RNA-Seq Differentiates Tumour and Host mRNA Expression Changes Induced by Treatment of Human Tumour Xenografts with the VEGFR Tyrosine Kinase Inhibitor Cediranib

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Bradford, James R ^a   Farren, Matthew ^a   Powell, Steve J ^a   Runswick, Sarah ^a   Weston, Susie L ^a   Brown, Helen ^a   Delpuech, Oona ^a   Wappett, Mark ^a   Smith, Neil R ^a   Carr, T Hedley ^a   Dry, Jonathan R ^a   Gibson, Neil J ^a   Barry, Simon T ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CEDIRANIB; MESSENGER RNA; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RESPONSE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MANIPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MICROARRAY ANALYSIS; NONHUMAN; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SEQUENCE ALIGNMENT; TREATMENT DURATION; TUMOR DIFFERENTIATION; TUMOR XENOGRAFT; ANIMAL; BIOLOGY; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL HYPOXIA; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; LUNG NEOPLASMS; MOUSE; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; TUMOR CELL LINE;

MURINAE;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL HYPOXIA; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HUMANS; LUNG NEOPLASMS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASE INHIBITORS; QUINAZOLINES; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; SPECIES SPECIFICITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84879229964     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066003     Document Type: Article

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