메뉴 건너뛰기




Volumn 157, Issue 2, 2013, Pages 125-136

Non-small cell lung cancer - Genetic predictors

Author keywords

ALK; C MET; EGFR; KRAS; NSCLC; Resistance; ROS1; Tyrosine kinase inhibitors

Indexed keywords

EML4 ALK FUSION PROTEIN, HUMAN; EML4-ALK FUSION PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; RAS PROTEIN; ROS1 PROTEIN, HUMAN; SCATTER FACTOR RECEPTOR; TUMOR MARKER;

EID: 84879284867     PISSN: 12138118     EISSN: 18047521     Source Type: Journal    
DOI: 10.5507/bp.2013.034     Document Type: Article
Times cited : (35)

References (148)
  • 4
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011;12:175-80.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 5
    • 0033392005 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in cancer therapy: Biology, rationale and preliminary clinical results
    • Huang SM, Harari PM. Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Invest New Drugs 1999;17:259-69.
    • (1999) Invest New Drugs , vol.17 , pp. 259-269
    • Huang, S.M.1    Harari, P.M.2
  • 6
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in nonsmall-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
    • Gazdar AF. Activating and resistance mutations of EGFR in nonsmall-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009;28 Suppl 1:S24-S31.
    • (2009) Oncogene , vol.28 , Issue.1 SUPPL.
    • Gazdar, A.F.1
  • 7
    • 49149127726 scopus 로고    scopus 로고
    • Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy
    • Hirsch FR, Herbst RS, Olsen C, Chansky K, Crowley J, Kelly K, Franklin WA, Bunn PA, Jr., Varella-Garcia M, Gandara DR. Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 2008;26:3351-7.
    • (2008) J Clin Oncol , vol.26 , pp. 3351-3357
    • Hirsch, F.R.1    Herbst, R.S.2    Olsen, C.3    Chansky, K.4    Crowley, J.5    Kelly, K.6    Franklin, W.A.7    Bunn Jr., P.A.8    Varella-Garcia, M.9    Gandara, D.R.10
  • 8
    • 43749090705 scopus 로고    scopus 로고
    • EGFR mutations in lung adenocarcinomas: Clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression
    • Li AR, Chitale D, Riely GJ, Pao W, Miller VA, Zakowski MF, Rusch V, Kris MG, Ladanyi M. EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression. J Mol Diagn 2008;10:242-8.
    • (2008) J Mol Diagn , vol.10 , pp. 242-248
    • Li, A.R.1    Chitale, D.2    Riely, G.J.3    Pao, W.4    Miller, V.A.5    Zakowski, M.F.6    Rusch, V.7    Kris, M.G.8    Ladanyi, M.9
  • 11
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch FR, Varella-Garcia M, McCoy J, West H, Xavier AC, Gumerlock P, Bunn PA, Jr., Franklin WA, Crowley J, Gandara DR. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 2005;23:6838-45.
    • (2005) J Clin Oncol , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3    West, H.4    Xavier, A.C.5    Gumerlock, P.6    Bunn Jr., P.A.7    Franklin, W.A.8    Crowley, J.9    Gandara, D.R.10
  • 12
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA, Jr., Di Maria MV, Veve R, Bremmes RM, Baron AE, Zeng C, Franklin WA. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003;21:3798-807.
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3    Di Maria, M.V.4    Veve, R.5    Bremmes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 14
    • 32544443644 scopus 로고    scopus 로고
    • Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: A meta-analysis
    • Nakamura H, Kawasaki N, Taguchi M, Kabasawa K. Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis. Thorax 2006;61:140-5.
    • (2006) Thorax , vol.61 , pp. 140-145
    • Nakamura, H.1    Kawasaki, N.2    Taguchi, M.3    Kabasawa, K.4
  • 20
    • 79952022309 scopus 로고    scopus 로고
    • EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: A systematic review and metaanalysis in non-small-cell lung cancer
    • Dahabreh IJ, Linardou H, Kosmidis P, Bafaloukos D, Murray S. EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: a systematic review and metaanalysis in non-small-cell lung cancer. Ann Oncol 2011;22:545-52.
    • (2011) Ann Oncol , vol.22 , pp. 545-552
    • Dahabreh, I.J.1    Linardou, H.2    Kosmidis, P.3    Bafaloukos, D.4    Murray, S.5
  • 23
  • 27
    • 80052651609 scopus 로고    scopus 로고
    • Mechanisms of resistance to EGFR TKIs and development of a new generation of drugs in nonsmall-cell lung cancer
    • Kosaka T, Yamaki E, Mogi A, Kuwano H. Mechanisms of resistance to EGFR TKIs and development of a new generation of drugs in nonsmall-cell lung cancer. J Biomed Biotechnol 2011;2011:165214.
    • (2011) J Biomed Biotechnol , pp. 165214
    • Kosaka, T.1    Yamaki, E.2    Mogi, A.3    Kuwano, H.4
  • 28
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De PS, Bianco AR, Tortora G. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 2000;6:2053-63.
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De, P.S.6    Bianco, A.R.7    Tortora, G.8
  • 29
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in nonsmall-cell lung cancer and other solid tumors: Results of a phase I trial
    • Herbst RS, Maddox AM, Rothenberg ML, Small EJ, Rubin EH, Baselga J, Rojo F, Hong WK, Swaisland H, Averbuch SD, Ochs J, LoRusso PM. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in nonsmall-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol 2002;20:3815-25.
    • (2002) J Clin Oncol , vol.20 , pp. 3815-3825
    • Herbst, R.S.1    Maddox, A.M.2    Rothenberg, M.L.3    Small, E.J.4    Rubin, E.H.5    Baselga, J.6    Rojo, F.7    Hong, W.K.8    Swaisland, H.9    Averbuch, S.D.10    Ochs, J.11    Lorusso, P.M.12
  • 33
    • 78349239505 scopus 로고    scopus 로고
    • The challenge of targeting EGFR: Experience with gefitinib in nonsmall cell lung cancer
    • Armour AA, Watkins CL. The challenge of targeting EGFR: experience with gefitinib in nonsmall cell lung cancer. Eur Respir Rev 2010;19:186-96.
    • (2010) Eur Respir Rev , vol.19 , pp. 186-196
    • Armour, A.A.1    Watkins, C.L.2
  • 37
    • 74949117339 scopus 로고    scopus 로고
    • Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer
    • Dahabreh IJ, Linardou H, Siannis F, Kosmidis P, Bafaloukos D, Murray S. Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2010;16:291-303.
    • (2010) Clin Cancer Res , vol.16 , pp. 291-303
    • Dahabreh, I.J.1    Linardou, H.2    Siannis, F.3    Kosmidis, P.4    Bafaloukos, D.5    Murray, S.6
  • 38
    • 80052054210 scopus 로고    scopus 로고
    • Personalizing therapy with targeted agents in non-small cell lung cancer
    • Dienstmann R, Martinez P, Felip E. Personalizing therapy with targeted agents in non-small cell lung cancer. Oncotarget 2011;2:165-77.
    • (2011) Oncotarget , vol.2 , pp. 165-177
    • Dienstmann, R.1    Martinez, P.2    Felip, E.3
  • 39
    • 84857414572 scopus 로고    scopus 로고
    • Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: A meta-analysis of 13 randomized trials
    • Petrelli F, Borgonovo K, Cabiddu M, Barni S. Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials. Clin Lung Cancer 2012;13:107-14.
    • (2012) Clin Lung Cancer , vol.13 , pp. 107-114
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3    Barni, S.4
  • 40
    • 84866758089 scopus 로고    scopus 로고
    • Cetuximab and biomarkers in non-smallcell lung carcinoma
    • Patil N, Abba M, Allgayer H. Cetuximab and biomarkers in non-smallcell lung carcinoma. Biologics 2012;6:221-31.
    • (2012) Biologics , vol.6 , pp. 221-231
    • Patil, N.1    Abba, M.2    Allgayer, H.3
  • 41
    • 77949886293 scopus 로고    scopus 로고
    • Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced nonsmall-cell lung cancer
    • Khambata-Ford S, Harbison CT, Hart LL, Awad M, Xu LA, Horak CE, Dakhil S, Hermann RC, Lynch TJ, Weber MR. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced nonsmall-cell lung cancer. J Clin Oncol 2010;28:918-27.
    • (2010) J Clin Oncol , vol.28 , pp. 918-927
    • Khambata-Ford, S.1    Harbison, C.T.2    Hart, L.L.3    Awad, M.4    Xu, L.A.5    Horak, C.E.6    Dakhil, S.7    Hermann, R.C.8    Lynch, T.J.9    Weber, M.R.10
  • 42
    • 77955637020 scopus 로고    scopus 로고
    • Chemotherapy with cetuximab or chemotherapy alone for untreated advanced non-small-cell lung cancer: A systematic review and meta-analysis
    • Lin H, Jiang J, Liang X, Zhou X, Huang R. Chemotherapy with cetuximab or chemotherapy alone for untreated advanced non-small-cell lung cancer: a systematic review and meta-analysis. Lung Cancer 2010;70:57-62.
    • (2010) Lung Cancer , vol.70 , pp. 57-62
    • Lin, H.1    Jiang, J.2    Liang, X.3    Zhou, X.4    Huang, R.5
  • 45
    • 84855310079 scopus 로고    scopus 로고
    • EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
    • Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol 2012;13:e23-e31.
    • (2012) Lancet Oncol , vol.13
    • Yasuda, H.1    Kobayashi, S.2    Costa, D.B.3
  • 49
    • 79957916527 scopus 로고    scopus 로고
    • Effectiveness of tyrosine kinase inhibitors on uncommon epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
    • Wu JY, Yu CJ, Chang YC, Yang CH, Shih JY, Yang PC. Effectiveness of tyrosine kinase inhibitors on uncommon epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res 2011;17:3812-21.
    • (2011) Clin Cancer Res , vol.17 , pp. 3812-3821
    • Wu, J.Y.1    Yu, C.J.2    Chang, Y.C.3    Yang, C.H.4    Shih, J.Y.5    Yang, P.C.6
  • 51
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
    • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med 2006;354:2619-21.
    • (2006) N Engl J Med , vol.354 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 52
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • Nguyen KS, Kobayashi S, Costa DB. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 2009;10:281-9.
    • (2009) Clin Lung Cancer , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3
  • 53
    • 84858408937 scopus 로고    scopus 로고
    • Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors
    • Ghosh G, Lian X, Kron SJ, Palecek SP. Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors. BMC Cancer 2012;12:95.
    • (2012) BMC Cancer , vol.12 , pp. 95
    • Ghosh, G.1    Lian, X.2    Kron, S.J.3    Palecek, S.P.4
  • 55
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 58
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka T, Yatabe Y, Endoh H, Yoshida K, Hida T, Tsuboi M, Tada H, Kuwano H, Mitsudomi T. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 2006;12:5764-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Yoshida, K.4    Hida, T.5    Tsuboi, M.6    Tada, H.7    Kuwano, H.8    Mitsudomi, T.9
  • 61
    • 78650026316 scopus 로고    scopus 로고
    • KRAS and BRAF: Drug targets and predictive biomarkers
    • Vakiani E, Solit DB. KRAS and BRAF: drug targets and predictive biomarkers. J Pathol 2011;223:219-29.
    • (2011) J Pathol , vol.223 , pp. 219-229
    • Vakiani, E.1    Solit, D.B.2
  • 62
    • 77956805993 scopus 로고    scopus 로고
    • KRAS gene mutations in lung cancer: Particulars established and issues unresolved
    • Okudela K, Woo T, Kitamura H. KRAS gene mutations in lung cancer: particulars established and issues unresolved. Pathol Int 2010;60:651-60.
    • (2010) Pathol Int , vol.60 , pp. 651-660
    • Okudela, K.1    Woo, T.2    Kitamura, H.3
  • 63
    • 33645052711 scopus 로고    scopus 로고
    • Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
    • Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK, Lam WK, Chiu SW, Girard L, Minna JD, Gazdar AF, Wong MP. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res 2006;12:1647-53.
    • (2006) Clin Cancer Res , vol.12 , pp. 1647-1653
    • Tam, I.Y.1    Chung, L.P.2    Suen, W.S.3    Wang, E.4    Wong, M.C.5    Ho, K.K.6    Lam, W.K.7    Chiu, S.W.8    Girard, L.9    Minna, J.D.10    Gazdar, A.F.11    Wong, M.P.12
  • 64
    • 77955096407 scopus 로고    scopus 로고
    • KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies
    • Mao C, Qiu LX, Liao RY, Du FB, Ding H, Yang WC, Li J, Chen Q. KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies. Lung Cancer 2010;69:272-8.
    • (2010) Lung Cancer , vol.69 , pp. 272-278
    • Mao, C.1    Qiu, L.X.2    Liao, R.Y.3    Du, F.B.4    Ding, H.5    Yang, W.C.6    Li, J.7    Chen, Q.8
  • 66
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
    • Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004;64:8919-23.
    • (2004) Cancer Res , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6
  • 67
    • 61549091557 scopus 로고    scopus 로고
    • Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma
    • Kosaka T, Yatabe Y, Onozato R, Kuwano H, Mitsudomi T. Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. J Thorac Oncol 2009;4:22-9.
    • (2009) J Thorac Oncol , vol.4 , pp. 22-29
    • Kosaka, T.1    Yatabe, Y.2    Onozato, R.3    Kuwano, H.4    Mitsudomi, T.5
  • 69
    • 33646418681 scopus 로고    scopus 로고
    • Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation
    • Han SW, Kim TY, Jeon YK, Hwang PG, Im SA, Lee KH, Kim JH, Kim DW, Heo DS, Kim NK, Chung DH, Bang YJ. Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. Clin Cancer Res 2006;12:2538-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 2538-2544
    • Han, S.W.1    Kim, T.Y.2    Jeon, Y.K.3    Hwang, P.G.4    Im, S.A.5    Lee, K.H.6    Kim, J.H.7    Kim, D.W.8    Heo, D.S.9    Kim, N.K.10    Chung, D.H.11    Bang, Y.J.12
  • 72
  • 73
    • 33745697763 scopus 로고    scopus 로고
    • Targeting the c-Met signaling pathway in cancer
    • Peruzzi B, Bottaro DP. Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 2006;12:3657-60.
    • (2006) Clin Cancer Res , vol.12 , pp. 3657-3660
    • Peruzzi, B.1    Bottaro, D.P.2
  • 74
    • 0034693753 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase: Enhanced signaling through adapter proteins
    • Furge KA, Zhang YW, Vande Woude GF. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene 2000;19:5582-9.
    • (2000) Oncogene , vol.19 , pp. 5582-5589
    • Furge, K.A.1    Zhang, Y.W.2    Vande Woude, G.F.3
  • 75
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010;11:834-48.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 77
    • 43749091506 scopus 로고    scopus 로고
    • Showering c-MET-dependent cancers with drugs
    • Knudsen BS, Vande WG. Showering c-MET-dependent cancers with drugs. Curr Opin Genet Dev 2008;18:87-96.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 87-96
    • Knudsen, B.S.1    Vande, W.G.2
  • 78
    • 33745697763 scopus 로고    scopus 로고
    • Targeting the c-Met signaling pathway in cancer
    • Peruzzi B, Bottaro DP. Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 2006;12:3657-60.
    • (2006) Clin Cancer Res , vol.12 , pp. 3657-3660
    • Peruzzi, B.1    Bottaro, D.P.2
  • 85
    • 77649308276 scopus 로고    scopus 로고
    • High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer
    • Go H, Jeon YK, Park HJ, Sung SW, Seo JW, Chung DH. High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer. J Thorac Oncol 2010;5:305-13.
    • (2010) J Thorac Oncol , vol.5 , pp. 305-313
    • Go, H.1    Jeon, Y.K.2    Park, H.J.3    Sung, S.W.4    Seo, J.W.5    Chung, D.H.6
  • 87
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K, Sasaki H, Yukiue H, Yano M, Fujii Y. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci 2008;99:2280-5.
    • (2008) Cancer Sci , vol.99 , pp. 2280-2285
    • Okuda, K.1    Sasaki, H.2    Yukiue, H.3    Yano, M.4    Fujii, Y.5
  • 92
    • 76749157917 scopus 로고    scopus 로고
    • Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency
    • McDermott U, Pusapati RV, Christensen JG, Gray NS, Settleman J. Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency. Cancer Res 2010;70:1625-34.
    • (2010) Cancer Res , vol.70 , pp. 1625-1634
    • McDermott, U.1    Pusapati, R.V.2    Christensen, J.G.3    Gray, N.S.4    Settleman, J.5
  • 94
    • 78349265779 scopus 로고    scopus 로고
    • Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer
    • Suda K, Murakami I, Katayama T, Tomizawa K, Osada H, Sekido Y, Maehara Y, Yatabe Y, Mitsudomi T. Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Clin Cancer Res 2010;16:5489-98.
    • (2010) Clin Cancer Res , vol.16 , pp. 5489-5498
    • Suda, K.1    Murakami, I.2    Katayama, T.3    Tomizawa, K.4    Osada, H.5    Sekido, Y.6    Maehara, Y.7    Yatabe, Y.8    Mitsudomi, T.9
  • 96
    • 77956251704 scopus 로고    scopus 로고
    • Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells
    • Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells. J Thorac Oncol 2010;5:1317-24.
    • (2010) J Thorac Oncol , vol.5 , pp. 1317-1324
    • Matsubara, D.1    Ishikawa, S.2    Oguni, S.3    Aburatani, H.4    Fukayama, M.5    Niki, T.6
  • 98
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
    • Zhang YW, Staal B, Essenburg C, Su Y, Kang L, West R, Kaufman D, Dekoning T, Eagleson B, Buchanan SG, Vande Woude GF. MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res 2010;70:6880-90.
    • (2010) Cancer Res , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1    Staal, B.2    Essenburg, C.3    Su, Y.4    Kang, L.5    West, R.6    Kaufman, D.7    Dekoning, T.8    Eagleson, B.9    Buchanan, S.G.10    Vande Woude, G.F.11
  • 99
    • 79959609860 scopus 로고    scopus 로고
    • Early clinical development of ARQ 197, a selective, non-ATP-competitive inhibitor targeting MET tyrosine kinase for the treatment of advanced cancers
    • Adjei AA, Schwartz B, Garmey E. Early clinical development of ARQ 197, a selective, non-ATP-competitive inhibitor targeting MET tyrosine kinase for the treatment of advanced cancers. Oncologist 2011;16:788-99.
    • (2011) Oncologist , vol.16 , pp. 788-799
    • Adjei, A.A.1    Schwartz, B.2    Garmey, E.3
  • 103
    • 84879297829 scopus 로고    scopus 로고
    • U.S.National Library of Medicine. A service of the U.S. National Institutes of Health [online]. [cited 2012 Dec 8]; Available from
    • U.S.National Library of Medicine. A service of the U.S. National Institutes of Health [online]. [cited 2012 Dec 8]; Available from: http://wwwclinicaltrialsgov/.
  • 105
    • 80052969848 scopus 로고    scopus 로고
    • MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in nonsmall cell lung cancer according to MET alterations
    • Tanizaki J, Okamoto I, Okamoto K, Takezawa K, Kuwata K, Yamaguchi H, Nakagawa K. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in nonsmall cell lung cancer according to MET alterations. J Thorac Oncol 2011;6:1624-31.
    • (2011) J Thorac Oncol , vol.6 , pp. 1624-1631
    • Tanizaki, J.1    Okamoto, I.2    Okamoto, K.3    Takezawa, K.4    Kuwata, K.5    Yamaguchi, H.6    Nakagawa, K.7
  • 116
  • 117
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki T, Rodig SJ, Chirieac LR, Janne PA. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer 2010;46:1773-80.
    • (2010) Eur J Cancer , vol.46 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Janne, P.A.4
  • 118
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-smallcell lung cancer
    • Horn L, Pao W. EML4-ALK: honing in on a new target in non-smallcell lung cancer. J Clin Oncol 2009;27:4232-5.
    • (2009) J Clin Oncol , vol.27 , pp. 4232-4235
    • Horn, L.1    Pao, W.2
  • 119
    • 84862865652 scopus 로고    scopus 로고
    • A novel EML4-ALK variant: Exon 6 of EML4 fused to exon 19 of ALK
    • Penzel R, Schirmacher P, Warth A. A novel EML4-ALK variant: exon 6 of EML4 fused to exon 19 of ALK. J Thorac Oncol 2012;7:1198-9.
    • (2012) J Thorac Oncol , vol.7 , pp. 1198-1199
    • Penzel, R.1    Schirmacher, P.2    Warth, A.3
  • 127
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong DW, Leung EL, So KK, Tam IY, Sihoe AD, Cheng LC, Ho KK, Au JS, Chung LP, Pik WM. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 2009;115:1723-33.
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3    Tam, I.Y.4    Sihoe, A.D.5    Cheng, L.C.6    Ho, K.K.7    Au, J.S.8    Chung, L.P.9    Pik, W.M.10
  • 130
    • 78650499456 scopus 로고    scopus 로고
    • Good response to gefitinib in lung adenocarcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation
    • Kuo YW, Wu SG, Ho CC, Shih JY. Good response to gefitinib in lung adenocarcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation. J Thorac Oncol 2010;5:2039-40.
    • (2010) J Thorac Oncol , vol.5 , pp. 2039-2040
    • Kuo, Y.W.1    Wu, S.G.2    Ho, C.C.3    Shih, J.Y.4
  • 133
    • 77954399760 scopus 로고    scopus 로고
    • Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
    • Zhang X, Zhang S, Yang X, Yang J, Zhou Q, Yin L, An S, Lin J, Chen S, Xie Z, Zhu M, Zhang X, Wu YL. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer 2010;9:188.
    • (2010) Mol Cancer , vol.9 , pp. 188
    • Zhang, X.1    Zhang, S.2    Yang, X.3    Yang, J.4    Zhou, Q.5    Yin, L.6    An, S.7    Lin, J.8    Chen, S.9    Xie, Z.10    Zhu, M.11    Zhang, X.12    Wu, Y.L.13
  • 136
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 2007;6:3314-22.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3    Li, Q.4    Lee, J.H.5    McDonnell, S.R.6    Yamazaki, S.7    Alton, G.R.8    Mroczkowski, B.9    Los, G.10
  • 142
    • 79960250811 scopus 로고    scopus 로고
    • Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors
    • Lovly CM, Heuckmann JM, de SE, Chen H, Thomas RK, Liang C, Pao W. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res 2011;71:4920-31.
    • (2011) Cancer Res , vol.71 , pp. 4920-4931
    • Lovly, C.M.1    Heuckmann, J.M.2    De, S.E.3    Chen, H.4    Thomas, R.K.5    Liang, C.6    Pao, W.7
  • 148
    • 84860709024 scopus 로고    scopus 로고
    • Guidelines for biomarker testing in advanced non-small-cell lung cancer. A national consensus of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP)
    • Garrido P, de CJ, Concha A, Felip E, Isla D, Lopez-Rios F, Paz-Ares L, Ramirez J, Sanz J, Gomez JJ. Guidelines for biomarker testing in advanced non-small-cell lung cancer. A national consensus of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP). Clin Transl Oncol 2012;14:338-49.
    • (2012) Clin Transl Oncol , vol.14 , pp. 338-349
    • Garrido, P.1    De, C.J.2    Concha, A.3    Felip, E.4    Isla, D.5    Lopez-Rios, F.6    Paz-Ares, L.7    Ramirez, J.8    Sanz, J.9    Gomez, J.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.