Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia

International Journal of Hematology

Volumn 97, Issue 6, 2013, Pages 717-725

  Tomita, Akihiro ^a   Kiyoi, Hitoshi ^a   Naoe, Tomoki ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

Author keywords

APL; Arsenic trioxide (As2O3); ATRA; Drug resistance; PML RAR

Indexed keywords

ARSENIC TRIOXIDE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEASOME; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CANCER PROGNOSIS; CANCER RESISTANCE; DRUG MECHANISM; DRUG TARGETING; GENE MUTATION; HUMAN; LIGAND BINDING; MOLECULAR MECHANICS; PROMYELOCYTIC LEUKEMIA; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION;

ANTINEOPLASTIC AGENTS; ARSENICALS; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MOLECULAR TARGETED THERAPY; OXIDES; TRETINOIN;

EID: 84879156094     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-013-1354-4     Document Type: Article

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