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Volumn 24, Issue 1, 2006, Pages 7-13

What is the current evidence for antigen involvement in the development of chronic lymphocytic leukemia?

Author keywords

Antigens; Chronic lymphocytic leukemia; Complementarity determining region; Immunoglobulin genes; Prognosis; VH gene usage; VH3 21

Indexed keywords

ANTIGEN; AUTOANTIGEN; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT ANTIBODY;

EID: 33645211013     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.760     Document Type: Review
Times cited : (13)

References (66)
  • 1
    • 0028149568 scopus 로고
    • The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL
    • Matutes E, Owusu-Ankomah K, Morilla R, et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 1994; 8(10): 1640-1645.
    • (1994) Leukemia , vol.8 , Issue.10 , pp. 1640-1645
    • Matutes, E.1    Owusu-Ankomah, K.2    Morilla, R.3
  • 3
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981; 48(1): 198-206.
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 4
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94(6): 1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 5
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94(6): 1840-1847.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 6
    • 0034214876 scopus 로고    scopus 로고
    • Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia
    • Maloum K, Davi F, Merle-Beral H, et al. Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia. Blood 2000; 96(1): 377-379.
    • (2000) Blood , vol.96 , Issue.1 , pp. 377-379
    • Maloum, K.1    Davi, F.2    Merle-Beral, H.3
  • 7
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • Tobin G, Thunberg U, Johnson A, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99(6): 2262-2264.
    • (2002) Blood , vol.99 , Issue.6 , pp. 2262-2264
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 8
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • Kröber A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100(4): 1410-1416.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1410-1416
    • Kröber, A.1    Seiler, T.2    Benner, A.3
  • 9
    • 0037103257 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors in CLL: Clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors
    • Oscier DG, Gardiner AC, Mould SJ, et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 2002; 100(4): 1177-1184.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1177-1184
    • Oscier, D.G.1    Gardiner, A.C.2    Mould, S.J.3
  • 10
    • 0642281445 scopus 로고    scopus 로고
    • Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia
    • Vasconcelos Y, Davi F, Levy V, et al. Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia. J Clin Oncol 2003; 21(21): 3928-3932.
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3928-3932
    • Vasconcelos, Y.1    Davi, F.2    Levy, V.3
  • 11
    • 17844365857 scopus 로고    scopus 로고
    • Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome
    • Tobin G, Thunberg U, Laurell A, et al. Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome. Haematologica 2005; 90(4): 465-469.
    • (2005) Haematologica , vol.90 , Issue.4 , pp. 465-469
    • Tobin, G.1    Thunberg, U.2    Laurell, A.3
  • 12
    • 10744222814 scopus 로고    scopus 로고
    • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003; 101(12): 4944-4951.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 13
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348(18): 1764-1775.
    • (2003) N Engl J Med , vol.348 , Issue.18 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 14
    • 0347318114 scopus 로고    scopus 로고
    • ZAP-70 expression and prognosis in chronic lymphocytic leukaemia
    • Orchard JA, Ibbotson RE, Davis Z, et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004; 363(9403): 105-111.
    • (2004) Lancet , vol.363 , Issue.9403 , pp. 105-111
    • Orchard, J.A.1    Ibbotson, R.E.2    Davis, Z.3
  • 15
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351(9): 893-901.
    • (2004) N Engl J Med , vol.351 , Issue.9 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 17
    • 0035869282 scopus 로고    scopus 로고
    • CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia
    • Thunberg U, Johnson A, Roos G, et al. CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia. Blood 2001; 97(6): 1892-1894.
    • (2001) Blood , vol.97 , Issue.6 , pp. 1892-1894
    • Thunberg, U.1    Johnson, A.2    Roos, G.3
  • 18
    • 0035869378 scopus 로고    scopus 로고
    • CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia
    • Matrai Z, Lin K, Dennis M, et al. CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia. Blood 2001; 97(6): 1902-1903.
    • (2001) Blood , vol.97 , Issue.6 , pp. 1902-1903
    • Matrai, Z.1    Lin, K.2    Dennis, M.3
  • 19
    • 0035412375 scopus 로고    scopus 로고
    • CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia
    • Ibrahim S, Keating M, Do KA, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001; 98(1): 181-186.
    • (2001) Blood , vol.98 , Issue.1 , pp. 181-186
    • Ibrahim, S.1    Keating, M.2    Do, K.A.3
  • 20
    • 0035679122 scopus 로고    scopus 로고
    • Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia
    • Jelinek DF, Tschumper RC, Geyer SM, et al. Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia. Br J Haematol 2001; 115(4): 854-861.
    • (2001) Br J Haematol , vol.115 , Issue.4 , pp. 854-861
    • Jelinek, D.F.1    Tschumper, R.C.2    Geyer, S.M.3
  • 21
    • 0035525731 scopus 로고    scopus 로고
    • Clinical significance of CD38 expression in chronic lymphocytic leukemia
    • Del Poeta G, Maurillo L, Venditti A, et al. Clinical significance of CD38 expression in chronic lymphocytic leukemia. Blood 2001; 98(9): 2633-2639.
    • (2001) Blood , vol.98 , Issue.9 , pp. 2633-2639
    • Del Poeta, G.1    Maurillo, L.2    Venditti, A.3
  • 22
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001; 194(11): 1639-1647.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3
  • 23
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002; 100(13): 4609-4614.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3
  • 24
    • 4644371975 scopus 로고    scopus 로고
    • Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia
    • Ferrer A, Ollila J, Tobin G, et al. Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia. Cancer Genet Cytogenet 2004; 153(1): 69-72.
    • (2004) Cancer Genet Cytogenet , vol.153 , Issue.1 , pp. 69-72
    • Ferrer, A.1    Ollila, J.2    Tobin, G.3
  • 25
    • 0842276675 scopus 로고    scopus 로고
    • ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia
    • Durig J, Nuckel H, Cremer M, et al. ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia. Leukemia 2003; 17(12): 2426-2434.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2426-2434
    • Durig, J.1    Nuckel, H.2    Cremer, M.3
  • 26
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343(26): 1910-1916.
    • (2000) N Engl J Med , vol.343 , Issue.26 , pp. 1910-1916
    • Döhner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 27
    • 0000634555 scopus 로고
    • Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
    • Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson DA. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1989; 86(15): 5913-5917.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.15 , pp. 5913-5917
    • Kipps, T.J.1    Tomhave, E.2    Pratt, L.F.3    Duffy, S.4    Chen, P.P.5    Carson, D.A.6
  • 28
    • 0028355650 scopus 로고
    • The pathogenesis of chronic lymphocytic leukemia: Analysis of the antibody repertoire
    • Schroeder HW, Jr., Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire [see comments]. Immunol Today 1994; 15(6): 288-294.
    • (1994) Immunol Today , vol.15 , Issue.6 , pp. 288-294
    • Schroeder Jr., H.W.1    Dighiero, G.2
  • 29
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997; 158(1): 235-246.
    • (1997) J Immunol , vol.158 , Issue.1 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 30
    • 0030905707 scopus 로고    scopus 로고
    • Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
    • Oscier DG, Thompsett A, Zhu D, Stevenson FK. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 1997; 89(11): 4153-4160.
    • (1997) Blood , vol.89 , Issue.11 , pp. 4153-4160
    • Oscier, D.G.1    Thompsett, A.2    Zhu, D.3    Stevenson, F.K.4
  • 31
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102(8): 1515-1525.
    • (1998) J Clin Invest , vol.102 , Issue.8 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 32
    • 0032914730 scopus 로고    scopus 로고
    • V(H) gene family utilization in different B-cell lymphoma subgroups
    • Rosenquist R, Lindström A, Holmberg D, Lindh J, Roos G. V(H) gene family utilization in different B-cell lymphoma subgroups. Eur J Haematol 1999; 62(2): 123-128.
    • (1999) Eur J Haematol , vol.62 , Issue.2 , pp. 123-128
    • Rosenquist, R.1    Lindström, A.2    Holmberg, D.3    Lindh, J.4    Roos, G.5
  • 33
    • 10744230550 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: Implicating recognition of a common antigen epitope
    • Tobin G, Thunberg U, Johnson A, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003; 101(12): 4952-4957.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4952-4957
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 34
    • 11144356992 scopus 로고    scopus 로고
    • Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    • Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004; 113(7): 1008-1016.
    • (2004) J Clin Invest , vol.113 , Issue.7 , pp. 1008-1016
    • Ghiotto, F.1    Fais, F.2    Valetto, A.3
  • 35
    • 7244232709 scopus 로고    scopus 로고
    • Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
    • Tobin G, Thunberg U, Karlsson K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104(9): 2879-2885.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2879-2885
    • Tobin, G.1    Thunberg, U.2    Karlsson, K.3
  • 36
    • 4944244255 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
    • Widhopf GF, II, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104(8): 2499-2504.
    • (2004) Blood , vol.104 , Issue.8 , pp. 2499-2504
    • Widhopf II, G.F.1    Rassenti, L.Z.2    Toy, T.L.3    Gribben, J.G.4    Wierda, W.G.5    Kipps, T.J.6
  • 37
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004; 200(4): 519-525.
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3
  • 38
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995; 16(5): 237-242.
    • (1995) Immunol Today , vol.16 , Issue.5 , pp. 237-242
    • Cook, G.P.1    Tomlinson, I.M.2
  • 39
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302(5909): 575-581.
    • (1983) Nature , vol.302 , Issue.5909 , pp. 575-581
    • Tonegawa, S.1
  • 40
    • 0041646843 scopus 로고
    • Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-JH fusions
    • Alt FW, Baltimore D. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci USA 1982; 79(13): 4118-4122.
    • (1982) Proc Natl Acad Sci USA , vol.79 , Issue.13 , pp. 4118-4122
    • Alt, F.W.1    Baltimore, D.2
  • 41
    • 0019214271 scopus 로고
    • Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    • Sakano H, Maki R, Kurosawa Y, Roeder W, Tonegawa S. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature 1980; 286(5774): 676-683.
    • (1980) Nature , vol.286 , Issue.5774 , pp. 676-683
    • Sakano, H.1    Maki, R.2    Kurosawa, Y.3    Roeder, W.4    Tonegawa, S.5
  • 42
    • 0029895262 scopus 로고    scopus 로고
    • The germinal center: A crucible for lymphocyte selection
    • Kelsoe G. The germinal center: a crucible for lymphocyte selection. Seminars in Immunology 1996; 8(3): 179-184.
    • (1996) Seminars in Immunology , vol.8 , Issue.3 , pp. 179-184
    • Kelsoe, G.1
  • 43
    • 0033711628 scopus 로고    scopus 로고
    • Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
    • Xu JL, Davis MM. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 2000; 13(1): 37-45.
    • (2000) Immunity , vol.13 , Issue.1 , pp. 37-45
    • Xu, J.L.1    Davis, M.M.2
  • 45
    • 0038281374 scopus 로고    scopus 로고
    • Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire
    • Potter KN, Orchard J, Critchley E, Mockridge CI, Jose A, Stevenson FK. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood 2003; 101(8): 3082-3084.
    • (2003) Blood , vol.101 , Issue.8 , pp. 3082-3084
    • Potter, K.N.1    Orchard, J.2    Critchley, E.3    Mockridge, C.I.4    Jose, A.5    Stevenson, F.K.6
  • 46
    • 0025742731 scopus 로고
    • Preferential rearrangement of developmentally regulated immunoglobulin VH1 genes in human B-lineage leukaemias
    • Deane M, Norton JD. Preferential rearrangement of developmentally regulated immunoglobulin VH1 genes in human B-lineage leukaemias. Leukemia 1991; 5(8): 646-650.
    • (1991) Leukemia , vol.5 , Issue.8 , pp. 646-650
    • Deane, M.1    Norton, J.D.2
  • 47
    • 0042744704 scopus 로고    scopus 로고
    • High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment
    • Lin K, Manocha S, Harris RJ, Matrai Z, Sherrington PD, Pettitt AR. High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment. Blood 2003; 102(3): 1145-1146.
    • (2003) Blood , vol.102 , Issue.3 , pp. 1145-1146
    • Lin, K.1    Manocha, S.2    Harris, R.J.3    Matrai, Z.4    Sherrington, P.D.5    Pettitt, A.R.6
  • 48
    • 3242883817 scopus 로고    scopus 로고
    • Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols
    • Matthews C, Catherwood M, Morris TC, Alexander HD. Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols. Leuk Lymphoma 2004; 45(9): 1899-1904.
    • (2004) Leuk Lymphoma , vol.45 , Issue.9 , pp. 1899-1904
    • Matthews, C.1    Catherwood, M.2    Morris, T.C.3    Alexander, H.D.4
  • 49
    • 0344364559 scopus 로고    scopus 로고
    • V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia
    • Duke VM, Gandini D, Sherrington PD, Lin K, Heelan B, Amlot P, et al. V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia. Haematologica 2003; 88(11): 1259-1271.
    • (2003) Haematologica , vol.88 , Issue.11 , pp. 1259-1271
    • Duke, V.M.1    Gandini, D.2    Sherrington, P.D.3    Lin, K.4    Heelan, B.5    Amlot, P.6
  • 50
    • 1942521277 scopus 로고    scopus 로고
    • The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process
    • Messmer BT, Albesiano E, Messmer D, Chiorazzi N. The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood 2004; 103(9): 3490-3495.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3490-3495
    • Messmer, B.T.1    Albesiano, E.2    Messmer, D.3    Chiorazzi, N.4
  • 51
    • 13544275555 scopus 로고    scopus 로고
    • Geographical patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: The lesson of the IGHV3-21 gene
    • Ghia P, Stamatopoulos K, Belessi C, et al. Geographical patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105(4): 1678-1685.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1678-1685
    • Ghia, P.1    Stamatopoulos, K.2    Belessi, C.3
  • 53
    • 22144464117 scopus 로고    scopus 로고
    • Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia
    • Fält S, Merup M, Tobin G, et al. Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia. Blood 2005; 106(2): 681-689.
    • (2005) Blood , vol.106 , Issue.2 , pp. 681-689
    • Fält, S.1    Merup, M.2    Tobin, G.3
  • 54
    • 2142758730 scopus 로고    scopus 로고
    • Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin
    • Kolar GR, Capra JD. Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin. J Clin Invest 2004; 113(7): 952-954.
    • (2004) J Clin Invest , vol.113 , Issue.7 , pp. 952-954
    • Kolar, G.R.1    Capra, J.D.2
  • 56
    • 0026555607 scopus 로고
    • Evidence for somatic selection of natural autoantibodies
    • Martin T, Duffy SF, Carson DA, Kipps TJ. Evidence for somatic selection of natural autoantibodies. J Exp Med 1992; 175(4): 983-991.
    • (1992) J Exp Med , vol.175 , Issue.4 , pp. 983-991
    • Martin, T.1    Duffy, S.F.2    Carson, D.A.3    Kipps, T.J.4
  • 57
    • 0029410847 scopus 로고
    • VH3-21 B cells escape from a state of tolerance in rheumatoid arthritis and secrete rheumatoid factor
    • He X, Goronzy JJ, Zhong W, Xie C, Weyand CM. VH3-21 B cells escape from a state of tolerance in rheumatoid arthritis and secrete rheumatoid factor. Mol Med 1995; 1(7): 768-780.
    • (1995) Mol Med , vol.1 , Issue.7 , pp. 768-780
    • He, X.1    Goronzy, J.J.2    Zhong, W.3    Xie, C.4    Weyand, C.M.5
  • 58
    • 0033499036 scopus 로고    scopus 로고
    • Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjogren's syndrome
    • Elagib KE, Tengner P, Levi M, et al. Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjogren's syndrome. Arthritis Rheum 1999; 42(11): 2471-2481.
    • (1999) Arthritis Rheum , vol.42 , Issue.11 , pp. 2471-2481
    • Elagib, K.E.1    Tengner, P.2    Levi, M.3
  • 59
    • 0034812910 scopus 로고    scopus 로고
    • Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse
    • Sasaki M, Van De Water J, Kenny TP, et al. Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse. Hepatology 2001; 34(4 Pt 1): 631-637.
    • (2001) Hepatology , vol.34 , Issue.4 PART 1 , pp. 631-637
    • Sasaki, M.1    Van De Water, J.2    Kenny, T.P.3
  • 60
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M, Xu K, Ng YS, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005; 115(6): 1636-1643.
    • (2005) J Clin Invest , vol.115 , Issue.6 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3
  • 61
    • 0028297396 scopus 로고
    • Epstein-Barr virus (EBV) can immortalize B-CLL cells activated by cytokines
    • Wendel-Hansen V, Sällström J, De Campos-Lima PO, et al. Epstein-Barr virus (EBV) can immortalize B-CLL cells activated by cytokines. Leukemia 1994; 8(3): 476-484.
    • (1994) Leukemia , vol.8 , Issue.3 , pp. 476-484
    • Wendel-Hansen, V.1    Sällström, J.2    De Campos-Lima, P.O.3
  • 62
    • 33645238521 scopus 로고    scopus 로고
    • +) identified in chronic lymphocytic leukemia: Evidence for autoantigen-driven leukemogenesis
    • +) identified in chronic lymphocytic leukemia: evidence for autoantigen-driven leukemogenesis. Leukemia & Lymphoma 2005; 46(suppl 1): S37-S38.
    • (2005) Leukemia & Lymphoma , vol.46 , Issue.SUPPL. 1
    • Lanemo, A.1    Hellqvist, E.2    Sidorova, E.3
  • 64
    • 0343339955 scopus 로고    scopus 로고
    • Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells
    • Nilsson J, Söderberg O, Nilsson K, Rosén A. Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells. Blood 2000; 95(4): 1420-1426.
    • (2000) Blood , vol.95 , Issue.4 , pp. 1420-1426
    • Nilsson, J.1    Söderberg, O.2    Nilsson, K.3    Rosén, A.4
  • 65
    • 3242689559 scopus 로고    scopus 로고
    • Differentiation-associated redox-regulation in human B cell lines from stem cell/pro-B to plasma cell
    • Nilsson J, Söderberg O, Nilsson K, Rosén A. Differentiation-associated redox-regulation in human B cell lines from stem cell/pro-B to plasma cell. Immunol Lett 2004; 94(1-2): 83-89.
    • (2004) Immunol Lett , vol.94 , Issue.1-2 , pp. 83-89
    • Nilsson, J.1    Söderberg, O.2    Nilsson, K.3    Rosén, A.4
  • 66
    • 33645228445 scopus 로고    scopus 로고
    • Overexpression of the tumor survival factor thioredoxin by accessory cells in the lymph nodes of B-CLL patients
    • Bäckman E, Lagerdahl I, Rydberg B, Rosén A. Overexpression of the tumor survival factor thioredoxin by accessory cells in the lymph nodes of B-CLL patients. Leukemia & Lymphoma 2005; 46(Suppl. 1): S80.
    • (2005) Leukemia & Lymphoma , vol.46 , Issue.SUPPL. 1
    • Bäckman, E.1    Lagerdahl, I.2    Rydberg, B.3    Rosén, A.4


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