메뉴 건너뛰기




Volumn 86, Issue 5, 2007, Pages 1384-1391

Low vitamin B-12 status and risk of cognitive decline in older adults

Author keywords

Cognitive decline; Folate; Holotranscobalamin; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID; TRANSCOBALAMIN;

EID: 36249025250     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.5.1384     Document Type: Article
Times cited : (160)

References (40)
  • 1
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55.
    • (1998) Arch Neurol , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 2
    • 33745617460 scopus 로고    scopus 로고
    • Vitamin B12, folic acid, and the prevention of dementia
    • Clarke R. Vitamin B12, folic acid, and the prevention of dementia. N Engl J Med 2006;354:2817-9.
    • (2006) N Engl J Med , vol.354 , pp. 2817-2819
    • Clarke, R.1
  • 3
    • 27744603884 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
    • Homocysteine Lower Trialists' Collaboration
    • Homocysteine Lower Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005;82:806-12.
    • (2005) Am J Clin Nutr , vol.82 , pp. 806-812
  • 4
    • 0031003514 scopus 로고    scopus 로고
    • Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?
    • Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 1997;52:76-9.
    • (1997) J Gerontol A Biol Sci Med Sci , vol.52 , pp. 76-79
    • Joosten, E.1    Lesaffre, E.2    Riezler, R.3
  • 6
    • 0029865065 scopus 로고    scopus 로고
    • Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study
    • Riggs KM, Spiro A III, Tucker K, Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996;63:306-14.
    • (1996) Am J Clin Nutr , vol.63 , pp. 306-314
    • Riggs, K.M.1    Spiro III, A.2    Tucker, K.3    Rush, D.4
  • 8
    • 0035050096 scopus 로고    scopus 로고
    • National Health and Nutrition Examination Survey. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J; National Health and Nutrition Examination Survey. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2001;73:927-33.
    • (2001) Am J Clin Nutr , vol.73 , pp. 927-933
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 10
    • 0034116129 scopus 로고    scopus 로고
    • Plasma total homocysteine and cognitive performance in a volunteer elderly population
    • Budge M, Johnston C, Hogervorst E, et al. Plasma total homocysteine and cognitive performance in a volunteer elderly population. Ann N Y Acad Sci 2000;903:407-10.
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 407-410
    • Budge, M.1    Johnston, C.2    Hogervorst, E.3
  • 11
    • 27244455440 scopus 로고    scopus 로고
    • High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans Affairs Normative Aging Study
    • Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A III. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005;82:627-35.
    • (2005) Am J Clin Nutr , vol.82 , pp. 627-635
    • Tucker, K.L.1    Qiao, N.2    Scott, T.3    Rosenberg, I.4    Spiro III, A.5
  • 12
    • 0036853298 scopus 로고    scopus 로고
    • Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging
    • Kado DM, Bucur A, Selhub J, Rowe JW, Seeman T. Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med 2002;113:537-42.
    • (2002) Am J Med , vol.113 , pp. 537-542
    • Kado, D.M.1    Bucur, A.2    Selhub, J.3    Rowe, J.W.4    Seeman, T.5
  • 13
    • 27744461645 scopus 로고    scopus 로고
    • Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: The Leiden 85-Plus study
    • Mooijaart SP, Gussekloo J, Frolich M, et al. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study. Am J Clin Nutr 2005;4:866-71.
    • (2005) Am J Clin Nutr , vol.4 , pp. 866-871
    • Mooijaart, S.P.1    Gussekloo, J.2    Frolich, M.3
  • 14
    • 28544447509 scopus 로고    scopus 로고
    • Plasma total homocysteine and memory in the elderly: The Hordaland Homocysteine Study
    • Nurk E, Refsum H, Tell GS, et al. Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 2005;58:847-57.
    • (2005) Ann Neurol , vol.58 , pp. 847-857
    • Nurk, E.1    Refsum, H.2    Tell, G.S.3
  • 15
    • 0037069282 scopus 로고    scopus 로고
    • Homocysteine and cognitive function in the elderly: The Rotterdam study
    • Prins ND, Den Heijer T, van Dijk EJ, et al. Homocysteine and cognitive function in the elderly: the Rotterdam study. Neurology 2002;59:1375-80.
    • (2002) Neurology , vol.59 , pp. 1375-1380
    • Prins, N.D.1    Den Heijer, T.2    van Dijk, E.J.3
  • 16
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
    • (2002) N Engl J Med , vol.346 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3
  • 17
    • 27244445944 scopus 로고    scopus 로고
    • Homocysteine and folate as risk factors for dementia and Alzheimer's disease
    • Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer's disease. Am J Clin Nutr 2005;82:636-43.
    • (2005) Am J Clin Nutr , vol.82 , pp. 636-643
    • Ravaglia, G.1    Forti, P.2    Maioli, F.3
  • 19
    • 0038474037 scopus 로고    scopus 로고
    • Screening for vitamin B12 and folate deficiency in older people
    • Clarke R, Refsum H, Birks J, et al. Screening for vitamin B12 and folate deficiency in older people. Am J Clin Nutr 2003;77:1241-7.
    • (2003) Am J Clin Nutr , vol.77 , pp. 1241-1247
    • Clarke, R.1    Refsum, H.2    Birks, J.3
  • 20
    • 16844370424 scopus 로고    scopus 로고
    • Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons
    • Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5.
    • (2005) Arch Neurol , vol.62 , pp. 641-645
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3
  • 21
    • 33846102164 scopus 로고    scopus 로고
    • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    • Morris MS, Jacques PF, Rosenberg IW, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.
    • (2007) Am J Clin Nutr , vol.85 , pp. 193-200
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.W.3    Selhub, J.4
  • 22
    • 0023946537 scopus 로고
    • Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis
    • Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8.
    • (1988) N Engl J Med , vol.318 , pp. 1720-1728
    • Lindenbaum, J.1    Healton, E.B.2    Savage, D.G.3
  • 23
    • 0031959352 scopus 로고    scopus 로고
    • Cognitive function and dementia in six areas of England and Wales: The distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    • Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Psychol Med 1998;28:319-35.
    • (1998) Psychol Med , vol.28 , pp. 319-335
  • 24
    • 33846637262 scopus 로고    scopus 로고
    • The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA Study
    • Matthews F, Brayne C. The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study. PLoS Med 2005;8:e193.
    • (2005) PLoS Med , vol.8
    • Matthews, F.1    Brayne, C.2
  • 28
    • 0030744634 scopus 로고    scopus 로고
    • Microbiological assay for serum, serum and red-cell folate using cryopreserved, microliter plate method
    • Molloy AM, Scott JM. Microbiological assay for serum, serum and red-cell folate using cryopreserved, microliter plate method. Meth Enzymol 1997;281:43-53.
    • (1997) Meth Enzymol , vol.281 , pp. 43-53
    • Molloy, A.M.1    Scott, J.M.2
  • 29
    • 0344352486 scopus 로고    scopus 로고
    • Husek P. Chloroformates in gas chromatography as general purpose derivatizating agents. J Chromatogr B Biomed Sci Appl 1998;717:57-91.
    • Husek P. Chloroformates in gas chromatography as general purpose derivatizating agents. J Chromatogr B Biomed Sci Appl 1998;717:57-91.
  • 30
    • 0017133178 scopus 로고
    • Inference and missing data
    • Rubin DB. Inference and missing data. Biometrika 1976;63:581-92.
    • (1976) Biometrika , vol.63 , pp. 581-592
    • Rubin, D.B.1
  • 31
    • 19344377753 scopus 로고    scopus 로고
    • Oral vitamin B12 supplementation in elderly people with vitamin B12 deficiency: A dose finding trial
    • Eussen SJPM, deGroot CPGM, Clark R, et al. Oral vitamin B12 supplementation in elderly people with vitamin B12 deficiency: a dose finding trial. Arch Intern Med 2005;165:1167-72.
    • (2005) Arch Intern Med , vol.165 , pp. 1167-1172
    • Eussen, S.J.P.M.1    deGroot, C.P.G.M.2    Clark, R.3
  • 32
    • 33750474443 scopus 로고    scopus 로고
    • Prospective study of plasma folate, vitamin B12, and cognitive function and decline
    • Kang JH, Irizarry MC, Grodstein F. Prospective study of plasma folate, vitamin B12, and cognitive function and decline. Epidemiology 2006;17:650-7.
    • (2006) Epidemiology , vol.17 , pp. 650-657
    • Kang, J.H.1    Irizarry, M.C.2    Grodstein, F.3
  • 33
    • 34248376360 scopus 로고    scopus 로고
    • Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    • Clarke R, Sherliker P, Hin H, et al. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clin Chem 2007;53:963-70.
    • (2007) Clin Chem , vol.53 , pp. 963-970
    • Clarke, R.1    Sherliker, P.2    Hin, H.3
  • 34
    • 33845496742 scopus 로고    scopus 로고
    • Medical Research Council Cognitive Function and Ageing Study. Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study
    • McCracken C, Hudson P, Ellis R, McCaddon A; Medical Research Council Cognitive Function and Ageing Study. Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. Am J Clin Nut 2006;84:1406-11.
    • (2006) Am J Clin Nut , vol.84 , pp. 1406-1411
    • McCracken, C.1    Hudson, P.2    Ellis, R.3    McCaddon, A.4
  • 35
    • 26044475183 scopus 로고    scopus 로고
    • Elevated methylmalonic acid is related to cognitive impairment in older adults enrolled in an elderly nutrition program
    • Lewis MS, Miller LS, Johnson MA, Dolce EB, Allen RH, Stabler SP. Elevated methylmalonic acid is related to cognitive impairment in older adults enrolled in an elderly nutrition program. J Nutr Elder 2005;24:47-65.
    • (2005) J Nutr Elder , vol.24 , pp. 47-65
    • Lewis, M.S.1    Miller, L.S.2    Johnson, M.A.3    Dolce, E.B.4    Allen, R.H.5    Stabler, S.P.6
  • 36
    • 0038480240 scopus 로고    scopus 로고
    • Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin
    • Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003;74:959-61.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 959-961
    • Refsum, H.1    Smith, A.D.2
  • 37
    • 0037100425 scopus 로고    scopus 로고
    • Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults
    • Miller JW, Ramos MI, Garrod MG, Flynn MA, Green R. Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults. Blood 2002;100:718-20.
    • (2002) Blood , vol.100 , pp. 718-720
    • Miller, J.W.1    Ramos, M.I.2    Garrod, M.G.3    Flynn, M.A.4    Green, R.5
  • 38
    • 33748427825 scopus 로고    scopus 로고
    • Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: A randomized, placebo-controlled trial
    • Eussen SJ, deGroot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84:361-70.
    • (2006) Am J Clin Nutr , vol.84 , pp. 361-370
    • Eussen, S.J.1    deGroot, L.C.2    Joosten, L.W.3
  • 40
    • 31344459617 scopus 로고    scopus 로고
    • B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • Clarke R, Armitage JM, Lewington S, Sherliker P, Collins R; B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006;151:282-7.
    • (2006) Am Heart J , vol.151 , pp. 282-287
    • Clarke, R.1    Armitage, J.M.2    Lewington, S.3    Sherliker, P.4    Collins, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.