Gastroprotective activity of the ethanolic extract and hexane phase of Combretum duarteanum Cambess. (Combretaceae)

Journal of Natural Medicines

Volumn 67, Issue 3, 2013, Pages 492-502

  De Morais Lima, Gedson Rodrigues ^a   De Albuquerque Montenegro, Camila ^a   De Sousa Falcão, Heloina ^a   De Jesus, Neyres Zínea Taveira ^a   Cabral, Analúcia Guedes Silveira ^a   Gomes, Isis Fernandes ^a   De Fátima Agra, Maria ^a   Tavares, Josean Fechine ^a   Batista, Leônia Maria ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Combretum duarteanum; Cytoprotection; Gastric ulcer; Gastroprotective activity; Medicinal plants

Indexed keywords

ALCOHOL; CARBENOXOLONE; CIMETIDINE; COMBRETUM DUARTEANUM EXTRACT; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; HEXANE; HYDROCHLORIC ACID; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; COMBRETUM; COMBRETUM DUARTEANUM; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; IMMOBILIZATION STRESS; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PYLORUS LIGATION; RAT; SINGLE DRUG DOSE; STOMACH JUICE; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH PROTECTION; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; COMBRETUM; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ETHANOL; GASTRIC MUCOSA; HEXANES; MALE; MICE; MUCUS; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SOLVENTS; STOMACH ULCER; SULFHYDRYL COMPOUNDS;

EID: 84879202646     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-012-0706-3     Document Type: Article

References (68)

1. Laine L, Takeuchi K, Tarnawski A (2008) Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135:41-60
2. Andrade SF, Antoniolli D, Comunello E, Cardoso LGV, Carvalho JCT, Bastos JK (2006) Antiulcerogenic activity of crude extract, fractions and populnoic acid isolated from Austroplenckia populnea (Celastraceae). Z Naturforsch C 61:329-333
3. Ishikawa T, Donatini RS, Diaz IEC, Yoshida M, Bacchi EM, Kato ETM (2008) Evaluation of gastroprotective activity of Plinia edulis (Vell.) Sobral (Mytaceae) leaves in rats. J Ethnopharmacol 118:527-529
4. Klein LC Jr, Gandolfi RB, Santin JR, Lemos M, Cechinel Filho V, Andrade SF (2010) Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Poligalaceae). Naunym-Schmiedberg's Arch Pharmacol 381:121-126
5. Konturek SJ, Konturek PC, Brzozowski T (2005) Prostaglandins and ulcer healing. J Physiol Pharmacol 56:5-31
6. Vonkeman HE, Klok RM, Postma MJ, Brouwers JR, Van de Laar MA (2007) Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs. Drugs Aging 24:681-690
7. Hoogerwerf WA, Pasricha PJ (2001) Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. In: Hardman JG, Limbird LE, Goodman Gilaman A (eds) The pharmacological basis of therapeutics, 10 edn. Mc Graw-Hill, New York, pp 1005-1019
8. Valle DL (2005) Peptic ulcer diseases and related disorders. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds) Harrison's principles of internal medicine, vol 16. McGraw-Hill, New York, pp 1746-1762
9. Bighetti AE, Antônio MA, Kohn LK, Rehder VLG, Foglio MA, Possenti A, Vilela L, Carvalho JE (2005) Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine 12:72-77
10. Lakshimi V, Singh N, Shrivastva S, Mishra SK, Dharmani P, Mishra V, Palit G (2010) Gedunian and photogedunin of Xilocarpus granatum show significant antisecretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 17:569-574
11. Jain KS, Shah AK, Bariwal J, Shelke SM, Kale AP, Jagtapc JR, Bhosale AV (2007) Recent advances in proton pump inhibitors and management of acid-peptic disorders. Bioorg Med Chem 15:1181-1205
12. Arun M, Asha VV (2008) Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models. J Ethnopharmacol 118:460-465
13. Borrelli F, Izzo AA (2000) The plant kingdom as a source of anti-ulcer remedies. Phytother Res 14:581-591
14. Calvo TR, Lima ZP, Silva JS, Ballesteros KV, Pellizzon CH, Hiruma-Lima CA, Tamashiro J, Brito AR, Takahira RK, Vilegas W (2007) Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. Biol Pharm Bull 30:451-459
15. Vasconcelos PCP, Kushima H, Andreo M, Hiruma-Lima CA, Vilegas W, Takahira RK, Pellizzon CH (2008) Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model. J Ethnopharmacol 115:293-301
16. Silva NCB, Esquibel MA, Alves IM, Velozo ES, Almeida MZ, Santos JES, Campos-Buzzi F, Meira AV, Cechinel-Filho V (2009) Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J. W. Grimes (Mimosaceae). Braz J Pharmacogn 19:46-50
17. Stace CA (2004) Flowering plants of the neotropics. Combretaceae. The New York Botanical Garden, Princenton University Press, United Kingdom, pp 110-111
18. Loiola MIB, Rocha EA, Baracho GS, Agra MF (2009) Flora da Paraíba, Brasil: Combretaceae. Acta Bot Bras 23:330-342
19. Klopper RR, Chatelain C, Bänninger V, Steyn HM, De Wet BC, Arnold TH, Gautier L, Smith GF, Spichiger R (2006) Checklist of the flowering plants of Sub-Saharan Africa. An index of accepted names and synonyms. Southern African botanical diversity network report 42, Sabonet, Pretoria
20. Bever BO (1986) Medicinal plants in tropical West Africa. Cambridge University Press, Cambridge
21. Iwu MM (1993) Handbook of African medicinal plants. CRC Press, Florida, p 257
22. Hutchings A, Scott AH, Lewis G, Cunninghan A (1996) Zulu medicinal plants: an inventory. University of Natal Press, Pietermaritzburg, p 219
23. Neuwinger HD (1996) African ethnobotany: chemistry, pharmacology, Toxicology edn. Champman and Hall, Bundesrepublik Deutschland, p 942
24. Asuzu IU, Njoku JC (1992) The pharmacological properties of the ethanolic root extract of Combretum dolichopetalum. Phytotherapy 6:125-128
25. Nunes PHM, Cavalcanti PMS, Galvão SMP, Martins MCC (2009) Antiulcerogenic activity of Combretum leprosum. Pharmazie 64:58-62
26. Gupta M, Mazumder UK, Manikandan L, Bhattacharya S, Senthilkumar GP, Suresh R (2005) Anti-ulcer activity of ethanol extract of Terminalia pallida Brandis. in Swiss albino rats. J Ethnopharmacol 97:405-408
27. Aniagu SO, Binda LG, Nwinyi FC, Orisadipe A, Amos S, Wambebe C, Gamaniel K (2005) Anti-diarrhea and ulcer-protective effects of the aqueous root extract of Guiera senegalensis in rodents. J Ethnopharmacol 97:549-554
28. Albuquerque UP, Medeiros PM, Almeida ALS et al (2007) Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach. J Ethnopharmacol 114:325-354
29. Agra MF, Baracho GS, Nurit B, Basílio IJLD, Coelho VPM (2007) Medicinal and poisonous diversity of the flora of "Cariri Paraibano", Brazil. J Ethnopharmacol 111:383-395
30. Gouveia MGS, Xavier AA, Barreto AS, Gelain DP, Santos JPA, Araújo AAS, Silva FA, Quintans JS, Agra MF, Cabral AGS, Tavares JF, Silva MS, Quintans-Júnior LJ (2011) Antioxidant, antinociceptive, and anti-inflammatory properties of the ethanolic extract of Combretum duarteanum in rodents. J Med Food 12:1-8
31. Mizui T, Douteuchi M (1983) Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol 33:934-945
32. Szelenyi I, Thiemer K (1978) Distention ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol 41:99-105
33. Morimoto Y, Shimohara K, Oshima S, Sukayuki T (1991) Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesion and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Jpn J Pharmacol 57:495-505
34. Levine RJ (1971) A method for rapid production of stress ulcers in rats. In: Pfeiffer CJ (ed) Peptic Ulcer. Munksgaard, Copenhagen, pp 92-97
35. Puscas I, Puscas C, Coltau M, Pasça R, Torres J, Márquez M, Herrero E, Fillat O, Ortiz JÁ (1997) Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxicaminduced gastroduodenal lesions. Arzneimittelforschung 47:568-572
36. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43-61
37. Raffatullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM (1990) Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol 29:25-34
38. Sikiric P, Seiwerth S, Grabarevic Z et al (1997) The influence of a novel pentadecapeptide, BPC 157, on Nω-nitro-l-arginine methylester and l-arginine effect on stomach mucosa integrity and blood pressure. Eur J Pharmacol 332:23-33
39. Matsuda H, Li Y, Yoshikawa M (1999) Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulphydryls, and prostaglandins in gastroprotection by mormodin Ic, an oleanolic acid oligoglycoside, on ethanolinduced gastric mucosal lesion in rats. Life Sci 65:27-32
40. Facundo VA, Rios KA, Moreira LS, Militão JSLT, Stabelli RG, Braz-Filho R, Silveira ER (2008). Two new cycloartanes from Combretum leprosum Mart. (Combretaceae). Revista Latinoameriacana de Química 36:3
41. 13C NMR spectra of pentacyclic triterpenoids - a compilation and some salient features. Phytochemistry 37:1517-1575
42. Lewis DA, Hanson PJ (1991) Anti-ulcer drugs of plant origin. Prog Med Chem 28:201-231
43. Hiruma-Lima CA, Calvo TR, Rodrigues CM, Andrade FDP, Vilegas W, Souza Brito ARM (2006) Antiulcerogenic activity of Alchornea castaneaefolia: effects on somatostatin, gastrin and prostaglandin. J Ethnopharmacol 104:215-224
44. Facundo VA, Andrade CHS, Silveira ER, Braz-Filho R, Hufford CD (1993) Triterpenes and flavonoids from Combretum leprosum. Phytochemistry 32:411-415
45. Masika PJ, Afolayan AJ (2002) Antimicrobial activity of some plants used for the treatment of livestock disease in the Eastern Cape, South Africa. J Ethnopharmacol 83:129-134
46. Katerere DR, Gray AI, Nash RJ, Waigh RD (2003) Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae. Phytochemistry 63:81-89
47. Chowdhury R, Islam N (2004) Ahydroxylated mansumbinem-28-oic acid from Combretum coccineum. Biochem Syst Ecol 32:443-445
48. Eloff JN, Katerere DR, Mcgaw LJ (2008) The biological activity and chemistry of the southern African Combretaceae. J Ethnopharmacol 119:686-699
49. Hiruma-Lima CA, Batista LM, Almeida ABA, Magri LP, Santos LC, Vilegas W, Brito ARMS (2009) Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae). J Ethnopharmacol 122:406-409
50. Massignani JJ, Lemos M, Maistro EL, Schaphauser HP, Jorge RF, Sousa JPB, Bastos JK, Andrade SF (2009) Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats. Phytother Res 23:1355-1360
51. Szabo S (1987) Mechanism of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional biochemical and histochemical studies. Scand J Gastroenterol 22:21-28
52. La Casa C, Villegas I, Alarcón de la Lastra C, Motilva V, Marin Calero MJ (2000) Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 71:45-53
53. Hase T, Moss BJ (1973) Microvascular changes of gastric mucosa in the development of stress ulcer in rats. Gastroenterology 65:224-228
54. Kitagawa H, Fujiwara M, Osumi Y (1979) Effect of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 77:298-302
55. Das D, Bandyopadhyay D, Bhattacharjee M, Banerjee RK (1997) Hydroxyl radical is the major causative factor in stress-induced gastric ulceration. Free Radical Biol Med 23:8-18
56. Shian WM, Sasaki I, Kamiyama Y, Naito H, Matsuno S, Miyazawa T (2000) The role of lipid peroxidation on gastric mucosal lesions induced by water immersion-restraint stress in rats. Surg Today 30:49-53
57. Yasukawa K, Kasazaki K, Hyodo F, Utsumi H (2004) Non-invasive analysis of reactive oxygen species generated in rats with water immersion restraint induced gastric lesions using in vivo electron spin resonance spectroscopy. Free Radical Res 38:147-155
58. Kushima H, Nishijima CM, Rodrigues CM, Rinaldo D, Sassá MF, Bauab TM, Di Stasi LC, Carlos IZ, Souza Brito ARM, Vilegas W, Hiruma-Lima CA (2009) Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. J Ethnopharmacol 123:430-438
59. Malfertheiner P, Chan FKL, McColl KEL (2009) Peptic ulcer disease. Lancet 374:1449-1461
60. (+)-ATPase inhibition and scavenging of hydroxyl radical. Life Sci 71:2845-2865
61. Schubert ML (2004) Gastric secretion. Curr Opin Gastroenterol 20:519-525
62. Allen A, Flemströn G (2005) Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288:1-19
63. Penissi A, Piezzi R (1999) Effect of dehydroleucodine on mucus production. A quantitative study. Dig Dis Sci 44:708-712
64. Hiruma-Lima CA, Santos LC, Kushima H, Pellizzon CH, Silveira GG, Vasconcelos PCP, Vilegas W, Souza Brito ARM (2006) Qualea grandiflora, a Brazilian "Cerrado" medicinal plant presents an important antiulcer activity. J Ethnopharmacol 104:207-214
65. Lanas A (2008) Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther 10:1-6
66. Chandranath SI, Bastaki SM, Singh J (2002) A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanoland indomethacin-induced gastric lesions in the rat. Clin Exp Pharmacol Physiol 29:173-180
67. Salim AS (1993) Sulfhydryl-containing agents: new approach to the problem of refractory peptic ulceration. Pharmacology 46:281-288
68. Kushima H, Hiruma-Lima CA, Santos MA, Viana E, Coelho-Ferreira M, Brito ARMS (2005) Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls and nitric oxide. J Ethnopharmacol 101:61-67