Relapsed acute promyelocytic leukemia previously treated with all-trans retinoic acid: Clinical experience with a new synthetic retinoid, Am-80

Leukemia and Lymphoma

Volumn 31, Issue 5-6, 1998, Pages 441-451

  Takeuchi, Makoto ^a   Yano, Tomofumi ^b   Omoto, Eijiro ^b   Takahashi, Kiyoshi ^a   Kibata, Masayoshi ^a   Shudo, Kouichi ^c   Harada, Mine ^b   Ueda, Ryuzo ^d   Ohno, Ryuzo ^e  

^a National Hospital Organization   (Japan)

^b OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

^e HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute promyelocytic leukemia; All trans retinoic acid; Am 80; Differentiation therapy; PML RAR chimeric messenger

Indexed keywords

RETINOIC ACID; RETINOID; TAMIBAROTENE;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CHEILITIS; DRUG RESISTANCE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; LEUKEMIA REMISSION; LEUKOCYTOSIS; PRIORITY JOURNAL; RELAPSE; RETINOIC ACID SYNDROME; XEROSIS;

EID: 0032464716     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057604     Document Type: Article

References (53)

1. Huang, ME., Ye, YC., Chen, SR., Chai, JR., Lu, J., Zhoa, L., Gu, LJ., and Wang, Z. (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 72, 567-572.
2. Castaigne, S., Chomienne, C., Daniel, M.T., Ballerini, P., Berger, R., Fenaux, P., and Degos, L. (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia I. Clinical results. Blood,76, 1704-1709.
3. Warrell, R.P. Jr, Frankel, S.R., Miller, W.H., Scheinberg, D.A., Itri, L.M., Hittelman, W.N., Vyas, R., Andreeff, M., Tafuri, A., Jakubowski, A., et al(1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). New England Journal of Medicine,324,1385-1393.
4. Ohno, R., Yoshida, H., Fukutani, H., Naoe, T., Ohshima, T., Kyo, T., Endoh, N., Fujimoto, T., Kobayashi, T., Hiraoka, A., Mizoguchi, H., Kodera, Y., Suzuki, H., Hirano, M., Akiyama, H., Aoki, N., Shindo, H., Yokomaru, S. and the Leukemia Study Group of the Ministry and Welfare (1993) Multi-institutional study of all-trans retinoic acid as a differentiation tharapy of refractory acute promyelocytic leukemia. Luekaemia Study group of the Ministry of Health and Welfare. Leukemia, 7, 1722-1727.
5. Ohno, R., Ohnishi, K., Taktshita, A., Tanomoto, M., Murakami, H., Kanamaru, A., Asou, N., Kobayashi, T., Kuriyama, K., Ohmoto, E., Sakamaki, H., Tsubaki, K., Hiraoka, A., Yamada, O., Oh, H., Furusawa, S., Matsuda, S., and Naoe, T. (1994) All-trans retinoic acid tharapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia(APL) in Japan. Leukemia 8 supplement 3,64-69.
6. Frankel, S.R., Eardley, A., Heller, G., Berman, E., Miller, WH., Dmitrovsky, E. and Warrell, R.P. Jr. (1994) All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study. Annals of Internal Medicine, 120, 278-286.
7. Kanamaru, A., Takemoto, Y., Tanimoto, M., Murakami, H., Asou, N., Kobayashi, T., Kuriyama, K., Ohmoto, E., Sakamaki, H., Tsubaki, K., Hiraoka, A., Yamada, O., Oh, H., Saito, K., Matsuda, S., Minato, K., Ueda, T., Ohno, R. and the Japan Adult Leukemia Study Group (1995) All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group. Blood, 85, 1202-1206.
8. Asou, N., Adachi, K., Tamura, J., Kanamaru, A., Kageyama, S., Hiraoka, A., Omoto, E., Sakamaki, H., Tsubaki, K., Saito, K., Ohono, R., and Japan Adult Leukemia Study Group (JALSG) (1997) All-trans retinoic acid tharapy for newly diagnosed acute promyelocytic leukemia: comparison with intensive chemotherapy, the Japan Adult Leukemia Study Group (JALSG). Cancer Chemotherapy and Pharmacology, 40 supplement, 30-35.
9. Chen, ZX., Xue, YQ., Zhang, R., Tao, RF., Xia, XM., Li, C., Wang, W., Zu, WY., Yao, XZ., and Ling, BJ. (1991) A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients. Blood,78, 1413-1419.
10. Warrell, R.P. Jr, de The' H, Wang, Z.Y., and Degos, L. (1993) Acute promyelocytic leukemia. New England Journal of Medicine,329,177-189.
11. Warrel, R.P. Jr, Maslak, P., Eardley, A., Heller, G., Miller, W.H. Jr., and Frankel, SR. (1994) Treatment of acute promyelocytic leukemia with all-trans retinoic acid: An update of the New York experience. Leukemia, 8 supplement 2, 33.
12. Yamada, O., Hatake, K., Tanimoto, M., Ishiyama, T., Ohno, R., Shirakawa, S., Horiuchi, A., Tomonaga, M., and Ohta, K. (1994) Co-operative study of all-trans retinoic acid as a differentiation induction therapy of acute promyelocytic leukemia. Gan To Kagakuryoho,21,1981-1989.
13. Degos, L., Dombret, H., Chomienne, C., Daniel, M.T., Miclea, J.M., Chastang, C., Castaigne, S., and Fenaux, P. (1995) All-trans retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood 85,2643-2653.
14. 3analogs. Leukemia Research,20,761-769.
15. Li, YP., Said, F., and Gallagher, RE. (1994) Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-α. Blood,83, 3298-3302.
16. Kizaki, M., Matsushita, H., Takayama, N., Muto, A., Ueno, H., Awaya, N., Kawai, Y., Asou, H, Kamada, N., and Ikeda, Y. (1996) Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features. Blood,88,1824-1833.
17. Robertson, KA., Emami, B., and Collins, SJ., (1992) Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood,80, 1885-1889.
18. Muindi, J., Frankel, S.R., Miller, W.H. Jr., Jakubowski, A., Scheinberg, D.A., Young, C.W., Dmitrovsky, E., and Warrell, R.P. Jr (1992) Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. Blood, 79,299-303.
19. Muindi, J.R., Frankel, S.R., Huselton, C., DeGrazia, F., Garland, W.A., Young, C.W., and Warrell, R.P. Jr (1992) Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia. Cancer Research, 52,2138-2142.
20. Usuki, K., Endo, M., Osawa, M., Kitazume, K., Iki, S. and Urabe, A (1996) Pharmacokinetics of all-trans-retinoic acid in Japanese patients with acute promyelocytic leukemia. International Journal of Hematology,63,19-23.
21. Agadir, A., Cornic, M., Lefebvre, P., Goumel, B., Jerome, M., Degos, L., Fenaux, P. and Chomienne, C. (1995) All trans retinoic acid pharmacokinetics and bioavailability in acute promyelocytic leukemia: Intracellular concentrations and biologic response relationship. Journal of Clinical Oncology, 13, 2517-2523.
22. Roberts, A.B., Nichols, M.D., Newton, D.L., and Sporn, M.B. (1979) In vitro metabolism of retinoic acid in hamster intestine and liver. Journal of Biological Chemistry,254, 6296-6302.
23. Roberts, A.B., Lamb, L.C., and Sporn, M.B. (1980) Metabolism of all-trans retinoic acid in hamster liver microsomes: Oxidation of 4-hydroxy-to 4-keto retinoic acid. Archives of Biochemistry and Biophysics,199,374-383.
24. Muindi, J.F. and Young, C.W. (1993) Lipid hydroperoxidases greatly increase the rate of oxidative catabolism of all-trans retinoic acid by human cell culture microsomes genetically enriched in specified cytochrome P-450 isoforms. Cancer Research, 53,1226-1229.
25. Kizaki, M., Ueno, H., Yamazoe, Y., Shimada, M., Takayama, N., Muto, A., Matsushita, H., Nakajima, H., Morikawa, M., Koeffler, HP. and Ikeda, Y. (1996) Mechanisms of retinoid resistance in leukemic cells: Possible role of cytochrome P450 and P-glycoprotein. Blood,87,725-733
26. Cornic, M., Delva, L., Guidez, F., Balitrand, N., Degos, L., and Chomienne, C. (1992) Induction of retinoic acid-binding protein in normal and malignant human myeloid cells by retinoic acid in acute promyelocytic leukemia patients. Cancer Research,52,3329-3334.
27. Cornic, M., Delva, L., Castaigne, S., Lefebvre, P., Balitrand, N., Degos, L., and Chomienne, C. (1994) In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia. Leukemia,8,914-917.
28. Adamson, P.C., Boylan, J.F., Balis, F.M., Murphy, R.F., Godwin, K.A., Gudas, L.J., and Poplack, D.G. (1993) Time Course of Induction of Metabolism of all-trans-retinoic acid and the up-regulation of cellular retinoic acid-binding protein. Cancer Research,53,472-476.
29. Delva, L., Cornic, M., Balitrand, N., Guidez, F., Miclea, J.M., Delmer, A., Teillet, F., Fanaux, P., Castaigne, S., Degos, L., Chomienne, C. et al (1993) Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: Study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells. Blood,82,2175-2181.
30. Hirschel-Scholz, S., Siegenthaler, G., and Saurat, JH. (1989) Ligand-specific and non-specific in vivo modulation of human epidermal cellular retinoic acid binding protein (CRABP). European Journal of Clinical investigation,19,220-227.
31. Hirschel-Scholz, S., Siegenthaler, G., and Saurat, JH. (1989) Isotretinoin differs from other synthetic retinoids in its modulation of human cellular retinoic acid binding protein (CRABP). British journal of dermatology, 120,639-644.
32. Miller W.H. Jr, Jakubowski, A., Tong W.P., Miller V.A., Rigas J.R., Benedetti F., Gill G.M., Truglia J.A., Ulm E., Shirley M. & Warrell R.P. (1995) 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood 85; 3021-3027.
33. Rigas, J.R., Francis, P.A., Muindi, J.R., Kris, M.G., Huselton, C., DeGrazia, F., Orazem, J.P., Young C.W., and Warrell, R.P. Jr. (1993) Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole. Journal of the National Cancer Institute,85,1921-1926.
34. Schwartz, E.L., Hallam, S., Gallagher, R.E., and Wiernik, P.H. (1995) Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia. Biochemical Pharmacology,50, 23-928.
35. Estey, E., Thall, P.F., Mehta, K., Rosenblum, M., Brewer, T. Jr, Simmons, V., Cabanillas, F., Kurzrock, R., and Lopez-Berestein, G. (1996) Alterations in tretinoin pharmacokinetics following administration of liposomal all-trans retinoic acid. Blood,87,3650-3654.
36. Hashimoto, Y. and Shudo, K. (1991) Retinoids and their nuclear receptors. Cell biology reviews,25,209-230.
37. Hashimoto, Y. (1991) Retinobenzoic acids and nuclear retinoic acid receptors. Cell structure and function, 16,113-123.
38. Zelent, A., Krust, A., Petkovich, M., Kastner, P., and Chambon, P. (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature,339,714-717.
39. Kagechika, H., Kawachi, E., Hashimoto, Y., Himi, T., and Shudo, K. (1988) Retinobenzoic acids.1.Structure-activity relationships of aromatic amides with retinoidal activity. Journal of Medical Chemistry,31,2182-2192.
40. Hashimoto, Y., Kagechika, H., Kawachi, E., Fukasawa, H., Saito, G., and Shudo, K. (1995) Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB-4. Journal of Cancer Research and Clinical Oncology,121,696-698.
41. Okamura, T., Masuda, M., Arai, Y. and Mizoguchi, H. (1995) Am-80 induced differentiation of HL60 myeloid leukemic cells. International Journal of Hematology 61 Supplement 159.
42. Tobita, T., Takeshita, A., Kitamura, K., Ohnishi, K., Yanagi, am., Hiraoka, A., Karasuno, T., Takeuchi, M., Miyawaki, S., Ueda, R., Naoe, T., and Ohno, R. (1997) Treatment with a new synthetic retinoid, Am-80, of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid. Blood,90,967-973.
43. Takeshita, A., Shibata, Y., Shinjo, K., Yanagi, M., Tobita, T., Ohnishi, K., Miyawaki, S., Shudo, K., and Ohono R. (1996) Successful treatment of relapse of acute promyelocytic leukemia with a new synthetic retinoid, Am80. Annals of Internal Medicine 124; 893-896.
44. Takeuchi, M., Yano, T., Omoto, E., Takahashi, K., Kibata, M., Shudo, K., Ueda, R., Ohono, R., and Harada, M. (1997) Re-induction of complete remission with a new synthetic retinoid, Am-80, for relapse of acute promyelocytic leukaemia previously treated with all-trans retinoic acid. British Journal of Haematology,97,137-140.
45. Chomienne, C., Ballerini, P., Balitrand, N., Daniel, M.T., Fenaux, P., Castaigne, S. and Degos, L. (1990) All-trans retinoic acid in acute promyelocytic leukemias. II In vitro studies; Structure-function relationship. Blood 76; 1710-1717.
46. Dyck, J.A., Maul, G.G., Miller, W.H. Jr., Chen, J.D., Kakizuka, A., and Evans, R.M. (1994) A novel macromolecular structure is a target for the promyelocytic-retinoic acid receptor oncoprotein. Cell,76, 333-343.
47. Dyck, J.A., Warrell, R.P. Jr., Evans, R.M., and Miller, W.H. Jr., (1995) Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RARα protein. Blood,86,862-867.
48. Naoe, T., Yoshida, H., Kitamura, K., Chino, M., Osumi, K., and Ohno, R. (1995) Delayed or insufficient restoration of PML and PML-RARα subcellular localization after exposure in vitro to retinoic acids in all-trans retinoic acid-resistant APL cells. Leukemia,9,1610-1611.
49. Weis, K., Ramboaud, S., Lavau, C., Jansen, J., Carvalho, T., Carmo-Fonseca, M., Lamond, A., and Dejean, A. (1994) Retinoic acid regulates aberrant nuclear localization of PML-RAR α in acute promyelocytic leukemia cells. Cell,76,345-356.
50. Yoshida, H., Kitamura, K., Tanaka, K., Omura, S., Miyazaki, T., Hachiya, T., Ohno, R., and Naoe, T. (1996) Accelerated degradation of PML-retinoic acid receptor α (PML-RARA) oncoprotein by all-trans retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Research,56,2945-2948.
51. 4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARα/PML proteins. Blood,88,1052-1061.
52. Kitamura, K., Yoshida, H., Ohno, R., and Naoe, T. (1997) Toxic effects of arsenic (As3+) and other metal ions on acute promyelocytic leukemia cells. International Journal of Hematology,65,179-185.
53. 3) in the treament of APL: II Remission induction in relapsed patients and pharmacokinetics. Blood, 88 (abstr,suppl), 1996.