Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: A comparison of experimental breast cancers and their lymph node metastases

Clinical and Experimental Metastasis

Volumn 25, Issue 1, 2008, Pages 81-88

  Harrell, Joshua Chuck ^a,b   Dye, Wendy W ^a   Harvell, Djuana M E ^a   Sartorius, Carol A ^a   Horwitz, Kathryn B ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Breast cancer; Estrogen receptors; Lymph node; Lymphatic vessel; Metastasis; Microarray; Progesterone receptors; Tumor xenografts; ZsGreen

Indexed keywords

ESTROGEN RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROGESTERONE RECEPTOR;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; LYMPH NODE METASTASIS; MICROARRAY ANALYSIS; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LASERS; LYMPHATIC METASTASIS; MICE; MICRODISSECTION;

EID: 38849181724     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10585-007-9105-7     Document Type: Article

References (24)

1. van de Rijn M, Perou CM, Tibshirani R et al (2002) Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome. Am J Pathol 161(6):1991-1996
2. Zajchowski DA, Bartholdi MF, Gong Y et al (2001) Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res 61(13):5168-5178
3. Livasy CA, Perou CM, Karaca G et al (2007) Identification of a basal-like subtype of breast ductal carcinoma in situ. Hum Pathol 38(2):197-204
4. Chang HY, Nuyten DS, Sneddon JB et al (2005) Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci USA 102(10):3738-3743
5. Chang HY, Sneddon JB, Alizadeh AA et al (2004) Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2(2):E7
6. Rouzier R, Perou CM, Symmans WF et al (2005) Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 11(16):5678-5685
7. Weigelt B, Hu Z, He X et al (2005) Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 65(20):9155-9158
8. Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752
9. Shipitsin M, Campbell LL, Argani P et al (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11(3):259-273
10. Fan C, Oh DS, Wessels L et al (2006) Concordance among gene-expression-based predictors for breast cancer. N Engl J Med 355(6):560-569
11. Harrell JC, Dye WW, Allred DC et al (2006) Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. Cancer Res 66(18):9308-9315
12. Sartorius CA, Shen T, Horwitz KB (2003) Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts. Breast Cancer Res Treat 79(3):287-299
13. Weigelt B, Wessels LF, Bosma AJ et al (2005) No common denominator for breast cancer lymph node metastasis. Br J Cancer 93(8):924-932
14. Montel V, Mose ES, Tarin D (2006) Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis, metastasis. Int J Cancer 119(2):251-263
15. Yang F, Foekens JA, Yu J et al (2006) Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways. Oncogene 25(9):1413-1419
16. Luzzi V, Mahadevappa M, Raja R, Warrington JA, Watson MA (2003) Accurate and reproducible gene expression profiles from laser capture microdissection, transcript amplification, and high density oligonucleotide microarray analysis. J Mol Diagn 5(1):9-14
17. Naef F, Huelsken J (2005) Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks. Nucleic Acids Res 33(13):e111
18. Bianco NR, Montano MM (2002) Regulation of prothymosin alpha by estrogen receptor alpha: molecular mechanisms and relevance in estrogen-mediated breast cell growth. Oncogene 21(34):5233-5244
19. Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277(5327):815-818
20. Force WR, Cheung TC, Ware CF (1997) Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. J Biol Chem 272(49):30835-30840
21. Lin ZP, Belcourt MF, Cory JG, Sartorelli AC (2004) Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. J Biol Chem 279(26):27030-27038
22. Barrons R (2004) Evaluation of personal digital assistant software for drug interactions. Am J Health Syst Pharm 61(4):380-385
23. Fiucci G, Ravid D, Reich R, Liscovitch M (2002) Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21(15):2365-2375
24. Hasebe T, Konishi M, Iwasaki M et al (2005) Histological characteristics of tumor cells and stromal cells in vessels and lymph nodes are important prognostic parameters of extrahepatic bile duct carcinoma: a prospective study. Hum Pathol 36(6):655-664