-
1
-
-
70349467775
-
Anthracycline dose intensification in acute myeloid leukemia
-
Fernandez HF, et al. Anthracycline dose intensification in acute myeloid leukemia. New Engl J Med. 2009;361:1249-59.
-
(2009)
New Engl J Med
, vol.361
, pp. 1249-1259
-
-
Fernandez, H.F.1
-
2
-
-
77449159028
-
Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the european leukemianet
-
Döhner H, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115:453-74.
-
(2010)
Blood
, vol.115
, pp. 453-474
-
-
Döhner, H.1
-
3
-
-
79952079063
-
Modern approaches to treating acute promyelocytic leukemia
-
Sanz MA, Lo-Coco F. Modern approaches to treating acute promyelocytic leukemia. J Clin Oncol. 2011;29:495-503.
-
(2011)
J Clin Oncol
, vol.29
, pp. 495-503
-
-
Sanz, M.A.1
Lo-Coco, F.2
-
4
-
-
61949441174
-
Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
-
Sanz MA, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2009;113:1875-91.
-
(2009)
Blood
, vol.113
, pp. 1875-1891
-
-
Sanz, M.A.1
-
5
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley TJ, et al. DNMT3A mutations in acute myeloid leukemia. New Engl J Med. 2010;363:2424-33.
-
(2010)
New Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
-
6
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F, et al. Mutation in TET2 in myeloid cancers. New Engl J Med. 2009;360:2289-301.
-
(2009)
New Engl J Med
, vol.360
, pp. 2289-2301
-
-
Delhommeau, F.1
-
7
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
-
Marcucci G, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28:2348-55.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2348-2355
-
-
Marcucci, G.1
-
8
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. New Engl J Med. 2009;361: 1058-66.
-
(2009)
New Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
-
9
-
-
33646404606
-
Age and acute myeloid leukemia
-
Appelbaum FR, et al. Age and acute myeloid leukemia. Blood. 2006;107:3481-5.
-
(2006)
Blood
, vol.107
, pp. 3481-3485
-
-
Appelbaum, F.R.1
-
10
-
-
77957715843
-
Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: The Southwest Oncology Group (SWOG) experience
-
Medeiros BC, Othus M, Fang M, Roulston D, Appelbaum FR. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood. 2010;116:2224-8.
-
(2010)
Blood
, vol.116
, pp. 2224-2228
-
-
Medeiros, B.C.1
Othus, M.2
Fang, M.3
Roulston, D.4
Appelbaum, F.R.5
-
11
-
-
0036839013
-
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
-
Richardson PG, et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood. 2002;100:3063-7.
-
(2002)
Blood
, vol.100
, pp. 3063-3067
-
-
Richardson, P.G.1
-
12
-
-
69949096727
-
Mechanism of action of lenalidomide in hematological malignancies
-
Kotla V, et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009;2:36.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 36
-
-
Kotla, V.1
-
13
-
-
79951495012
-
A phase 2 study of high-dose lenalidomide as initial therapy for older patients with acute myeloid leukemia
-
Fehniger TA, et al. A phase 2 study of high-dose lenalidomide as initial therapy for older patients with acute myeloid leukemia. Blood. 2011;117:1828-33.
-
(2011)
Blood
, vol.117
, pp. 1828-1833
-
-
Fehniger, T.A.1
-
14
-
-
79952384705
-
Cancer epigenetics reaches mainstream oncology
-
doi:10.1038/nm. 2305
-
Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med. 2012:1-10.doi:10.1038/nm. 2305.
-
(2012)
Nat Med
, pp. 1-10
-
-
Rodríguez-Paredes, M.1
Esteller, M.2
-
15
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M. Epigenetics in cancer. New Engl J Med. 2008;358: 1148-59.
-
(2008)
New Engl J Med
, vol.358
, pp. 1148-1159
-
-
Esteller, M.1
-
16
-
-
79952377463
-
Resistance, epigenetics and the cancer ecosystem
-
Baylin SB. Resistance, epigenetics and the cancer ecosystem. Nat Med. 2011;17:288-9.
-
(2011)
Nat Med
, vol.17
, pp. 288-289
-
-
Baylin, S.B.1
-
17
-
-
33750078985
-
Treatment of acute myelogenous leukemia with outpatient azacitidine
-
Sudan N, et al. Treatment of acute myelogenous leukemia with outpatient azacitidine. Cancer. 2006;107:1839-43.
-
(2006)
Cancer
, vol.107
, pp. 1839-1843
-
-
Sudan, N.1
-
18
-
-
77952140672
-
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
-
Blum W, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA. 2010;107:7473-8.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7473-7478
-
-
Blum, W.1
-
19
-
-
77449149373
-
Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
-
Fenaux P, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol. 2010;28:562-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 562-569
-
-
Fenaux, P.1
-
20
-
-
77449149374
-
Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
-
Cashen AF, Schiller GJ, O'Donnell MR, DiPersio JF. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol. 2010;28:556-61.
-
(2010)
J Clin Oncol
, vol.28
, pp. 556-561
-
-
Cashen, A.F.1
Schiller, G.J.2
O'Donnell, M.R.3
Dipersio, J.F.4
-
21
-
-
80051604949
-
Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
-
Scandura JM, et al. Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood. 2011;118:1472-80.
-
(2011)
Blood
, vol.118
, pp. 1472-1480
-
-
Scandura, J.M.1
-
23
-
-
51649097598
-
A pilot pharmacokinetic study of oral azacitidine
-
Garcia-Manero G, Stoltz ML, Ward MR, Kantarjian H, Sharma S. A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008;22:1680-4.
-
(2008)
Leukemia
, vol.22
, pp. 1680-1684
-
-
Garcia-Manero, G.1
Stoltz, M.L.2
Ward, M.R.3
Kantarjian, H.4
Sharma, S.5
-
24
-
-
79959318635
-
Phase i study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia
-
Garcia-Manero G, et al. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. J Clin Oncol. 2011;29:2521-7.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2521-2527
-
-
Garcia-Manero, G.1
-
25
-
-
79952977561
-
Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
-
Piekarz RL, et al. Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma. Blood. 2011;117:5827-34.
-
(2011)
Blood
, vol.117
, pp. 5827-5834
-
-
Piekarz, R.L.1
-
26
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen EA, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol. 2007;25:3109-15.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
-
27
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol. 2009;27:5459-68.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
28
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
Gore SD, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res. 2006;66:6361-9.
-
(2006)
Cancer Res
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
-
29
-
-
84855448173
-
HDAC inhibitors: Modulating leukocyte differentiation, survival, proliferation and inflammation
-
Sweet MJ, Shakespear MR, Kamal NA, Fairlie DP. HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation. Immunol Cell Biol. 2012;90:14-22.
-
(2012)
Immunol Cell Biol
, vol.90
, pp. 14-22
-
-
Sweet, M.J.1
Shakespear, M.R.2
Kamal, N.A.3
Fairlie, D.P.4
-
30
-
-
84864011031
-
Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome
-
doi:10.1200/JCO.2011.8.3265
-
Garcia-Manero G, et al. Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome. J Clin Oncol. 2012. doi:10.1200/JCO.2011.8.3265.
-
(2012)
J Clin Oncol
-
-
Garcia-Manero, G.1
-
31
-
-
80054694510
-
Global identification of modular cullin-RING ligase substrates
-
Emanuele MJ, et al. Global identification of modular cullin-RING ligase substrates. Cell. 2011;147:459-74.
-
(2011)
Cell
, vol.147
, pp. 459-474
-
-
Emanuele, M.J.1
-
32
-
-
77952558703
-
Inhibition of NEDD8-activating enzyme: A novel approach for the treatment of acute myeloid leukemia
-
Swords RT, et al. Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood. 2010;115:3796-800.
-
(2010)
Blood
, vol.115
, pp. 3796-3800
-
-
Swords, R.T.1
-
34
-
-
77950929054
-
Phase i study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia
-
Lancet JE, et al. Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia. Leukemia. 2010;24:699-705.
-
(2010)
Leukemia
, vol.24
, pp. 699-705
-
-
Lancet, J.E.1
-
35
-
-
55049108527
-
Vivo maintenance of synergistic cytarabine: Daunorubicin ratios greatly enhances therapeutic efficacy
-
Tardi P, et al. In vivo maintenance of synergistic cytarabine: daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res. 2009;33:129-39.
-
(2009)
Leuk Res
, vol.33
, pp. 129-139
-
-
Tardi, P.1
-
36
-
-
79952757852
-
First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia
-
Feldman EJ, et al. First-in-man study of CPX-351: a liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia. J Clin Oncol. 2011;29:979-85.
-
(2011)
J Clin Oncol
, vol.29
, pp. 979-985
-
-
Feldman, E.J.1
-
38
-
-
66249093516
-
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo
-
Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009;69:4150-8.
-
(2009)
Cancer Res
, vol.69
, pp. 4150-4158
-
-
Oke, A.1
-
39
-
-
82955217793
-
Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
-
Lowenberg B, et al. Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia. Blood. 2011;118:6030-6.
-
(2011)
Blood
, vol.118
, pp. 6030-6036
-
-
Lowenberg, B.1
-
40
-
-
33751175224
-
Barriers in phase i cancer clinical trials referrals and enrollment: Five-year experience at the princess margaret hospital
-
Ho J, et al. Barriers in phase I cancer clinical trials referrals and enrollment: five-year experience at the Princess Margaret Hospital. BMC Cancer. 2006;6:263.
-
(2006)
BMC Cancer
, vol.6
, pp. 263
-
-
Ho, J.1
-
41
-
-
84860747223
-
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
-
doi:10.1038/nature11016
-
Smith CC, et al. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature. 2012;1-6. doi:10.1038/ nature11016.
-
(2012)
Nature
, pp. 1-6
-
-
Smith, C.C.1
-
42
-
-
82655184653
-
Personalized oncology through integrative high-throughput sequencing: A pilot study
-
Roychowdhury S, et al. Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med. 2011;3:111ra121.
-
(2011)
Sci Transl Med
, vol.3
-
-
Roychowdhury, S.1
|