Effect of oral l-arginine supplementation on blood pressure: A meta-analysis of randomized, double-blind, placebo-controlled trials

American Heart Journal

Volumn 162, Issue 6, 2011, Pages 959-965

  Dong, Jia Yi ^a   Qin, Li Qiang ^a   Zhang, Zengli ^a   Zhao, Youyou ^b   Wang, Junkuan ^b   Arigoni, Fabrizio ^b,c   Zhang, Weiguo ^b  

^a SOOCHOW UNIVERSITY   (China)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ARGININE; PLACEBO;

CONFIDENCE INTERVAL; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DRUG EFFECT; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIHYPERTENSIVE AGENTS; ARGININE; BLOOD PRESSURE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; YOUNG ADULT;

EID: 82555170266     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2011.09.012     Document Type: Review

References (33)

1. P.M. Kearney, M. Whelton, and K. Reynolds Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223 (Pubitemid 40138015)
2. L.J. Appel, T.J. Moore, and E. Obarzanek A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group N Engl J Med 336 1997 1117 1124
3. R.H. Boger, and E.S. Ron L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor Altern Med Rev 10 2005 14 23 (Pubitemid 40397188)
4. E. Pimenta, and S. Oparil Prehypertension: epidemiology, consequences and treatment Nat Rev Nephrol 6 2010 21 30
5. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-9, W64.
6. A.R. Jadad, R.A. Moore, and D. Carroll Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17 1996 1 12 (Pubitemid 26120810)
7. D. Follmann, P. Elliott, and I. Suh Variance imputation for overviews of clinical trials with continuous response J Clin Epidemiol 45 1992 769 773
8. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539 1558 (Pubitemid 34746062)
9. J.P. Higgins, S.G. Thompson, and J.J. Deeks Measuring inconsistency in meta-analyses BMJ 327 2003 557 560 (Pubitemid 37088507)
10. C.B. Begg, and M. Mazumdar Operating characteristics of a rank correlation test for publication bias Biometrics 50 1994 1088 1101
11. M. Egger, G. Davey Smith, and M. Schneider Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634 (Pubitemid 27387172)
12. J.P. Chin-Dusting, C.T. Alexander, and P.J. Arnold Effects of in vivo and in vitro l-arginine supplementation on healthy human vessels J Cardiovasc Pharmacol 28 1996 158 166 (Pubitemid 26190467)
13. P. Clarkson, M.R. Adams, and A.J. Powe Oral l-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults J Clin Invest 97 1996 1989 1994 (Pubitemid 26129888)
14. P.M. Piatti, L.D. Monti, and G. Valsecchi Long-term oral l-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients Diabetes Care 24 2001 875 880 (Pubitemid 33636062)
15. K. Sydow, E. Schwedhelm, and N. Arakawa ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of l-arginine and B vitamins Cardiovasc Res 57 2003 244 252 (Pubitemid 36009457)
16. S.G. West, A. Likos-Krick, and P. Brown Oral l-arginine improves hemodynamic responses to stress and reduces plasma homocysteine in hypercholesterolemic men J Nutr 135 2005 212 217 (Pubitemid 40194480)
17. P. Lucotti, E. Setola, and L.D. Monti Beneficial effects of a long-term oral l-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients Am J Physiol Endocrinol Metab 291 2006 E906 E912
18. F. Facchinetti, G.R. Saade, and I. Neri l-arginine supplementation in patients with gestational hypertension: a pilot study Hypertens Pregnancy 26 2007 121 130 (Pubitemid 46649344)
19. P. Lucotti, L. Monti, and E. Setola Oral l-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass Metabolism 58 2009 1270 1276
20. J. Ast, A. Jablecka, and P. Bogdanski Evaluation of the antihypertensive effect of l-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring Med Sci Monit 16 2010 CR266 CR271
21. C. Battaglia, F. Mancini, and B. Battaglia l-arginine plus drospirenone-ethinyl estradiol in the treatment of patients with PCOS: a prospective, placebo controlled, randomised, pilot study Gynecol Endocrinol 26 2010 861 868
22. I. Neri, F. Monari, and L. Sgarbi l-arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications J Matern Fetal Neonatal Med 23 2010 1456 1460
23. G.D. Thomas, W. Zhang, and R.G. Victor Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension JAMA 285 2001 2055 2057 (Pubitemid 32367811)
24. R.A. Augustyniak, G.D. Thomas, and R.G. Victor Nitric oxide pathway as new drug targets for refractory hypertension Curr Pharm Des 11 2005 3307 3315 (Pubitemid 41300780)
25. Y. Bai, L. Sun, and T. Yang Increase in fasting vascular endothelial function after short-term oral l-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials Am J Clin Nutr 89 2009 77 84
26. T.C. Wascher, W.F. Graier, and P. Dittrich Effects of low-dose l-arginine on insulin-mediated vasodilatation and insulin sensitivity Eur J Clin Invest 27 1997 690 695 (Pubitemid 27368301)
27. E. Ferrannini, G. Buzzigoli, and R. Bonadonna Insulin resistance in essential hypertension N Engl J Med 317 1987 350 357 (Pubitemid 17118813)
28. G.M. Reaven Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension Am J Med 90 1991 7S 12S
29. R.H. Boger Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the " l-arginine paradox" and acts as a novel cardiovascular risk factor J Nutr 134 2004 2842S 2847S [discussion 2853S] (Pubitemid 39315233)
30. P. Vallance, A. Leone, and A. Calver Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure Lancet 339 1992 572 575
31. N.W. Rajapakse, and D.L. Mattson Role of l-arginine in nitric oxide production in health and hypertension Clin Exp Pharmacol Physiol 36 2009 249 255
32. V. Martina, A. Masha, and V.R. Gigliardi Long-term N-acetylcysteine and l-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes Diabetes Care 31 2008 940 944
33. A. Figueroa, M.A. Sanchez-Gonzalez, and P.M. Perkins-Veazie Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study Am J Hypertens 24 2011 40 44