Cognitive enhancement in middle-aged and old cats with dietary supplementation with a nutrient blend containing fish oil, B vitamins, antioxidants and arginine

British Journal of Nutrition

Volumn 110, Issue 1, 2013, Pages 40-49

  Pan, Yuanlong ^a   Araujo, Joseph A ^b,c   Burrows, Joey ^b   De Rivera, Christina ^b,c   Gore, Asa ^a   Bhatnagar, Sandeep ^a   Milgram, Norton W ^b,c  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b CanCog Technologies Incorporated   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Arginine: Antioxidants; B vitamins; Feline cognitive functions; Fish oil

Indexed keywords

ANTIOXIDANT; ARGININE; CYANOCOBALAMIN; FISH OIL; FOLIC ACID; VITAMIN B GROUP;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; APTITUDE TEST; ARTICLE; BODY WEIGHT; BRAIN FUNCTION; BRAIN PROTECTION BLEND; CAT; COGNITION; CONTROLLED STUDY; DEMENTIA; DIET SUPPLEMENTATION; DISCRIMINATION LEARNING; DISEASE ASSOCIATION; EGOCENTRIC LEARNING; LEARNING; MEMORY; MENTAL PERFORMANCE; MIDDLE AGED; NONHUMAN; NUTRIENT CONTENT; NUTRITIONAL ASSESSMENT; RISK FACTOR; SPATIAL SUMMATION;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; ARGININE; BRAIN; CATS; COGNITION; COGNITION DISORDERS; DEMENTIA; DIETARY FATS; DIETARY SUPPLEMENTS; DISCRIMINATION (PSYCHOLOGY); FISH OILS; LEARNING; MEMORY; MENTAL PROCESSES; MICRONUTRIENTS; RISK FACTORS; VITAMIN B COMPLEX;

FELIDAE;

EID: 84879225722     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512004771     Document Type: Article

References (55)

1. Pan YL (2011) Enhancing brain functions in senior dogs: a new nutritional approach. Top Companion Anim Med 26, 10-16.
2. Head E, Milgram NW & Cotman CW (2001) Neurobiological models of aging in the dog and other vertebrate species. In Functional Neurobiology of Aging, pp. 457-465 [PR Hof and CV Mobbs, editors]. San Diego, CA: Academic Press.
3. Hof PR & Morrison JH (2004) The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci 27, 607-613.
4. Brellou G, Vlemmas I, Lekkas S, et al. (2005) Immunohistochemical investigation of amyloid beta-protein (Abeta) in the brain of aged cats. Histol Histopathol 20, 725-731.
5. Head E, Moffat K, Das P, et al. (2005) Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging 26, 749-763.
6. Cummings BJ, Pike CJ, Shankle R, et al. (1996) Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol Aging 17, 921-933.
7. Gunn-Moore DA, McVee J, Bradshaw JM, et al. (2006) Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg 8, 234-242.
8. Zhang JH, Sampogna S, Morales FR, et al. (2005) Age-related changes in cholinergic neurons in the laterodorsal and the pedunculo-pontine tegmental nuclei of cats: a combined light and electron microscopic study. Brain Res 1052, 47-55.
9. McCune S, Stevenson J, Fretwell L, et al. (2008) Ageing does not significantly affect performance in a spatial learning task in the domestic cat (Felis silvestris catus). Appl Anim Behav Sci 112, 345-356.
10. Levine S, Lloyd RL, Fisher RS, et al. (1987) Sensory, motor and cognitive alternations in aged cats. Neurobiol Aging 8, 253-263.
11. Milgram NW (2010) Neuropsychological function and aging in the cat. In Presentation given at the 15th Annual Conference on Canine Cognition and Aging, 10-12 November, Laguna Beach, CA, USA.
12. Gunn-Moore DA, Moffat K, Christie LA, et al. (2007) Cognitive dysfunction and the neurobiology of aging in cats. J Small Anim Pract 48, 546-553.
13. Landsberg GM, Denenberg S & Araujo JA (2010) Cognitive dysfunction in cats: a syndrome we used to dismiss as 'old age'. J Feline Med Surg 11, 837-848.
14. Pugliese M, Gangitano C, Ceccariglia S, et al. (2007) Canine cognitive dysfunction and the cerebellum: acetylcholinesterase reduction, neuronal and glial changes. Brain Res 1139, 85-94.
15. Siwak-Tapp CT, Head E, Muggenburg BA, et al. (2008) Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging 29, 39-50.
16. Cole GM, Ma QL & Frautschy SA (2009) Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids 81, 213-221.
17. Duron E & Hanon O (2008) Hypertension, cognitive decline and dementia. Arch Cardiovasc Dis 101, 181-189.
18. Selhub J, Bagley LC, Miller J, et al. (2000) B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 71, 614S-620S.
19. Jellinger KA & Attems J (2006) Prevalence and impact of cerebrovascular pathology in Alzheimer's disease and Parkinsonism. Acta Neurol Scand 114, 38-46.
20. Miller JW, Green R, Ramos MI, et al. (2003) Homocysteine and cognitive function in the Sacramento Area. Latino Study on Aging. Am J Clin Nutr 78, 441-447.
21. Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23, 134-147.
22. Qiu C, Winblad B & Fratiglioni L (2005) The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 4, 487-499.
23. Weninger SC & Yankner BA (2001) Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med 7, 527-528.
24. Taupin P (2010) A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease. Cent Nerv Syst Agents Med Chem 10, 16-21.
25. Ciubotaru I, Lee YS & Wander RC (2003) Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglyceride to HDL-cholesterol ration in postmenopausal women on HRT. J Nutr Biochem 14, 513-521.
26. Wall R, Ross RP, Fitzgerald GF, et al. (2010) Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev 68, 280-289.
27. Dong JY, Qin LQ, Zhang Z, et al. (2011) Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J 162, 959-965.
28. Yamada K, Noda Y, Nakayama S, et al. (1995) Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain. Br J Pharmacol 115, 852-858.
29. Bryan J, Calvaresi E & Hughes D (2002) Short-term folate, vitamin B-12, or vitamin B-6 supplementation slightly affects memory performance, but not mood in women of various ages. J Nutr 132, 1345-1356.
30. Smith AD, Smith SM, de Jager CA, et al. (2010) Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One 5, e12244.
31. Frank B & Gupta S (2005) A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry 17, 269-286.
32. Loef M, Schrauzer GN & Walach H (2011) Selenium and Alzheimer's disease: a systematic review. J Alzheimers Dis 26, 81-104.
33. Lynch SM, Gaziano JM & Frei B (1996) Ascorbic acid and atherosclerotic cardiovascular disease. Subcell Biochem 25, 331-367.
34. Peluzio Mdo C, Teixeira TF, Oliveira VP, et al. (2011) Grape extract and a-tocopherol effect in cardiovascular disease model of Apo E2/2 mice. Acta Cir Bras 26, 253-260.
35. Pocernich CB, Lange ML, Sultana R, et al. (2011) Nutritional approaches to modulate oxidative stress in Alzheimer's disease. Curr Alzheimer Res 8, 452-469.
36. Schwenke DC & Behr SR (1998) Vitamin E combined with selenium inhibits atherosclerosis in hypercholesterolemic rabbits independently of effects on plasma cholesterol concentrations. Circ Res 83, 366-377.
37. Milgram NW, Adams B, Callahan H, et al. (1999) Landmark discrimination learning in the dog. Learn Mem 6, 54-61.
38. Milgram NW, Head E, Muggenburg B, et al. (2002) Landmark discrimination learning in the dog: effects of age, an antioxidant fortified diet, and cognitive strategy. Neurosci Biobehav Rev 26, 679-695.
39. Christie LA, Studzinski C, Araujo J, et al. (2005) A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharm Biol Psychiatry 29, 361-369.
40. Head E, Callahan H, Cummings BJ, et al. (1998) Visual-discrimination learning ability and ß-amyloid accumulation in the dog. Neurobiol Aging 19, 415-425.
41. Tapp PD, Siwak CT, Estrada J, et al. (2003) Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem 10, 64-73.
42. Head E, Mehta R, Hartley J, et al. (1995) Spatial learning and memory as a function of age in the dog. Behavioral Neurosci 109, 851-858.
43. Milgram NW, Head E, Weiner E, et al. (1994) Cognitive functions and aging in the dog: acquisition of non spatial visual tasks. Behav Neurosci 108, 57-68.
44. Watkins BA, Allen KG, Hoffmann WE, et al. (2000) Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats. J Nutr 130, 2274-2284.
45. Feart C, Samieri C & Barberger-Gateau P (2010) Mediterranean diet and cognitive function in older adults. Curr Opin Clin Nutr Metab Care 13, 14-18.
46. De Jager CA, Oulhaj A, Jacoby R, et al. (2011) Cognitive and clinical outcome of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 27, 592-600.
47. Conquer JA, Tierney MC, Zecevic J, et al. (2000) Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 35, 1305-1312.
48. Heude B, Ducimetière P & Berr C (2003) Cognitive decline and fatty acid composition of erythrocyte membranes-The EVA Study. Am J Clin Nutr 77, 803-808.
49. Yurko-Mauro K, McCarthy D, Rom D, et al. (2010) Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 6, 456-464.
50. Jiang LH, Shi Y, Wang LS, et al. (2009) The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice. J Nutr Biochem 20, 735-741.
51. Harris WS (2008) The omega-3 index as a risk factor for coronary heart disease. Am J Clin Nutr 87, 1997S-2002S.
52. Manukhina EB, Pshennikova MG, Goryacheva AV, et al. (2008) Role of nitric oxide in prevention of cognitive disorders in neurodegenerative brain injuries in rats. Bull Exp Biol Med 146, 391-395.
53. Rajapakse NW, De Miguel C, Das S, et al. (2008) Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats. Hypertension 52, 1084-1090.
54. Ast J, Jablecka A, Bogdanski P, et al. (2010) Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med Sci Monit 16, CR266-CR271.
55. AAFCO (2011) Official Publication. Atlanta, GA: Association of American Feed Control Officials.