메뉴 건너뛰기




Volumn 31, Issue 3, 2012, Pages 132-138

Mammalian target of rapamycin inhibition in polycystic kidney disease: From bench to bedside

Author keywords

Everolimus; Mammalian target of rapamycin; Polycystic kidney; Polycystic kidney disease; Sirolimus

Indexed keywords

CURCUMIN; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METFORMIN; PLACEBO; POLYCYSTIN 1; POLYCYSTIN 2; RAPAMYCIN;

EID: 84879194299     PISSN: 22119132     EISSN: 22119140     Source Type: Journal    
DOI: 10.1016/j.krcp.2012.07.002     Document Type: Review
Times cited : (21)

References (47)
  • 1
    • 0027925829 scopus 로고
    • Autosomal dominant polycystic kidney disease
    • P.A. Gabow Autosomal dominant polycystic kidney disease N Engl J Med 329 1993 332 342
    • (1993) N Engl J Med , vol.329 , pp. 332-342
    • Gabow, P.A.1
  • 3
    • 76949097377 scopus 로고    scopus 로고
    • Novel targets for the treatment of autosomal dominant polycystic kidney disease
    • F. Belibi, and C.L. Edelstein Novel targets for the treatment of autosomal dominant polycystic kidney disease Expert Opin Investig Drugs 19 2010 315 328
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 315-328
    • Belibi, F.1    Edelstein, C.L.2
  • 4
    • 84859436061 scopus 로고    scopus 로고
    • Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: Recent progress and future prospects
    • M. Chang, and A.C. Ong Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects Nephron Clin Pract 120 2012 c25 c35
    • (2012) Nephron Clin Pract , vol.120
    • Chang, M.1    Ong, A.C.2
  • 5
    • 0347357836 scopus 로고    scopus 로고
    • Polycystic kidney disease
    • P.D. Wilson Polycystic kidney disease N Engl J Med 350 2004 151 164
    • (2004) N Engl J Med , vol.350 , pp. 151-164
    • Wilson, P.D.1
  • 6
    • 0025801311 scopus 로고
    • C-myc as an inducer of polycystic kidney disease in transgenic mice
    • M. Trudel, V. D'Agati, and F. Costantini C-myc as an inducer of polycystic kidney disease in transgenic mice Kidney Int 39 1991 665 671
    • (1991) Kidney Int , vol.39 , pp. 665-671
    • Trudel, M.1    D'Agati, V.2    Costantini, F.3
  • 8
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • D.C. Fingar, and J. Blenis Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression Oncogene 23 2004 3151 3171
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 14
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • J. Huang, and B.D. Manning A complex interplay between Akt, TSC2 and the two mTOR complexes Biochem Soc Trans 37 2009 217 222
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 15
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 16
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
    • K.G. Foster, and D.C. Fingar Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony J Biol Chem 285 2010 14071 14077
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 17
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 18
    • 77954235821 scopus 로고    scopus 로고
    • Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy
    • C.A. Sparks, and D.A. Guertin Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy Oncogene 29 2010 3733 3744
    • (2010) Oncogene , vol.29 , pp. 3733-3744
    • Sparks, C.A.1    Guertin, D.A.2
  • 20
    • 34250703569 scopus 로고    scopus 로고
    • Classical PKC isoforms in cancer
    • G. Martiny-Baron, and D. Fabbro Classical PKC isoforms in cancer Pharmacol Res 55 2007 477 486
    • (2007) Pharmacol Res , vol.55 , pp. 477-486
    • Martiny-Baron, G.1    Fabbro, D.2
  • 25
    • 18744380752 scopus 로고    scopus 로고
    • Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease (PKD)
    • Y. Tao, J. Kim, R.W. Schrier, and C.L. Edelstein Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease (PKD) J Am Soc Nephrol 16 2005 46 51
    • (2005) J Am Soc Nephrol , vol.16 , pp. 46-51
    • Tao, Y.1    Kim, J.2    Schrier, R.W.3    Edelstein, C.L.4
  • 26
    • 33644859253 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
    • P.R. Wahl, A.L. Serra, M. Le Hir, K.D. Molle, M.N. Hall, and R.P. Wüthrich Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD) Nephrol Dial Transplant 21 2006 598 604
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 598-604
    • Wahl, P.R.1    Serra, A.L.2    Le Hir, M.3    Molle, K.D.4    Hall, M.N.5    Wüthrich, R.P.6
  • 27
    • 34447514158 scopus 로고    scopus 로고
    • Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease
    • M. Wu, P.R. Wahl, M. Le Hir, Y. Wackerle-Men, R.P. Wuthrich, and A.L. Serra Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease Kidney Blood Press Res 30 2007 253 259
    • (2007) Kidney Blood Press Res , vol.30 , pp. 253-259
    • Wu, M.1    Wahl, P.R.2    Le Hir, M.3    Wackerle-Men, Y.4    Wuthrich, R.P.5    Serra, A.L.6
  • 29
    • 67651087241 scopus 로고    scopus 로고
    • Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)
    • I. Zafar, F.A. Belibi, Z. He, and C.L. Edelstein Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD) Nephrol Dial Transplant 24 2009 2349 2353
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2349-2353
    • Zafar, I.1    Belibi, F.A.2    He, Z.3    Edelstein, C.L.4
  • 31
    • 77949887674 scopus 로고    scopus 로고
    • Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
    • J.M. Shillingford, K.B. Piontek, G.G. Germino, and T. Weimbs Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1 J Am Soc Nephrol 21 2010 489 497
    • (2010) J Am Soc Nephrol , vol.21 , pp. 489-497
    • Shillingford, J.M.1    Piontek, K.B.2    Germino, G.G.3    Weimbs, T.4
  • 32
    • 77957595691 scopus 로고    scopus 로고
    • Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease
    • I. Zafar, K. Ravichandran, F. Belibi, R.B. Doctor, and C.L. Edelstein Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease Kidney Int 78 2010 754 761
    • (2010) Kidney Int , vol.78 , pp. 754-761
    • Zafar, I.1    Ravichandran, K.2    Belibi, F.3    Doctor, R.B.4    Edelstein, C.L.5
  • 33
    • 71449093471 scopus 로고    scopus 로고
    • Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease
    • M. Wu, A. Arcaro, Z. Varga, A. Vogetseder, M. Le Hir, R.P. Wuthrich, and A.L. Serra Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease Am J Physiol Renal Physiol 297 2012 F1597 F1605
    • (2012) Am J Physiol Renal Physiol , vol.297
    • Wu, M.1    Arcaro, A.2    Varga, Z.3    Vogetseder, A.4    Le Hir, M.5    Wuthrich, R.P.6    Serra, A.L.7
  • 34
    • 78349246353 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats
    • C. Renken, D.C. Fischer, G. Kundt, N. Gretz, and D. Haffner Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats Nephrol Dial Transplant 26 2011 92 100
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 92-100
    • Renken, C.1    Fischer, D.C.2    Kundt, G.3    Gretz, N.4    Haffner, D.5
  • 38
    • 77957847881 scopus 로고    scopus 로고
    • Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
    • S. Qin, M. Taglienti, S.M. Nauli, L. Contrino, A. Takakura, J. Zhou, and J.A. Kreidberg Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease J Clin Invest 120 2010 3617 3628
    • (2010) J Clin Invest , vol.120 , pp. 3617-3628
    • Qin, S.1    Taglienti, M.2    Nauli, S.M.3    Contrino, L.4    Takakura, A.5    Zhou, J.6    Kreidberg, J.A.7
  • 43
    • 77956048123 scopus 로고    scopus 로고
    • MTOR inhibitors in polycystic kidney disease
    • T. Watnick, and G.G. Germino mTOR inhibitors in polycystic kidney disease New Engl J Med 363 2010 879 881
    • (2010) New Engl J Med , vol.363 , pp. 879-881
    • Watnick, T.1    Germino, G.G.2
  • 44
    • 79955007824 scopus 로고    scopus 로고
    • Do mTOR inhibitors still have a future in ADPKD?
    • N. Perico, and G. Remuzzi Do mTOR inhibitors still have a future in ADPKD? Nar Rev Nephrol 6 2010 696 698
    • (2010) Nar Rev Nephrol , vol.6 , pp. 696-698
    • Perico, N.1    Remuzzi, G.2
  • 45
    • 79959342471 scopus 로고    scopus 로고
    • Pallet N, Heyer CM, Letavernier E, Bienaimé F, Thervet E, Martinez F, Terzi F, Legendre C: Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level?
    • G. Canaud, B. Knebelmann, P.C. Harris, F. Vrtovsnik, and J.M. Correas Pallet N, Heyer CM, Letavernier E, Bienaimé F, Thervet E, Martinez F, Terzi F, Legendre C: Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level? Am J Transplant 10 2010 1701 1706
    • (2010) Am J Transplant , vol.10 , pp. 1701-1706
    • Canaud, G.1    Knebelmann, B.2    Harris, P.C.3    Vrtovsnik, F.4    Correas, J.M.5
  • 46
    • 78649503269 scopus 로고    scopus 로고
    • Autosomal dominant polycystic kidney disease and mTOR inhibitors: The narrow road between hope and disappointment
    • C. Ponticelli, and F. Locatelli Autosomal dominant polycystic kidney disease and mTOR inhibitors:the narrow road between hope and disappointment Nephrol Dial Transplant 25 2010 3809 3812
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 3809-3812
    • Ponticelli, C.1    Locatelli, F.2
  • 47
    • 74849131091 scopus 로고    scopus 로고
    • Targeting mTOR globally in cancer; Thinking beyond rapamycin
    • B. Shor, J.J. Gibbons, R.T. Abraham, and K. Yu Targeting mTOR globally in cancer; thinking beyond rapamycin Cell Cycle 8 2009 3831 3837
    • (2009) Cell Cycle , vol.8 , pp. 3831-3837
    • Shor, B.1    Gibbons, J.J.2    Abraham, R.T.3    Yu, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.