A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Perez Aguilar, Jose Manuel ^a,d   Xi, Jin ^a   Matsunaga, Felipe ^a   Cui, Xu ^a,b   Selling, Bernard ^c   Saven, Jeffery G ^a   Liu, Renyu ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c Impact Biologicals Inc   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; G PROTEIN COUPLED RECEPTOR; MU OPIATE RECEPTOR; NALTREXONE; WATER;

AQUEOUS SOLUTION; ARTICLE; DISULFIDE BOND; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MATHEMATICAL PHENOMENA; MUTATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR AFFINITY; SOLUBILITY; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; COMPUTATIONAL BIOLOGY; COMPUTER-AIDED DESIGN; ESCHERICHIA COLI; HEK293 CELLS; HUMANS; MERCAPTOETHANOL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN DENATURATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, OPIOID, MU; REDUCING AGENTS; SOLUBILITY; SOLUTIONS; UREA; WATER;

ESCHERICHIA COLI; MURINAE;

EID: 84879163818     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066009     Document Type: Article

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