Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxide

Journal of Ethnopharmacology

Volumn 101, Issue 1-3, 2005, Pages 61-67

  Kushima, Hélio ^a   Hiruma Lima, Clélia Akiko ^a   Santos, Maria Aparecida ^b   Viana, Elizabeth ^b   Coelho Ferreira, Márlia ^c   Souza Brito, Alba Regina Monteiro ^d  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b IEPA   (Brazil)

^c MUSEU PARAENSE EMÍLIO GOELDI   (Brazil)

^d Instituto de Biologia   (Brazil)

Author keywords

Amazon forest; Antiulcerogenic activity; Endogenous sulphydryls; Pradosia huberi

Indexed keywords

ALCOHOL; CARBENOXOLONE; CIMETIDINE; LANSOPRAZOLE; N ETHYLMALEIMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; PRADOSIA HUBERI EXTRACT; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG SCREENING; GASTRITIS; GASTROINTESTINAL TOXICITY; INTESTINE MOTILITY; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRADOSIA HUBERI; PROTECTION; PYLORUS LIGATION; RAT; RODENT; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH JUICE; STOMACH MUCOSA; STOMACH PH; STOMACH ULCER; STOMACH VOLUME; SYMPTOM; SYSTEMIC THERAPY; TOXICOLOGY;

ANIMALS; ANTI-ULCER AGENTS; GASTRIC MUCOSA; MALE; MICE; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SAPOTACEAE; SULFHYDRYL COMPOUNDS;

ANIMALIA; PRADOSIA; RODENTIA;

EID: 24644453633     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.03.014     Document Type: Article

References (22)

1. J. Arrieta, J. Benitez, E. Flores, C. Castillo, and A. Navarrete Purification of gastroprotective triterpenoids from stem bark of Amphipterygium adstringens; roles of prostaglandins, sulphidryls, nitric oxide and capsaicin neurons Planta Medica 69 2003 905 909
2. J.R. Avila, C.A. de la Lastra, M.J. Martin, V. Motilva, I. Luque, D. Delgado, J. Esteban, and J. Herrerias Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats Inflammation Research 45 1996 83 88
3. J. Belaiche, A. Burette, M. De Vos, E. Louis, M. Huybrechts, and M. Deltenre Study group of NSAID-GI complications. Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium Acta Gastroenterology Belgiam 65 2002 65 73
4. F. Borrelli, and A.A. Izzo The plant kingdom as a source of anti-ulcer remedies Phytotherapy Research 14 2000 581 591
5. F.K.L. Chan, and W.K. Leung Peptic ulcer disease Lacet 360 2002 933 941
6. S.I. Chandranath, S.M. Bastaki, and J. Singh A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat Clinical Experimental Pharmacology and Physiology 29 2002 173 180
7. J.S. Gracioso, C.A. Hiruma-Lima, and A.R. Souza Brito Antiulcerogenic effect of a hydroalcoholic extract and its organic fractions of Neurolaena lobata (L.) R.Br Phytomedicine 7 2000 283 289
8. L.J. Hayden, G. Thomas, and G.B. West Inhibitors of gastric lesions in the rat Journal of Pharmacology 30 1978 244 246
9. C.A. Hiruma-Lima, J.S. Gracioso, E.J. Bighetti, D.M. Grassi-Kassisse, D.S. Nunes, and A.R. Brito Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa Phytomedicine 9 2002 523 529
10. H. Jacquemin, A. Boissonnat, G. Faugeras, F. Tilliquin, and P. Delaveau Flavonoids of Glycoxylon huberi Ducke Annual Pharmacology France 43 1985 521 525
11. D.A. Lewis, and P.J. Hanson Anti-ulcer drugs of plant origin Progress in Medicinal Chemistry 28 1991 201 231
12. H. Matsuda, Y. Li, and M. Yoshikawa Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulphydryls, and prostaglandins in gastroprotection by mormodin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesion in rats Life Sciences 65 1999 27 32
13. T. Mizui, and M. Doteuchi Effect of polyamines on acidified ethanol-induced gastric lesions in rats Japanese Journal of Pharmacology 33 1983 939 945
14. Y. Morimoto, K. Shimohara, S. Oshima, and T. Sukamoto Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terprenone and cimetidine Japanese Journal of Pharmacology 57 1991 595 605
15. E.D. Olfert, B.M. Cross, and A.A. McWilliam Guide to the Care and Use of Experimental Animals 1993 Canadian Council on Animal Care Co. Ontario pp. 1-213
16. G.E. Samonina, G.N. Kopylova, G.V. Lukjanzeva, S.E. Zhuykova, E.A. Smirnova, S.V. German, and A.A. Guseva Antiulcer effects of amylin: a review Pathophysiology 11 2004 1 6
17. H. Shay, S.A. Komarov, S.S. Fels, D. Meranze, M. Gruestein, and H. Siplet A simple method for the uniform production of gastric ulceration in the rat Gastroenterology 5 1945 43 61
18. A.R.M. Souza Brito Manual de Ensaios Toxicológicos in vivo 1995 Editora da Unicamp Campinas, São Paulo p. 22
19. A.R.M. Souza Brito How to study the pharmacology of medicinal plants in underdeveloped countries? Journal of Ethnopharmacology 54 1996 131 138
20. J.C. Stickney, and D.W. Northup Effect of gastric emptying upon propulsive motility of small intestine in rat Proceedings of the Society of Experimental Biology and Medicine 101 1959 582
21. I. Szelenyi, and K. Thiemer Distention ulcer as a model for testing of drugs for ulcerogenic side effects Archieves of Toxicology 41 1978 99 105
22. W. Toma, J.S. Gracioso, C.A. Hiruma-Lima, F.D. Andrade, W. Vilegas, and A.R.M. Souza Brito Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract Journal of Ethnopharmacology 85 2003 19 23