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Volumn 9, Issue 3, 2011, Pages 207-214

New targets in advanced NSCLC: EML4-ALK

Author keywords

ALK; Crizotinib; EML4 ALK; Lung cancer; NSCLC

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; AP 26113; CARBOPLATIN; CISPLATIN; CYSTEINE; DOCETAXEL; ECHINODERM MICROTUBULE ASSOCIATED PROTEIN LIKE 4 ANAPLASTIC LYMPHOMA KINASE FUSION PROTEIN; LEUCINE; METHIONINE; ONCOPROTEIN; PEMETREXED; PROTEIN KINASE INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

EID: 79953241519     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (36)

References (53)
  • 3
    • 0035810147 scopus 로고    scopus 로고
    • Efcacy and safety of a specifc inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efcacy and safety of a specifc inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 4
    • 77749273521 scopus 로고    scopus 로고
    • First-line use of EGFR tyrosine kinase inhibitors in patients with NSCLC containing EGFR mutations
    • Neal JW, Sequist LV. First-line use of EGFR tyrosine kinase inhibitors in patients with NSCLC containing EGFR mutations. Clin Adv Hematol Oncol. 2010;8:119-126.
    • (2010) Clin Adv Hematol Oncol , vol.8 , pp. 119-126
    • Neal, J.W.1    Sequist, L.V.2
  • 5
    • 27544503230 scopus 로고    scopus 로고
    • Geftinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Tatcher N, Chang A, Parikh P, et al. Geftinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366:1527-1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Tatcher, N.1    Chang, A.2    Parikh, P.3
  • 6
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
    • Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 2004;64:8919-8923.
    • (2004) Cancer Res , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6
  • 7
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005;97:339-346.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 8
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to geftinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to geftinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101:13306-13311.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 9
    • 69949162760 scopus 로고    scopus 로고
    • Geftinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Tongprasert S, et al. Geftinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Tongprasert, S.3
  • 10
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to geftinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to geftinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 11
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to geftinib therapy
    • Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to geftinib therapy. Science. 2004;304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 12
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of geftinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A, Suzuki T, Fukuhara T, et al. Prospective phase II study of geftinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol. 2006;24:3340-3346.
    • (2006) J Clin Oncol , vol.24 , pp. 3340-3346
    • Inoue, A.1    Suzuki, T.2    Fukuhara, T.3
  • 13
    • 34249752278 scopus 로고    scopus 로고
    • Prospective validation for prediction of geftinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer
    • Yoshida K, Yatabe Y, Park JY, et al. Prospective validation for prediction of geftinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer. J Torac Oncol. 2007;2:22-28.
    • (2007) J Torac Oncol , vol.2 , pp. 22-28
    • Yoshida, K.1    Yatabe, Y.2    Park, J.Y.3
  • 14
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of geftinib as frst-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • Asahina H, Yamazaki K, Kinoshita I, et al. A phase II trial of geftinib as frst-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer. 2006;95:998-1004.
    • (2006) Br J Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3
  • 15
    • 0035005624 scopus 로고    scopus 로고
    • Alk+ CD30+ lymphomas: A distinct molecular genetic subtype of non-Hodgkin's lymphoma
    • Morris SW, Xue L, Ma Z, Kinney MC. Alk+ CD30+ lymphomas: a distinct molecular genetic subtype of non-Hodgkin's lymphoma. Br J Haematol. 2001;113:275-295.
    • (2001) Br J Haematol , vol.113 , pp. 275-295
    • Morris, S.W.1    Xue, L.2    Ma, Z.3    Kinney, M.C.4
  • 16
    • 54049149961 scopus 로고    scopus 로고
    • Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    • Janoueix-Lerosey I, Lequin D, Brugières L, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008; 455:967-970.
    • (2008) Nature , vol.455 , pp. 967-970
    • Janoueix-Lerosey, I.1    Lequin, D.2    Brugières, L.3
  • 17
    • 0033842958 scopus 로고    scopus 로고
    • Expression of the ALK tyrosine kinase gene in neuroblastoma
    • Lamant L, Pulford K, Bischof D, et al. Expression of the ALK tyrosine kinase gene in neuroblastoma. Am J Pathol. 2000;156:1711-1721.
    • (2000) Am J Pathol , vol.156 , pp. 1711-1721
    • Lamant, L.1    Pulford, K.2    Bischof, D.3
  • 18
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, Iafrate AJ, Gray NS, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008;68:3389-3395.
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3
  • 20
    • 34547638047 scopus 로고    scopus 로고
    • Identifcation of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identifcation of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 21
    • 77953291664 scopus 로고    scopus 로고
    • Te biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki T, Rodig SJ, Chirieac LR, Jänne PA. Te biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer. 2010;46:1773-1780.
    • (2010) Eur J Cancer , vol.46 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Jänne, P.A.4
  • 22
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifes oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifes oncogenic kinases in lung cancer. Cell. 2007;131:1190-1203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 23
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A. 2008;105:19893-19897.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 24
    • 78649973178 scopus 로고    scopus 로고
    • Inhibition of ALK, PI3K/MEK and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
    • Chen Z, Sasaki T, Tan X, et al. Inhibition of ALK, PI3K/MEK and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res. 2010;70:9827-9836.
    • (2010) Cancer Res , vol.70 , pp. 9827-9836
    • Chen, Z.1    Sasaki, T.2    Tan, X.3
  • 25
    • 40149109522 scopus 로고    scopus 로고
    • EML4-ALK fusion lung cancer: A rare acquired event
    • Perner S, Wagner PL, Demichelis F, et al. EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia. 2008;10:298-302.
    • (2008) Neoplasia , vol.10 , pp. 298-302
    • Perner, S.1    Wagner, P.L.2    Demichelis, F.3
  • 26
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009;15:5216-5223.
    • (2009) Clin Cancer Res , vol.15 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 27
    • 77649091118 scopus 로고    scopus 로고
    • A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res. 2010;16:1561-1571.
    • (2010) Clin Cancer Res , vol.16 , pp. 1561-1571
    • Mino-Kenudson, M.1    Chirieac, L.R.2    Law, K.3
  • 28
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to his-tological characteristics in a subset of lung cancers
    • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to his-tological characteristics in a subset of lung cancers. J Torac Oncol. 2008;3:13-17.
    • (2008) J Torac Oncol , vol.3 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 29
    • 47649105190 scopus 로고    scopus 로고
    • EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas
    • Shinmura K, Kageyama S, Tao H, et al. EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer. 2008;61:163-169.
    • (2008) Lung Cancer , vol.61 , pp. 163-169
    • Shinmura, K.1    Kageyama, S.2    Tao, H.3
  • 30
    • 57349113565 scopus 로고    scopus 로고
    • Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
    • Takeuchi K, Choi YL, Soda M, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res. 2008;14:6618-6624.
    • (2008) Clin Cancer Res , vol.14 , pp. 6618-6624
    • Takeuchi, K.1    Choi, Y.L.2    Soda, M.3
  • 31
    • 65249095599 scopus 로고    scopus 로고
    • Te EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong DW, Leung EL, So KK, et al. Te EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 2009;115:1723-1733.
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3
  • 32
    • 59649127007 scopus 로고    scopus 로고
    • EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
    • Martelli M P, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol. 2009;174: 661-670.
    • (2009) Am J Pathol , vol.174 , pp. 661-670
    • Martelli, M.P.1    Sozzi, G.2    Hernandez, L.3
  • 33
    • 77149130499 scopus 로고    scopus 로고
    • Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene
    • Takahashi, T, Sonobe M, Kobayashi M, et al. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol. 2010;17:889-897.
    • (2010) Ann Surg Oncol , vol.17 , pp. 889-897
    • Takahashi, T.1    Sonobe, M.2    Kobayashi, M.3
  • 34
    • 63949086127 scopus 로고    scopus 로고
    • KIF5B-ALK, a novel fusion oncokinase identifed by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    • Takeuchi K, Choi YL, Togashi Y, et al. KIF5B-ALK, a novel fusion oncokinase identifed by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 2009;15:3143-3149.
    • (2009) Clin Cancer Res , vol.15 , pp. 3143-3149
    • Takeuchi, K.1    Choi, Y.L.2    Togashi, Y.3
  • 35
    • 79953235890 scopus 로고    scopus 로고
    • Bronchoscopic microsampling is a useful complementary diagnostic tool for detecting lung cancer
    • Aug 31. Epub ahead of print
    • Yasuda H, Soejima K, Nakayama S, et al. Bronchoscopic microsampling is a useful complementary diagnostic tool for detecting lung cancer. Lung Cancer. 2010 Aug 31. Epub ahead of print.
    • (2010) Lung Cancer
    • Yasuda, H.1    Soejima, K.2    Nakayama, S.3
  • 36
    • 63949087355 scopus 로고    scopus 로고
    • EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
    • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol. 2009;22:508-515.
    • (2009) Mod Pathol , vol.22 , pp. 508-515
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 37
    • 67650441507 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcrip-tional up-regulation in non-small cell lung carcinomas
    • Boland JM, Erdogan S, Vasmatzis G, et al. Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcrip-tional up-regulation in non-small cell lung carcinomas. Hum Pathol. 2009;40: 1152-1158.
    • (2009) Hum Pathol , vol.40 , pp. 1152-1158
    • Boland, J.M.1    Erdogan, S.2    Vasmatzis, G.3
  • 38
    • 78649633452 scopus 로고    scopus 로고
    • Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma
    • Jokoji R, Yamasaki T, Minami S, et al. Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma. J Clin Pathol. 2010;63:1066-1070.
    • (2010) J Clin Pathol , vol.63 , pp. 1066-1070
    • Jokoji, R.1    Yamasaki, T.2    Minami, S.3
  • 39
    • 77958072736 scopus 로고    scopus 로고
    • EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration
    • Sakairi Y, Nakajima T, Yasufuku K, et al. EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration. Clin Cancer Res. 2010;16:4938-4945.
    • (2010) Clin Cancer Res , vol.16 , pp. 4938-4945
    • Sakairi, Y.1    Nakajima, T.2    Yasufuku, K.3
  • 40
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27:4247-4253.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 41
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efcacy of an ALK kinase inhibitor in lung cancer
    • Koivunen J P, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efcacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 2008;14: 4275-4283.
    • (2008) Clin Cancer Res , vol.14 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3
  • 42
    • 77954399760 scopus 로고    scopus 로고
    • Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
    • Zhang X, Zhang S, Yang X, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer. 2010;9:188.
    • (2010) Mol Cancer , vol.9 , pp. 188
    • Zhang, X.1    Zhang, S.2    Yang, X.3
  • 43
    • 43249099270 scopus 로고    scopus 로고
    • EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers
    • Fukuyoshi Y, Inoue H, Kita Y, Utsunomiya T, Ishida T, Mori M. EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers. Br J Cancer. 2008;98:1536-1539.
    • (2008) Br J Cancer , vol.98 , pp. 1536-1539
    • Fukuyoshi, Y.1    Inoue, H.2    Kita, Y.3    Utsunomiya, T.4    Ishida, T.5    Mori, M.6
  • 44
    • 70349510460 scopus 로고    scopus 로고
    • Exon array profling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
    • Lin E, Li L, Guan Y, et al. Exon array profling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res. 2009;7: 1466-1476.
    • (2009) Mol Cancer Res , vol.7 , pp. 1466-1476
    • Lin, E.1    Li, L.2    Guan, Y.3
  • 45
    • 78049515002 scopus 로고    scopus 로고
    • Lung adenocarcinoma from East Asian never-smokers is a disease largely defned by targetable oncogenic mutant kinases
    • Sun Y, Ren Y, Fang Z, et al. Lung adenocarcinoma from East Asian never-smokers is a disease largely defned by targetable oncogenic mutant kinases. J Clin Oncol. 2010;28:4616-4620.
    • (2010) J Clin Oncol , vol.28 , pp. 4616-4620
    • Sun, Y.1    Ren, Y.2    Fang, Z.3
  • 46
    • 78650499456 scopus 로고    scopus 로고
    • Good response to geftinib in lung adeno-carcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation
    • Kuo YW, Wu SG, Ho CC, Shih JY. Good response to geftinib in lung adeno-carcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation. J Torac Oncol. 2010;5:2039-2040.
    • (2010) J Torac Oncol , vol.5 , pp. 2039-2040
    • Kuo, Y.W.1    Wu, S.G.2    Ho, C.C.3    Shih, J.Y.4
  • 47
    • 78650191544 scopus 로고    scopus 로고
    • Prognostic versus predictive value of EML4-ALK translocation in metastatic non-small cell lung cancer (NSCLC)
    • ASCO Annual Meeting Abstracts
    • Shaw AT, Yeap B, Costa DB, et al. Prognostic versus predictive value of EML4-ALK translocation in metastatic non-small cell lung cancer (NSCLC). J Clin Oncol (ASCO Annual Meeting Abstracts). 2010;28:Abstract 7606.
    • (2010) J Clin Oncol , vol.28 , pp. 7606
    • Shaw, A.T.1    Yeap, B.2    Costa, D.B.3
  • 48
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 49
    • 84859499671 scopus 로고    scopus 로고
    • Clinical activity of crizotinib (PF-02341066), in ALK-positive patients with non-small cell lung cancer (NSCLC)
    • Milan, Italy; October
    • Camidge DR. Clinical activity of crizotinib (PF-02341066), in ALK-positive patients with non-small cell lung cancer (NSCLC). Presented at: 35th Congress of the European Society for Medical Oncology. Milan, Italy; October 8-12, 2010.
    • (2010) Presented At: 35th Congress of the European Society For Medical Oncology , pp. 8-12
    • Camidge, D.R.1
  • 50
    • 78049426513 scopus 로고    scopus 로고
    • EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • Choi YL, Soda M, Yamashita Y, et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363:1734-1739.
    • (2010) N Engl J Med , vol.363 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 51
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarci-nomas to geftinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • e73
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarci-nomas to geftinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2:e73.
    • (2005) PLoS Med , pp. 2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 52
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 2002;99:3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 53
    • 79953242428 scopus 로고    scopus 로고
    • AP26113, a Potent ALK Inhibitor
    • Presented at the 101st American Association for Cancer Research Annual Meeting; April 17-21, 2010; Washington D.C. Abstract LB-298
    • Zhang S, Wang F, Keats J, et al. AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Presented at the 101st American Association for Cancer Research Annual Meeting; April 17-21, 2010; Washington D.C. Abstract LB-298.
    • Overcomes Mutations In EML4-ALK That Confer Resistance to PF-02341066 (PF1066)
    • Zhang, S.1    Wang, F.2    Keats, J.3


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