., Beynen A.C., Plekkringa R. Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. Vet. Pathol. 1999, 36:152-156.
95. VMD (Veterinary Medicines Directorate UK) The Veterinary Medicines Directorate Annual Reports on Surveillance for Veterinary Residues, published annually by the UK's Veterinary Medicines Directorate http://www.vmd.gov.uk/Publications/AnnReps/AnnReps.htm.
96. Yakkundi S., Cannavan A., Young P.B., Elliott C.T., Kennedy D.G. Halofuginone contamination in feeds as a cause of residues in eggs. Anal. Chim. Acta 2002, 473:177-182.
97. Watkins P.B., Wrighton S.A., Schuetz E.G., Maurel P., Guzelian P.S. Macrolide antibiotics inhibit the degradation of the glucocorticoid responsive cytochrome P450 in rat hepatocytes in vivo and in primary monolayer culture. J. Biol. Chem. 1986, 261:6264-6271.
98. Wendt M., Fuhrmann H., Damsch S. The effect of treatment with vitamin E or selenium on the course of salinomycin poisoning in swine. Article in German. Dtsch Tierarztl Wochenschr 1994, 101:141-145.
99. Witkamp R.F., Nijmeijer S.M., Van miert A.S.J.P.A.M. Cytochrome P450 complex formation in rat liver by the antibiotic tiamulin. Antimicrob. Agents Chemother. 1996, 40:50-54.