P2Y receptors in bone

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Volumn 1, Issue 6, 2012, Pages 805-814

  Orriss, Isabel R ^a   Arnett, Timothy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; UNCLASSIFIED DRUG;

BONE TURNOVER; CELL FUNCTION; HUMAN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PURINERGIC P2Y RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84879193033     PISSN: 2190460X     EISSN: 21904618     Source Type: Journal    
DOI: 10.1002/wmts.67     Document Type: Review

References (69)

1. Burnstock G, Dumsday B, Smythe A. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol 1972, 44:451-461.
2. Burnstock G. Purinergic nerves. Pharmacol Rev 1972, 24:509-581.
3. Burnstock G, Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 1985, 16:433-440.
4. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998, 50:413-492.
5. Abbracchio MP, Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 1994, 64:445-475.
6. Burnstock G. Purine and pyrimidine receptors. Cell Mol Life Sci 2007, 64:1471-1483.
7. Kirsch T. Annexins-their role in cartilage mineralization. Front Biosci 2005, 10:576-581.
8. Balcerzak M, Hamade E, Zhang L, Pikula S, Azzar G, Radisson J, Bandorowicz-Pikula J, Buchet R. The roles of annexins and alkaline phosphatase in mineralization process. Acta Biochim Pol 2003, 50:1019-1038.
9. Hamade E, Azzar G, Radisson J, Buchet R, Roux B. Chick embryo anchored alkaline phosphatase and mineralization process in vitro. Eur J Biochem 2003, 270:2082-2090.
10. Fleisch H, Neuman W. The role of phosphatase and polyphosphates in calcification of collagen. Helv Physiol Pharmacol Acta 1961, 19:C17-C18.
11. Fleisch H, Bisaz S. The inhibitory role of pyrophosphate in calcification. J Physiol (Paris) 1962, 54:340-341.
12. Meyer JL. Can biological calcification occur in the presence of pyrophosphate? Arch Biochem Biophys 1984, 231:1-8.
13. Jande SS, Belanger LF. The life cycle of the osteocyte. Clin Orthop Relat Res 1973, 94:281-305.
14. Orriss IR, Syberg S, Wang N, Robaye B, Gartland A, Jorgensen N, Arnett TR, Boeynaems JM. Bone phenotypes displayed by P2 receptor knockout mice. Front Biosci 2011, S3:1038-1046.
15. Kumagai H, Sakamoto H, Guggino S, Filburn CR, Sacktor B. Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells. Calcif Tissue Int 1989, 45:251-254.
16. Kumagai H, Sacktor B, Filburn CR. Purinergic regulation of cytosolic calcium and phosphoinositide metabolism in rat osteoblast-like osteosarcoma cells. J Bone Miner Res 1991, 6:697-708.
17. 2+]i in rat osteoblastic cells by interaction with two receptor subtypes. Am J Physiol 1992, 263:C1040-C1048.
18. Yu H, Ferrier J. Osteoblast-like cells have a variable mixed population of purino/nucleotide receptors. FEBS Lett 1993, 328:209-214.
19. Bowler WB, Birch MA, Gallagher JA, Bilbe G. Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts. J Bone Miner Res 1995, 10:1137-1145.
20. Dixon CJ, Bowler WB, Walsh CA, Gallagher JA. Effects of extracellular nucleotides on single cells and populations of human osteoblasts: contribution of cell heterogeneity to relative potencies. Br J Pharmacol 1997, 120:777-780.
21. Orriss IR, Knight GE, Ranasinghe S, Burnstock G, Arnett TR. Osteoblast responses to nucleotides increase during differentiation. Bone 2006, 39:300-309.
22. 6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Biochem Biophys Res Commun 1997, 240:298-302.
23. Nakamura E, Uezono Y, Narusawa K, Shibuya I, Oishi Y, Tanaka M, Yanagihara N, Nakamura T, Izumi F. ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells. Am J Physiol Cell Physiol 2000, 279:C510-C519.
24. Gartland A, Hipskind RA, Gallagher JA, Bowler WB. Expression of a P2X7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res 2001, 16:846-856.
25. Hoebertz A, Townsend-Nicholson A, Glass R, Burnstock G, Arnett TR. Expression of P2 receptors in bone and cultured bone cells. Bone 2000, 27:503-510.
26. Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, et al. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol 2003, 17:1356-1367.
27. Ihara H, Hirukawa K, Goto S, Togari A. ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. Biochem Biophys Res Commun 2005, 326:329-334.
28. Alqallaf SM, Evans BA, Kidd EJ. Atypical P2X receptor pharmacology in two human osteoblast-like cell lines. Br J Pharmacol 2009, 156:1124-1135.
29. 1 receptor. Bone 2010, 46:355-362.
30. 2+]i release in rat osteoblasts independently of Gq activation or cyclic monophosphate accumulation. A mechanism for localizing systemic responses in bone. J Biol Chem 2001, 276:9565-9571.
31. Jorgensen NR, Geist ST, Civitelli R, Steinberg TH. ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells. J Cell Biol 1997, 139:497-506.
32. Orriss IR, Burnstock G, Arnett TR. Expression of multiple P2 receptor subtypes by osteoblasts and osteoclasts. Bone 2009, 44:S304.
33. Orriss IR, Burnstock G, Arnett TR. Purinergic signalling and bone remodelling. Curr Opin Pharmacol 2010, 10:322-330.
34. 12 receptor antagonist, inhibits bone cell function in vitro and decreases trabecular bone in vivo. J Bone Miner Res (Epub ahead of print; June 19, 2012).
35. 13 receptor of ADP. Mol Endocrinol 2012, 26:142-152.
36. 2 receptor in bone remodeling. J Cell Biochem 2002, 86:413-419.
37. 2 receptors and pyrophosphate. Endocrinology 2007, 148:4208-4216.
38. 2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase. J Biol Chem 1999, 274:14315-14324.
39. Costessi A, Pines A, D'andrea P, Romanello M, Damante G, Cesaratto L, Quadrifoglio F, Moro L, Tell G. Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 2005, 36:418-432.
40. Pines A, Romanello M, Cesaratto L, Damante G, Moro L, D'andrea P, Tell G. Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line. Biochem J 2003, 373:815-824.
41. Katz S, Boland R, Santillan G. Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation Int. J Biochem Cell Biol 2006, 38:2082-2091.
42. 2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases. Arch Biochem Biophys 2008, 477:244-252.
43. Romanello M, Pani B, Bicego M, D'andrea P. Mechanically induced ATP release from human osteoblastic cells. Biochem Biophys Res Commun 2001, 289:1275-1281.
44. Buckley KA, Golding SL, Rice JM, Dillon JP, Gallagher JA. Release and interconversion of P2 receptor agonists by human osteoblast-like cells. FASEB J 2003, 17:1401-1410.
45. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid Shear-Induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res 2005, 20:41-49.
46. Orriss IR, Knight GE, Utting JC, Taylor SEB, Burnstock G, Arnett TR. Hypoxia stimulates vesicular ATP release from rat osteoblasts. J Cell Physiol 2009, 220:155-162.
47. Brandao-Burch A, Key ML, Patel JJ, Arnett TR, Orriss IR. The P2X7 receptor is an important regulator of extracellular ATP levels. Front Endocrinol (Lausanne) 2012, 3:41.
48. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 2000, 362:299-309.
49. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding JW, Sano K, Millan JL, Terkeltaub R. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol 2000, 279:R1365-R1377.
50. Pines A, Bivi N, Romanello M, Damante G, Kelley MR, Adamson ED, D'andrea P, Quadrifoglio F, Moro L, Tell G. Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radic Res 2005, 39:269-281.
51. Jorgensen NR, Henriksen Z, Brot C, Eriksen EF, Sorensen OH, Civitelli R, Steinberg TH. Human osteoblastic cells propagate intercellular calcium signals by two different mechanisms. J Bone Miner Res 2000, 15:1024-1032.
52. Jorgensen NR, Henriksen Z, Sorensen OH, Eriksen EF, Civitelli R, Steinberg TH. Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 2002, 277:7574-7580.
53. You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem 2002, 277:48724-48729.
54. Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol 2007, 212:207-214.
55. Thompson WR, Majid AS, Czymmek KJ, Ruff AL, Garcia J, Duncan RL, Farach-Carson MC. Association of the alpha(2)delta(1) subunit with Ca(v)3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes. J Bone Miner Res 2011, 26:2125-2139.
56. Gartland A, Buckley KA, Bowler WB, Gallagher JA. Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif Tissue Int 2003, 73:361-369.
57. Buckley KA, Hipskind RA, Gartland A, Bowler WB, Gallagher JA. Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone 2002, 31:582-590.
58. 6 nucleotide receptors activate NF-{kappa}B and increase survival of osteoclasts. J Biol Chem 2005, 280:16909-16915.
59. Naemsch LN, Weidema AF, Sims SM, Underhill TM, Dixon SJ. P2X4 purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts. J Cell Sci 1999, 112(Pt 23):4425-4435.
60. 6 receptor stimulates bone resorption by osteoclasts. Endocrinology 2011, 152:3706-3716.
61. Li J, Liu D, Ke HZ, Duncan RL, Turner CH. The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem 2005, 280:42952-42959.
62. 2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption. Bone 1998, 22:195-200.
63. Morrison MS, Turin L, King BF, Burnstock G, Arnett TR. ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J Physiol 1998, 511(Pt 2):495-500.
64. 1 receptor on bone cells. FASEB J 2001, 15:1139-1148.
65. 2 receptor knockout mice demonstrates significant changes in bone phenotype. Calcif Tissue Int 2008, 83:2-3.
66. 1 receptor-null mice. J Clin Invest 1999, 104:1731-1737.
67. Wesselius A, Bours MJ, Agrawal A, Gartland A, Dagnelie PC, Schwarz P, Jorgensen NR. Role of purinergic receptor polymorphisms in human bone. Front Biosci 2012, 17:2572-2585.
68. 2 receptor polymorphism: identification and pharmacological characterization of two allelic variants. Br J Pharmacol 1999, 127:709-716.
69. 2+ influx. Pharmacogenet Genomics 2006, 16:199-205.