Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model

Journal of Ethnopharmacology

Volumn 115, Issue 2, 2008, Pages 293-301

  Vasconcelos, P C P ^a   Kushima, H ^a   Andreo, M ^a   Hiruma Lima, C A ^a   Vilegas, W ^a   Takahira, R K ^a   Pellizzon, C H ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Healing gastric ulcer; Melastomataceae; Mouriri pusa; Toxicity

Indexed keywords

ACETIC ACID; CYCLINE; EPICATECHIN; FLAVONOID; METHANOL; MOURIRI PUSA EXTRACT; PHENOL DERIVATIVE; PLANT EXTRACT; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL PROLIFERATION; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG SAFETY; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; MEDICINAL PLANT; MICROSCOPY; MOURIRI PUSA; MUCUS SECRETION; NEUTROPHIL; NONHUMAN; ORGAN WEIGHT; PLANT LEAF; RAT; SCAR FORMATION; STOMACH LESION; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; TISSUE REGENERATION; TREATMENT DURATION; ULCER HEALING;

ACETIC ACID; ADMINISTRATION, ORAL; ANIMALS; ANTI-ULCER AGENTS; CELL PROLIFERATION; GASTRIC MUCOSA; MALE; MAST CELLS; MELASTOMATACEAE; MUCUS; NEUTROPHILS; PHENOLS; PLANT EXTRACTS; RATS; RATS, WISTAR; STOMACH ULCER; TIME FACTORS;

MELASTOMATACEAE; MOURIRI; PUSA; RATTUS; RODENTIA;

EID: 37249069349     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.10.005     Document Type: Article

References (47)

1. Allen A., Cunliffe W.J., Pearson J.P., Sellers L.A., and Ward R. Studies on gastrointestinal mucus. Scandinavian Journal of Gastroenterology Supplementary 93 (1984) 101-113
2. Andreo M.A., Ballesteros K.V., Hiruma-Lima C.A., Rocha L.R.M., Souza Brito A.R., and Vilegas W. Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. Journal of Ethnopharmacology 107 (2006) 431-441
3. Avila J.R., de la Lastra C.A., Martin M.J., Motilva V., Luque I., Delgado D., Esteban J., and Herrerias J. Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflammation research: official journal of the European Histamine Research Society 45 (1996) 83-88
4. Azuma K., Ippoushi K., Nakayama M., Ito H., Higashio H., and Terao J. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Journal of Agricultural and Food Chemistry 48 (2000) 5496-5500
5. Behmer O.A., Tolosa E.M.C., and Freitas Neto A.G. Manual de técnicas para histologia normal e patológica (1976), Editora da USP, São Paulo, SP, Brazil pp. 80-195
6. Blane G.F. Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives. The American Journal of Medicine 83 (1987) 26-36
7. Bonney R.J., Naruns P., Davies P., and Humes J.L. Antigen-antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages. Prostaglandins 18 (1979) 605-616
8. Bravo R., Frank R., Blundell P.A., and Donald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 326 (1987) 515-517
9. Calvo T.R., Lima Z.P., Silva J.S., Ballesteros K.V., Pellizzon C.H., Hiruma-Lima C.A., Tamashiro J., Brito A.R., Takahira R.K., and Vilegas W. Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. Biological & Pharmaceutical Bulletin 30 (2007) 451-459
10. Celis J.E., and Celis A. Individual nuclei in polykaryons can control cyclin distribution and DNA synthesis. The EMBO Journal 4 (1985) 1187-1192
11. Corrêa M.P. Dicionário de Planta úteis do Brasil e das Exóticas Cultivadas (1984), Imprensa Nacional, Rio de Janeiro pp. 538-541
12. Chandranath S.I., Bastaki S.M., and Singh J. A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. Clinical and Experimental Pharmacology & Physiology 29 (2002) 173-180
13. Di Stasi L.C. Planta Medicinais: Arte e Ciência-Um guia de estudo interdisciplinar (1996), Editora da UNESP, São Paulo, SP, Brazil p. 230
14. 2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. European Journal of Pharmacology 498 (2004) 295-301
15. 2 antagonist cimetidine on the growth and migration of human neoplastic glia. Neuropathology and Applied Neurobiology 22 (1996) 317-324
16. Galati E.M., Monforte M.T., Tripodo M.M., d'Aquino A., and Mondello M.R. Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): ultrastructural study. Journal of Ethnopharmacology 76 (2001) 1-9
17. Gracioso J.S., Vilegas W., Hiruma-Lima C.A., and Souza Brito A.R. Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs. Biological & Pharmaceutical Bulletin 25 (2002) 487-491
18. Grob G.N. The rise of peptic ulcer, 1900-1950. Perspectives in Biology and Medicine 46 (2003) 550-566
19. Hashizume T., Hirokawa K., Aibara S., Ogawa H., and Kasahara A. Pharmacological and histological studies of gastric mucosal lesion induced by serotonin in rats. Archives Internationales de Pharmacodynamie et de Thérapie 236 (1978) 96-108
20. Hayes J.D., and McLellan L.I. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defense against oxidative stress. Free Radical Research 31 (1999) 273-300
21. Hung C.R., and Wang P.S. Gastric oxidative stress and hemorrhagic ulcer in Salmonella typhimurium-infected rats. European Journal of Pharmacology 491 (2004) 61-68
22. Ishihara M., and Ito M. Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. European Journal of Pharmacology 444 (2002) 209-215
23. John T.A., and Onabanjo A.O. Gastroprotective effects of an aqueous extract of Entandrophragma utile bark in experimental ethanol-induced peptic ulceration in mice and rats. Journal of Ethnopharmacology 29 (1990) 87-93
24. Loguercio C., and Di Pierro M. The role of glutathione in the gastrointestinal tract: a review. Italian Journal of Gastroenterology and Hepatology 31 (1999) 401-407
25. Nakajima S., Arizono N., Hattori T., and Bamba T. Increase in mucosal and connective tissue-type mast cells in the stomach with acetic acid-induced ulcer in rat. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 104 (1996) 19-29
26. Nanji A.A., and Tahan S.R. Association between endothelial cell proliferation and pathologic changes in experimental alcoholic liver disease. Toxicology and Applied Pharmacology 140 (1996) 101-107
27. Nwafor P.A., Effraim K.D., and Jacks T.W. Gastroprotective effect of aqueous extract of Khaia senegalensis bark on indomethacin-induced ulceration in rats. West African Journal of Pharmacology and Drug Research 12 (1996) 46-50
28. Okabe S., and Amagase K. An overview of acetic acid ulcer models-the history and state of the art of peptic ulcer research. Biological & Pharmaceutical Bulletin 28 (2005) 1321-1341
29. Penissi A.B., Rudolph M.I., and Piezzi R.S. Role of mast cells in gastrointestinal mucosal defense. Biocell: Official Journal of the Sociedades Latinoamericanas de Microscopía Electronica 27 (2003) 163-172
30. Prelich G., Tan C.K., Kostura M., Mathews M.B., So A.G., Downey K.M., and Stillman B. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 326 (1987) 517-520
31. Rates S.M. Plants as source of drugs. Toxicon: Official Journal of the International Society on Toxinology 39 (2001) 603-613
32. Reynolds E.S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. The Journal of Cell Biology 17 (1963) 208-212
33. Rudzki Z., Stachura J., Dabros W., and Brzozowski T. The mast cells and an experimental gastric ulcer. Histochemical, ultrastructural and quantitative study in the rat. Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists 46 (1995) 225-234
34. Schroeter H., Heiss C., Balzer J., Kleinbongard P., Keen C.L., Hollenberg N.K., Sies H., Kwik-Uribe C., Schmitz H.H., and Kelm M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proceedings of the National Academy of Sciences of the United States of America, 103 (2006) 1024-1029
35. Silva E.M., Hiruma-Lima C.A., and Lolis S.F. Levantamento etnofarmacológico no municipio de Porto Nacional, Tocantins. XVI Simpósio de Plantas Medicinais do Brasil. Recife, PE, Brazil (2000) p.106
36. Souza-Brito A.R.M., and Nunes D.S. Ethnopharmacology and sustainable development of new plant-derived drugs. Ciência e Cultura 49 (1997) 402-412
37. Souza-Brito A.R.M. Manual de Ensaios Toxicológicos in vivo (1994), Editora da UNICAMP, Campinas, SP, Brazil p. 122
38. Spencer J.P., Schroeter H., Kuhnle G., Srai S.K., Tyrrell R.M., Hahn U., and Rice-Evans C. Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation. The Biochemical Journal 354 (2001) 493-500
39. Strobel S., Miller H.R., and Ferguson A. Human intestinal mucosal mast cells: evaluation of fixation and staining techniques. Journal of Clinical Pathology 34 (1981) 851-858
40. Tarnawski A.S. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Digestive Diseases and Sciences 50 (2005) S24-S33
41. Tarnawski A., Szabo I.L., Husain S.S., and Soreghan B. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. Journal of Physiology-Paris 95 (2001) 337-344
42. Tatematsu M., Tsukamoto T., and Inada K. Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Science 94 (2003) 135-141
43. Taylor D.N., and Blaser M.J. The epidemiology of Helicobacter pylori infection. Epidemiologic Reviews 13 (1991) 42-59
44. Vacca L.L. Laboratory Manual of Histochemistry (1985), Raven Press, New York pp. 176-224
45. Valcheva-Kuzmanova S., Marazova K., Krasnaliev I., Galunska B., Borisova P., and Belcheva A. Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft für Toxikologische Pathologie 56 (2005) 385-392
46. Veiga Junior V.F., Pino A.C., and Maciel M.A.M. Plantas medicinais: cura segura. Química Nova 28 (2005) 519-528
47. Yoshida T., Hatano T., and Ito H. Chemistry and function of vegetable polyphenols with high molecular weights. BioFactors (Oxford, England) 13 (2000) 121-125