Good response to gefitinib in lung adenocarcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation

Journal of Thoracic Oncology

Volumn 5, Issue 12, 2010, Pages 2039-2040

  Kuo, Yao Wen ^a   Wu, Shang Gin ^a   Ho, Chao Chi ^a   Shih, Jin Yuan ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CARCINOEMBRYONIC ANTIGEN; ECHINODERM MICROTUBULE ASSOCIATED PROTEIN LIKE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MICROTUBULE ASSOCIATED PROTEIN 4; UNCLASSIFIED DRUG;

AGED; ARTICLE; BRONCHUS BIOPSY; CANCER GROWTH; CANCER STAGING; CASE REPORT; CYTOLOGY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EFFICACY; EXON; FEMALE; FUSION GENE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG ASPIRATION; MARKER GENE; MOLECULAR GENETICS; PLEURA EFFUSION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE;

ADENOCARCINOMA; AGED; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; LUNG NEOPLASMS; MUTATION; ONCOGENE PROTEINS, FUSION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 78650499456     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181f43274     Document Type: Article

References (6)

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3. Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-128.
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5. Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14:4275-4283.
6. Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4- ALK. J Clin Oncol 2009;27:4247-4253.