메뉴 건너뛰기




Volumn 120, Issue 4, 2012, Pages 847-857

The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; ARSENIC TRIOXIDE; NUCLEOPORIN; PROMYELOCYTIC LEUKEMIA PROTEIN;

EID: 84864459686     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-10-388496     Document Type: Article
Times cited : (35)

References (46)
  • 1
    • 77958456360 scopus 로고    scopus 로고
    • Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
    • Powell BL, Moser B, Stock W, et al. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood. 2010;116(19):3751-3757.
    • (2010) Blood , vol.116 , Issue.19 , pp. 3751-3757
    • Powell, B.L.1    Moser, B.2    Stock, W.3
  • 2
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II Clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II Clinical efficacy and pharmacokinetics in relapsed patients. Blood. 1997;89(9):3354-3360.
    • (1997) Blood. , vol.89 , Issue.9 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3
  • 4
    • 33646386643 scopus 로고    scopus 로고
    • Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia
    • Estey E, Garcia-Manero G, Ferrajoli A, et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood. 2006;107(9):3469-3473.
    • (2006) Blood. , vol.107 , Issue.9 , pp. 3469-3473
    • Estey, E.1    Garcia-Manero, G.2    Ferrajoli, A.3
  • 5
    • 59149089411 scopus 로고    scopus 로고
    • Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin
    • Ravandi F, Estey E, Jones D, et al. Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin. J Clin Oncol. 2009;27(4):504-510.
    • (2009) J Clin Oncol. , vol.27 , Issue.4 , pp. 504-510
    • Ravandi, F.1    Estey, E.2    Jones, D.3
  • 6
    • 77954287020 scopus 로고    scopus 로고
    • PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3
    • Jeanne M, Lallemand-Breitenbach V, Ferhi O, et al. PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. Cancer Cell. 2010;18(1):88-98.
    • (2010) Cancer Cell. , vol.18 , Issue.1 , pp. 88-98
    • Jeanne, M.1    Lallemand-Breitenbach, V.2    Ferhi, O.3
  • 7
    • 77950826446 scopus 로고    scopus 로고
    • Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
    • Zhang XW, Yan XJ, Zhou ZR, et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science. 2010;328(5975):240-243.
    • (2010) Science. , vol.328 , Issue.5975 , pp. 240-243
    • Zhang, X.W.1    Yan, X.J.2    Zhou, Z.R.3
  • 10
    • 0032402135 scopus 로고    scopus 로고
    • Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells
    • Müller S, Miller WH Jr, Dejean A. Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. Blood. 1998;92(11):4308-4316. (Pubitemid 28544348)
    • (1998) Blood , vol.92 , Issue.11 , pp. 4308-4316
    • Muller, S.1    Miller Jr., W.H.2    Dejean, A.3
  • 11
    • 77957716030 scopus 로고    scopus 로고
    • Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
    • Isakson P, Bjørås M, Bøe SO, Simonsen A. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. 2010;116(13):2324-2331.
    • (2010) Blood. , vol.116 , Issue.13 , pp. 2324-2331
    • Isakson, P.1    Bjørås, M.2    Bøe, S.O.3    Simonsen, A.4
  • 12
    • 77958510339 scopus 로고    scopus 로고
    • Acute promyelocytic leukaemia: Novel insights into the mechanisms of cure
    • de Thé H, Chen Z. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat Rev Cancer. 2010;10(11):775-783.
    • (2010) Nat Rev Cancer. , vol.10 , Issue.11 , pp. 775-783
    • De Thé, H.1    Chen, Z.2
  • 13
    • 57349152259 scopus 로고    scopus 로고
    • Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
    • Nasr R, Guillemin MC, Ferhi O, et al. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med. 2008;14(12):1333-1342.
    • (2008) Nat Med. , vol.14 , Issue.12 , pp. 1333-1342
    • Nasr, R.1    Guillemin, M.C.2    Ferhi, O.3
  • 14
    • 79959473062 scopus 로고    scopus 로고
    • From an old remedy to a magic bullet: Molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia
    • Chen SJ, Zhou GB, Zhang XW, Mao JH, de Thé H, Chen Z. From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood. 2011;117(24):6425-6437.
    • (2011) Blood. , vol.117 , Issue.24 , pp. 6425-6437
    • Chen, S.J.1    Zhou, G.B.2    Zhang, X.W.3    Mao, J.H.4    De Thé, H.5    Chen, Z.6
  • 15
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • DOI 10.1038/nrm2277, PII NRM2277
    • Bernardi R, Pandolfi PP. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol. 2007;8(12):1006-1016. (Pubitemid 350174636)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 16
    • 4644351274 scopus 로고    scopus 로고
    • PML nuclear bodies: Dynamic sensors of DNA damage and cellular stress
    • DOI 10.1002/bies.20089
    • Dellaire G, Bazett-Jones DP. PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays. 2004;26(9):963-977. (Pubitemid 39273070)
    • (2004) BioEssays , vol.26 , Issue.9 , pp. 963-977
    • Dellaire, G.1    Bazett-Jones, D.P.2
  • 18
    • 51349118145 scopus 로고    scopus 로고
    • Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis
    • Chen YC, Kappel C, Beaudouin J, Eils R, Spector DL. Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. Mol Biol Cell. 2008;19(7):3147-3162.
    • (2008) Mol Biol Cell. , vol.19 , Issue.7 , pp. 3147-3162
    • Chen, Y.C.1    Kappel, C.2    Beaudouin, J.3    Eils, R.4    Spector, D.L.5
  • 19
    • 33645749156 scopus 로고    scopus 로고
    • Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1
    • Dellaire G, Eskiw CH, Dehghani H, Ching RW, Bazett-Jones DP. Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1. J Cell Sci. 2006;119(6):1034-1042.
    • (2006) J Cell Sci. , vol.119 , Issue.6 , pp. 1034-1042
    • Dellaire, G.1    Eskiw, C.H.2    Dehghani, H.3    Ching, R.W.4    Bazett-Jones, D.P.5
  • 21
    • 66849101623 scopus 로고    scopus 로고
    • Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins
    • Jul-Larsen A, Grudic A, Bjerkvig R, Bøe SO. Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins. J Cell Sci. 2009;122(8):1201-1210.
    • (2009) J Cell Sci. , vol.122 , Issue.8 , pp. 1201-1210
    • Jul-Larsen, A.1    Grudic, A.2    Bjerkvig, R.3    Bøe, S.O.4
  • 23
    • 40149085109 scopus 로고    scopus 로고
    • Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100
    • DOI 10.1128/JVI.02308-07
    • Everett RD, Parada C, Gripon P, Sirma H, Orr A. Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100. J Virol. 2008;82(6):2661-2672. (Pubitemid 351329157)
    • (2008) Journal of Virology , vol.82 , Issue.6 , pp. 2661-2672
    • Everett, R.D.1    Parada, C.2    Gripon, P.3    Sirma, H.4    Orr, A.5
  • 24
    • 79251547017 scopus 로고    scopus 로고
    • PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication
    • Cuchet D, Sykes A, Nicolas A, et al. PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. J Cell Sci. 2011;124(2):280-291.
    • (2011) J Cell Sci , vol.124 , Issue.2 , pp. 280-291
    • Cuchet, D.1    Sykes, A.2    Nicolas, A.3
  • 25
    • 65249179464 scopus 로고    scopus 로고
    • Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes
    • Kita-Matsuo H, Barcova M, Prigozhina N, et al. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. PLoS One. 2009;4(4):e5046.
    • (2009) PLoS One , vol.4 , Issue.4
    • Kita-Matsuo, H.1    Barcova, M.2    Prigozhina, N.3
  • 26
    • 77953100418 scopus 로고    scopus 로고
    • A phase I study of 5-fluorouracil/leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma
    • Ardalan B, Subbarayan PR, Ramos Y, et al. A phase I study of 5-fluorouracil/leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma. Clin Cancer Res. 2010;16(11):3019- 3027.
    • (2010) Clin Cancer Res , vol.16 , Issue.11 , pp. 3019-3027
    • Ardalan, B.1    Subbarayan, P.R.2    Ramos, Y.3
  • 27
    • 38349129611 scopus 로고    scopus 로고
    • Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma
    • Fox E, Razzouk BI, Widemann BC, et al. Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma. Blood. 2008;111(2):566-573.
    • (2008) Blood. , vol.111 , Issue.2 , pp. 566-573
    • Fox, E.1    Razzouk, B.I.2    Widemann, B.C.3
  • 31
    • 0742289410 scopus 로고    scopus 로고
    • Oxidative mechanism of arsenic toxicity and carcinogenesis
    • DOI 10.1023/B:MCBI.0000007262.26044.e8
    • Shi H, Shi X, Liu KJ. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem. 2004;255(1-2):67-78. (Pubitemid 38159766)
    • (2004) Molecular and Cellular Biochemistry , vol.255 , Issue.1-2 , pp. 67-78
    • Shi, H.1    Shi, X.2    Liu, K.J.3
  • 32
    • 33745728153 scopus 로고    scopus 로고
    • Characterization of endogenous human promyelocytic leukemia isoforms
    • Condemine W, Takahashi Y, Zhu J, et al. Characterization of endogenous human promyelocytic leukemia isoforms. Cancer Res. 2006;66(12):6192-6198.
    • (2006) Cancer Res. , vol.66 , Issue.12 , pp. 6192-6198
    • Condemine, W.1    Takahashi, Y.2    Zhu, J.3
  • 33
    • 0035969125 scopus 로고    scopus 로고
    • PML protein isoforms and the RBCC/TRIM motif
    • DOI 10.1038/sj.onc.1204765
    • Jensen K, Shiels C, Freemont PS. PML protein isoforms and the RBCC/TRIM motif. Oncogene. 2001;20(49):7223-7233. (Pubitemid 33105011)
    • (2001) Oncogene , vol.20 , Issue.49 REV. IIS. 6 , pp. 7223-7233
    • Jensen, K.1    Shiels, C.2    Freemont, P.S.3
  • 34
    • 33750447586 scopus 로고    scopus 로고
    • The Mechanisms of PML-Nuclear Body Formation
    • DOI 10.1016/j.molcel.2006.09.013, PII S1097276506006617
    • Shen TH, Lin HK, Scaglioni PP, Yung TM, Pandolfi PP. The mechanisms of PML-nuclear body formation. Mol Cell. 2006;24(3):331-339. (Pubitemid 44647906)
    • (2006) Molecular Cell , vol.24 , Issue.3 , pp. 331-339
    • Shen, T.H.1    Lin, H.-K.2    Scaglioni, P.P.3    Yung, T.M.4    Pandolfi, P.P.5
  • 35
    • 80051635934 scopus 로고    scopus 로고
    • Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment
    • Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T. Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment. Blood. 2011;118(6):1600-1609.
    • (2011) Blood. , vol.118 , Issue.6 , pp. 1600-1609
    • Goto, E.1    Tomita, A.2    Hayakawa, F.3    Atsumi, A.4    Kiyoi, H.5    Naoe, T.6
  • 36
    • 0028179010 scopus 로고
    • A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
    • DOI 10.1016/0092-8674(94)90340-9
    • Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell. 1994;76(2):333-343. (Pubitemid 24046695)
    • (1994) Cell , vol.76 , Issue.2 , pp. 333-343
    • Dyck, J.A.1    Maul, G.G.2    Miller Jr., W.H.3    Chen, J.D.4    Kakizuka, A.5    Evans, R.M.6
  • 38
    • 0028158682 scopus 로고
    • Retinoic acid regulates aberrant nuclear localization of PML-RARalpha in acute promyelocytic leukemia cells
    • DOI 10.1016/0092-8674(94)90341-7
    • Weis K, Rambaud S, Lavau C, et al. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. Cell. 1994;76(2):345-356. (Pubitemid 24046696)
    • (1994) Cell , vol.76 , Issue.2 , pp. 345-356
    • Weis, K.1    Rambaud, S.2    Lavau, C.3    Jansen, J.4    Carvalho, T.5    Carmo-Fonseca, M.6    Lamond, A.7    Dejeant, A.8
  • 39
    • 78649425814 scopus 로고    scopus 로고
    • PML regulates apoptosis at endoplasmic reticulum by modulating calcium release
    • Giorgi C, Ito K, Lin HK, et al. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 2010;330(6008):1247-1251.
    • (2010) Science. , vol.330 , Issue.6008 , pp. 1247-1251
    • Giorgi, C.1    Ito, K.2    Lin, H.K.3
  • 40
    • 4544256756 scopus 로고    scopus 로고
    • Cytoplasmic PML function in TGF-beta signalling
    • DOI 10.1038/nature02783
    • Lin HK, Bergmann S, Pandolfi PP. Cytoplasmic PML function in TGF-beta signalling. Nature. 2004;431(7005):205-211. (Pubitemid 39243475)
    • (2004) Nature , vol.431 , Issue.7005 , pp. 205-211
    • Lin, H.-K.1    Bergmann, S.2    Pandolfi, P.P.3
  • 41
    • 78449241862 scopus 로고    scopus 로고
    • Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
    • Jul-Larsen A, Grudic A, Bjerkvig R, Bøe SO. Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein. BMC Mol Biol. 2010;11:89.
    • (2010) BMC Mol Biol. , vol.11 , pp. 89
    • Jul-Larsen, A.1    Grudic, A.2    Bjerkvig, R.3    Bøe, S.O.4
  • 43
    • 43849086108 scopus 로고    scopus 로고
    • Arsenic trioxide in environmentally and clinically relevant concentrations interacts with calcium homeostasis and induces cell type specific cell death in tumor and non-tumor cells
    • Florea AM, Busselberg D. Arsenic trioxide in environmentally and clinically relevant concentrations interacts with calcium homeostasis and induces cell type specific cell death in tumor and non-tumor cells. Toxicol Lett. 2008;179(1):34-42.
    • (2008) Toxicol Lett. , vol.179 , Issue.1 , pp. 34-42
    • Florea, A.M.1    Busselberg, D.2
  • 45
    • 80052798438 scopus 로고    scopus 로고
    • Arsenic exposure and toxicology: A historical perspective
    • Hughes MF, Beck BD, Chen Y, Lewis AS, Thomas DJ. Arsenic exposure and toxicology: a historical perspective. Toxicol Sci. 2011;123(2):305-332.
    • (2011) Toxicol Sci , vol.123 , Issue.2 , pp. 305-332
    • Hughes, M.F.1    Beck, B.D.2    Chen, Y.3    Lewis, A.S.4    Thomas, D.J.5
  • 46
    • 0037150531 scopus 로고    scopus 로고
    • Public health: Worldwide occurrences of arsenic in ground water
    • Nordstrom DK. Public health: worldwide occurrences of arsenic in ground water. Science. 2002;296(5576):2143-2145.
    • (2002) Science. , vol.296 , Issue.5576 , pp. 2143-2145
    • Nordstrom, D.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.